A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
U-ENDURE
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433
3 other identifiers
interventional
747
45 countries
441
Brief Summary
A multicenter study to evaluate the efficacy and safety of maintenance and long-term treatment administration of upadacitinib, an orally administered Janus kinase 1 inhibitor, in adult participants with Crohn's Disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2018
Longer than P75 for phase_3
441 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 15, 2017
CompletedFirst Posted
Study publicly available on registry
November 17, 2017
CompletedStudy Start
First participant enrolled
March 21, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 1, 2027
April 9, 2026
April 1, 2026
9.5 years
November 15, 2017
April 6, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Sub-Study 1: Percentage of Participants with Clinical Remission per Crohn's Disease Activity Index (CDAI)
Clinical remission per CDAI is defined as CDAI \<150.
Week 52
Sub-Study 1: Percentage of Participants with Endoscopic Response
Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline.
Week 52
Number of Participants with Adverse Events
An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. For more details on adverse events please see the Adverse Event section.
Through Week 240
Secondary Outcomes (11)
Sub-Study 1: Percentage of Participants with Clinical Remission per Patient-Reported Outcomes (PROs)
Week 52
Sub-Study 1: Percentage of Participants Achieving Clinical Response 100 (CR-100)
Week 52
Sub-Study 1: Percentage of Participants with Endoscopic Remission
Week 52
Sub-Study 1: Percentage of Participants without Corticosteroid use for Crohn's Disease Among All Participants
Week 52
Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI and Endoscopic Remission
Week 52
- +6 more secondary outcomes
Study Arms (9)
Substudy 1: Cohort 1 Upadacitinib Dose A
EXPERIMENTALThis is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose A for 52 weeks.
Substudy 1: Cohort 1 Upadacitinib Dose B
EXPERIMENTALThis is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose B for 52 weeks.
Substudy 1: Cohort 1 Placebo
EXPERIMENTALThis is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive placebo for 52 weeks.
Substudy 1: Cohort 2 Placebo
EXPERIMENTALThis is a maintenance group which includes participants who received double-blind placebo in studies M14-431 and M14-433 and achieved clinical response will continue to receive blinded placebo for 52 Weeks.
Substudy 1: Cohort 3 Upadacitinib Dose B
EXPERIMENTALThis is a maintenance group which includes participants who achieved clinical response to upadacitinib from the extended treatment period of studies M14-431 and M14-433 and will receive upadacitinib Dose B for 52 Weeks.
Substudy 2: Cohort 4 Upadacitinib Dose B
EXPERIMENTALThis is a long-term extension group which includes participants who achieved clinical response in the open-label extended treatment period of study M14-431 and will receive upadacitinib dose B for 240 weeks.
Substudy 2: Cohort 5 Upadacitinib Dose A
EXPERIMENTALThis is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose A for 240 weeks.
Substudy 2: Cohort 5 Upadacitinib Dose B
EXPERIMENTALThis is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose B for 240 weeks.
Substudy 2: Cohort 5 Placebo
EXPERIMENTALThis is a long-term extension group which includes participants who complete Substudy 1 and will receive placebo for 240 weeks.
Interventions
Oral; Tablet
Oral; Tablet
Eligibility Criteria
You may qualify if:
- For Substudy 1:
- Participant who achieve clinical response in Study M14-431 or Study M14-433.
- Participant completes study procedures in the parent study. The final endoscopy for Studies M14-431 or M14-433 may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
- For Substudy 2:
- Participant completes Substudy 1. The Week 52 endoscopy may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
- Participant who achieved clinical response at the time described in the protocol and completes study procedures in the parent study/ substudy.
You may not qualify if:
- For Substudies 1 and 2:
- Participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study.
- Participant who has a known hypersensitivity to upadacitinib or its excipients, or had an adverse event during Studies M14-431 and M14-433 or Substudy 1 or 2 of Study M14-430 that in the investigator's judgment makes the participant unsuitable for this study.
