Effects of Tai Chi on Cognition, I-ADLs, and HRQOL in Older People With MCI

NCT03404765 | Completed DMC

• 1 other identifier: CREC.Ref,No:2015.348
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

The prevalence of older people with cognitive decline is increasing since the aging population is growing substantially worldwide. Cognitive impairment places older adults at high risk for functional disability. Previous researches have provided strong evidence on the beneficial effects of physical exercise on maintaining cognitive functions in older adults. Tai Chi is considered as a low to moderate intensity exercise, which is performed in a slow and rhythmic movement. It is a popular and safe exercise suitable for older people who have weaker muscle strength. The aim of this study was to determine the effects of Tai Chi on cognition and instrumental activities of daily living (I-ADLs), and health-related quality of life (HRQOL) in older Chinese adults with mild cognitive impairment (MCI). The research hypothesis of the study stated: There is significant improvement in the general cognitive performance, functional capabilities of instrumental ADLs,the physical component and mental component of HRQOL between the group of community-dwelling older people with MCI who have participated and the control group who have not participated in the Tai Chi program.

Conditions

Mild Cognitive Impairment

Keywords

Tai Chi; Cognition; Instrumental activities of daily living; Health-related Quality of Life

Outcome Measures

Primary Outcomes (1)

• Change from baseline C-MMSE score at four months

  The Chinese version of Mini-Mental State Examination (C-MMSE) is a global cognitive assessment tool.The first part of the CMMSE assesses respondent's abilities on orientation, memory and attention and the second part tests respondent's ability to name objects, understanding on verbal and written commands; higher score indicates for better cognitive performance.

  he outcome assessment was conducted at baseline, and at 4 month (at the end of study)

Secondary Outcomes (2)

• Change from baseline IADL-CV score at four months

  The outcome assessment was conducted at baseline, and at 4 month (at the end of study)

• Change from baseline SF-12 score at four months

  The outcome assessment was conducted at baseline, and at 4 month (at the end of study)

Study Arms (2)

Tai Chi group

EXPERIMENTAL

The Tai Chi group (i.e. the intervention group) received a 16-week Tai Chi program, of 32 sessions (2 sessions per week), each being one hour long.

Behavioral: Tai Chi

Ususal care group

NO INTERVENTION

The control group received the usual care offered by the respective centers. No intervention had been arranged for the control group during the study period. Participants in the control group were advised to attend different kinds of recreational activities provided by their community centers and to continue with their daily activities, including their usual general physical mobility and social activities.

Interventions

Tai Chi BEHAVIORAL

Tai Chi group

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Chinese people aged 60 years or above;
• Obtained the CMMSE screening score ranging from 19 to 28, which was corrected based on educational level (≥ 18 for illiterate respondents and ≥ 22 for those having received more than two years of education);
• Have ability to perform self-care functions on their own;
• No confirmed diagnosis of dementia, depression or other psychiatric illnesses;
• Not engaged in any structured physical exercise program or Tai Chi practice in the preceding year.

You may not qualify if:

• Had a medical history of chronic alcoholism or brain trauma occurred in previous years; - Regular users of medications that could affect cognition;
• Contraindicated light to moderate physical exercise.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, 999077, Hong Kong

Location

Related Publications (2)

• Siu MY, Lee DTF. Is Tai Chi an effective intervention for enhancing health-related quality of life in older people with mild cognitive impairment? An interventional study. Int J Older People Nurs. 2021 Sep;16(5):e12400. doi: 10.1111/opn.12400. Epub 2021 Jul 13.

  PMID: 34254731 DERIVED

• Siu MY, Lee DTF. Effects of tai chi on cognition and instrumental activities of daily living in community dwelling older people with mild cognitive impairment. BMC Geriatr. 2018 Feb 2;18(1):37. doi: 10.1186/s12877-018-0720-8.

  PMID: 29394884 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Tai Ji

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Exercise Movement Techniques; Physical Therapy Modalities

Study Officials

• Siu Mei Yi

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Masking Details: All personals involved the study (participants, community center supporting staff, investigators and outcome assessors) had not masked for treatment assignment.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This interventional study involved two groups of participants, the experimental and usual-care control groups, with no randomization taking place. The participants were recruited from four community health centers and allocated to the experimental or control groups according to the centers to which they belonged.This arrangement avoided possible contamination of the experiment by diffusing the Tai Chi learning. The intervention group received a 16-week Tai Chi program, of 32 sessions (2 sessions per week), each being one hour long. The control group had no treatment regime and joined different recreational activity groups in the respective community centers as usual within the study period.

Study Record Dates

• First Submitted: January 8, 2018
• First Posted: January 19, 2018
• Study Start: December 15, 2015
• Primary Completion: September 1, 2016
• Study Completion: September 1, 2016
• Last Updated: January 19, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: The supporting information (as listed above) will become available starting from 1 year after publication for 6 months
• Access Criteria: The datasets used and/or analyzed during the current study are available from the corresponding author ( Name: Siu Mei Yi at minniesiumy@gmail.com) on reasonable request. All data analyzed during this study are included in this published article and its supplementary information files.

Locations

HK (1)