Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

NCT04423211 | Recruiting Phase 3 FDA Drug

• 3 other identifiers: EA8191NCI-2020-02686U10CA180820
• Study Type: interventional
• Target: 804
• Locations: 1 country
• Sites: 303

Brief Summary

This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in patients with prostate cancer who experience biochemical recurrence (a rise in the blood level of prostate specific antigen \[PSA\] after surgical removal of the prostate cancer). A second question tests treatment in patients with biochemical recurrence who show prostate cancer spreading outside the pelvis (metastasis) by positron emission tomography (PET) imaging. In these patients, the benefit of adding metastasis-directed radiation to enhanced therapy (apalutamide in combination with abiraterone + prednisone) is tested. Diagnostic procedures, such as PET, may help doctors look for cancer that has spread to the pelvis. Androgens are hormones that may cause the growth of prostate cancer cells. Apalutamide may help fight prostate cancer by blocking the use of androgens by the tumor cells. Metastasis-directed targeted radiation therapy uses high energy rays to kill tumor cells and shrink tumors that have spread. This trial may help doctors determine if using PET results to deliver more tailored treatment (i.e., adding apalutamide, with or without targeted radiation therapy, to standard of care treatment) works better than standard of care treatment alone in patients with biochemical recurrence of prostate cancer.

Conditions

Metastatic Prostate Carcinoma; Prostate Adenocarcinoma; Stage IVB Prostate Cancer AJCC v8; Biochemically Recurrent Prostate Carcinoma

Outcome Measures

Primary Outcomes (4)

• Progression-free survival (PFS)

  The power of the PFS analysis is 85% using one-sided 0.025 level stratified logrank test. The overall type I error will be controlled using an O'Brien-Fleming boundary function

  From randomization to radiographic progression by conventional imaging or positron emission tomography (PET), symptomatic disease or death, whichever occurs first, assessed up to 10 years

• PFS prolongation in patients without PET-evidence of extrapelvic metastases

  Will evaluate whether the addition of enhanced systemic therapy to standard of care salvage therapy could prolong PFS in this patient population. Will be an intention-to-treat analysis of all randomized patients and performed in parallel with patients with PET-evidence of extrapelvic metastases.

  Up to 10 years

• PFS prolongation in patients with PET-evidence of extrapelvic metastases

  Will evaluate whether the addition of metastasis-directed radiation therapy to standard of care salvage therapy and enhanced systemic therapy could prolong PFS in this patient population. Will be an intention-to-treat analysis of all randomized patients and performed in parallel without patients with PET-evidence of extrapelvic metastases.

  Up to 10 years

• Quality of life (QOL)

  Descriptive statistics will be used to characterize QOL over time in each arm.

  Up to 24 months

Secondary Outcomes (12)

• Overall survival (OS)

  From randomization to death or date last known alive, assessed up to 10 years

• Event-free survival

  From randomization to radiographic progression by conventional imaging or PET, symptomatic disease, or initiation of new treatment for the disease or death, whichever occurs first, assessed up to 10 years

• Time to prostate-specific antigen (PSA) progression

  From randomization to documented PSA progression or radiographic progression, whichever occurs first, assessed up to 10 years

• Incidence of adverse events

  Up to 10 years

• Detection rate of fluciclovine F18 (18F-fluciclovine) PET

  At time of PSA recurrence, as clinically indicated or 12 months after completion of enhanced systemic therapy (whichever occurs first), assessed up to 10 years

Study Arms (4)

Arm A (EBRT, short-term androgen deprivation therapy [STAD])

ACTIVE COMPARATOR

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2. STEP 1: Patients who are PET negative for extera pelvic metastases undergo SOC EBRT for 6 months. Patients also receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC for 6 months starting up to 3 months prior to EBRT but no later than 7 days after start of EBRT. All treatment continues for 6 months in the absence of disease progression or unacceptable toxicity.

Procedure: Computed Tomography; Drug: Degarelix; Radiation: External Beam Radiation Therapy; Other: Fluciclovine F18; Drug: Goserelin Acetate; Drug: Leuprolide Acetate; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Relugolix; Drug: Triptorelin

Arm B (EBRT, STAD, apalutamide)

EXPERIMENTAL

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2. STEP 1: Patients who are PET negative for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD for 6 months in the absence of disease progression or unacceptable toxicity.