- Participant at the final visit of M14-431 or M14-433 with any active or chronic recurring infections based on the investigator's assessment that makes the participant an unsuitable candidate for the study. Participants with serious infections undergoing treatment may be enrolled BUT NOT dosed until the infection treatment has been completed and the infection is resolved, based on the investigator's assessment.
- Participants with high grade colonic dysplasia or malignancy diagnosed at the endoscopy performed at the final visit of Studies M14-431, M14-433 or Substudy 1 of Study M14-430 (Week 52).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
Study Sites (466)
East View Medical Research, LLC /ID# 171132
Mobile, Alabama, 36606, United States
CB Flock Research Corporation /ID# 166239
Mobile, Alabama, 36608, United States
Delsol Research Management, Ll /Id# 170164
Chandler, Arizona, 85224, United States
Duplicate_HonorHealth Research Institute - Shea /ID# 164725
Scottsdale, Arizona, 85258, United States
Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702
Sun City, Arizona, 85306, United States
Southern California Res. Ctr. /ID# 169653
Coronado, California, 92118-1408, United States
Citrus Valley Gastroenterology /ID# 166230
Covina, California, 91722-3797, United States
Hoag Memorial Hosp Presbyterian /ID# 222538
Irvine, California, 92618, United States
UC San Diego Health System /ID# 164763
La Jolla, California, 92037, United States
United Medical Doctors /ID# 207458
Los Alamitos, California, 90720-3309, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640
Los Angeles, California, 90067-2001, United States
Facey Medical Foundation /ID# 203138
Mission Hills, California, 91345, United States
United Medical Doctors - Murrieta /ID# 164602
Murrieta, California, 92563, United States
Medical Assoc Research Grp /ID# 169704
San Diego, California, 92123, United States
UCSF Medical Center - Mount Zion /ID# 202372
San Francisco, California, 94115, United States
Univ of California San Francis /ID# 164653
San Francisco, California, 94158, United States
Care Access Research /ID# 167765
San Pablo, California, 94806, United States
Peak Gastroenterology Associates, PC /ID# 170166
Colorado Springs, Colorado, 80907, United States
Delta Waves, Inc. /ID# 164656
Colorado Springs, Colorado, 80918, United States
Western States Clinical Res /ID# 164625
Wheat Ridge, Colorado, 80033-2896, United States
Gastroenterology Center of Connecticut /ID# 164614
Hamden, Connecticut, 06518, United States
Advanced Research - Coral Springs /ID# 218019
Coral Springs, Florida, 33067-3173, United States
Encore Borland-Groover Clinical Research /Id# 203500
Jacksonville, Florida, 32256, United States
Ctr for Advanced Gastroenterol /ID# 165306
Maitland, Florida, 32751-6108, United States
Crystal Pharmacology Research /ID# 166118
Miami, Florida, 33165, United States
Coral Research Clinic /ID# 164604
Miami, Florida, 33186-4643, United States
Advanced Research Institute, Inc /ID# 164601
New Port Richey, Florida, 34653, United States
Endoscopic Research, Inc. /ID# 206139
Orlando, Florida, 32803, United States
Omega Research Group /ID# 203482
Orlando, Florida, 32808, United States
Duplicate_Clinical Research of West Florida, Inc /ID# 205828
Tampa, Florida, 33606-1246, United States
Duplicate_Clinical Research of West Florida, Inc /ID# 208119
Tampa, Florida, 33606-1246, United States
Clinical Research Trials of Florida, Inc. /ID# 203486
Tampa, Florida, 33607, United States
Duplicate_AdventHealth Tampa /ID# 171181
Tampa, Florida, 33613-4680, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 165492
Macon, Georgia, 31201, United States
Gastroenterology Consultants, P.C /ID# 218218
