Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed

NCT04534374 | Completed

• 1 other identifier: 201807HM004
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.

Conditions

Cognitive Decline; Aging

Keywords

exercise; resistance training; kinesiology; cognition; ERP; neuroimage

Outcome Measures

Primary Outcomes (2)

• Change of Information processing speed between resistance and stretching exercises

  Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.

  5-30 minutes before and 10-35 minutes after each intervention.

• Change of Inhibitory control between resistance and stretching exercises

  Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.

  5-30 minutes before and 10-35 minutes after each intervention.

Secondary Outcomes (2)

• Change of Conflict-related neural activity between resistance and stretching exercises

  5-30 minutes before and 10-35 minutes after each intervention.

• Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises

  5-30 minutes before and 10-35 minutes after each intervention.

Study Arms (2)

Resistance exercise

EXPERIMENTAL

The experimental intervention is a session of resistance exercise described in the intervention section.

Behavioral: Resistance exercise

Stretching exercise

ACTIVE COMPARATOR

The active control intervention is a session of stretching exercise described in the intervention section.

Behavioral: Stretching exercise (sham exercise)

Interventions

Resistance exercise BEHAVIORAL

Barbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes.

Resistance exercise

Stretching exercise (sham exercise) BEHAVIORAL

Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (≈ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM.

Stretching exercise

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• male adults aged 50-65 years old
• exercise ≥ 150 minutes/week
• normal or corrected-to-normal vision
• right-handed

You may not qualify if:

• dementia (MMSE ≥ 24)
• any medical condition listed on PARQ
• depression (BDI-II score ≤ 13)
• any diagnostic cardiovascular, neurological and other chronic diseases

Sponsors & Collaborators

• National Taiwan Normal University: lead

Study Sites (1)

National Taiwan Normal University

Taipei, Taiwan

Location

Related Publications (1)

• Lin TY, Hsieh SS, Chueh TY, Huang CJ, Hung TM. The effects of barbell resistance exercise on information processing speed and conflict-related ERP in older adults: a crossover randomized controlled trial. Sci Rep. 2021 Apr 28;11(1):9137. doi: 10.1038/s41598-021-88634-5.

  PMID: 33911153 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Tsung-Min Hung, Ph.D.

  Department of Physical Education, National Taiwan Normal University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 25, 2020
• First Posted: September 1, 2020
• Study Start: August 1, 2017
• Primary Completion: August 1, 2019
• Study Completion: August 1, 2019
• Last Updated: September 1, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
• Time Frame: Three years within the publication.

Locations

TW (1)