Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

NCT04513717 | Active Not Recruiting Phase 3 FDA Drug

• 3 other identifiers: NRG-GU009NCI-2020-04705U10CA180868
• Study Type: interventional
• Target: 2,753
• Locations: 2 countries
• Sites: 602

Brief Summary

This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving a shorter hormone therapy treatment may work the same at controlling prostate cancer compared to the usual 24 month hormone therapy treatment in patients with low gene risk score. Adding apalutamide to the usual treatment may increase the length of time without prostate cancer spreading as compared to the usual treatment in patients with high gene risk score.

Conditions

Stage III Prostate Cancer AJCC v8; Prostate Adenocarcinoma; Stage IVA Prostate Cancer AJCC v8

Outcome Measures

Primary Outcomes (4)

• Metastasis-free survival (MFS)

  Assessed based on conventional imaging. MFS will be estimated using the Kaplan-Meier method (Kaplan 1958).

  From randomization to the date of detection of distant metastasis on standard imaging or date of death from any cause, assessed up to 13 years

• Sexual quality of life (De-intensification study)

  Measured by Expanded Prostate Cancer Index Composite-26 sexual domain

  Up to 13 years

• Hormonal quality of life (De-intensification study)

  Measured by EPIC-26 hormonal domain

  Up to 13 years

• Fatigue (Intensification study)

  Measured by Patient Reported Outcomes Measurement Information Systems (PROMIS) Fatigue short form (SF)

  Up to 13 years

Secondary Outcomes (10)

• MFS

  From randomization to the date of detection of distant metastasis on standard imaging or date of death from any cause, assessed up to 13 years

• Overall survival

  From the date of randomization to the date of death or last known follow-up date, with patients alive at the last known follow-up time treated as censored, assessed up to 13 years

• Prostate cancer specific mortality (PCSM)

  From the date of randomization to the date of prostate cancer death, assessed up to 13 years

• Prostate specific antigen (PSA) failure-free survival with non-castrate testosterone and no additional therapies

  From the date of randomization to the date event, or death or censored at the last known follow-up date, assessed up to 13 years

• Time to testosterone recovery

  Up to 13 years

Other Outcomes (11)

• Cardio-metabolic markers including body mass index and waist circumference

  Up to 13 years

• Machine learning/artificial intelligence algorithm

  Up to 13 years

• Impact of PET use

  Up to 13 years

Study Arms (4)

Arm I (de-intensification study)

ACTIVE COMPARATOR

Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 24 months in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.

Drug: Bicalutamide; Procedure: Biospecimen Collection; Procedure: Bone Scan; Drug: Buserelin; Procedure: Computed Tomography; Drug: Degarelix; Drug: Flutamide; Drug: Goserelin; Drug: Histrelin; Drug: Leuprolide; Procedure: Magnetic Resonance Elastography; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Relugolix; Drug: Triptorelin

Arm II (de-intensification study)

EXPERIMENTAL

Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.

Drug: Bicalutamide; Procedure: Biospecimen Collection; Procedure: Bone Scan; Drug: Buserelin; Procedure: Computed Tomography; Drug: Degarelix; Drug: Flutamide; Drug: Goserelin; Drug: Histrelin; Drug: Leuprolide; Procedure: Magnetic Resonance Elastography; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Relugolix; Drug: Triptorelin

Arm III (intensification study)

ACTIVE COMPARATOR

Patients undergo RT over 2-11 weeks and receive ADT as in Arm I. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.

Drug: Bicalutamide; Procedure: Biospecimen Collection; Procedure: Bone Scan; Drug: Buserelin; Procedure: Computed Tomography; Drug: Degarelix; Drug: Flutamide; Drug: Goserelin; Drug: Histrelin; Drug: Leuprolide; Procedure: Magnetic Resonance Elastography; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Relugolix; Drug: Triptorelin

Arm IV (intensification study)

EXPERIMENTAL

Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix) for 24 months in the absence of disease progression or unacceptable toxicity. Patients also receive apalutamide PO QD. Treatment repeats every 90 days for up to 8 cycles (24 months) in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.

