NCT05051306

Brief Summary

Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
11

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 18, 2021

Completed
17 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 7, 2021

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

August 30, 2021

Completed
22 days until next milestone

First Posted

Study publicly available on registry

September 21, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2021

Completed
Last Updated

March 16, 2022

Status Verified

March 1, 2022

Enrollment Period

17 days

First QC Date

August 30, 2021

Last Update Submit

March 14, 2022

Conditions

Inflammatory Response

Keywords

resistance exerciseequal training volumeimmune response

Outcome Measures

Primary Outcomes (4)

  • Changes in glucose

    glucose in mg/dL

    4-hour during each study intervention

  • Changes in insulin

    insulin in mU/L

    4-hour during each study intervention

  • Changes in TG

    TG mg/dL

    4-hour during each study intervention

  • Changes in uric acid

    uric acid mg/dL.

    4-hour during each study intervention

Secondary Outcomes (11)

  • Changes in biomarkers of inflammation

    4-hour during each study intervention

  • Changes in cortisol

    4-hour during each study intervention

  • Changes in lactate

    4-hour during each study intervention

  • Changes in complete blood count

    4-hour during each study intervention

  • Borgs Ratings of Perceived Exertion (RPE)

    1-hour during each exercise intervention

  • +6 more secondary outcomes

Study Arms (3)

High-load resistance exercise

EXPERIMENTAL

4 high-load resistance exercises that target all major muscle groups.

Other: High-load resistance exercise

Low-load resistance exercise

EXPERIMENTAL

4 low-load resistance exercises that target all major muscle groups.

Other: Low-load resistance exercise

Sedentary control

NO INTERVENTION

Subjects in control trial stayed sedentary during the period.

Interventions

High-load resistance exerciseOTHER

Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets.

High-load resistance exercise
Low-load resistance exerciseOTHER

Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets.

Low-load resistance exercise

Eligibility Criteria

Age20 Years - 30 Years
Sexmale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age: 20-30
  • Healthy male
  • Without experience of resistance training

You may not qualify if:

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan Normal University

Taipei, 162, Taiwan

Location

Study Officials

  • Hung-Wen Liu, Ph.D.

    National Taiwan Normal University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 30, 2021

First Posted

September 21, 2021

Study Start

February 18, 2021

Primary Completion

March 7, 2021

Study Completion

December 31, 2021

Last Updated

March 16, 2022

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will not share

Locations

TW(1)