Postprandial Lipemia and Glycemia Following a High-Fat Meal
Acute Effects of White Button and Shiitake Mushroom Powder Supplementation on Postprandial Lipemia and Glycemia Following a High-Fat Meal
1 other identifier
interventional
16
0 countries
N/A
Brief Summary
The goal of this clinical trial is to determine the acute effects on postprandial lipemia and glycemia by supplementing a high-fat meal with either white button (WB) or shiitake (SH) mushroom powder in relatively healthy adults, aged 18 to 35.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2014
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 29, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2022
CompletedFirst Submitted
Initial submission to the registry
November 9, 2022
CompletedFirst Posted
Study publicly available on registry
November 17, 2022
CompletedMarch 27, 2023
March 1, 2023
1.5 years
November 9, 2022
March 23, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Postprandial Lipemia
Total cholesterol, LDL, HDL, triglycerides
Baseline, up to 6 hours postprandial
Postprandial Glycemia
blood glucose
Baseline, up to 6 hours postprandial
Study Arms (3)
White Button Mushroom
EXPERIMENTAL368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams white button mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun
Shiitake Mushroom
EXPERIMENTAL368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams Shiitake mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun
Control
NO INTERVENTION368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) and a Wegmans Food Market Brand Big Hawaiian bun.
Interventions
Ground shiitake mushrooms or ground white button mushrooms
Eligibility Criteria
You may qualify if:
- generally healthy
- non-diabetic
- normal to mildly hypercholesterolemic (Total Cholesterol 200-239 mg/dL and LDL-C 130-159 mg/dL)
- have BMI \<30 or BF% (men \<25%, women \<32%)
- no known disease of the liver or gallbladder
- no documented problems with fat metabolism
- normal lipemic response to a lipid challenge
- No known mushroom allergy
You may not qualify if:
- diabetic
- pregnant
- BMI \>30
- liver disease
- gallbladder disease
- mushroom allergy
- lipid disorder
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Lillian A. Talal, Huipei Wang, Brian T. Wil-liams, Matthew J. Morris, Peter J. Horvath (2023) Acute Effects of White Button and Shiitake Mushroom Powder Supplementa-tion on Postprandial Lipemia and Glycemia Following a High-Fat Meal . International Journal of Nutrition - 7(2):42-56.
RESULT
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Masking Details
- Double-blind, randomized
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
November 9, 2022
First Posted
November 17, 2022
Study Start
December 29, 2014
Primary Completion
July 1, 2016
Study Completion
June 1, 2022
Last Updated
March 27, 2023
Record last verified: 2023-03