Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
1 other identifier
interventional
315
1 country
1
Brief Summary
This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomized into three six-month programmes, namely Health Education group, Tai Chi group and Conventional Exercise group. Assessments will be conducted at baseline, after the 26-week interventions, and 26-week after the competition of the intervention.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 12, 2022
CompletedFirst Posted
Study publicly available on registry
September 14, 2022
CompletedStudy Start
First participant enrolled
November 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2026
CompletedDecember 11, 2024
December 1, 2024
2.2 years
September 12, 2022
December 5, 2024
Conditions
Outcome Measures
Primary Outcomes (2)
The score of the Montreal Cognitive Assessment (MoCA)
Change in the score of the Montreal Cognitive Assessment. The score ranged from 0 to 30. Higher score indicates a better cognitive function. Participants scoring equal or below the 7th percentile of the age- and education-corrected normative data will be considered as having MCI.
26 weeks
The score of the Montreal Cognitive Assessment (MoCA)
Change in the score of the Montreal Cognitive Assessment. The score ranged from 0 to 30. Higher score indicates a better cognitive function. Participants scoring equal or below the 7th percentile of the age- and education-corrected normative data will be considered as having MCI.
52 weeks
Secondary Outcomes (10)
Clinical Dementia Rating
26 weeks and 52 weeks
Neurocognitive Test
26 weeks and 52 weeks
Subjective Cognitive Performance
26 weeks and 52 weeks
Subjective Memory complaints
26 weeks and 52 weeks
Subjective Sleep Quality
26 weeks and 52 weeks
- +5 more secondary outcomes
Study Arms (3)
Health Education
SHAM COMPARATORA 26 weeks brain health and general health education program with two 1.5-hour sessions weekly.
Conventional Exercise
ACTIVE COMPARATORA 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly.
Tai Chi
EXPERIMENTALA 26 weeks Tai Chi training with two 1.5-hour sessions weekly.
Interventions
A 26 weeks brain health and general health education program with two 1.5-hour sessions weekly.
A 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly.
Eligibility Criteria
You may qualify if:
- Chinese older adults aged equal or larger than 50 years
- Ethnic Chinese
- MCI under criteria of Mayo Clinic, including the following
- i. people with subjective complaint about a decline in cognitive function. ii. total score in the Montreal Cognitive Assessment is equal or below the 7th percentile of the age- and education- corrected normative data of Hong Kong. iii. the decline in cognitive function does not impair daily functioning, as revealed by getting ≥2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living 4-point Scale).
You may not qualify if:
- medical history of major chronic diseases such as cancer, stroke, cerebro- and cardio-vascular diseases, and renal disease
- uncontrolled diabetes
- diagnosed with dementia or using anti-dementia medication
- diagnosed with psychiatric diseases or using psychiatric medication
- with diseases or on medications known to severely affect cognitive performance
- somatic condition (e.g., limb lost) that prevent participation in exercise
- impaired mobility by chronic diseases (e.g., neurological, musculoskeletal and autoimmune diseases)
- incapable to perform physical exercise
- regular exercise habit (\>3 times 60-min Tai Chi or moderate-intensity conventional exercise weekly) in the past 3 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Hong Kong
Hong Kong, 00, Hong Kong
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Parco Siu, PhD
The University of Hong Kong
Central Study Contacts
Parco Siu, PhD
CONTACT
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 12, 2022
First Posted
September 14, 2022
Study Start
November 1, 2022
Primary Completion
January 1, 2025
Study Completion
January 1, 2026
Last Updated
December 11, 2024
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will not share