Effect of Age on the Median Effective Dose(ED50) for Motor Block With Intrathecal Ropivacaine

NCT02102607 | Completed DMC

• 2 other identifiers: intrathecal ropivacaineChina Three Gorges University
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of this study was to determine the median effective dose (ED50) for motor block of intrathecally-administered ropivacaine in adults (20-80 years), and to assess the effect of age on ED50 required for motor block.

Conditions

Anesthesia

Keywords

intrathecal; ropivacaine; motor blockade; local anesthetics

Outcome Measures

Primary Outcomes (1)

• the dose of intrathecal ropivacaine

  at 5-min after administered ropivacaine

Study Arms (1)

age

subjects stratified according to age: 20-30 years (Group 1), 31-40 years (Group 2), 41-50 years (Group 3), 51-60 years (Group 4), 61-70 years (Group 5), and 71-80 years (Group 6).

Other: age

Interventions

age OTHER

subjects stratified according to age: 20-30 years (Group 1), 31-40 years (Group 2), 41-50 years (Group 3), 51-60 years (Group 4), 61-70 years (Group 5), and 71-80 years (Group 6).

age

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who were undergoing transurethral, urological or lower limb surgery, primarily under the spinal anesthesia

You may qualify if:

• Adult patients who were undergoing transurethral, urological or lower limb surgery, primarily under the spinal anesthesia

You may not qualify if:

• Patients with diabetes, obesity, neuromuscular diseases, bleeding diathesis, hypersensitivity to amide local anesthetics, lumbar vertebrae abnormality, chronic back pain, or who were pregnant

Sponsors & Collaborators

• China Three Gorges University, Yichang, China: lead

Study Sites (1)

China Three Gorges University

Yichang, Hubei, 443003, China

Location

Related Publications (2)

• Lee YY, Ngan Kee WD, Fong SY, Liu JT, Gin T. The median effective dose of bupivacaine, levobupivacaine, and ropivacaine after intrathecal injection in lower limb surgery. Anesth Analg. 2009 Oct;109(4):1331-4. doi: 10.1213/ane.0b013e3181b1912b.

  PMID: 19762766 BACKGROUND

• Gupta R, Bogra J, Singh PK, Saxena S, Chandra G, Kushwaha JK. Comparative study of intrathecal hyperbaric versus isobaric ropivacaine: A randomized control trial. Saudi J Anaesth. 2013 Jul;7(3):249-53. doi: 10.4103/1658-354X.115326.

  PMID: 24015125 BACKGROUND

MeSH Terms

Interventions

Aging

Intervention Hierarchy (Ancestors)

Growth and Development; Physiological Phenomena

Study Officials

• jun yang, PhD

  China Three Gorges University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: the First College of Clinical Medical Science, China Three Gorges University (China)

Study Record Dates

• First Submitted: March 24, 2014
• First Posted: April 3, 2014
• Study Start: January 1, 2014
• Primary Completion: March 1, 2015
• Study Completion: June 1, 2015
• Last Updated: October 27, 2015

Record last verified: 2015-10

Locations

CN (1)