Drug: Apalutamide; Procedure: Computed Tomography; Drug: Degarelix; Radiation: External Beam Radiation Therapy; Other: Fluciclovine F18; Drug: Goserelin Acetate; Drug: Leuprolide Acetate; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Relugolix; Drug: Triptorelin

Arm C (EBRT, STAD, apalutamide)

EXPERIMENTAL

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2. STEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD as in Arm B.

Drug: Apalutamide; Procedure: Computed Tomography; Drug: Degarelix; Radiation: External Beam Radiation Therapy; Other: Fluciclovine F18; Drug: Goserelin Acetate; Drug: Leuprolide Acetate; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Relugolix; Drug: Triptorelin

Arm D (EBRT, STAD, apalutamide, RT)

EXPERIMENTAL

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2. STEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A and apalutamide PO QD as in Arm B. Patients also undergo SBRT or 3D CRT, IMRT (including VMAT), and IMPT over 3-10 fractions in the absence of disease progression or unacceptable toxicity.

Radiation: 3-Dimensional Conformal Radiation Therapy; Drug: Apalutamide; Procedure: Computed Tomography; Drug: Degarelix; Radiation: External Beam Radiation Therapy; Other: Fluciclovine F18; Drug: Goserelin Acetate; Procedure: Intensity-Modulated Proton Therapy; Radiation: Intensity-Modulated Radiation Therapy; Drug: Leuprolide Acetate; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Relugolix; Radiation: Stereotactic Body Radiation Therapy; Drug: Triptorelin; Radiation: Volume Modulated Arc Therapy

Interventions

Computed Tomography PROCEDURE

Undergo PET/CT

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Degarelix DRUG

Given SC

Also known as: FE200486, Firmagon

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Intensity-Modulated Radiation Therapy RADIATION

Undergo IMRT

Also known as: IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy

Arm D (EBRT, STAD, apalutamide, RT)

Leuprolide Acetate DRUG

Given IM

Also known as: A-43818, Abbott 43818, Abbott-43818, Carcinil, Depo-Eligard, Eligard, Enanton, Enantone, Enantone-Gyn, Ginecrin, LEUP, Leuplin, Leuprorelin Acetate, Lucrin, Lucrin Depot, Lupron, Lupron Depot, Lupron Depot-3 Month, Lupron Depot-4 Month, Lupron Depot-Ped, Lutrate, Procren, Procrin, Prostap, TAP-144, Trenantone, Uno-Enantone, Viadur

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Magnetic Resonance Imaging PROCEDURE

Undergo PET/MR

Also known as: Magnetic Resonance, Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Questionnaire Administration OTHER

Ancillary studies

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

3-Dimensional Conformal Radiation Therapy RADIATION

Undergo 3D CRT

Also known as: 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D radiotherapy, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Three dimensional external beam radiation therapy (procedure)

Arm D (EBRT, STAD, apalutamide, RT)

Apalutamide DRUG

Given PO

Also known as: ARN 509, ARN-509, ARN509, Erleada, JNJ 56021927, JNJ-56021927

Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

External Beam Radiation Therapy RADIATION

Undergo EBRT

Also known as: Definitive Radiation Therapy, EBRT, External Beam Radiation, External Beam Radiotherapy, External Beam Radiotherapy (conventional), External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Radiation, External Beam, Teleradiotherapy, Teletherapy, Teletherapy Radiation

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Fluciclovine F18 OTHER

Given IV

Also known as: (18F)Fluciclovine, (18F)GE-148, 18F-Fluciclovine, [18F]FACBC, Anti-(18f)FABC, Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid, Anti-[18F] FACBC, Axumin, Fluciclovine (18F), FLUCICLOVINE F-18, GE-148 (18F), GE-148 F-18

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Positron Emission Tomography PROCEDURE

Undergo PET/CT or PET/MR

Also known as: Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Quality-of-Life Assessment OTHER

Ancillary studies

Also known as: Quality of Life Assessment

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Relugolix DRUG

Given PO

Also known as: N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea, Orgovyx, TAK 385, TAK-385

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Stereotactic Body Radiation Therapy RADIATION

Undergo SBRT

Also known as: SABR, SBRT, Stereotactic Ablative Body Radiation Therapy

Arm D (EBRT, STAD, apalutamide, RT)

Triptorelin DRUG

Given IM

Also known as: 6-D-Tryptophan-LH-RH, 6-D-Tryptophanluteinizing Hormone-releasing Factor, AY-25650, CL-118,532, Detryptoreline

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Volume Modulated Arc Therapy RADIATION