Drug: Apalutamide; Procedure: Biospecimen Collection; Procedure: Bone Scan; Drug: Buserelin; Procedure: Computed Tomography; Drug: Degarelix; Drug: Goserelin; Drug: Histrelin; Drug: Leuprolide; Procedure: Magnetic Resonance Elastography; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Relugolix; Drug: Triptorelin

Interventions

Apalutamide DRUG

Given PO

Also known as: ARN 509, ARN-509, ARN509, Erleada, JNJ 56021927, JNJ-56021927

Arm IV (intensification study)

Bicalutamide DRUG

Given bicalutamide

Also known as: Casodex, Cassotide, Cosudex, ICI 176,334, ICI 176334, Utamide

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study)

Biospecimen Collection PROCEDURE

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Bone Scan PROCEDURE

Undergo bone scan

Also known as: Bone Scintigraphy

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Buserelin DRUG

Given buserelin

Also known as: 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig), BSRL, Busereline, Etilamide, HOE 766, HOE-766, HOE766, ICI 123215, ICI-123215, ICI123215, S74 6766, S74-6766, S746766, Tiloryth

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Degarelix DRUG

Given degarelix

Also known as: ASP 3550, ASP-3550, ASP3550, FE 200486, FE-200486, FE200486, Firmagon

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Leuprolide DRUG

Given leuprolide

Also known as: Leuprorelin

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Magnetic Resonance Elastography PROCEDURE

Undergo MRI

Also known as: MRE

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Quality-of-Life Assessment OTHER

Ancillary studies

Also known as: Quality of Life Assessment

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Questionnaire Administration OTHER

Ancillary studies

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Relugolix DRUG

Given relugolix

Also known as: N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea, Orgovyx, Relumina, TAK 385, TAK-385, TAK385

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Triptorelin DRUG

Given triptorelin

Also known as: 6-D-Tryptophan-LH-RH, 6-D-Tryptophanluteinizing Hormone-releasing Factor, AY 25650, AY-25650, AY25650, CL 118532, CL-118,532, CL-118532, CL118532, Detryptoreline

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Radiation Therapy RADIATION

Undergo radiation therapy

Also known as: Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Positron Emission Tomography PROCEDURE

Undergo PET scan

Also known as: Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, PT

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Computed Tomography PROCEDURE

Undergo CT scan

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Flutamide DRUG

Given flutamide

Also known as: 4'-Nitro-3'-trifluoromethylisobutyranilide, Apimid, Cebatrol, Chimax, Cytomid, Drogenil, Euflex, Eulexine, Flucinom, Flucinome, Flugerel, Fluken, Flulem, FLUT, Fluta-Gry, Flutabene, Flutacan, Flutamex, Flutamin, Flutan, Flutaplex, Fugerel, Grisetin, Niftolide, Oncosal, Profamid, Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-, Prostacur, Prostadirex, Prostica, Prostogenat, Sch 13521, Tafenil, Tecnoflut, Testotard

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study)

Goserelin DRUG

Given goserelin

Also known as: ICI-118630

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Histrelin DRUG

Given histrelin

Arm I (de-intensification study); Arm II (de-intensification study); Arm III (intensification study); Arm IV (intensification study)

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• PRIOR TO STEP 1 REGISTRATION
• Pathologically proven diagnosis of adenocarcinoma of prostate cancer within 180 days prior to registration
• High-risk disease defined as having at least one or more of the following:
• PSA \> 20 ng/mL prior to starting ADT
• Note: Patients receiving a 5-alpha reductase inhibitor (ex. finasteride) at the time of enrollment are eligible. The baseline PSA value should be doubled for PSAs taken while on 5-alpha reductase inhibitors and the medication should be discontinued prior to randomization but a washout period is not required
• cT3a-T4 by digital exam or imaging (American Joint Committee on Cancer \[AJCC\] 8th edition \[Ed.\])
• Gleason score of 8-10
• Node positive by conventional imaging with a short axis of at least 1.0 cm
• Appropriate stage for study entry based on the following diagnostic workup:
• History/physical examination within 120 days prior to registration;
• Bone imaging within 120 days prior to registration;
• Note: To be eligible, patient must have no definitive evidence of bone metastases (M0) on bone scan or sodium fluoride (NaF) PET within 120 days prior to registration (negative NaF PET/CT or negative Axumin or choline PET or negative fluciclovine, choline or prostate-specific membrane antigen (PSMA) PET within 120 days prior to registration is an acceptable substitute if they have been performed). Patients who have bone metastases established only fluciclovine, choline, or PSMA PET but not definitive on bone scan or NaF PET will still be eligible
• CT or MRI of the pelvis within 120 days prior to registration (negative fluciclovine, choline, or PSMA PET within 120 days prior to registration is an acceptable substitute). As with bone staging, nodal staging for trial purposes will be based off of conventional imaging findings only
• Patients with confirmed N1 metastases on conventional imaging (CT/MRI) as defined by \>= 10 mm on short axis are eligible but will be automatically assigned to the intensification study. Patients who are positive by fluciclovine, choline, or PSMA PET (i.e. N1), but whose nodes do not meet traditional size criteria for positivity (i.e. they measure \>= 10 mm on either the CT or MRI portion of the PET or on a dedicated CT or MRI) will not be considered N1 for the trial and will not automatically be assigned to the intensification study
• Age \>= 18

