Effects of a Short-term Aerobic Interval Exercise Program on Cardiac Fat and Function in Women With Obesity: A Pilot Study

NCT04802005 | Withdrawn DMC

• 1 other identifier: 1063
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of this project is to the study the effects of an aerobic interval training program on cardiac fat, and its relationship to cardiac function using cardiac Magnetic Resonance Imaging.

Conditions

Obesity

Keywords

Cardiac fat; Cardiac function; Aerobic interval training; Cardiac Magnetic Resonance; Vascular health

Outcome Measures

Primary Outcomes (2)

• Changes in Cardiac Adipose Tissue (CAT)

  CAT will be measured using cardiac Magnetic Resonance

  2 assessment points: at baseline and week 5

• Changes in Cardiac Function

  Cardiac Function will be measured using cardiac Magnetic Resonance

  2 assessment points: at baseline and week 5

Secondary Outcomes (4)

• Changes in Body Composition

  2 assessment points: at baseline and week 5

• Changes in Cardiorespiratory Function

  2 assessment points: at baseline and week 5

• Changes in Muscular Strength

  2 assessment points: at baseline and week 5

• Changes in Blood Pressure

  2 assessment points: at baseline and week 5

Study Arms (2)

Aerobic interval

EXPERIMENTAL

Aerobic interval will consist of a supervised aerobic interval training sessions 3 times/week. Duration will range between 45-50 min/session depending on the exercise energy expenditure (target expenditure \~450-500kcal/session). Each interval will have a total duration of 5 min, and it will be divided into 2 periods. The first period will consist of 3 minutes of high-intensity activity at 70-85% of predicted HRmax, and for the second period the intensity will be reduced to 60-65% of predicted HRmax for 2 minutes. The training sessions will be carried out outdoors at the trails located on campus. The activity will consist of walking and/or light jogging. The speed/incline will be changed depending on the participants' heart rate and perception using the Borg's rating of perceived exertion (RPE) as needed. The RPE for the first period range will be 13-17 (15-17 at the end of the period) and 10-12 for the second period.

Other: Aerobic Interval Training

Control group

NO INTERVENTION

Participants in the control group will not participate in the training programs.

Interventions

Aerobic Interval Training OTHER

The aerobic interval training group

Aerobic interval

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• females, age 18-40 years old, body mass index (BMI) ≥ 30 kg/m2 and \< 39.9 kg/m2, without known metabolic and/or cardiovascular disease

You may not qualify if:

• known CV, metabolic or pulmonary diseases or conditions, muscular-skeletal injuries (i.e. spine, knees, hips or shoulders, taking medications that affect endocrine or cardiovascular function, hypertension, being engaged in moderate intensity exercise more than two times per week or moderate-high intensity training of any type and frequency, being pregnant, cigarette smoking, having non-removable pieces or devices incompatible with DXA and CMR assessment

Sponsors & Collaborators

• Southern Illinois University Edwardsville: lead

Study Sites (1)

Southern Illinois University Edwardsville

Edwardsville, Illinois, 62026, United States

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Maria Fernandez Del Valle, PhD

  Southern Illinois University of Edwardsville

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 13, 2021
• First Posted: March 17, 2021
• Study Start: March 16, 2021
• Primary Completion: April 16, 2021
• Study Completion: April 16, 2021
• Last Updated: September 21, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)