Undergo VMAT

Also known as: VMAT, Volumetric Modulated Arc Therapy (procedure)

Arm D (EBRT, STAD, apalutamide, RT)

Goserelin Acetate DRUG

Given SC

Also known as: ZDX, Zoladex

Arm A (EBRT, short-term androgen deprivation therapy [STAD]); Arm B (EBRT, STAD, apalutamide); Arm C (EBRT, STAD, apalutamide); Arm D (EBRT, STAD, apalutamide, RT)

Intensity-Modulated Proton Therapy PROCEDURE

Undergo IMPT

Also known as: IMPT

Arm D (EBRT, STAD, apalutamide, RT)

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• STEP 0: REGISTRATION ELIGIBILITY CRITERIA
• Patient must be male and \>= 18 years of age.
• Patient must have had a radical prostatectomy (RP) as definitive therapy for histopathologically-proven prostatic adenocarcinoma
• Patient must have biochemical recurrence (BCR) after RP, defined as follows:
• If time to BCR, defined as time to first detectable PSA ( \> lower limit of normal for assay used) after RP, is \< 12 months, a minimum PSA level of \>= 0.2 ng/mL and a confirmatory reading of \>= 0.2 ng/mL is required, per the American Urological Association (AUA) definition (Note: patients with a persistent PSA reading of at least 0.2 ng/mL are eligible)
• If time to BCR, defined as time to first detectable PSA (\> lower limit of normal for assay used) after RP, is \>= 12 months, a minimum absolute PSA of 0.5 ng/mL is required
• If the patient has a detectable PSA (\> lower limit of normal for assay used) at any time after RP AND has an eligible baseline SOC PET (PET1) with at least one positive lesion in any location, then there is no minimum PSA requirement
• Patients must have no definite evidence for extrapelvic metastatic disease by conventional imaging modalities (CIM) (CT abdomen/pelvis or MRI abdomen/pelvis AND bone scintigraphy, or equivalent), within 26 weeks prior to Step 0 registration. If a patient only has a study-eligible PET/CT or PET/MR (i.e., PET done without prior CIM): if the PET is negative for extrapelvic lesions, then baseline CIM is NOT required. If the PET positive for extrapelvic lesions, then patient should have a baseline CT/MRI for soft tissue lesions and/or a bone scan for osseous lesions
• Study eligible = PET using FDA-approved radiotracer and performed within 16 weeks prior to study registration
• Extra-pelvic metastases is defined as any osseous metastases and/or any extrapelvic soft tissue, lymph nodes and organ metastases; extra-pelvic is defined as superior to common iliac bifurcation, outside of standard prostate bed + whole pelvis nodal RT fields. Baseline PET/CT or PET/MR scan (PET1) is eligible for this study if the SOC PET scan is completed with an FDA approved radiotracer for prostate cancer after Step 0 registration and prior to Step 1 randomization OR up to 16 weeks prior to Step 0 registration
• Patient must be a candidate for SOC post-prostatectomy radiation therapy (RT) to the prostate bed and pelvic nodes with androgen deprivation therapy (ADT)
• Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
• Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Patient must not have started ADT for biochemical recurrence prior to baseline PET (PET1) imaging. A short course of low-dose anti-androgen such as bicalutamide, given after baseline study PET/CT but prior to study registration, is permitted as a brief temporizing measure in advance of starting protocol-approved SOC ADT.
• Patient must not be enrolled in another therapeutic clinical trial

Sponsors & Collaborators

• ECOG-ACRIN Cancer Research Group: lead
• National Cancer Institute (NCI): collaborator

Study Sites (303)