You may not qualify if:

• PRIOR TO STEP 1 REGISTRATION:
• Definitive radiologic evidence of metastatic disease outside of the pelvic nodes (M1a, M1b or M1c) on conventional imaging (i.e. bone scan, CT scan, MRI)
• Prior systemic chemotherapy within =\< 3 years prior to registration; note that prior chemotherapy for a different cancer is allowed (completed \> 3 years prior to registration
• Prior radical prostatectomy
• Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
• Current use of 5-alpha reductase inhibitor. NOTE: If the alpha reductase inhibitor is stopped prior to randomization the patient is eligible
• History of any of the following:
• Seizure disorder
• Current severe or unstable angina
• New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.)
• History of any condition that in the opinion of the investigator, would preclude participation in this study
• Evidence of any of the following at registration:
• Active uncontrolled infection requiring IV antibiotics
• Baseline severe hepatic impairment (Child Pugh Class C)
• Inability to swallow oral pills

Sponsors & Collaborators

• NRG Oncology: lead
• National Cancer Institute (NCI): collaborator

Study Sites (602)

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States

Location

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States

Location

Arizona Center for Cancer Care - Gilbert

Gilbert, Arizona, 85297, United States

Location

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381, United States

Location

Arizona Center for Cancer Care - Phoenix

Phoenix, Arizona, 85027, United States

Location

Arizona Center for Cancer Care - Scottsdale

Scottsdale, Arizona, 85258, United States

Location

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

Location

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Location

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States

Location

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, 93301, United States

Location

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States

Location

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States

Location

Enloe Medical Center

Chico, California, 95926, United States

Location

City of Hope Corona

Corona, California, 92882, United States

Location

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States

Location

Kaiser Permanente Dublin

Dublin, California, 94568, United States

Location

UC San Diego Health System - Encinitas

Encinitas, California, 92024, United States

Location

Kaiser Permanente-Fremont

Fremont, California, 94538, United States

Location

Palo Alto Medical Foundation-Fremont

Fremont, California, 94538, United States

Location

Washington Hospital

Fremont, California, 94538, United States

Location

Kaiser Permanente-Fresno

Fresno, California, 93720, United States

Location

Marin General Hospital

Greenbrae, California, 94904, United States

Location

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States

Location

City of Hope at Irvine Lennar

Irvine, California, 92618, United States

Location

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

Location

City of Hope Antelope Valley

Lancaster, California, 93534, United States

Location

Los Angeles General Medical Center

Los Angeles, California, 90033, United States

Location

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

Location

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

Location

Fremont - Rideout Cancer Center

Marysville, California, 95901, United States

Location

Memorial Medical Center

Modesto, California, 95355, United States

Location

Kaiser Permanente-Modesto

Modesto, California, 95356, United States

Location

Providence Queen of The Valley

Napa, California, 94558, United States

Location

Kaiser Permanente-Oakland

Oakland, California, 94611, United States

Location

Saint Joseph Hospital - Orange

Orange, California, 92868, United States

Location

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States

Location

Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301, United States

Location

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States

Location

Kaiser Permanente-Roseville

Roseville, California, 95661, United States

Location

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States

Location

Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States

Location

Sutter Medical Center Sacramento

Sacramento, California, 95816, United States

Location

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

Location

Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States

Location

California Protons Cancer Therapy Center

San Diego, California, 92121, United States

Location

Sharp Memorial Hospital

San Diego, California, 92123, United States

Location

Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States

Location

UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States

Location

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States

Location

Stanford Cancer Center South Bay

San Jose, California, 95124, United States

Location

Kaiser Permanente San Leandro

San Leandro, California, 94577, United States

Location

UCSF Cancer Center - San Mateo

San Mateo, California, 94402, United States

Location

Ridley-Tree Cancer Center

Santa Barbara, California, 93105, United States

Location

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States

Location

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States

Location

City of Hope South Pasadena

South Pasadena, California, 91030, United States

Location

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States

Location

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, 94086, United States

Location

Cedars-Sinai Cancer - Tarzana

Tarzana, California, 91356, United States

Location

City of Hope South Bay

Torrance, California, 90503, United States

Location

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505, United States

Location

Torrance Memorial Medical Center

Torrance, California, 90509, United States

Location

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States

Location

City of Hope Upland

Upland, California, 91786, United States

Location

Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States

Location

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States

Location

BASS Medical Group - Lennon

Walnut Creek, California, 94598, United States

Location

John Muir Medical Center-Walnut Creek

Walnut Creek, California, 94598, United States

Location

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States

Location

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States

Location

Memorial Hospital North

Colorado Springs, Colorado, 80920, United States

Location

Shaw Cancer Center

Edwards, Colorado, 81632, United States

Location

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

Location

