Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study

NCT02589327 | Completed DMC

• 1 other identifier: 504792C
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Conditions

Obesity

Outcome Measures

Primary Outcomes (1)

• Changes in Cardiac fat volumes

  Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging

  2 assessment points: at baseline and week 4

Secondary Outcomes (7)

• Changes in Vascular function

  2 assessment points: at baseline and week 4

• Changes in Cardiorespiratory Function

  2 assessment points: at baseline and week 4

• Changes in Muscular Strength

  2 assessment points: at baseline and week 4

• Changes in Body Composition

  2 assessment points: at baseline and week 4

• Changes in Diet

  5 assessment points: baseline, week 1, 2, 3, and 4

Study Arms (2)

Exercise Intervention

EXPERIMENTAL

Hight intensity resistance training group

Other: Exercise Intervention

Control

NO INTERVENTION

No-exercise control group

Interventions

Exercise Intervention OTHER

The intervention will consist of 3 weeks of whole body circuit training (resistance training) where participants in the intervention group will perform 7 different exercises. The circuit will consist of 10 repetitions per exercise of 7 exercises: leg press, bent-over row, bench press, squats, dumbbell jump squats with raises, dead-lifts and weighted abdominal crunches, with approximately 30 sec of rest in between each exercise (based on the estimated time needed to move from one position to the next). Each participant will move through the circuit 3 times, with 2 to 3 minutes of rest between each round. Intensity will be 6-7 of RPE at the first set, and 9-10 at the third set.

Exercise Intervention

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI 30-39.99
• White/Caucasian

You may not qualify if:

• Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded.
• Pregnant females.
• Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study.
• Participants that exercise more than three times per week or strength train more than twice per week.
• Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded.
• Cigarette smoking (current or those who quit within the previous 6 months
• Hypertension
• Diabetics

Sponsors & Collaborators

• Texas Tech University: lead

Study Sites (1)

Kinesiology and Sport Management

Lubbock, Texas, 79423, United States

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Maria Fernandez del Valle, PhD

  Texas Tech University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 14, 2015
• First Posted: October 28, 2015
• Study Start: October 1, 2015
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: May 11, 2016

Record last verified: 2015-09

Locations

US (1)