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States

RECRUITING

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States

RECRUITING

Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States

SUSPENDED

Katmai Oncology Group

Anchorage, Alaska, 99508, United States

RECRUITING

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

RECRUITING

Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States

RECRUITING

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States

RECRUITING

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States

RECRUITING

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

RECRUITING

Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States

RECRUITING

Mercy San Juan Medical Center

Carmichael, California, 95608, United States

RECRUITING

City of Hope Corona

Corona, California, 92879, United States

RECRUITING

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States

RECRUITING

Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States

RECRUITING

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

RECRUITING

City of Hope Antelope Valley

Lancaster, California, 93534, United States

RECRUITING

Los Angeles General Medical Center

Los Angeles, California, 90033, United States

RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

RECRUITING

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States

RECRUITING

Mercy Cancer Center

Merced, California, 95340, United States

SUSPENDED

Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States

RECRUITING

Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States

RECRUITING

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States

RECRUITING

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States

RECRUITING

City of Hope South Pasadena

South Pasadena, California, 91030, United States

RECRUITING

City of Hope Upland

Upland, California, 91786, United States

RECRUITING

Woodland Memorial Hospital

Woodland, California, 95695, United States

RECRUITING

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

RECRUITING

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States

RECRUITING

Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States

RECRUITING

Porter Adventist Hospital

Denver, Colorado, 80210, United States

SUSPENDED

Saint Anthony Hospital

Lakewood, Colorado, 80228, United States

RECRUITING

Littleton Adventist Hospital

Littleton, Colorado, 80122, United States

SUSPENDED

Longmont United Hospital

Longmont, Colorado, 80501, United States

RECRUITING

Parker Adventist Hospital

Parker, Colorado, 80138, United States

SUSPENDED

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States

RECRUITING

Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States

RECRUITING

Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States

RECRUITING

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States

RECRUITING

Moffitt Cancer Center

Tampa, Florida, 33612, United States

RECRUITING

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States

RECRUITING

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States

RECRUITING

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

RECRUITING

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

RECRUITING

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States

RECRUITING

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

RECRUITING

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686, United States

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

RECRUITING

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

RECRUITING

Alton Memorial Hospital

Alton, Illinois, 62002, United States

SUSPENDED

Rush - Copley Medical Center

Aurora, Illinois, 60504, United States

RECRUITING

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

RECRUITING

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

RECRUITING

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

RECRUITING

SIH Cancer Institute

Carterville, Illinois, 62918, United States

RECRUITING

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

RECRUITING

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

RECRUITING

Saint Mary's Hospital

Centralia, Illinois, 62801, United States

RECRUITING

Northwestern University

Chicago, Illinois, 60611, United States

RECRUITING

Rush University Medical Center

Chicago, Illinois, 60612, United States

RECRUITING

University of Illinois

Chicago, Illinois, 60612, United States

RECRUITING

Carle at The Riverfront

Danville, Illinois, 61832, United States

RECRUITING

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

RECRUITING

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States

RECRUITING

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

RECRUITING

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

RECRUITING

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

RECRUITING

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

RECRUITING

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

RECRUITING

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

SUSPENDED

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States

RECRUITING

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

RECRUITING

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

RECRUITING

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

RECRUITING

Loyola University Medical Center

Maywood, Illinois, 60153, United States

ACTIVE NOT RECRUITING

Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States

RECRUITING

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

RECRUITING

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269, United States

RECRUITING

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

RECRUITING

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

RECRUITING

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

RECRUITING

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

RECRUITING

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

RECRUITING

Valley Radiation Oncology

Peru, Illinois, 61354, United States

RECRUITING

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

RECRUITING

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States

RECRUITING

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

RECRUITING

Springfield Clinic

Springfield, Illinois, 62702, United States

RECRUITING

Memorial Medical Center

Springfield, Illinois, 62781, United States

RECRUITING

Carle Cancer Center

Urbana, Illinois, 61801, United States

RECRUITING

The Carle Foundation Hospital

Urbana, Illinois, 61801, United States

RECRUITING

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States

RECRUITING

Illinois CancerCare - Washington

Washington, Illinois, 61571, United States

RECRUITING

Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States

RECRUITING

Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States

RECRUITING

Saint Joseph Hospital

Lexington, Kentucky, 40504, United States

RECRUITING

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States

RECRUITING

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

RECRUITING

Jewish Hospital

Louisville, Kentucky, 40202, United States

SUSPENDED

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530, United States

ACTIVE NOT RECRUITING

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

Biddeford, Maine, 04005, United States

ACTIVE NOT RECRUITING

Maine Medical Center-Bramhall Campus