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States

Location

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States

Location

Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States

Location

UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States

Location

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States

Location

Medical Center of the Rockies

Loveland, Colorado, 80538, United States

Location

Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States

Location

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606, United States

Location

Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418, United States

Location

Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824, United States

Location

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830, United States

Location

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437, United States

Location

Hartford Hospital

Hartford, Connecticut, 06102, United States

Location

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States

Location

Midstate Medical Center

Meriden, Connecticut, 06451, United States

Location

The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States

Location

Yale University

New Haven, Connecticut, 06520, United States

Location

Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473, United States

Location

Smilow Cancer Hospital-Orange Care Center

Orange, Connecticut, 06477, United States

Location

Smilow Cancer Hospital Care Center at Long Ridge

Stamford, Connecticut, 06902, United States

Location

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, 06904, United States

Location

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States

Location

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States

Location

Bayhealth Hospital Kent Campus

Dover, Delaware, 19901, United States

Location

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

Location

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

Location

Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States

Location

Bay Pines VA Healthcare System

Bay Pines, Florida, 33744, United States

Location

Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States

Location

UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States

Location

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States

Location

GenesisCare USA - Lakewood Ranch

Lakewood Rch, Florida, 34202, United States

Location

Miami Cancer Institute

Miami, Florida, 33176, United States

Location

Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States

Location

GenesisCare USA - Plantation

Plantation, Florida, 33324, United States

Location

Miami Cancer Institute at Plantation

Plantation, Florida, 33324, United States

Location

Tampa General Hospital

Tampa, Florida, 33606, United States

Location

Grady Health System

Atlanta, Georgia, 30303, United States

Location

Emory Proton Therapy Center

Atlanta, Georgia, 30308, United States

Location

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

Location

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Location

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States

Location

Emory Decatur Hospital

Decatur, Georgia, 30033, United States

Location

Emory Johns Creek Hospital

Johns Creek, Georgia, 30097, United States

Location

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States

Location

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States

Location

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States

Location

Queen's Medical Center

Honolulu, Hawaii, 96813, United States

Location

Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States

Location

University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States

Location

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States

Location

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States

Location

Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States

Location

Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States

Location

The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States

Location

The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States

Location

Alton Memorial Hospital

Alton, Illinois, 62002, United States

Location

Rush-Copley Medical Center

Aurora, Illinois, 60504, United States

Location

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States

Location

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

Location

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

Location

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States

Location

University of Illinois

Chicago, Illinois, 60612, United States

Location

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States

Location

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States

Location

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014, United States

Location

Carle at The Riverfront

Danville, Illinois, 61832, United States

Location

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

Location

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States

Location

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515, United States

Location

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

Location

Advocate Sherman Hospital

Elgin, Illinois, 60123, United States

Location

Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126, United States

Location

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States

Location

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026, United States

Location

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030, United States

Location

Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States

Location

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States

Location

Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States

Location

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

Location

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States

Location

AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States

Location

Condell Memorial Hospital

Libertyville, Illinois, 60048, United States

Location

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

Location

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

Location

Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States

Location

UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States

Location

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269, United States

Location

Northwestern Medicine Oak Brook

Oak Brook, Illinois, 60523, United States

Location

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States

Location

Northwestern Medicine Orland Park

Orland Park, Illinois, 60462, United States

Location

University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Advocate High Tech Medical Park

