Effects of Exercise on Thyroid Stimulating Hormone Among Class-I Obese Patients With Diabetes Mellitus and Lipid Disorders

NCT06119737 | Completed

• 1 other identifier: Batool_H
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is characterized by an excessive accumulation of body fat that gives rise to significant comorbidities, such as diabetes, hypertension, dyslipidemia, cardiovascular disease, and many cancers. According to WHO, Obesity is a worldwide epidemic, with an estimated 57.8% of adults worldwide expected to be classified as obese by 2030. Therefore, obesity is invariably referred to as a crucial public health problem that requires urgent attention to prevent obesity-related health outcomes. Thyroid dysfunction is often accompanied by changes in body weight and body composition, leading to obesity. The rising risk of obesity has created susceptibility for every individual irrespective of age, gender and demography. Hence, the focus of researchers is now shifting to devising preventive strategies from the treatment approaches for obesity. To guide healthcare professionals in treating obesity, several guidelines from The Obesity Society (TOS) have been prepared that outline multiple therapies like lifestyle modifications, increased physical activities, dietary modifications, use of medications and in some cases, even surgeries are recommended. However, poor receptivity of exercise among the general population required healthcare professionals to design an exercise program that could be cost and time-effective for the patient. Hence, the present study aims to determine the effect of exercise and the documentation of the best possible exercise regime that could increase TSH among the class I obese population.

Conditions

Obesity

Outcome Measures

Primary Outcomes (1)

• Thyroid Stimulating Hormone

  The levels of TSH were measured using blood sample (Biodata Diagnostic brand RIA kit)12. The samples were taken twice once before the start of the training protocol and second after the completion of 16 weeks of training. The difference in the values between the groups was used to evaluate the impact of exercises thyroid hormone levels in the body.

  16 weeks

Study Arms (4)

Moderate Intensity Continuous Training

EXPERIMENTAL

Other: Exercise

Resistance Training

ACTIVE COMPARATOR

Other: Exercise

High-Intensity Interval Training

ACTIVE COMPARATOR

Other: Exercise

1/2- High-Intensity Interval Training

ACTIVE COMPARATOR

Other: Exercise

Interventions

Exercise OTHER

Effects of exercises on TSH levels

1/2- High-Intensity Interval Training; High-Intensity Interval Training; Moderate Intensity Continuous Training; Resistance Training

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Class I obese population BMI ≥25.0 -30.0
• Young adults aged 20-40 years
• Diagnosed patients with DM and dyslipidemia.

You may not qualify if:

• Patients diagnosed with pre-existing heart conditions, major illness (acute or chronic), beta-blockers, pregnant or lactating women, and smokers, including any that would limit the ability to perform the necessary exercises, will be excluded from the study.

Sponsors & Collaborators

• Ziauddin University: lead

Study Sites (1)

Ziauddin University

Karachi, Sindh, Pakistan

Location

MeSH Terms

Conditions

Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 1, 2023
• First Posted: November 7, 2023
• Study Start: May 2, 2021
• Primary Completion: July 15, 2023
• Study Completion: October 2, 2023
• Last Updated: November 7, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)