Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia
1 other identifier
interventional
80
0 countries
N/A
Brief Summary
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2014
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2015
CompletedFirst Submitted
Initial submission to the registry
August 26, 2015
CompletedFirst Posted
Study publicly available on registry
January 13, 2016
CompletedJanuary 13, 2016
August 1, 2015
6 months
August 26, 2015
January 12, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change of serum glucose levels
a week interval
Secondary Outcomes (2)
Change of serum insulin levels
a week interval
Change of serum C-peptide levels
a week interval
Study Arms (4)
Control group
PLACEBO COMPARATORsucrose drink (Control, sucrose 50g + deionized water 100g)
5 g xylose group
ACTIVE COMPARATOR5 g xylose (Test 1, sucrose : xylose = 10:1),
3.33 g xylose group
ACTIVE COMPARATOR3.33 g xylose (Test 2, sucrose : xylose = 15:1)
2.5 g xylose group
ACTIVE COMPARATOR2.5 g xylose (Test 3, sucrose : xylose = 20:1)
Interventions
sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g
sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g
sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g
Eligibility Criteria
You may qualify if:
- \) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)
You may not qualify if:
- history of taking an insulin-injection or oral hypoglycemic agents
- evidence of alcohol abuse or alcoholism
- pregnancy or breast feeding
- chronic gastrointestinal disorder
- seriously abnormal liver or renal function
- an occupation at risk of death when hypoglycemia occurs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Jun YJ, Lee J, Hwang S, Kwak JH, Ahn HY, Bak YK, Koh J, Lee JH. Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design. Trials. 2016 Mar 15;17(1):139. doi: 10.1186/s13063-016-1261-0.
PMID: 26979433DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jong Ho Lee, Ph.D
Laboratory of clinical nutrigenetics/nutrigenomics, Yonsei University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Department of Food and Nutrition
Study Record Dates
First Submitted
August 26, 2015
First Posted
January 13, 2016
Study Start
June 1, 2014
Primary Completion
December 1, 2014
Study Completion
February 1, 2015
Last Updated
January 13, 2016
Record last verified: 2015-08