Palos Heights, Illinois, 60463, United States

Location

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States

Location

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

Location

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

Location

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

Location

Edward Hospital/Cancer Center?Plainfield

Plainfield, Illinois, 60585, United States

Location

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

Location

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States

Location

Memorial Hospital East

Shiloh, Illinois, 62269, United States

Location

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

Location

Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States

Location

Illinois CancerCare - Washington

Washington, Illinois, 61571, United States

Location

IU Health West Hospital

Avon, Indiana, 46123, United States

Location

IU Health North Hospital

Carmel, Indiana, 46032, United States

Location

UChicago Medicine Northwest Indiana

Crown Point, Indiana, 46307, United States

Location

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

Location

IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States

Location

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States

Location

Saint Luke's Hospital

Cedar Rapids, Iowa, 52402, United States

Location

Mercy Hospital

Cedar Rapids, Iowa, 52403, United States

Location

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States

Location

Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States

Location

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States

Location

Broadlawns Medical Center

Des Moines, Iowa, 50314, United States

Location

University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States

Location

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

Location

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States

Location

Salina Regional Health Center

Salina, Kansas, 67401, United States

Location

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States

Location

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States

Location

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States

Location

Wesley Medical Center

Wichita, Kansas, 67214, United States

Location

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

Location

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States

Location

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

Location

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States

Location

Mary Bird Perkins Cancer Center - Metairie

Metairie, Louisiana, 70002, United States

Location

East Jefferson General Hospital

Metairie, Louisiana, 70006, United States

Location

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006, United States

Location

Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States

Location

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530, United States

Location

MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States

Location

Penobscot Bay Medical Center

Rockport, Maine, 04856, United States

Location

MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073, United States

Location

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States

Location

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States

Location

Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401, United States

Location

Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States

Location

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

Location

Veterans Administration Medical Center-Baltimore

Baltimore, Maryland, 21201, United States

Location

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

Location

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States

Location

Suburban Hospital

Bethesda, Maryland, 20814, United States

Location

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601, United States

Location

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States

Location

UM Capital Region Medical Center

Largo, Maryland, 20774, United States

Location

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

Location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

Cape Cod Hospital

Hyannis, Massachusetts, 02601, United States

Location

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional

Milford, Massachusetts, 01757, United States

Location

Dana-Farber/Brigham and Women's Cancer Center at South Shore

South Weymouth, Massachusetts, 02190, United States

Location

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

Location

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States

Location

McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States

Location

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States

Location

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116, United States

Location

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States

Location

Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States

Location

Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States

Location

Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States

Location

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States

Location

Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States

Location

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States

Location

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334, United States

Location

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

Location

Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States

Location

McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States

Location

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

Location

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

Location

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

Location

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States

Location

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

Location

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States

Location

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

Location

Michigan Healthcare Professionals Macomb

Macomb, Michigan, 48044, United States

Location

Michigan Healthcare Professionals Madison Heights

Madison Heights, Michigan, 48071, United States

Location

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States

Location

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858, United States

Location

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

Location

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States

Location

McLaren-Port Huron

Port Huron, Michigan, 48060, United States

Location

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States

Location

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

Location

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

Location

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

Location

Henry Ford Macomb Health Center - Shelby Township

Shelby, Michigan, 48315, United States

Location

Munson Medical Center

Traverse City, Michigan, 49684, United States

Location

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States

Location

Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States

Location

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States

Location

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

Location

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States

Location

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007, United States

Location

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

Location

Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States

Location

Unity Hospital

Fridley, Minnesota, 55432, United States

Location

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

Location

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

Location

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

Location

Monticello Cancer Center

Monticello, Minnesota, 55362, United States

Location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

Location

Regions Hospital

Saint Paul, Minnesota, 55101, United States

Location

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

Location

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

Location

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

