Hypercholesterolemia
850
20
36
677
Key Insights
Highlights
Success Rate
94% trial completion (above average)
Treatment Research
20 treatments under study, led by Atorvastatin
Published Results
201 trials with published results (24%)
Research Leaders
20 sponsors active, led by Organon and Co
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 30/100
5.1%
43 terminated out of 850 trials
94.0%
+7.4% vs benchmark
37%
311 trials in Phase 3/4
30%
201 of 677 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 677 completed trials
Clinical Trials (850)
Causes and Natural History of Dyslipidemias
PET Imaging of Inflammation and Lipid Lowering Study
Long-Term Cardiovascular Impact of ArmoLIPID Cholesterol Plus: An In Silico Study Using Digital Twins
A Non-interventional Implementation Study to Evaluate Treatment With Inclisiran (Leqvio®) and Other Lipid Lowering Treatments in a Real-world Setting
A Study to Evaluate the Effectiveness and Safety of Fixed-Dose Combination of Pitavastatin/ Ezetimibe
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
A Clinical Study of Enlicitide (MK-0616) in Adults With Hyperlipidemia in India (MK-0616-038)
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental Disabilities
Guideline Oriented Approach To Lipid Lowering In Asia-Pacific
Metabolic Effects of an Ophiocordyceps Sinensis- and CoQ10-Based Formulation in Mild-to-Moderate Hypercholesterolemia
Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia
A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular Events
A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial
Berberol P for Mild-to-Moderate Hypercholesterolaemia
Research Network
Common Treatments
- Atorvastatin92
- Ezetimibe91
- Rosuvastatin50
- Simvastatin45
- Alirocumab41
Active Sponsors
- Organon and Co85
- Sanofi45
- National Heart, Lung, and Blood Institute (NHLBI)43
- Regeneron Pharmaceuticals, Inc.41
- Merck Sharp & Dohme LLC39
Top Investigators
AstraZeneca
Esperion Therapeutics, Inc.
LIB Therapeutics
Laval University
NewAmsterdam Pharma
Related Conditions
- Hypertension87
- Cardiovascular Diseases54
- Atherosclerosis41
- Dyslipidemias33
- Dyslipidemia32