Age-dependent EEG Characteristics During Desflurane Anesthesia From Adults to Elderlies

NCT07240870 | Completed

• 1 other identifier: PLAGH-Des-EEG
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a prospective cohort study that records bilateral frontal EEG data from patients undergoing elective non-cardiac or non-neurosurgical surgeries and divides them into different age groups based on age. All patients received maintenance of general anesthesia with desflurane, and the periodic and aperiodic components, permutation cross mutual information (PCMI), and phase lag entropy (PLE) of EEG data were analyzed under different states of wakefulness, general anesthesia, and recovery. Professional correlation analysis methods were used to analyze the EEG spectrum.

Conditions

EEG; Aging; Desflurane Anesthesia

Outcome Measures

Primary Outcomes (1)

• Electroencephalogram-derived Features

  The following quantitative features will be extracted and assessed from the electroencephalogram (EEG) recordings: Periodic Component: The oscillatory power within standard frequency bands: Delta (1-4 Hz), Theta (4-8 Hz), Alpha (8-13 Hz), Beta (13-30 Hz), and Gamma (30-45 Hz). Aperiodic Component: The offset and exponent of the background '1/f' activity, extracted via spectral parameterization. Permutation Cross Mutual Information (PCMI): A measure to assess nonlinear coupling and directional information flow between different brain regions. Phase Lag Entropy (PLE): A measure to evaluate the dynamic stability of functional brain connectivity.

  Assessed from 2-minute EEG segments at each of three states: Baseline, Under General Anesthesia, and Recovery.

Study Arms (3)

18-40 years age group

18-40 years

Other: Age

40-65 years age group

40-65 years

Other: Age

>65 years age group

\>65 years

Other: Age

Interventions

Age OTHER

Divided into three age groups based on the age of the included patients

18-40 years age group; 40-65 years age group; >65 years age group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients from a tertiary hospital

You may qualify if:

• Age ≥ 18 years old, male or female not limited
• Patients who undergo elective non cardiac surgery or non neurosurgical surgery;
• ASA classification levels 1-3

You may not qualify if:

• Individuals with central nervous system disorders such as autism, attention deficit/hyperactivity disorder, epilepsy, or any congenital mental illness;
• Patients with any contraindications to the use of desflurane, such as those with a history of malignant hyperthermia (MH), allergies to halogenated anesthetics, and patients with significantly elevated intracranial pressure (ICP);
• Patients with unstable clinical conditions, such as severe hypotension or circulatory failure

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

First Medical center of Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location

MeSH Terms

Interventions

Aging

Intervention Hierarchy (Ancestors)

Growth and Development; Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: September 29, 2025
• First Posted: November 21, 2025
• Study Start: April 24, 2025
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: November 21, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)