Location

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States

Location

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

Location

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

Location

Freeman Health System

Joplin, Missouri, 64804, United States

Location

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States

Location

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States

Location

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States

Location

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States

Location

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

Location

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

Location

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

Location

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States

Location

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

Location

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

Location

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123, United States

Location

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301, United States

Location

Exeter Hospital

Exeter, New Hampshire, 03833, United States

Location

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States

Location

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103, United States

Location

Clara Maass Medical Center

Belleville, New Jersey, 07109, United States

Location

Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States

Location

AtlantiCare Surgery Center

Egg Harbor, New Jersey, 08234, United States

Location

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

Elizabeth, New Jersey, 07207, United States

Location

Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States

Location

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690, United States

Location

Jersey City Medical Center

Jersey City, New Jersey, 07302, United States

Location

Saint Barnabas Medical Center

Livingston, New Jersey, 07039, United States

Location

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

Location

Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States

Location

Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States

Location

The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652, United States

Location

Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450, United States

Location

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080, United States

Location

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States

Location

Community Medical Center

Toms River, New Jersey, 08755, United States

Location

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, 08043, United States

Location

Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, 87102, United States

Location

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

Location

Lovelace Radiation Oncology

Albuquerque, New Mexico, 87109, United States

Location

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States

Location

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124, United States

Location

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States

Location

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Sands Cancer Center

Canandiaqua, New York, 14424, United States

Location

Mary Imogene Bassett Hospital

Cooperstown, New York, 13326, United States

Location

Noyes Memorial Hospital/Myers Cancer Center

Dansville, New York, 14437, United States

Location

The New York Hospital Medical Center of Queens

Flushing, New York, 11355, United States

Location

Northwell Health Physicians Partners Radiation Medicine at Queens

Forest Hills, New York, 11375, United States

Location

Glens Falls Hospital

Glens Falls, New York, 12801, United States

Location

Northwell Health Cancer Institute at Huntington

Greenlawn, New York, 11740, United States

Location

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

Location

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

Location

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States

Location

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065, United States

Location

NYP/Weill Cornell Medical Center

New York, New York, 10065, United States

Location

Lenox Hill Hospital

New York, New York, 10075, United States

Location

Queens Cancer Center

Rego Park, New York, 11374, United States

Location

Highland Hospital

Rochester, New York, 14620, United States

Location

University of Rochester

Rochester, New York, 14642, United States

Location

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591, United States

Location

Staten Island University Hospital

Staten Island, New York, 10305, United States

Location

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

Location

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

Location

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

Location

Westchester Medical Center

Valhalla, New York, 10595, United States

Location

Wilmot Cancer Institute at Webster

Webster, New York, 14580, United States

Location

Duke Cancer Center Cary

Cary, North Carolina, 27518, United States

Location

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States

Location

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States

Location

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210, United States

Location

Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262, United States

Location

Levine Cancer Institute-Ballantyne

Charlotte, North Carolina, 28277, United States

Location

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States

Location

Durham VA Medical Center

Durham, North Carolina, 27705, United States

Location

Duke University Medical Center

Durham, North Carolina, 27710, United States

Location

Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078, United States

Location

Novant Health Presbyterian Medical Center Huntersville

Huntersville, North Carolina, 28078, United States

Location

Matthews Radiation Oncology Center

Matthews, North Carolina, 28105, United States

Location

Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105, United States

Location

Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112, United States

Location

Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117, United States

Location

UNC Health Cancer Care Raleigh

Raleigh, North Carolina, 27607, United States

Location

Duke Cancer Center Raleigh

Raleigh, North Carolina, 27609, United States

Location

UNC Health Cancer Care Wakefield

Raleigh, North Carolina, 27614, United States

Location

Novant Cancer Institute Radiation Oncology - Supply

Supply, North Carolina, 28462, United States

Location

Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401, United States

Location

Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401, United States

Location

Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States

Location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Location

Altru Cancer Center

Grand Forks, North Dakota, 58201, United States

Location

Summa Health System - Akron Campus

Akron, Ohio, 44304, United States

Location

Cleveland Clinic Akron General

Akron, Ohio, 44307, United States

Location

Summa Health System - Barberton Campus

Barberton, Ohio, 44203, United States

Location

Aultman Health Foundation

Canton, Ohio, 44710, United States

Location

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States

Location

The Christ Hospital

Cincinnati, Ohio, 45219, United States

Location

MetroHealth Medical Center

Cleveland, Ohio, 44109, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

Location

Grant Medical Center

Columbus, Ohio, 43215, United States

Location

Doctors Hospital

Columbus, Ohio, 43228, United States

Location

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States

Location

Dublin Methodist Hospital

Dublin, Ohio, 43016, United States

Location

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

Location

OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States

Location

Summa Health Medina Medical Center

Medina, Ohio, 44256, United States

Location

ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States

Location

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, 73505, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Saint Charles Health System

