Sleep, Exercise and Insulin Sensitivity

NCT03556410 | Completed

• 1 other identifier: Sleep and Exercise
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

Insufficient or disrupted sleep, lack of physical activity and poor diet are linked with obesity and are now potential targets to combat obesity. Sleep related issues have become more important as people have been able to work, socialize, and use electronic devices outside of daylight hours. This has also altered how we eat and how we exercise. All of these factors can cause the body to not handle glucose (sugar) well resulting in insulin resistance. In time this could lead to type 2 diabetes.

Conditions

Obesity

Keywords

Sleep; Obesity; Metabolic Syndrome; Physical Activity

Outcome Measures

Primary Outcomes (1)

• glucose tolerance

  integrated area under the curve

  3 hour glucose before the shortened sleep, 5 days after the shortened sleep and after 2 days of ad libitum sleep

Secondary Outcomes (2)

• insulin

  3 hour insulin before the shortened sleep, 5 days after the shortened sleep and after 2 days of ad libitum sleep

• FFA

  fasting values at the beginning of the OGTT

Study Arms (2)

sleep

PLACEBO COMPARATOR

Subject will undergo 5 days of shortened sleep and then 2 days of ad libitum sleep.

Behavioral: sleep

sleep+exercise

EXPERIMENTAL

Subject will undergo 5 days of shortened sleep but also have 45 min of moderate exercise/day and then 2 days of ad libitum sleep

Behavioral: sleep; Behavioral: exercise

Interventions

sleep BEHAVIORAL

Shortened sleep will be requested of all subjects. During this time normal physical activity will be monitored.

sleep; sleep+exercise

exercise BEHAVIORAL

Shortened sleep will be requested of all subjects. During this time normal physical activity will be monitored and 45 min of exercise will be required during the shortened sleep days .

sleep+exercise

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight and obese men and women
• BMI of 25-35 kg/m2
• normally active (\>5000 steps per day)
• normal sleeping habits of 7-9 hours per night

You may not qualify if:

• type 2 diabetics
• diagnosed with cardiovascular disease
• hypertensive
• smokers
• pregnant
• taking lipid-lowering medications
• have any recent changes in hormonal birth control
• night shift workers or take regular daytime naps
• on any medications known to impact metabolism, appetite, or sleep
• have any allergies to milk and soy
• sleep apnea or other sleep disorders
• if the 7 days of sleep monitoring prior to sleep restriction period shows inconsistent sleep hours outside of 7-9 hours per night.

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Conditions

Obesity; Metabolic Syndrome; Motor Activity

Interventions

Sleep; Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Motor Activity; Movement; Musculoskeletal Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 23, 2018
• First Posted: June 14, 2018
• Study Start: October 1, 2018
• Primary Completion: December 15, 2020
• Study Completion: December 15, 2020
• Last Updated: January 28, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)