NCT05156580

Brief Summary

Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
31,080

participants targeted

Target at P75+ for all trials

Timeline
1mo left

Started Jul 2016

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress99%
Jul 2016Sep 2026

Study Start

First participant enrolled

July 1, 2016

Completed
5.4 years until next milestone

First Submitted

Initial submission to the registry

November 24, 2021

Completed
20 days until next milestone

First Posted

Study publicly available on registry

December 14, 2021

Completed
4.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Expected
Last Updated

October 2, 2025

Status Verified

August 1, 2024

Enrollment Period

10 years

First QC Date

November 24, 2021

Last Update Submit

September 29, 2025

Conditions

ObesityHypertension

Keywords

ObesityHypertensionCardiovascular risk

Outcome Measures

Primary Outcomes (1)

  • Percentage of participants with major adverse cardiovascular events (MACEs)

    Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization.

    2021-2026

Secondary Outcomes (9)

  • Percentage of participants with all-cause death

    2021-2026

  • Percentage of participants with MI

    2021-2026

  • Percentage of participants with stroke

    2021-2026

  • Percentage of participants undergoing coronary revascularization

    2021-2026

  • Change in BP control rate

    2021-2026

  • +4 more secondary outcomes

Study Arms (6)

Obese hypertensive group

Patients who were diagnosed with obesity (body mass index (BMI)≥28kg/m2) and hypertension (systolic blood pressure (SBP)/diastolic blood pressure (DBP) ≥ 140/90 mmHg).

Other: No intervention

Overweight hypertensive group

Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with hypertension (SBP/DBP≥140/90 mmHg).

Other: No intervention

Lean hypertensive group

Lean patients (BMI ≤ 24 kg/m2) diagnosed with hypertension (SBP/DBP ≥ 140/90 mmHg).

Other: No intervention

Lean normotensive

Lean patients (BMI ≤ 24 kg/m2) diagnosed with normotensive (SBP/DBP \< 140/90 mmHg).

Other: No intervention

Overweight normotensive

Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with normotensive (SBP/DBP\<140/90 mmHg)

Other: No intervention

Obese normotensive

Patients who were diagnosed with obesity (BMI≥28kg/m2) and normotensive (SBP/DBP\<140/90 mmHg).

Other: No intervention

Interventions

No interventionOTHER

This is an observational study without any intervention

Lean hypertensive groupLean normotensiveObese hypertensive groupObese normotensiveOverweight hypertensive groupOverweight normotensive

Eligibility Criteria

Age45 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults undergoing routine physical examinations at community health service centers in Tongzhou, China.

You may qualify if:

  • Ages of ≥ 45 years
  • Participants from routine health examinations at Tongzhou Community Health Service Center
  • Availability for follow-up until 2026
  • No major barriers to provide written consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China

Location

MeSH Terms

Conditions

ObesityHypertension

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsVascular DiseasesCardiovascular Diseases

Study Officials

  • Rongchong Huang, M.D.

    Beijing Friendship Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 24, 2021

First Posted

December 14, 2021

Study Start

July 1, 2016

Primary Completion

July 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

October 2, 2025

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)