Effects of Sweetness on Neurocognitive Responses, Glycemia and Food Intake

NCT03711084 | Completed

• 1 other identifier: 2310
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine potential differences in neurocognitive responses to food-related cues, physiological and appetite responses as well as subsequent energy intake following the consumption of preloads differing in sweetness and/ or postprandial metabolic effects in healthy normal weight subjects.

Conditions

Obesity

Keywords

non-nutritive sweeteners; sucrose; food-cue responses; appetite; blood glucose; energy intake

Outcome Measures

Primary Outcomes (4)

• Energy intake

  Examine how the consumption of sweet vs. non- sweet and energy-containing vs. non-energy containing preloads affects energy intake (kcal) in healthy lean individuals.

  1 hour

• Appetite ratings

  Examine how the consumption of sweet vs. non- sweet and energy-containing vs. non-energy containing preloads affects appetite ratings (VAS scales) in healthy lean individuals.

  1 hour

• Food-cue responses

  Examine how the consumption of sweet vs. non- sweet and energy-containing vs. non-energy containing preloads affects food-cue responses (reaction times) in healthy lean individuals.

  1 hour

• Blood glucose levels

  Examine how the consumption of sweet vs. non- sweet and energy-containing vs. non-energy containing preloads affects blood glucose levels (mmol/L) in healthy lean individuals.

  1 hour

Secondary Outcomes (1)

• Hedonic ratings

  1 hour

Study Arms (5)

Water

PLACEBO COMPARATOR

Beverage containing either water, glucose, sucrose, maltodextrin or a natural high potency sweetener from leaf extract

Dietary Supplement: Water

Natural high potency sweetener from leaf extract

EXPERIMENTAL

Beverage containing either water, glucose, sucrose, maltodextrin or a natural high potency sweetener from leaf extract

Dietary Supplement: Natural high potency sweetener from leaf extract

Glucose

EXPERIMENTAL

Beverage containing either water, glucose, sucrose, maltodextrin or a natural high potency sweetener from leaf extract

Dietary Supplement: Glucose

Sucrose

EXPERIMENTAL

Beverage containing either water, glucose, sucrose, maltodextrin or a natural high potency sweetener from leaf extract

Dietary Supplement: Sucrose

Maltodextrin

EXPERIMENTAL

Beverage containing either water, glucose, sucrose, maltodextrin or a natural high potency sweetener from leaf extract

Dietary Supplement: Maltodextrin

Interventions

Natural high potency sweetener from leaf extract DIETARY_SUPPLEMENT

Upon arrival, participant's blood will be collected at 0 (before the consumption of the test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will rate their feelings of hunger, fullness etc using VAS at 0, 15, 30 and 60 min. Fifteen min after the consumption of the drink, participants will complete a set of computer-based tasks designed to capture behaviour in response to food cue presentation. Thirty min after the consumption of the drink, a lunch buffet will be served and participants will be free to eat as much or as little as they like until feeling comfortably full.

Natural high potency sweetener from leaf extract

Glucose DIETARY_SUPPLEMENT

Upon arrival, participant's blood will be collected at 0 (before the consumption of the test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will rate their feelings of hunger, fullness etc using VAS at 0, 15, 30 and 60 min. Fifteen min after the consumption of the drink, participants will complete a set of computer-based tasks designed to capture behaviour in response to food cue presentation. Thirty min after the consumption of the drink, a lunch buffet will be served and participants will be free to eat as much or as little as they like until feeling comfortably full.

Glucose

Sucrose DIETARY_SUPPLEMENT

Upon arrival, participant's blood will be collected at 0 (before the consumption of the test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will rate their feelings of hunger, fullness etc using VAS at 0, 15, 30 and 60 min. Fifteen min after the consumption of the drink, participants will complete a set of computer-based tasks designed to capture behaviour in response to food cue presentation. Thirty min after the consumption of the drink, a lunch buffet will be served and participants will be free to eat as much or as little as they like until feeling comfortably full.

Sucrose

Maltodextrin DIETARY_SUPPLEMENT

Upon arrival, participant's blood will be collected at 0 (before the consumption of the test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will rate their feelings of hunger, fullness etc using VAS at 0, 15, 30 and 60 min. Fifteen min after the consumption of the drink, participants will complete a set of computer-based tasks designed to capture behaviour in response to food cue presentation. Thirty min after the consumption of the drink, a lunch buffet will be served and participants will be free to eat as much or as little as they like until feeling comfortably full.

Maltodextrin

Water DIETARY_SUPPLEMENT

Upon arrival, participant's blood will be collected at 0 (before the consumption of the test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will rate their feelings of hunger, fullness etc using VAS at 0, 15, 30 and 60 min. Fifteen min after the consumption of the drink, participants will complete a set of computer-based tasks designed to capture behaviour in response to food cue presentation. Thirty min after the consumption of the drink, a lunch buffet will be served and participants will be free to eat as much or as little as they like until feeling comfortably full.

Water

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 - 40 years
• BMI between 18.5-24.9 kg/m2
• DEBQ for restraint eating ≤ 3
• Healthy - general good health
• Currently not taking any medication (other than females taking the oral contraceptives)
• Normal or corrected vision
• Regular breakfast eaters (≥5 times per week)
• Stable weight, ≤ 5 kg last 12 months
• Fasting blood glucose ≤6.0 mmol/L
• No self-reported food allergy or intolerance to foods supplied during the study
• The participant is capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
• The participant is able to read, comprehend and record information written in English.
• A signed and dated written informed consent is obtained from the participant.

You may not qualify if:

• Age under 18 years or over 40 years old.
• BMI ≥25 kg/m2 and \<18.5kg/m2
• Subjects who are currently on a diet
• Subjects who follow special diets for weight maintenance, such as Atkins Diet, Weight Watchers, gluten-free diet, The Zone diet, Vegetarian Diet, Raw Food Diet etc.
• Subjects having breakfast fewer than 5 times per week.
• Vegetarians, vegans.
• Presence of any chronic condition requiring medication that might affect our results (e.g. diabetes, mental diseases, gastrointestinal diseases)
• Subjects with eating disorders (binge eating disorder, bulimia etc)
• Subjects who are currently experiencing anxiety or depression.
• Subjects who do not have normal vision and do not correct it with glasses or contact lenses.
• Participants who drink more than the NHS guidelines (14 units per week)
• Female participants who are, or may be, pregnant, or currently lactating.
• Subjects who regularly consume dietary supplements for weight loss, muscle building etc.
• Subjects who have aversions to foods related with the study.
• Subjects with food allergies or intolerance related with the foods/ drinks of the study.

Sponsors & Collaborators

• University of Manchester: lead
• Cargill: collaborator

Study Sites (1)

University of Manchester

Manchester, M13 9PL, United Kingdom

Location

Related Publications (1)

• Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Stevia Beverage Consumption prior to Lunch Reduces Appetite and Total Energy Intake without Affecting Glycemia or Attentional Bias to Food Cues: A Double-Blind Randomized Controlled Trial in Healthy Adults. J Nutr. 2020 May 1;150(5):1126-1134. doi: 10.1093/jn/nxaa038.

  PMID: 32125421 DERIVED

MeSH Terms

Conditions

Obesity

Interventions

Glucose; Sucrose; maltodextrin; Water

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Disaccharides; Oligosaccharides; Polysaccharides; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Study Record Dates

• First Submitted: October 8, 2018
• First Posted: October 18, 2018
• Study Start: April 26, 2018
• Primary Completion: October 15, 2018
• Study Completion: November 15, 2018
• Last Updated: February 15, 2019

Record last verified: 2019-02

Locations

GB (1)