Effect of Muscle Damage After Downhill Running on Postprandial Lipids

NCT04688073 | Completed

• 1 other identifier: 201903HM011
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

All participants underwent three experimental trials, namely downhill running (DR), level running (LR), and the control (CON) in a cross-over design. Each trial lasted for 2 days. The participants were fed the same breakfast and lunch on day 1 in each trial. The participants arrived at the laboratory at 18:00 on day 1 and ran on the treadmill at 60% VO2max (downhill and level surface trials) or rested (CON trial) for 30 min. Subsequently, they were fed a standardized dinner (A meal box containing chicken, vegetables, and rice, 692 kcal, with 50% energy from carbohydrate, 32% from fat, and 18% from protein) within 20 min. The participants returned to the laboratory at 07:30 on day 2 after an overnight fast. After baseline blood and gas samples were collected, the participants were fed a high-fat meal that included cereal, white bread, whipping cream, cheese, and butter. The high-fat meal provided fat 1.2 g/kg (65% energy), carbohydrate 1.1 g/kg (27% energy), protein 0.33 g/kg (8% energy), and 16.5 kcal/kg. A 10-mL blood sample was collected from a forearm vein into nonheparinized tubes before and immediately after exercise or rest on day 1. On day 2, postprandial blood samples were collected from forearm veins into nonheparinized tubes by using an indwelling venous needle and a three-way stopcock. A 10-mL blood sample was collected before (0 h) and 0.5, 1, 2, 3, 4, 5, and 6 h after the high-fat meal.

Conditions

Nutritional and Metabolic Diseases; Lipemia

Keywords

triglyceride; non-esterified fatty acids; eccentric exercise; cardiovascular disease

Outcome Measures

Primary Outcomes (1)

• TG AUC

  area under the curve for serum triglyceride concentrations within 6 hours after the high-fat meal

  6 hours

Secondary Outcomes (1)

• NEFA AUC

  6 hours

Study Arms (3)

Downhill running

EXPERIMENTAL

Running at 60% VO2max on -15% slope for 30 min on a treadmill

Behavioral: Exercise

Level running

EXPERIMENTAL

Running at 60% VO2max on level surface for 30 min on a treadmill

Behavioral: Exercise

Control

PLACEBO COMPARATOR

Rest 30 min

Behavioral: Rest

Interventions

Exercise BEHAVIORAL

Running

Downhill running; Level running

Rest BEHAVIORAL

sit and rest

Control

Eligibility Criteria

• Age: 20 Years - 40 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• generally healthy, had not engaged in regular exercise or received any medication in the past 6 months

You may not qualify if:

• history of cardiovascular disease, hypertension, hyperlipidemia, diabetes, atherosclerosis, or osteoporosis, free of any musculoskeletal injury during the study

Sponsors & Collaborators

• National Taiwan Sport University: lead

Study Sites (1)

National Taiwan University of Sport

Taichung, 404, Taiwan

Location

MeSH Terms

Conditions

Nutritional and Metabolic Diseases; Hyperlipidemias; Cardiovascular Diseases

Interventions

Exercise; RE1-silencing transcription factor

Condition Hierarchy (Ancestors)

Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 23, 2020
• First Posted: December 29, 2020
• Study Start: May 15, 2019
• Primary Completion: July 1, 2019
• Study Completion: July 1, 2019
• Last Updated: December 29, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)