Effects of Exercise Mode on Cardiac Fat and Function

NCT03297333 | Terminated DMC

• 1 other identifier: 16-1208-4C-1
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.

Conditions

Obesity

Keywords

Obesity; Exercise; Cardiac Fat; Cardiac Magnetic Resonance; Vascular Health

Outcome Measures

Primary Outcomes (2)

• Changes in Epicardial adipose tissue (EAT)

  EAT will be measured using cardiac Magnetic Resonance

  2 assessment points: at baseline and week 4

• Changes in Vascular Health

  Atrial stiffness will be measured using a pulse wave analysis

  2 assessment points: at baseline and week 4

Secondary Outcomes (4)

• Changes in Paracardial adipose tissue (PAT)

  2 assessment points: at baseline and week 4

• Changes in Body Composition

  2 assessment points: at baseline and week 4

• Changes in Cardiorespiratory Function

  2 assessment points: at baseline and week 4

• Changes in Muscular Strength

  2 assessment points: at baseline and week 4

Study Arms (3)

Resistance training group

EXPERIMENTAL

Resistance training will consist of a supervised circuit training 3 sessions/week for approximately 45-50 min/session. The circuit will include 7 strength exercises engaging the major muscle groups (leg press, rows, back squats, weighted crunches, deadlifts, bench press, and squat jumps with weights). The participants will perform 3 sets of 10 repetitions with resting periods of 30 seconds between exercises, and 2 minutes between sets. The overall OMNI-Resistance Exercise Scale per set will range between 8-10. Heart rate and exercise energy expenditure during the workout will be monitored. The load will be changed depending on the participants' perception when needed. In addition, the intensity will be monitored assessing Lactate concentrations at baseline and at the end of each session. Circuit will be repeated until meeting the targeted exercise energy expenditure of 450-500 kcal/session.

Other: Resistance training

Aerobic interval training group

EXPERIMENTAL

Aerobic interval will consist of a supervised aerobic interval training sessions 3 times/week. Duration will range between 45-50 min/session depending on the exercise energy expenditure. Each interval will have a total duration of 5 min, and it will be divided into 2 periods. The first period will consist of 3 minutes of high-intensity activity, and the second period the intensity will be reduced for 2 minutes. The speed/incline will be changed depending on the participants' heart rate and perception using the Borg's rating of perceived exertion as needed. Heart rate and exercise energy expenditure during the workout will be monitored. Intensity will be monitored assessing Lactate concentrations at the end of each session. Intervals will be repeated until meeting the targeted exercise energy expenditure (450-500 kcal/session).

Other: Aerobic interval training

Control group

NO INTERVENTION

Participants in the control group will not participate in the training programs.

Interventions

Resistance training OTHER

The resistance training group

Resistance training group

Aerobic interval training OTHER

The aerobic interval training group

Aerobic interval training group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Sedentary
• Caucasian
• BMI \>30 kg/m2 and \< 39.9 kg/m2

You may not qualify if:

• Known cardiovascular, metabolic, pulmonary disease or conditions
• Muscular-skeletal injuries
• Taking medications that affect endocrine or cardiovascular function
• Hypertension
• Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency
• Being pregnant
• Cigarette smoking
• Having non-removable pieces or devices incompatible with DXA and CMR assessment.

Sponsors & Collaborators

• Southern Illinois University Edwardsville: lead

Study Sites (1)

Southern Illinois University of Edwardsville

Edwardsville, Illinois, 62026, United States

Location

MeSH Terms

Conditions

Obesity; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Maria Fernandez del Valle, PhD

  Southern Illinois University of Edwardsville

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2017
• First Posted: September 29, 2017
• Study Start: October 1, 2017
• Primary Completion: March 16, 2020
• Study Completion: March 16, 2020
• Last Updated: October 4, 2021

Record last verified: 2019-07

Locations

US (1)