Effects of SUDOKU Mind Activation & Revitalizing Training on Cognitive Function in People With Mild Cognitive Impairment

NCT04913857 | Completed

• 1 other identifier: SMART
• Study Type: interventional
• Target: 262
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to implement a SUDOKU Mind Activation and Revitalization Training (SMART) Program to promote cognitive health among patients with mild cognitive impairment (MCI), and the use of active mind strategy in preventing dementia among the older adults. The SMART Program consists of two components including, a community empowerment-educational campaign on active mind strategies for older adults, and a 24-week SUDOKU Training Programme for people with MCI.

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (12)

• Cantonese version of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog)

  To evaluate various domains of cognition

  Baseline

• Cantonese version of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog)

  To evaluate various domains of cognition

  12-week

• Cantonese version of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog)

  To evaluate various domains of cognition

  24-week

• The digit span-forward and backward test

  To measure attention and working memory

  Baseline

• The digit span-forward and backward test

  To measure attention and working memory

  12-week

• The digit span-forward and backward test

  To measure attention and working memory

  24-week

• The list learning delayed recall test

  To measure episodic memory

  Baseline

• The list learning delayed recall test

  To measure episodic memory

  12-week

• The list learning delayed recall test

  To measure episodic memory

  24-week

• Trail-Making Test Part A and B

  To measure complex attention, executive function and task switching

  Baseline

• Trail-Making Test Part A and B

  To measure complex attention, executive function and task switching

  12-week

• Trail-Making Test Part A and B

  To measure complex attention, executive function and task switching

  24-week

Secondary Outcomes (5)

• Memory Inventory for Chinese

  Baseline

• Memory Inventory for Chinese

  12-week

• Memory Inventory for Chinese

  24-week

• The 36-item Chinese version of the Short Form 36 (SF-36)

  Baseline

• The 36-item Chinese version of the Short Form 36 (SF-36)

  24-week

Other Outcomes (2)

• 13-item satisfaction survey - for SMART Program

  12-week

• 10-item satisfaction survey - for community empowerment-educational campaign

  10-month

Study Arms (2)

24-week SUDOKU Training Programme

EXPERIMENTAL

The SUDOKU training program include a 12-week face-to-face training session and a 12-week facilitated self-practice. The 12-week (60-minute sessions) training program will be evenly divided into 3 modules of increasing difficulty for the suboptimal cognitive function of the participants with MCI. As the use of T-code in solving the SUDOKU allows communicating the way a number is assigned to a box, participants are grouped into a small team of 3, so that they will work together during the tutorial practice. Facilitated self-practice will last for another 12 weeks immediately after the group training session. The instructor will give them a workbook with 12 SUDOKU puzzles of increasing level of difficulty for completion. The instructor will encourage and facilitate their accomplishment by giving them guidance on the taught method through regular phone call. Solutions of the assigned puzzle and the T-code will be provided in the following week.

Behavioral: 24-week SUDOKU Training Programme

wait-list

ACTIVE COMPARATOR

wait-list comparison group will receive the same program upon completion of the 6-month posttest evaluation on study outcomes

Other: Control Arm (wait-list)

Interventions

24-week SUDOKU Training Programme BEHAVIORAL

12-week face-to-face training session and a 12-week facilitated self-practice

Also known as: SMART

24-week SUDOKU Training Programme

Control Arm (wait-list) OTHER

wait-list comparison group will receive the same program upon completion of the 6-month posttest evaluation on study outcomes

wait-list

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• People with MCI as defined by a score of 19-26 out of the 30 on the Montreal Cognitive Assessment in the general public and aged 55 or above.

You may not qualify if:

• Persons with dementia and communication problems will be excluded.

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Department of Medicine and Geriatrics, United Christian Hospital

Hong Kong, Hong Kong

Location

Related Publications (15)

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  PMID: 23776645 BACKGROUND

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  PMID: 17892609 BACKGROUND

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  PMID: 27489876 BACKGROUND

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  PMID: 24656834 BACKGROUND

• Reuter-Lorenz PA, Park DC. How does it STAC up? Revisiting the scaffolding theory of aging and cognition. Neuropsychol Rev. 2014 Sep;24(3):355-70. doi: 10.1007/s11065-014-9270-9. Epub 2014 Aug 21.

  PMID: 25143069 BACKGROUND

• Sherman DS, Mauser J, Nuno M, Sherzai D. The Efficacy of Cognitive Intervention in Mild Cognitive Impairment (MCI): a Meta-Analysis of Outcomes on Neuropsychological Measures. Neuropsychol Rev. 2017 Dec;27(4):440-484. doi: 10.1007/s11065-017-9363-3. Epub 2017 Dec 27.

  PMID: 29282641 BACKGROUND

• Tardif S, Simard M. Cognitive stimulation programs in healthy elderly: a review. Int J Alzheimers Dis. 2011;2011:378934. doi: 10.4061/2011/378934. Epub 2011 Aug 15.

  PMID: 21876829 BACKGROUND

• Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, McCambridge L, Corbett A. An online investigation of the relationship between the frequency of word puzzle use and cognitive function in a large sample of older adults. Int J Geriatr Psychiatry. 2019 Jul;34(7):921-931. doi: 10.1002/gps.5033. Epub 2019 May 16.

  PMID: 30443984 BACKGROUND

• Schultz SA, Larson J, Oh J, Koscik R, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Johnson SC, Sager M, LaRue A, Okonkwo OC. Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging Behav. 2015 Dec;9(4):729-36. doi: 10.1007/s11682-014-9329-5.

  PMID: 25358750 BACKGROUND

• Pillai JA, Hall CB, Dickson DW, Buschke H, Lipton RB, Verghese J. Association of crossword puzzle participation with memory decline in persons who develop dementia. J Int Neuropsychol Soc. 2011 Nov;17(6):1006-13. doi: 10.1017/S1355617711001111.

  PMID: 22040899 BACKGROUND

• Ferreira N, Owen A, Mohan A, Corbett A, Ballard C. Associations between cognitively stimulating leisure activities, cognitive function and age-related cognitive decline. Int J Geriatr Psychiatry. 2015 Apr;30(4):422-30. doi: 10.1002/gps.4155. Epub 2014 Jul 3.

  PMID: 24989949 BACKGROUND

• Chu LW, Chiu KC, Hui SL, Yu GK, Tsui WJ, Lee PW. The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong. Ann Acad Med Singap. 2000 Jul;29(4):474-85.

  PMID: 11056778 BACKGROUND

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  PMID: 15831139 BACKGROUND

Related Links

• Global Council on Brain Health. "Engaging your brain: GCBH recommendations on cognitively stimulating activities."
• Lam J. Numbers add up for scores of seniors in Sudoku competition.

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Waiting Lists

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Appointments and Schedules; Organization and Administration; Health Services Administration

Study Officials

• Doris, Sau Fung YU, PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: To implement a SMART Program to promote cognitive health among patients with MCI, and the use of active mind strategy in preventing dementia among the older adults

Study Record Dates

• First Submitted: April 16, 2021
• First Posted: June 4, 2021
• Study Start: September 15, 2020
• Primary Completion: October 31, 2023
• Study Completion: December 31, 2023
• Last Updated: January 9, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)