Healthy Age-dependent Reference Values for Microvascular Structure and Function

NCT04897191 | Unknown

• 1 other identifier: OCTA1
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes. How healthy ageing affects the smallest blood vessels (microcirculation) and is not well understood. One reason for this is that no generally available medical instrument has the resolution to study the microcirculation. The recently developed optical coherence tomography angiography (OCTA), currently mainly used by eye doctors, is able to visualise the microcirculation. We have developed an automated software (OCTAVA) to determine metrics to characterise the microcirculation on the layers of density, diameter and tortuosity. In the current study we aim at providing reference values of these metrics in hands and feet of healthy people according to age together with macrovascular function in arms and legs.

Conditions

Vascular Endothelium; Microvascular Circulation; Arterial Stiffness; Healthy Ageing

Outcome Measures

Primary Outcomes (3)

• Microvascular density

  Density of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion

  1 day (One timepoint during single visit)

• Microvascular diameter

  Diameter of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion

  1 day (One timepoint during single visit)

• Microvascular turtuosity

  Turtuosity of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion

  1 day (One timepoint during single visit)

Secondary Outcomes (4)

• Blood pressure

  1 day (One timepoint during single visit)

• Endothelial function

  1 day (One timepoint during single visit)

• Arterial stiffness

  1 day (One timepoint during single visit)

• Arterial stiffness

  1 day (One timepoint during single visit)

Study Arms (1)

Healthy

Healthy people age 20-70 years

Other: Age

Interventions

Age OTHER

Determination of age-dependence

Healthy

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adults aiming at n=10 of each decade

You may qualify if:

• Healthy, 20-70 years, BMI 20-30 kg/m\^2

You may not qualify if:

• Diabetes mellitus, symptoms of acute infection, cardiac arrhythmias, active malignancy, clinical signs or symptoms of cardiovascular disease (coronary artery disease, lower extremity artery disease, cerebrovascular disease): angina pectoris, dyspnea, palpitation, syncope, claudication, active vasoactive medication.

Sponsors & Collaborators

• University of Surrey: lead

Study Sites (1)

University of Surrey

Guildford, GU2 7XH, United Kingdom

RECRUITING

MeSH Terms

Interventions

Aging

Intervention Hierarchy (Ancestors)

Growth and Development; Physiological Phenomena

Study Officials

• Christian Heiss, Prof.

  University of Surrey

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christian Heiss, Prof.

CONTACT

+441737231749; c.heiss@surrey.ac.uk

Danuta Sampson, Dr.

CONTACT

danuta.sampson@surrey.ac.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 18, 2021
• First Posted: May 21, 2021
• Study Start: May 18, 2021
• Primary Completion: July 1, 2021
• Study Completion: August 1, 2021
• Last Updated: May 21, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)