Perioperative Baroreflex Sensitivity

NCT02435875 | Unknown

• 1 other identifier: Renji1501
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension. Perioperative patients with hypertension is rapidly growing in all populations worldwide. However, no study has reported the values of BRS in this cohort. The aim of this study was to estimate the value of BRS for hypertension in a surgery cohort.

Conditions

Hypertension; Hemodynamic Instability; Surgery

Keywords

hypertension; perioperative; baroreflex sensitivity

Outcome Measures

Primary Outcomes (1)

• baroreflex sensitivity

  Baroreflex sensitivity will be measured at three points include preoperation,intraoperation and postoperation

  during operation

Secondary Outcomes (4)

• interoperation complication

  during operation

• length of hospital stay

  participants will be followed for the duration of hospital stay, an expected average of 5 days

• post-operative complications

  3 days postoperation

• hospitalization costs

  2 weeks postoperation

Study Arms (2)

hypertensive

Patients with confirmed hypertension or systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg without antihypertensive treatment.After anesthesia induction,baroreflex sensitivity will be measured by nitroglycerin.

Other: no intervention

nonhypertensive

systolic blood pressure \<140 mmHg and diastolic blood pressure\<90 mmHg.After anesthesia induction,baroreflex sensitivity will be measured by nitroglycerin.

Other: no intervention

Interventions

no intervention OTHER

Antihypertensive drug as intervention is used to see if it can improve baroreflex sensitivity to stable perioperative hemodynamic

hypertensive; nonhypertensive

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing ordinary thoracic surgery

You may qualify if:

• Patients undergoing ordinary thoracic surgery and age between 18 and 70;
• American society of anesthesiologists(ASA) classification I to II level;
• Willing to participate in this study and signed an informed consent

You may not qualify if:

• Patients with diabetes mellitus, cardiopulmonary dysfunction, severe liver and kidney dysfunction and disease of nervous system;

Sponsors & Collaborators

• RenJi Hospital: lead

Study Sites (1)

Renji Hospital, Shanghai Jiao Tong University, School of Medicine

Shanghai, Shanghai Municipality, 200127, China

RECRUITING

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• WEIFENG YU, MD

  Anesthesiology Department Renji Hospital, Shanghai Jiao Tong University, School of Medicine

  STUDY CHAIR

Central Study Contacts

DAN HUANG, MS

CONTACT

15921108822; huangdan363@163.com

JIE CHE, MS

CONTACT

13611906592; 13611906592@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: April 15, 2015
• First Posted: May 6, 2015
• Study Start: April 1, 2015
• Primary Completion: April 1, 2016
• Study Completion: April 1, 2016
• Last Updated: May 6, 2015

Record last verified: 2015-04

Locations

CN (1)