Roswell, Georgia, 30076-4913, United States
Atlanta Gastroenterology Spec /ID# 164698
Suwanee, Georgia, 30024, United States
Treasure Valley Medical Research /ID# 215030
Boise, Idaho, 83706, United States
Duplicate_Rush University Medical Center /ID# 165470
Chicago, Illinois, 60612, United States
Duplicate_University of Chicago Medicine /ID# 165509
Chicago, Illinois, 60637-1426, United States
DuPage Medical Group /ID# 205320
Downers Grove, Illinois, 60515-5509, United States
MediSphere Medical Research Center /ID# 166233
Evansville, Indiana, 47714-8011, United States
Indianapolis Gastroenterology /ID# 164649
Indianapolis, Indiana, 46237, United States
Aquiant Research /ID# 205505
New Albany, Indiana, 47150-4053, United States
University of Iowa Hospitals and Clinics /ID# 165405
Iowa City, Iowa, 52242, United States
Tri-State Gastroenterology /ID# 165469
Crestview Hills, Kentucky, 41017, United States
Duplicate_University of Louisville /ID# 165391
Louisville, Kentucky, 40202, United States
University of Louisville Hospital /ID# 168520
Louisville, Kentucky, 40202, United States
Houma Digestive Health Special /ID# 164727
Houma, Louisiana, 70360, United States
Nola Research Works, LLC /ID# 164612
New Orleans, Louisiana, 70115, United States
Louisiana Research Center, LLC /ID# 164694
Shreveport, Louisiana, 71105-6800, United States
Duplicate_Johns Hopkins University School of Medicine /ID# 211939
Baltimore, Maryland, 21287-0010, United States
Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647
Chevy Chase, Maryland, 20815, United States
Gastro Center of Maryland /ID# 171180
Columbia, Maryland, 21045, United States
Duplicate_Lahey Hospital and Medical Center /ID# 214724
Burlington, Massachusetts, 01805, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654
Ann Arbor, Michigan, 48109, United States
Clin Res Inst of Michigan, LLC /ID# 170163
Chesterfield, Michigan, 48047, United States
Digestive Health Associates (DHA) - Farmington Hills /ID# 206101
Farmington Hills, Michigan, 48334-3230, United States
Center for Digestive Health /ID# 164726
Troy, Michigan, 48098-6363, United States
Mayo Clinic - Rochester /ID# 164691
Rochester, Minnesota, 55905-0001, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 165295
Jackson, Mississippi, 39216, United States
Quality Clinical Research Inc. /ID# 170162
Omaha, Nebraska, 68114-3723, United States
CHI Health Research Center /ID# 168513
Omaha, Nebraska, 68124, United States
Las Vegas Medical Research /ID# 168551
Las Vegas, Nevada, 89113, United States
Cooper Gastroenterology at Fire Road /ID# 164641
Egg Harbor, New Jersey, 08234, United States
Rutgers Robert Wood Johnson /ID# 166110
New Brunswick, New Jersey, 08901, United States
NY Scientific /ID# 164630
Brooklyn, New York, 11235, United States
United Health Services Hospitals, Inc /ID# 217483
Johnson City, New York, 13790-2107, United States
NYU Langone Long Island Clinical Research Associates /ID# 164627
Lake Success, New York, 11042, United States
The Mount Sinai Hospital /ID# 170256
New York, New York, 10029, United States
Columbia Univ Medical Center /ID# 164692
New York, New York, 10032-3725, United States
Gastoenterology Group of Rochester /ID# 166235
Rochester, New York, 14618-5703, United States
Richmond University Medical Center /ID# 201858
Staten Island, New York, 10310-1664, United States
Montefiore Medical Center - Moses Campus /ID# 166242
The Bronx, New York, 10467, United States
Advantage Clinical Trials /ID# 168582
The Bronx, New York, 10468, United States
Atrium Health Carolinas Medical Center /ID# 164632
Charlotte, North Carolina, 28203, United States
Duplicate_PMG Research of Charlotte /ID# 171178
