A Comparative Study of Brain Structure and Amyloid Load in MCI Patients

NCT03773185 | Withdrawn

• 1 other identifier: 2018.454
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Older people with DM are at greater risk of cognitive decline than their counterparts with DM. Cognitive impairment in older people with DM may be associated with non-AD related brain atrophy and white matter disease. The investigators therefore propose to compare DM and non-DM older people with amnesic MCI in brian volumes, white matter disease and amyloid load. 30 older people with aMCI, 30 older people with aMCI and DM, age 65-85 will be recruited. They all will have amyloid PET scan and MRI brain scan.

Conditions

Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Amyloid load

  Two years

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

MCI patients with DM or without DM

You may qualify if:

• MCI patients

You may not qualify if:

• Patients with depression

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Timothy Kwok, MD

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 30, 2018
• First Posted: December 12, 2018
• Study Start: December 15, 2018
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: October 21, 2021

Record last verified: 2021-10

Locations

HK (1)