NCT05590546

Brief Summary

Central (abdominal) obesity is associated with elevated adrenergic activity and arterial blood pressure (BP). Therefore, we tested the hypothesis that transduction of spontaneous muscle sympathetic nerve activity (MSNA) to BP, i.e., sympathetic transduction, is augmented in abdominal obesity (increased waist circumference) and positively related to prevailing BP.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
28

participants targeted

Target at below P25 for all trials

Timeline
7mo left

Started Oct 2025

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress53%
Oct 2025Dec 2026

First Submitted

Initial submission to the registry

October 18, 2022

Completed
3 days until next milestone

First Posted

Study publicly available on registry

October 21, 2022

Completed
2.9 years until next milestone

Study Start

First participant enrolled

October 1, 2025

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 19, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 19, 2026

Last Updated

October 3, 2024

Status Verified

October 1, 2024

Enrollment Period

1.1 years

First QC Date

October 18, 2022

Last Update Submit

October 1, 2024

Conditions

Hypertension

Outcome Measures

Primary Outcomes (1)

  • Sympathetic transduction

    signal averaging was performed in which bursts of MSNA act as a trigger and beat-to-beat BP was tracked for 15 subsequent cardiac cycles thereafter.

    15 min

Study Arms (2)

Obese

No intervention, only performing cross-sectional analysis of pooled data collected in previous studies

Other: No intervention

Control

No intervention, only performing cross-sectional analysis of pooled data collected in previous studies

Other: No intervention

Interventions

No interventionOTHER

No intervention, only performing cross-sectional analysis of pooled data collected in previous studies

ControlObese

Eligibility Criteria

Age35 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Otherwise healthy

You may qualify if:

  • Nonsmokers
  • free of metabolic or neurological disease
  • waist circumference \> 102 cm for men and \> 88 cm for women or waist circumference was \< 94 cm for men and \< 80 cm for women.

You may not qualify if:

  • Use of anti-hypertensive medications
  • history of diabetes
  • history of smoking within 3 months prior to study participation
  • hypertension determined by 24-hour ambulatory average BP (\<130/80 mmHg).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Central Study Contacts

Seth Holwerda

CONTACT

9729223230sholwerda@kumc.edu

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 18, 2022

First Posted

October 21, 2022

Study Start

October 1, 2025

Primary Completion (Estimated)

November 19, 2026

Study Completion (Estimated)

December 19, 2026

Last Updated

October 3, 2024

Record last verified: 2024-10