Effect of Exercise on Metabolic Health

NCT02001142 | Completed

• 1 other identifier: ADA 7-13-TS-35
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

One of the main objectives of this study will be to assess potential differences in important risk factors associated with Metabolic Syndrome in overweight adults who do not participate in a regular exercise program compared with overweight individuals who do exercise regularly. In addition, we will determine the effects of a single, modest session of exercise on the body's ability to control blood sugar and regulate fat metabolism in obese sedentary adults vs. obese adults who live a physically active lifestyle. Our study focuses on identifying mechanisms responsible for improved insulin action related to regular exercise and to provide novel targets for preventing and treating type 2 diabetes.

Conditions

Obesity

Keywords

Insulin Sensitivity; Exercise; Metabolism

Outcome Measures

Primary Outcomes (1)

• Insulin Sensitivity

  A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity. Insulin sensitivity will be calculated from the clamp data as the rate of glucose infusion during the steady state period of the clamp - divided by the plasma insulin concentration at this time (units: mg/uU/ml/min)

  2-3 hours

Secondary Outcomes (2)

• Resting Metabolic Rate

  20-30 min

• Meal Tolerance Test

  3 hours

Study Arms (2)

Exercise

EXPERIMENTAL

Other: Exercise

Sedentary Control

NO INTERVENTION

Interventions

Exercise OTHER

single session of exercise

Exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body Mass Index \[BMI\] = 30-45 kg/m2, fasting blood glucose concentration must be \< or = to125 mg/dl, Hematocrit \> or = to 34%, all women must be pre-menopausal

You may not qualify if:

• pregnancy or actively breastfeeding, weight instability (\> or = to ± 5 lbs in the past month) evidence of cardiovascular or metabolic diseases, taking medications know to affect lipid and/or glucose metabolism.

Sponsors & Collaborators

• University of Michigan: lead
• American Diabetes Association: collaborator

Study Sites (1)

Michigan Clincal Research Unit

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Obesity; Insulin Resistance; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jeffrey F Horowitz, PhD

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Movement Science, School of Kinesiology

Study Record Dates

• First Submitted: November 27, 2013
• First Posted: December 4, 2013
• Study Start: November 1, 2013
• Primary Completion: September 17, 2016
• Study Completion: September 17, 2016
• Last Updated: March 21, 2022

Record last verified: 2022-03

Locations

US (1)