Charlotte, North Carolina, 28209, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752
Raleigh, North Carolina, 27612, United States
Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 164755
Winston-Salem, North Carolina, 27157-0001, United States
Plains Clinical Research Center, LLC /ID# 170169
Fargo, North Dakota, 58104-5925, United States
Gastro Health Research /ID# 164668
Cincinnati, Ohio, 45219, United States
Duplicate_Duplicate_University Of Cincinnati Medical Center /ID# 164729
Cincinnati, Ohio, 45267-0585, United States
Cleveland Clinic Main Campus /ID# 209230
Cleveland, Ohio, 44195, United States
Ohio State University/ Gastroe /ID# 170159
Columbus, Ohio, 43210, United States
Optimed Research, Ltd. /ID# 205625
Columbus, Ohio, 43235, United States
Hometown Urgent Care and Resea /ID# 201289
Dayton, Ohio, 45424, United States
Dayton Gastroenterology, Inc. /ID# 167623
Englewood, Ohio, 45415, United States
Great Lakes Gastroenterology Research, LLC /ID# 202006
Mentor, Ohio, 44060-6211, United States
Digestive Disease Specialists /ID# 201063
Oklahoma City, Oklahoma, 73112, United States
Options Health Research, LLC /ID# 164704
Tulsa, Oklahoma, 74104, United States
Healthcare Research Consultant /ID# 166244
Tulsa, Oklahoma, 74135, United States
University of Pennsylvania /ID# 168406
Philadelphia, Pennsylvania, 19104-5502, United States
Duplicate_Thomas Jefferson University /ID# 168003
Philadelphia, Pennsylvania, 19107-4414, United States
Pharmacorp Clinical Trials /ID# 165008
Charleston, South Carolina, 29412, United States
Gastroenterology Associates, P.A. of Greenville /ID# 164643
Greenville, South Carolina, 29607, United States
Rapid City Medical Center - GI Research /ID# 201733
Rapid City, South Dakota, 57701, United States
Gastro One /ID# 164730
Cordova, Tennessee, 38018, United States
Duplicate_East Tennessee Research Institute /ID# 203614
Johnson City, Tennessee, 37604, United States
Quality Medical Research /ID# 205264
Nashville, Tennessee, 37211, United States
Vanderbilt University Medical Center /ID# 164607
Nashville, Tennessee, 37232-0011, United States
TX Clinical Research Institute /ID# 164719
Arlington, Texas, 76012, United States
Inquest Clinical Research /ID# 164676
Baytown, Texas, 77521-2415, United States
GI Alliance /ID# 209803
Cedar Park, Texas, 78613, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161
Dallas, Texas, 75246, United States
Baylor College of Medicine /ID# 164609
Houston, Texas, 77030, United States
Centex Studies, Inc. - Houston /ID# 201212
Houston, Texas, 77058, United States
GI Specialists of Houston /ID# 202340
Houston, Texas, 77070-4347, United States
Caprock Gastro Research - Lubbock - 80th Street /ID# 215436
Lubbock, Texas, 79424, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 164675
San Antonio, Texas, 78212, United States
Southern Star Research Institute, LLC /ID# 169756
San Antonio, Texas, 78229-5390, United States
Carl R. Meisner Medical Clinic /ID# 171057
Sugar Land, Texas, 77478, United States
Tyler Research Institute, LLC /ID# 168679
Tyler, Texas, 75701, United States
Gastro Health & Nutrition - Victoria /ID# 167810
Victoria, Texas, 77904, United States
Texas Digestive Disease Consultants /ID# 209954
Webster, Texas, 77598, United States
HP Clinical Research /ID# 164631
Bountiful, Utah, 84010, United States
Advanced Research Institute /ID# 164689
Ogden, Utah, 84405, United States
Duplicate_Care Access Research /ID# 164685
Salt Lake City, Utah, 84124-1377, United States
Duplicate_Velocity Clinical Research - Salt Lake City /ID# 166113
West Jordan, Utah, 84088, United States
Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728
