NCT03799653

Brief Summary

The Nurse Cohort Study Xiamen (NCSX) is an open-ended prospective cohort study with very broad research aims. The primary objectives of the NCSX is planned to examine genetic, epigenetic, biological, psychological, social, lifestyle and other environmental factors of nurses in relation to incidence and progression of the common chronic diseases, such as hypertension, ischemic heart disease, stroke, diabetes, chronic kidney disease and some cancers, which are emerging with economic development in Xiamen, China. Specifically, we intend to test whether empirically driven hypothesis and emerging risk factors mainly developed in response to observations in economically developed Western societies apply in a population living in a rapid changing lifestyle in China now.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
32mo left

Started Mar 2019

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress73%
Mar 2019Dec 2028

First Submitted

Initial submission to the registry

January 8, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 10, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

March 20, 2019

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2023

Completed
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Expected
Last Updated

November 3, 2023

Status Verified

November 1, 2023

Enrollment Period

4.8 years

First QC Date

January 8, 2019

Last Update Submit

November 2, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence rate

    The incidence rates of common chronic diseases, such as hypertension, The stroke, CKD and cancers

    2019.1.21-2024.12.31

Secondary Outcomes (1)

  • Mortality

    2019.1.21-2024.12.31

Study Arms (1)

Nurses

All subjects are registered nurses in Xiamen, China

Other: No intervention

Interventions

This is a prospective observational study, and there is no intervention.

Nurses

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

* Registered nurses in public hospitals in Xiamen, China; * Aged 20 years or over and living in Xiamen for at least 1 year and will not move out of Xiamen for at least 5 years;

You may qualify if:

  • Registered nurses of public hospitals in Xiamen, China;
  • aged 20 years or over;
  • Working in the public hospitals for at least 1 year;
  • Signed the informed consent and agreed to participate in the study;
  • Assuming not moved out of Xiamen for at least 5 years;

You may not qualify if:

  • who are unambulatory;
  • who are receiving treatment modalities, which , if omitted, may result in immediate life threatening risk such as chemotherapy or radiotherapy for cancer, or dialysis for renal failure.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

serum, plasma and urin.

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Study Officials

  • Weihua Li, Ph.D.

    The First Affiliated Hospital of Xiamen University

    STUDY CHAIR

Central Study Contacts

Haihua Zhu, Master

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director

Study Record Dates

First Submitted

January 8, 2019

First Posted

January 10, 2019

Study Start

March 20, 2019

Primary Completion

December 31, 2023

Study Completion (Estimated)

December 31, 2028

Last Updated

November 3, 2023

Record last verified: 2023-11

Locations