The Moderating Roles of Social Support, Coping Resources and Personality and Mediating Role of Self-esteem on the Impact of Cognitive Deficit on Neuropsychiatric Symptoms Among Persons With Mild Cognitive Impairment: A Mixed-method Sequential Explanatory Design

NCT04085107 | Completed

• 1 other identifier: 00000
• Study Type: observational
• Target: 152
• Locations: 1 country
• Sites: 1

Brief Summary

This is a sequential mixed study to test the hypothesized models with seven hypotheses of the relationship between cognitive deficit (subject and objective) and neuropsychiatric symptoms (NPS) among persons with mild cognitive impairment (PwMCI). The study will also examine the psychometric properties of the Chinese version of Mild Behavioural Impairment -Checklist (MBI-C).

Conditions

Mild Cognitive Impairment; Behavioral Symptoms

Keywords

mild cognitive impairment; neuropsychiatric symptoms; instrument validation; coping styles; cognitive deficit; neuroticism; social support

Outcome Measures

Primary Outcomes (3)

• Chinese Version of the Neuropsychiatric Inventory Questionnaire (NPI-Q)

  NPI-Q is a caregiver-administered instrument that assesses measure the frequency and severity of NPS among the participants.This instrument measures 12 domains including delusion, hallucination, anxiety, depression, euphoria, apathy, disinhibition, irritability and aberrant motor behaviour, sleep disturbance and appetite. The instrument will be completed by an informant to rate the frequency of NPS on a four-point scale (1 - sporadically, 4 - very often) and the severity of NPS on a three-point scale (1 - mild, 3 - severe).

  Baseline

• Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA)

  This 12-item instrument will be used to measure cognitive functions including visuospatial functions, naming, verbal memory, abstraction, delay memory, calculation and orientation. Total score ranges from 0 to 30, with lower scores indicating more severe cognitive impairment.

  Baseline

• Chinese version of Chinese version of Mild Behavioural Impairment -Checklist

  This 34-item questionnaire will be used to measure five domains of NPS, including decreased motivation, emotional dysregulation, impulse dyscontrol, social inappropriateness and abnormal perception or thought content. It involves closed-ended questions on the existence of symptoms followed by a 3-point Likert scale on their severity. Total scores of all domains range from 0 to 102, with higher scores indicating more NPS.

  Baseline

Secondary Outcomes (4)

• Chinese version of Simplified Coping Scale Questionnaire (SCSQ)

  Baseline

• Chinese version of Multidimensional Scale of Perceived Social Support (MSPSS-C)

  Baseline

• Chinese version of the neuroticism subscale of NEO Personality Inventory (NEO-PI)

  Baseline

• Rosenberg self-esteem scale (RSES)

  Baseline

Study Arms (1)

243 PwMCI

Behavioral: Face-to-face interviews

Interventions

Face-to-face interviews BEHAVIORAL

243 PwMCI will receive two face-to-face interviews to complete two sets of questionnaires, of which 30 participants will be recruited attend a 1-hour semi-structured interview.

243 PwMCI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Persons with mild cognitive impairment in Hong Kong

You may qualify if:

• Aged 18 years old or above
• Able to communicate in Cantonese
• Diagnosis with MCI as defined by the following criteria:
• Presence of significant cognitive complaints, as defined by more than three complaints on the Memory Inventory for Chinese (MIC), which is a 27-item instrument measuring subjective memory deficit
• Abnormal objective cognitive performance defined as \< 1.5 standard deviations from age and education matched normal persons on Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA), which is a 12-item instrument measuring cognitive functions
• Independence in daily living as evaluated through clinical interview
• Both patients and one of their guardian or family members are consented to participate in the study

You may not qualify if:

• With the confirmed diagnosis of any forms of dementia
• With the confirmed diagnosis of psychiatric morbidities, or history with stroke, brain injury and other neurological conditions that may affect cognitive, behavioural and emotional functioning which may confound outcome measurement and limit their participation in the study
• With hearing or visual impairment that may hinder participation in research activities
• Current use of cognitive intervention or electromagnetic stimulation

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

University of Hong Kong

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Behavioral Symptoms; Cognition Disorders

Condition Hierarchy (Ancestors)

Neurocognitive Disorders; Mental Disorders; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 5, 2019
• First Posted: September 11, 2019
• Study Start: March 29, 2020
• Primary Completion: December 29, 2020
• Study Completion: December 29, 2020
• Last Updated: January 20, 2021

Record last verified: 2021-01

Locations

HK (1)