Bellevue, Washington, 98004, United States
Virginia Mason Hospital & Medical Center /ID# 164862
Seattle, Washington, 98101, United States
University of Washington /ID# 164646
Seattle, Washington, 98109, United States
The Vancouver Clinic, INC. PS /ID# 164874
Vancouver, Washington, 98664, United States
Froedtert Memorial Lutheran Hospital /ID# 202285
Milwaukee, Wisconsin, 53226-3522, United States
Allegiance Research Specialists /ID# 165298
Wauwatosa, Wisconsin, 53226, United States
Cemic /Id# 169183
Ciudad Autonoma Buenos Aires, Buenos Aires, 1431, Argentina
Cardio Alem /ID# 211283
San Isidro, Buenos Aires, 1642, Argentina
Hospital Italiano de Buenos Aires /ID# 215542
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., 1199, Argentina
Gedyt /ID# 210018
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1115, Argentina
Hospital Provincial del Centenario /ID# 171251
Rosario, Santa Fe Province, 2000, Argentina
Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 169229
Córdoba, 5016, Argentina
Concord Repatriation General Hospital /ID# 171506
Concord, New South Wales, 2139, Australia
Coral Sea Clinical Research institute /ID# 212989
North Mackay, Queensland, 4740, Australia
Mater Misericordiae Limited /ID# 204910
South Brisbane, Queensland, 4101, Australia
Royal Adelaide Hospital /ID# 171508
Adelaide, South Australia, 5000, Australia
Box Hill Hospital /ID# 203735
Box Hill, Victoria, 3128, Australia
Fiona Stanley Hospital /ID# 171507
Murdoch, Western Australia, 6150, Australia
Klinik Landstrasse /ID# 203438
Vienna, Vienna, 1030, Austria
Medizinische Universitaet Wien /ID# 169459
Vienna, Vienna, 1090, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 214468
Salzburg, 5020, Austria
Cliniques Universitaires UCL Saint-Luc /ID# 200293
Brussels, Brussels Capital, 1200, Belgium
Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 200295
Yvoir, Namur, 5530, Belgium
Duplicate_AZ Sint-Lucas /ID# 200296
Ghent, Oost-Vlaanderen, 9000, Belgium
Universitair Ziekenhuis Leuven /ID# 200031
Leuven, Vlaams-Brabant, 3000, Belgium
CHU de Liege /ID# 200294
Liège, 4000, Belgium
Duplicate_University Clinical Centre of the Republic of Srpska /ID# 200743
Banja Luka, Republika Srpska, 78000, Bosnia and Herzegovina
University Clinical Center Tuzla /ID# 210323
Tuzla, Tuzlanski, 75000, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 201346
Sarajevo, 71000, Bosnia and Herzegovina
Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217843
Sarajevo, 71000, Bosnia and Herzegovina
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166853
Goiânia, Goiás, 74535-170, Brazil
Faculdade de Medicina do ABC /ID# 166854
Santo André, La Spezia, 09060-870, Brazil
Hospital Nossa Senhora das Graças /ID# 166856
Curitiba, Paraná, 80810-040, Brazil
Hospital de Clinicas de Porto Alegre /ID# 166855
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Upeclin Fmb - Unesp /Id# 166860
Botucatu, São Paulo, 18618-686, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 166859
Ribeirão Preto, São Paulo, 14049-900, Brazil
Kaiser Clinica e Hospital Dia /ID# 166858
São José do Rio Preto, São Paulo, 15015-110, Brazil
Duplicate_UMHAT Kaspela EOOD /ID# 167615
Plovdiv, 4001, Bulgaria
Duplicate_Second MHAT Sofia /ID# 167616
Sofia, 1202, Bulgaria
MHAT Trakia /ID# 201677
Stara Zagora, 6004, Bulgaria
University of Calgary /ID# 166990
Calgary, Alberta, T2N 4Z6, Canada
Allen Whey Khye Lim Professional Corporation /ID# 168047
Edmonton, Alberta, T5R 1W2, Canada
University of Alberta Hospital /ID# 166987
Edmonton, Alberta, T6G 2B7, Canada
Covenant Health /ID# 166996
Edmonton, Alberta, T6K 4B2, Canada
Fraser Clinical Trials Inc /ID# 166984
New Westminster, British Columbia, V3L 3W4, Canada
