Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance

NCT03159065 | Completed

• 1 other identifier: InVeg (1)
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being. It has previously been observed that consumption of a bilberry drink decreases the postprandial insulin demand. In the present study, the impact of probiotic fruit beverages with different polyphenol profiles on the postprandial levels of glucose and insulin, were investigated.

Conditions

Postprandial Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• Efficacy of the study products on the postprandial serum insulin

  The postprandial incremental area under the curve for serum insulin

  Incremental area under the curve for serum insulin from 0 min up to 120 min following the ingestion of the study product

Secondary Outcomes (1)

• Efficacy of the study products on the postprandial serum glucose

  Incremental area under the curve for serum glucose from 0 min up to 120 min following the ingestion of the study product

Study Arms (6)

Bilberry

EXPERIMENTAL

A bilberry-based beverage with fermented oatmeal

Other: Bilberry

Blackcurrant

EXPERIMENTAL

A blackcurrant-based beverage with fermented oatmeal

Other: Blackcurrant

Mango

EXPERIMENTAL

A mango-based based beverage with fermented oatmeal

Other: Mango

Beetroot

EXPERIMENTAL

A beetroot-based based beverage with fermented oatmeal

Other: Beetroot

Rose hip

EXPERIMENTAL

A rose hip-based based beverage with fermented oatmeal

Other: Rose hip

Glucose drink

ACTIVE COMPARATOR

A reference glucose drink

Other: Glucose drink

Interventions

Bilberry OTHER

Fruit beverage with bilberry and fermented oatmeal

Bilberry

Blackcurrant OTHER

Fruit beverage with blackcurrant and fermented oatmeal

Blackcurrant

Mango OTHER

Fruit beverage with mango and fermented oatmeal

Mango

Beetroot OTHER

Fruit beverage with beetroot and fermented oatmeal

Beetroot

Rose hip OTHER

Fruit beverage with rose hip and fermented oatmeal

Rose hip

Glucose drink OTHER

A reference glucose drink

Glucose drink

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy, not on medication, non-allergic, individuals aged 18-65 years old, having a BMI between 20-30 kg/m2 and also maintaining stable body weight, i.e. less than 5% weight change in the last three months before the study.

Sponsors & Collaborators

• Lund University: lead

Related Publications (1)

• Xu J, Jonsson T, Plaza M, Hakansson A, Antonsson M, Ahren IL, Turner C, Spegel P, Granfeldt Y. Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response. Nutr J. 2018 Feb 27;17(1):34. doi: 10.1186/s12937-018-0335-0.

  PMID: 29486772 DERIVED

MeSH Terms

Conditions

Hyperglycemia

Interventions

Vaccinium myrtillus extract; Mangifera indica extract

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Yvonne Granfeldt, Prof

  Lund University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SCREENING
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Senior Lecturer

Study Record Dates

• First Submitted: May 17, 2017
• First Posted: May 18, 2017
• Study Start: September 1, 2014
• Primary Completion: November 1, 2014
• Study Completion: January 1, 2015
• Last Updated: May 19, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share