Peking University Birth Cohort in Tongzhou

NCT03814395 | Unknown

• 2 other identifiers: NNSF8170324081703240
• Study Type: observational
• Target: 5,426
• Locations: 1 country
• Sites: 1

Brief Summary

The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.

Conditions

Health Problems in Pregnancy; Pregnancy Outcomes; Gestational Diabetes; Gestational Hypertension; Preterm Birth; Obesity; Mother-Infant Interaction; Child Development; Anemia

Outcome Measures

Primary Outcomes (2)

• Numbers of participants with pregnancy complications

  Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy

  At delivery

• Numbers of participants with adverse pregnancy outcomes

  Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects.

  At delivery

Secondary Outcomes (13)

• Weight in kilogram changes during childhood

  At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years

• Height in centimeter changes during childhood

  At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years

• Early Child development 1

  Age at 6 weeks and 3 years

• Early Child development 2

  Age at 8-12 months

• Incidence of diabetes mellitus in women

  6 weeks after delivery and 3 years after delivery

Study Arms (2)

Exposure group

Group with environmental, nutritional or lifestyle exposures

Other: No intervention

Non-exposed group

Group without any environmental, nutritional and lifestyle exposures

Interventions

No intervention OTHER

This is an observational study without any intervention

Exposure group

Eligibility Criteria

• Age: 18 Years - 49 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women and their children in Tongzhou, China

You may qualify if:

• Pregnant women, \<14 gestational weeks
• Resided in Tongzhou in the past half years and have no plan to move out after delivery
• Pregnant women who plan to have antenatal care and delivery in Tongzhou maternal\&Child Hospital.
• Pregnant women who is willing to participate in this study with informed consent

You may not qualify if:

• Pregnant women have chronic disease before pregnancy, including diabetes，hypertension, liver disease and kidney disease.

Sponsors & Collaborators

• Peking University: lead
• National Natural Science Foundation of China: collaborator

Study Sites (1)

Peking University

Beijing, Beijing Municipality, 100191, China

Location

Related Publications (1)

• Jin C, Lin L, Han N, Zhao Z, Liu Z, Luo S, Xu X, Liu J, Wang H. Effects of dynamic change in fetuin-A levels from the first to the second trimester on insulin resistance and gestational diabetes mellitus: a nested case-control study. BMJ Open Diabetes Res Care. 2020 Jan;8(1):e000802. doi: 10.1136/bmjdrc-2019-000802.

  PMID: 31958310 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

During pregnancy: maternal blood. At delivery: cord blood，umbilical cord and placenta. During childhood: blood.

MeSH Terms

Conditions

Diabetes, Gestational; Hypertension, Pregnancy-Induced; Premature Birth; Obesity; Anemia

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Obstetric Labor, Premature; Obstetric Labor Complications; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Haijun Wang, Ph.D

  Peking University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: January 16, 2019
• First Posted: January 24, 2019
• Study Start: June 28, 2018
• Primary Completion: August 27, 2019
• Study Completion: August 28, 2025
• Last Updated: November 18, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)