Giri Gi Research Institute - Vancouver /ID# 166994
Vancouver, British Columbia, V5Z 2K5, Canada
QEII - Health Sciences Centre /ID# 169308
Halifax, Nova Scotia, B3H 2Y9, Canada
Medicor Research Inc /ID# 166997
Greater Sudbury, Ontario, P3A 1W8, Canada
London Health Sciences Center- University Hospital /ID# 221039
London, Ontario, N6A 5W9, Canada
Scott Shulman Medicine Professional Corporation /ID# 169065
North Bay, Ontario, P1B 2H3, Canada
Taunton surgical centre /ID# 168045
Oshawa, Ontario, L1H 7K4, Canada
Ottawa Hospital Research Institute /ID# 212412
Ottawa, Ontario, K1H 8L6, Canada
Toronto Digestive Disease Associates /ID# 166988
Vaughan, Ontario, L4L 4Y7, Canada
Hotel Dieu de Levis /ID# 166985
Lévis, Quebec, G6V 3Z1, Canada
Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170122
Montreal, Quebec, H2X 0A9, Canada
Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 170011
Montreal, Quebec, H4A 3J1, Canada
CIUSSS de l'Estrie - CHUS /ID# 170936
Sherbrooke, Quebec, J1G 2E8, Canada
Hospital Guillermo Grant Benavente de Concepción /ID# 212421
Concepción, Bio-Bio, 4070038, Chile
CTR Estudios Clinicos /ID# 203940
Providencia, Region Metropolitana Santiago, 7500571, Chile
Research Group /ID# 203178
Santiago, Santiago Metropolitan, 2540364, Chile
CEC SpA /ID# 169872
Ñuñoa, 7750495, Chile
Hospital Clinico Universidad De Los Andes /ID# 207463
Santiago, 7501504, Chile
Beijing Friendship Hospital /ID# 204175
Beijing, Beijing Municipality, 100032, China
Zhongshan Hospital Xiamen University /ID# 204986
Xiamen, Fujian, 361004, China
The First Affiliated Hospital, Sun Yat-sen University /ID# 205227
Guangzhou, Guangdong, 510080, China
Nanfang Hospital of Southern Medical University /ID# 204056
Guangzhou, Guangdong, 510515, China
The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 204054
Guangzhou, Guangdong, 510655, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204065
Wuhan, Hubei, 430022, China
Tongji Hospital Tongji Medical College of HUST /ID# 204051
Wuhan, Hubei, 430030, China
The Second Xiangya Hospital Of Central South University /ID# 204057
Changsha, Hunan, 410011, China
Nanjing Drum Tower Hospital /ID# 204899
Nanjing, Jiangsu, 210008, China
The First Affiliated Hospital of Nanchang University /ID# 204052
Nanchang, Jiangxi, 330006, China
The First Hospital of Jilin University /ID# 206865
Changchun, Jilin, 130021, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204055
Shanghai, Shanghai Municipality, 200065, China
The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 204058
Hangzhou, Zhejiang, 310009, China
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204050
Hangzhou, Zhejiang, 310018, China
Duplicate_Tianjin Med Univ General Hosp /ID# 206979
Tianjin, 300052, China
Duplicate_Hospital Pablo Tobon Uribe /ID# 202403
Medellín, Antioquia, 50034, Colombia
Hospital San Vicente de Paul /ID# 200020
Medellín, Antioquia, 50034, Colombia
Clinical Hospital Dubrava /ID# 171165
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Sestre milosrdnice /ID# 171194
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb /ID# 171168
Zagreb, City of Zagreb, 10000, Croatia
Poliklinika Solmed /ID# 211517
Zagreb, City of Zagreb, 10000, Croatia
Klinicki Bolnicki Centar KBC Split /ID# 171205
Split, Split-Dalmatia County, 21000, Croatia
Zadar General Hospital /ID# 205533
Zadar, 23000, Croatia
Nemocnice Ceske Budejovice a.s. /ID# 224390
České Budějovice, 370 01, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 171564
Hradec Králové, 500 12, Czechia
ARTROSCAN s.r.o. /ID# 171575
Ostrava, 722 00, Czechia
ResTrial s.r.o. /ID# 208651
Prague, 143 00, Czechia
Herlev Hospital /ID# 200785
Herlev, Capital Region, 2730, Denmark
