Carbohydrate Intake and Gut Hormone Release During Exercise

NCT04019418 | Completed

• 1 other identifier: 18HH4889
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

It is well known that following a single session of moderate-to-high intensity exercise individuals experience a temporary suppression of hunger and a delay in the commencement of eating. This effect is believed to be due to changes in blood concentrations of specific hormones released from the gut that influence appetite. Individuals undertaking physical activity often consume foods immediately before exercise in order to improve their performance. However, it is currently unknown whether this eating practice influences the gut hormone response to exercise as well as how hungry an individual feels post-exercise. Therefore, the aim of this study is to investigate the effect of consuming a sugary (carbohydrate) drink immediately before starting an exercise session on the concentration of these gut hormones as well as the amount of food eaten in the hours following exercise completion.

Conditions

Obesity

Keywords

carbohydrate; exercise; PYY; GLP-1; ghrelin; hormones

Outcome Measures

Primary Outcomes (3)

• Changes in GLP-1 concentration

  Changes in GLP-1 concentration between exercise and resting conditions, and between carbohydrate and control conditions

  During the study visit, 165 minutes

• Changes in PYY concentration

  Changes in PYY concentration between exercise and resting conditions, and between carbohydrate and control conditions

  During the study visit, 165 minutes

• Changes in acylated ghrelin concentration

  Changes in acylated ghrelin concentration between exercise and resting conditions, and between carbohydrate and control conditions

  During the study visit, 165 minutes

Secondary Outcomes (6)

• Changes in energy intake

  During the study visit, 165 minutes

• Changes in Energy expenditure

  During the study visit, 165 minutes

• Changes in energy balance

  During the study visit, 165 minutes

• Glucose homeostasis

  During the study visit, 165 minutes

• Changes in subjective nausea

  During the study visit, 165 minutes

Study Arms (4)

No Carbohydrate Drink + Rest

PLACEBO COMPARATOR

Participants will consume the no carbohydrate drink (300ml water) followed by a rest session

Other: Rest; Other: Water

No Carbohydrate Drink + Exercise

ACTIVE COMPARATOR

Participants will consume the no carbohydrate drink (300ml water) followed by an exercise session (75% VO2 max on a cycle ergometer)

Other: Exercise; Other: Water

Carbohydrate Drink + Rest

ACTIVE COMPARATOR

Participants will consume the carbohydrate drink (300ml water + 75g maltodextrin) followed by a rest session

Dietary Supplement: Maltodextrin (carbohydrate); Other: Rest

Carbohydrate Drink + Exercise

EXPERIMENTAL

Participants will consume the carbohydrate drink (300ml water + 75g maltodextrin) followed by an exercise session (75% VO2 max on a cycle ergometer)

Dietary Supplement: Maltodextrin (carbohydrate); Other: Exercise

Interventions

Maltodextrin (carbohydrate) DIETARY_SUPPLEMENT

A drink containing 300ml of water and 75g of maltodextrin

Carbohydrate Drink + Exercise; Carbohydrate Drink + Rest

Exercise OTHER

30 minutes on a cycle ergometer working at 75% VO2 max

Carbohydrate Drink + Exercise; No Carbohydrate Drink + Exercise

Rest OTHER

30 minutes laying on a bed

Carbohydrate Drink + Rest; No Carbohydrate Drink + Rest

Water OTHER

A drink containing 300ml of water

No Carbohydrate Drink + Exercise; No Carbohydrate Drink + Rest

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: Male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Age between 18-40 years (inclusive)
• Body mass index (BMI) of 18-30 kg/m2
• Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

You may not qualify if:

• Abnormal ECG
• Screening blood results outside of normal reference values
• Current smokers
• Current or history of substance abuse and/or excess alcohol intake
• Diabetes
• Cardiovascular disease
• Cancer
• Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
• Kidney disease
• Liver disease
• Pancreatitis
• Started new medication within the last 3 months likely to interfere with energy metabolism, appetite regulation and hormonal balance, including: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones.
• Participation in a research study in the 12 week period prior to entering this study.
• Any blood donation within the 12 week period prior to entering this study

Sponsors & Collaborators

• Imperial College London: lead

Study Sites (1)

Imperial Clinical Research Facility

London, W12 0HS, United Kingdom

Location

Related Publications (1)

• Frampton J, Serrano-Contreras JI, Garcia-Perez I, Franco-Becker G, Penhaligan J, Tan ASY, de Oliveira ACC, Milner AJ, Murphy KG, Frost G, Chambers ES. The metabolic interplay between dietary carbohydrate and exercise and its role in acute appetite regulation in males: a randomized controlled study. J Physiol. 2023 Aug;601(16):3461-3480. doi: 10.1113/JP284294. Epub 2023 Jun 15.

  PMID: 37269207 RESULT

MeSH Terms

Conditions

Obesity; Motor Activity

Interventions

maltodextrin; Carbohydrates; Exercise; RE1-silencing transcription factor; Water

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• Edward Chambers, PhD

  Imperial College London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Participants and investigators will be masked to the contents of the beverage. They will not be masked to whether it is a resting or exercise condition as this is not possible.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants perform all four trials in a randomized order

Study Record Dates

• First Submitted: July 9, 2019
• First Posted: July 15, 2019
• Study Start: February 21, 2019
• Primary Completion: February 12, 2020
• Study Completion: February 12, 2020
• Last Updated: August 9, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)