Bend, Oregon, 97701, United States

Location

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States

Location

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

Location

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States

Location

Providence Portland Medical Center

Portland, Oregon, 97213, United States

Location

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

Location

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062, United States

Location

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104, United States

Location

UPMC Altoona

Altoona, Pennsylvania, 16601, United States

Location

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009, United States

Location

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States

Location

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008, United States

Location

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015, United States

Location

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States

Location

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

Location

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026, United States

Location

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045, United States

Location

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522, United States

Location

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States

Location

Saint Vincent Hospital

Erie, Pennsylvania, 16544, United States

Location

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121, United States

Location

Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States

Location

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342, United States

Location

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States

Location

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

Location

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

Location

IRMC Cancer Center

Indiana, Pennsylvania, 15701, United States

Location

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025, United States

Location

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901, United States

Location

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042, United States

Location

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States

Location

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132, United States

Location

Yolanda G Barco Oncology Institute

Meadville, Pennsylvania, 16335, United States

Location

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050, United States

Location

Forbes Hospital

Monroeville, Pennsylvania, 15146, United States

Location

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146, United States

Location

UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, 15108, United States

Location

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

Location

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

Location

Einstein Medical Center Philadelphia

Philadelphia, Pennsylvania, 19141, United States

Location

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States

Location

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

Location

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215, United States

Location

West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States

Location

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

Location

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

Location

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States

Location

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243, United States

Location

Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States

Location

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951, United States

Location

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951, United States

Location

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346, United States

Location

Saint Luke's Hospital - Monroe Campus

Stroudsburg, Pennsylvania, 18360, United States

Location

UPMC Cancer Center-Uniontown

Uniontown, Pennsylvania, 15401, United States

Location

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401, United States

Location

UPMC Cancer Center-Washington

Washington, Pennsylvania, 15301, United States

Location

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301, United States

Location

Chester County Hospital

West Chester, Pennsylvania, 19380, United States

Location

Reading Hospital

West Reading, Pennsylvania, 19611, United States

Location

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States

Location

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States

Location

Divine Providence Hospital

Williamsport, Pennsylvania, 17754, United States

Location

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States

Location

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403, United States

Location

UPMC Memorial

York, Pennsylvania, 17408, United States

Location

Rhode Island Hospital

Providence, Rhode Island, 02903, United States

Location

Smilow Cancer Hospital Care Center - Westerly

Westerly, Rhode Island, 02891, United States

Location

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States

Location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

MUSC Health Florence Medical Center

Florence, South Carolina, 29505, United States

Location

Saint Francis Hospital

Greenville, South Carolina, 29601, United States

Location

Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States

Location

Self Regional Healthcare

Greenwood, South Carolina, 29646, United States

Location

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

Location

The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926, United States

Location

Carolina Regional Cancer Center

Myrtle Beach, South Carolina, 29577, United States

Location

Beaufort Memorial/New River Cancer Center

Okatie, South Carolina, 29909, United States

Location

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

Location

Covenant Health Cancer Centers

Knoxville, Tennessee, 37916, United States

Location

Covenant Health Oncology Group - Maryville

Maryville, Tennessee, 37804, United States

Location

Covenant Health Oncology Group - Oak Ridge

Oak Ridge, Tennessee, 37830, United States

Location

Houston Methodist San Jacinto Hospital

Baytown, Texas, 77521, United States

Location

MD Anderson in The Woodlands

Conroe, Texas, 77384, United States

Location

Houston Methodist Hospital

Houston, Texas, 77030, United States

Location

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Methodist Willowbrook Hospital

