Acute Cognition and Exercise

NCT05078203 | Completed

• 1 other identifier: ACE
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims: Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity. Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity. Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.

Conditions

Obesity

Keywords

Myokine; Cognition; CTSB; BDNF; Exercise

Outcome Measures

Primary Outcomes (6)

• Circulating Cathepsin B (CTSB) Myokine

  Changes in peripheral myokine concentration

  3 hours

• Attentional Inhibition Accuracy

  Behavioral performance measured as accuracy (%) during Flanker task

  3 hours

• Attentional Inhibition Reaction Time

  Behavioral performance measured as response time (ms) during Flanker task

  3 hours

• Attentional Resource Allocation

  Changes in P3 event related potential amplitude (microvolts) using a computerized flanker task

  3 hours

• Attentional Processing Speed

  Changes in P3 event related potential latency (ms) using a computerized flanker task

  3 hours

• Relational Memory

  Accuracy during a spatial reconstruction task

  3 hours

Secondary Outcomes (1)

• Brain derived neurotrophic factor (BDNF)

  3 hours

Study Arms (2)

Exercise

EXPERIMENTAL

36 minutes of exercise

Behavioral: Exercise

Rest

PLACEBO COMPARATOR

36 minutes of rest

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

36 minutes of Exercise

Exercise; Rest

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between ages 18 and 35
• No prior diagnosis of neurological disorders (e.g., autism spectrum disorder)
• No prior diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
• No physical disability that would preclude the participant from completing a VO2max test
• Corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
• Not pregnant
• BMI between 18.5 and 25.0 kg/m2, or BMI greater than 30.0 kg/m2
• Readiness for exercise (determined through PAR-Q)

You may not qualify if:

• \<18 years and \>35 years
• Diagnosis of neurological disorders (e.g., autism spectrum disorder)
• Diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
• Physical disability that would preclude the participant from completing a VO2max test
• Lack of corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
• Pregnancy
• BMI less than 18.5 kg/m2 or BMI greater than 25.0 but less than 30.0 kg/m2

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead

Study Sites (1)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

MeSH Terms

Conditions

Obesity; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order.

Study Record Dates

• First Submitted: October 1, 2021
• First Posted: October 14, 2021
• Study Start: September 2, 2021
• Primary Completion: April 28, 2022
• Study Completion: April 28, 2022
• Last Updated: February 20, 2024

Record last verified: 2024-02

Locations

US (1)