Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

NCT05355662 | Completed DMC

• 1 other identifier: No. XJTU1AF-CRF-2019-029
• Study Type: observational
• Target: 11,569
• Locations: 0 countries
• Sites: N/A

Brief Summary

Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Conditions

Liver Transplantation; Hepatocellular Carcinoma; Survival

Keywords

elderly donor; liver transplantation; donation after cardiac death; hepatocellular carcinoma; survival

Outcome Measures

Primary Outcomes (3)

• Post-operative survival time

  Postoperative survival time for patients receiving liver transplantation

  Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.

• Transplanted liver status

  Postoperative Liver Function in Patients Undergoing Liver Transplantation

  Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.The functional status of the transplanted liver was recorded during this period.

• Recurrence of the primary disease after surgery

  Recurrence of primary disease in patients who underwent liver transplantation after surgery

  The time period between liver transplantation and the initial examination revealing a recurrence of primary disease, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 72 months.

Secondary Outcomes (2)

• Surgery details

  Intraoperative

• Post-operative complications in patients who underwent liver transplantation

  Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.During this period, all postoperative complications of the patient will be recorded.

Study Arms (3)

OLDs

Older liver donors (OLDs) and recipients were defined as individuals whose donor age was equal to or greater than 60 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Other: Age

ILDs

Ideal or young liver donors (ILDs) and recipients were defined as donors aged 18-40 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Other: Age

ALDs

Average liver donors (ALDs) and recipients were defined as donor age 40-59 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Other: Age

Interventions

Age OTHER

The study was retrospective and did not involve the application of interventions.

ALDs; ILDs; OLDs

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering.

You may qualify if:

• Recipient age ≥ 18 years and \< 65 years.
• Donor age ≥ 18 years.

You may not qualify if:

• Recipient age \<18 years or ≥65 years.
• Donor age \<18 years.
• Patients who died within 30 days after transplantation.
• Secondary liver transplantation.
• Multiple organ transplantation.
• Patients with incomplete data or failed follow-up.

Sponsors & Collaborators

• First Affiliated Hospital Xi'an Jiaotong University: lead

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Interventions

Aging

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Intervention Hierarchy (Ancestors)

Growth and Development; Physiological Phenomena

Study Officials

• Bo Wang, MD PhD

  First Affiliated Hospital Xi'an Jiaotong University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 16, 2022
• First Posted: May 2, 2022
• Study Start: January 1, 2015
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: May 2, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share