Houston, Texas, 77070, United States

Location

MD Anderson West Houston

Houston, Texas, 77079, United States

Location

Houston Methodist West Hospital

Houston, Texas, 77094, United States

Location

MD Anderson League City

League City, Texas, 77573, United States

Location

Texas Oncology-McKinney

McKinney, Texas, 75071, United States

Location

Houston Methodist Saint John Hospital

Nassau Bay, Texas, 77058, United States

Location

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

Location

MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States

Location

Houston Methodist Sugar Land Hospital

Sugar Land, Texas, 77479, United States

Location

Houston Methodist The Woodlands Hospital

The Woodlands, Texas, 77385, United States

Location

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States

Location

Farmington Health Center

Farmington, Utah, 84025, United States

Location

Logan Regional Hospital

Logan, Utah, 84321, United States

Location

Intermountain Medical Center

Murray, Utah, 84107, United States

Location

McKay-Dee Hospital Center

Ogden, Utah, 84403, United States

Location

Utah Valley Regional Medical Center

Provo, Utah, 84604, United States

Location

Riverton Hospital

Riverton, Utah, 84065, United States

Location

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106, United States

Location

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States

Location

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

Location

LDS Hospital

Salt Lake City, Utah, 84143, United States

Location

Saint George Regional Medical Center

St. George, Utah, 84770, United States

Location

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States

Location

University of Vermont Medical Center

Burlington, Vermont, 05401, United States

Location

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States

Location

Inova Alexandria Hospital

Alexandria, Virginia, 22304, United States

Location

Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States

Location

Inova Fair Oaks Hospital

Fairfax, Virginia, 22033, United States

Location

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114, United States

Location

Bon Secours Cancer Institute at Reynolds Crossing

Richmond, Virginia, 23230, United States

Location

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

Location

Oncology and Hematology Associates of Southwest Virginia

Roanoke, Virginia, 24014, United States

Location

Virginia Mason Medical Center

Seattle, Washington, 98101, United States

Location

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684, United States

Location

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States

Location

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

Location

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

Location

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States

Location

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States

Location

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States

Location

Ascension Saint Elizabeth Hospital

Appleton, Wisconsin, 54915, United States

Location

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States

Location

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045, United States

Location

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States

Location

Ascension Calumet Hospital

Chilton, Wisconsin, 53014, United States

Location

HSHS Sacred Heart Hospital

Eau Claire, Wisconsin, 54701, United States

Location

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

Location

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132, United States

Location

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States

Location

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States

Location

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

Location

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States

Location

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States

Location

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States

Location

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States

Location

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States

Location

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States

Location

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

Location

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States

Location

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States

Location

Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, 53097, United States

Location

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States

Location

Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211, United States

Location

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States

Location

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

Location

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

Location

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154, United States

Location

Ascension Mercy Hospital

Oshkosh, Wisconsin, 54904, United States

Location

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States

Location

Ascension All Saints Hospital

Racine, Wisconsin, 53405, United States

Location

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States

Location

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States

Location

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

Location

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081, United States

Location

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States

Location

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States

Location

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

Location

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States

Location

Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States

Location

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States

Location

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States

Location

Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, 53226, United States

Location

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States

Location

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States

Location

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States

Location

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

Location

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States

Location

Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada

Location

Ottawa Hospital and Cancer Center-General Campus

Ottawa, Ontario, K1H 8L6, Canada

Location

University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada

Location

The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada

Location

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, G1R 2J6, Canada

Location

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada

Location

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada

Location

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada

Location

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

apalutamide; bicalutamide; Specimen Handling; Buserelin; acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide; Flutamide; Salicylic Acid; Goserelin; histrelin; Leuprolide; Magnetic Resonance Spectroscopy; Radiotherapy; Radiation; relugolix; Triptorelin Pamoate

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Gonadotropin-Releasing Hormone; Pituitary Hormone-Releasing Hormones; Hypothalamic Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Neuropeptides; Peptides; Amino Acids, Peptides, and Proteins; Oligopeptides; Nerve Tissue Proteins; Proteins; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines; Salicylates; Hydroxybenzoates; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Hydroxy Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Phenols; Spectrum Analysis; Chemistry Techniques, Analytical; Therapeutics; Physical Phenomena

Study Officials

• Paul L Nguyen

  NRG Oncology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2020
• First Posted: August 14, 2020
• Study Start: January 21, 2021
• Primary Completion (Estimated): December 31, 2033
• Study Completion (Estimated): December 31, 2033
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

CA (8); US (594)