Portland, Maine, 04102, United States

ACTIVE NOT RECRUITING

MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073, United States

ACTIVE NOT RECRUITING

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, 04073, United States

ACTIVE NOT RECRUITING

Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074, United States

ACTIVE NOT RECRUITING

Maine Medical Partners - South Portland

South Portland, Maine, 04106, United States

ACTIVE NOT RECRUITING

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

ACTIVE NOT RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

RECRUITING

Suburban Hospital

Bethesda, Maryland, 20814, United States

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States

ACTIVE NOT RECRUITING

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

RECRUITING

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

RECRUITING

Fairview Southdale Hospital

Edina, Minnesota, 55435, United States

RECRUITING

Unity Hospital

Fridley, Minnesota, 55432, United States

ACTIVE NOT RECRUITING

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States

RECRUITING

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

RECRUITING

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

RECRUITING

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

RECRUITING

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

RECRUITING

Health Partners Inc

Minneapolis, Minnesota, 55454, United States

RECRUITING

Monticello Cancer Center

Monticello, Minnesota, 55362, United States

RECRUITING

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States

RECRUITING

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

RECRUITING

Regions Hospital

Saint Paul, Minnesota, 55101, United States

RECRUITING

United Hospital

Saint Paul, Minnesota, 55102, United States

RECRUITING

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States

RECRUITING

Lakeview Hospital

Stillwater, Minnesota, 55082, United States

RECRUITING

Ridgeview Medical Center

Waconia, Minnesota, 55387, United States

RECRUITING

Rice Memorial Hospital

Willmar, Minnesota, 56201, United States

RECRUITING

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States

RECRUITING

Baptist Cancer Center-Grenada

Grenada, Mississippi, 38901, United States

RECRUITING

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

ACTIVE NOT RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, 38652, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655, United States

RECRUITING

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States

RECRUITING

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

RECRUITING

Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States

RECRUITING

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

RECRUITING

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

RECRUITING

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

RECRUITING

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

SUSPENDED

Freeman Health System

Joplin, Missouri, 64804, United States

RECRUITING

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

RECRUITING

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States

RECRUITING

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States

RECRUITING

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States

RECRUITING

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

RECRUITING

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

RECRUITING

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

RECRUITING

Washington University School of Medicine

St Louis, Missouri, 63110, United States

RECRUITING

Mercy Hospital South

St Louis, Missouri, 63128, United States

RECRUITING

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

RECRUITING

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

RECRUITING

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

RECRUITING

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

RECRUITING

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

RECRUITING

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

RECRUITING

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

RECRUITING

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

RECRUITING

Great Falls Clinic

Great Falls, Montana, 59405, United States

RECRUITING

Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States

RECRUITING

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

RECRUITING

Community Medical Center

Missoula, Montana, 59804, United States

RECRUITING

CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States

RECRUITING

Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States

RECRUITING

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

RECRUITING

Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States

RECRUITING

Creighton University Medical Center

Omaha, Nebraska, 68131, United States

RECRUITING

Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States

RECRUITING

Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States

RECRUITING

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

RECRUITING

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States

RECRUITING

Community Medical Center

Toms River, New Jersey, 08755, United States

RECRUITING

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, 08043, United States

RECRUITING

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States

RECRUITING

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

RECRUITING

Mount Sinai Union Square

New York, New York, 10003, United States

RECRUITING

Mount Sinai Chelsea

New York, New York, 10011, United States

RECRUITING

Mount Sinai West

New York, New York, 10019, United States

RECRUITING

Lenox Hill Hospital

New York, New York, 10021, United States

RECRUITING

Mount Sinai Hospital

New York, New York, 10029, United States

RECRUITING

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065, United States

RECRUITING

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591, United States

RECRUITING

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

RECRUITING

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

RECRUITING

Westchester Medical Center

Valhalla, New York, 10595, United States

RECRUITING

ECU Health Oncology Kenansville

Kenansville, North Carolina, 28349, United States

RECRUITING

ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States

RECRUITING

ECU Health Oncology Richlands

Richlands, North Carolina, 28574, United States

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

ACTIVE NOT RECRUITING

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States

RECRUITING

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

ACTIVE NOT RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

RECRUITING

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

RECRUITING

Saint Charles Health System

Bend, Oregon, 97701, United States

RECRUITING

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

RECRUITING

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

RECRUITING

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

RECRUITING

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States

ACTIVE NOT RECRUITING

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

RECRUITING

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

RECRUITING

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States

ACTIVE NOT RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Oregon Health and Science University

