NCT01926431

Brief Summary

The primary aim of this study was to determine the effects of an acute bout of high intensity exercise on the brains response to viewing pictures of food using functional magnetic resonance imaging (fMRI).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2009

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2009

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2011

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

August 20, 2013

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 21, 2013

Completed
Last Updated

August 21, 2013

Status Verified

August 1, 2013

Enrollment Period

1.7 years

First QC Date

August 20, 2013

Last Update Submit

August 20, 2013

Conditions

Neural ResponsesAppetite HormonesSubjective Appetite Sensations

Outcome Measures

Primary Outcomes (1)

  • Neural responses following exercise and rest

    Volunteers completed an fMRI assessment following 60 minutes of intense exercise and 60 minutes of rest on two separate occasions.

    Ten minutes post-exercise/rest

Secondary Outcomes (1)

  • Appetite hormones

    Blood samples taken at baseline, following exercise/rest, prior to the fMRI assessment and immediately following the fMRI assessment

Study Arms (2)

Exercise

EXPERIMENTAL

60 minutes of high intensity treadmill running

Other: Exercise

Rest

EXPERIMENTAL

60 minutes of seated rest (control trial)

Other: Rest

Interventions

ExerciseOTHER
Exercise
RestOTHER
Rest

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy, non-smokers, free from cardiovascular disease and metabolic disease, no medication, participated in moderate/vigorous physical activity (\>2 hours per week)

You may not qualify if:

  • Smokers, history of cardiovascular/metabolic disease, low physical activity levels, inability to participate in fMRI scanning sessions including contraindications to MRI

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Birmingham University Imaging Centre

Birmingham, Midlands, B15 2TT, United Kingdom

Location

Related Publications (1)

  • Crabtree DR, Chambers ES, Hardwick RM, Blannin AK. The effects of high-intensity exercise on neural responses to images of food. Am J Clin Nutr. 2014 Feb;99(2):258-67. doi: 10.3945/ajcn.113.071381. Epub 2013 Dec 4.

    PMID: 24305681DERIVED

MeSH Terms

Interventions

ExerciseRE1-silencing transcription factor

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Andrew Blannin, PhD

    University of Birmingham

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

August 20, 2013

First Posted

August 21, 2013

Study Start

September 1, 2009

Primary Completion

May 1, 2011

Study Completion

May 1, 2011

Last Updated

August 21, 2013

Record last verified: 2013-08

Locations

GB(1)