Portland, Oregon, 97239, United States

RECRUITING

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062, United States

ACTIVE NOT RECRUITING

UPMC Altoona

Altoona, Pennsylvania, 16601, United States

RECRUITING

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009, United States

RECRUITING

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008, United States

RECRUITING

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015, United States

RECRUITING

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026, United States

RECRUITING

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

East Norriton, Pennsylvania, 19401, United States

RECRUITING

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States

RECRUITING

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121, United States

RECRUITING

Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, 18925, United States

RECRUITING

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342, United States

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

RECRUITING

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

RECRUITING

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901, United States

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050, United States

RECRUITING

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146, United States

RECRUITING

UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, 15108, United States

RECRUITING

UPMC Cancer Center-Natrona Heights

Natrona Heights, Pennsylvania, 15065, United States

RECRUITING

UPMC Hillman Cancer Center - New Castle

New Castle, Pennsylvania, 16105, United States

RECRUITING

Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

RECRUITING

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

RECRUITING

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215, United States

RECRUITING

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States

RECRUITING

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243, United States

RECRUITING

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346, United States

RECRUITING

UPMC Cancer Center-Uniontown

Uniontown, Pennsylvania, 15401, United States

RECRUITING

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401, United States

RECRUITING

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301, United States

RECRUITING

UPMC Susquehanna

Williamsport, Pennsylvania, 17701, United States

RECRUITING

UPMC Memorial

York, Pennsylvania, 17408, United States

RECRUITING

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

RECRUITING

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

SUSPENDED

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

SUSPENDED

UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, 75237, United States

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

RECRUITING

Tarrant County Hospital District/JPS Health Network

Fort Worth, Texas, 76104, United States

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104, United States

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080, United States

RECRUITING

Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States

ACTIVE NOT RECRUITING

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

SUSPENDED

University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States

RECRUITING

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298, United States

RECRUITING

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States

RECRUITING

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

RECRUITING

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States

RECRUITING

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

RECRUITING

Providence Regional Cancer Partnership

Everett, Washington, 98201, United States

RECRUITING

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

RECRUITING

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

RECRUITING

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States

RECRUITING

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

RECRUITING

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, 98274, United States

RECRUITING

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States

RECRUITING

FHCC South Lake Union

Seattle, Washington, 98109, United States

RECRUITING

Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States

RECRUITING

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

RECRUITING

FHCC at Northwest Hospital

Seattle, Washington, 98133, United States

RECRUITING

University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States

RECRUITING

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States

RECRUITING

Saint Michael Cancer Center

Silverdale, Washington, 98383, United States

RECRUITING

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States

RECRUITING

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684, United States

ACTIVE NOT RECRUITING

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States

ACTIVE NOT RECRUITING

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

RECRUITING

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States

RECRUITING

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States

RECRUITING

William S Middleton VA Medical Center

Madison, Wisconsin, 53705, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

RECRUITING

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

RECRUITING

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States

RECRUITING

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

RECRUITING

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, 54501, United States

RECRUITING

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

RECRUITING

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481, United States

RECRUITING

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

RECRUITING

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States

RECRUITING

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States

RECRUITING

Welch Cancer Center

Sheridan, Wyoming, 82801, United States

RECRUITING

Related Publications (1)

• Morgan TM, Boorjian SA, Buyyounouski MK, Chapin BF, Chen DYT, Cheng HH, Chou R, Jacene HA, Kamran SC, Kim SK, Kirkby E, Luckenbaugh AN, Nathanson BJ, Nyame YA, Posadas EM, Tran PT, Chen RC. Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part II: Treatment Delivery for Non-metastatic Biochemical Recurrence After Primary Radical Prostatectomy. J Urol. 2024 Apr;211(4):518-525. doi: 10.1097/JU.0000000000003891. Epub 2024 Feb 29.

  PMID: 38421243 DERIVED

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Radiotherapy, Conformal; apalutamide; acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide; Congresses as Topic; Radiation; fluciclovine F-18; Goserelin; Radiotherapy, Intensity-Modulated; Leuprolide; luprolide acetate gel depot; Magnetic Resonance Spectroscopy; relugolix; Radiosurgery; Triptorelin Pamoate

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Radiotherapy, Computer-Assisted; Radiotherapy; Therapeutics; Organizations; Health Care Economics and Organizations; Physical Phenomena; Gonadotropin-Releasing Hormone; Pituitary Hormone-Releasing Hormones; Hypothalamic Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Neuropeptides; Peptides; Amino Acids, Peptides, and Proteins; Oligopeptides; Nerve Tissue Proteins; Proteins; Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Stereotaxic Techniques; Neurosurgical Procedures; Surgical Procedures, Operative

Study Officials

• Neha Vapiwala

  ECOG-ACRIN Cancer Research Group

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 5, 2020
• First Posted: June 9, 2020
• Study Start: October 8, 2020
• Primary Completion (Estimated): December 31, 2032
• Study Completion (Estimated): December 31, 2032
• Last Updated: May 5, 2026

Record last verified: 2026-04

Locations

US (303)