Nordsjaellands Hospital /ID# 200788
Hilleroed, Capital Region, 3600, Denmark
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 200787
Hvidovre, Capital Region, 2650, Denmark
Duplicate_Sjaellands Universitets Hospital /ID# 200786
Roskilde, Region Sjælland, 4000, Denmark
Alexandria University /ID# 171008
Alexandria, Alexandria Governorate, 21131, Egypt
Alexandria University /ID# 171017
Alexandria, Alexandria Governorate, 21131, Egypt
National Liver Institute /ID# 170987
Menoufiya, Monufia Governorate, 35111, Egypt
Duplicate_Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209561
Alexandria, 21131, Egypt
National Hepatology and Tropical Medicine Research Institute /ID# 170991
Cairo, 11559, Egypt
Ain Shams University Faculty of Medicine /ID# 209566
Cairo, 11566, Egypt
Air Force Specialized Hospital /ID# 170993
Cairo, Egypt
West Tallinn Central Hospital /ID# 202787
Tallinn, Harju, 10617, Estonia
Tartu University Hospital /ID# 203141
Tartu, 50406, Estonia
Chu de Nice-Hopital Larchet Ii /Id# 171004
Nice, Alpes-Maritimes, 06202, France
Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 207812
Pessac, Gironde, 33604, France
CHU Toulouse - Hopital Rangueil /ID# 169784
Toulouse, Haute-Garonne, 31400, France
Duplicate_Hopital Saint Eloi /ID# 170039
Montpellier, Herault, 34295, France
Duplicate_CHU Grenoble - Hopital Michallon /ID# 222403
La Tronche, Isere, 38700, France
Duplicate_CHRU Nancy - Hopitaux de Brabois /ID# 170970
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France
CHRU Lille - Hopital Claude Huriez /ID# 206653
Lille, Nord, 59037, France
CH Valenciennes /ID# 222399
Valenciennes, Nord, 59300, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 171027
St-Priest-en-Jarez, Pays de la Loire Region, 42270, France
HCL - Hopital Lyon Sud /ID# 171030
Pierre-Bénite, Rhone, 69495, France
Duplicate_CHU Amiens-Picardie Site Sud /ID# 171023
Amiens, Somme, 80054, France
CHRU Tours - Hopital Trousseau /ID# 169783
Chambray-lès-Tours, 37170, France
Duplicate_CHU Henri Mondor /ID# 169782
Créteil, 94000, France
Clinique Jules Verne /ID# 222240
Nantes, 44300, France
Polyclinique Grand Sud /ID# 170037
Nîmes, 30932, France
Hopital Beaujon /ID# 171007
Clichy, Île-de-France Region, 92110, France
Universitatsklinikum Mannheim /ID# 168754
Mannheim, Baden-Wurttemberg, 68167, Germany
Universitaetsklinikum Ulm /ID# 203554
Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsklinikum Erlangen /ID# 203550
Erlangen, Bavaria, 91054, Germany
Duplicate_Agaplesion Markus Krankenhaus /ID# 168753
Frankfurt am Main, Hesse, 60431, Germany
Universitaetsklinikum Frankfurt /ID# 203567
Frankfurt am Main, Hesse, 60590, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206739
Saarbrücken, Saarland, 66111, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168755
Kiel, Schleswig-Holstein, 24105, Germany
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 169271
Berlin, 12203, Germany
Gastroenterologie am Mexikoplatz /ID# 203574
Berlin, 14163, Germany
Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203569
Essen, 45239, Germany
Universitaetsklinikum Halle (Saale) /ID# 207453
Halle, 06120, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 200212
Münster, 48155, Germany
General Hospital of Athens Ippokratio /ID# 167032
Athens, Attica, 11527, Greece
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202102
Athens, Attica, 11527, Greece
Tzaneio general hospital of Piraeus /ID# 206435
Piraeus, Attica, 18536, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 167031
Heraklion, Crete, 71500, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 167033
Athens, 10676, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 208823
Thessaloniki, 54642, Greece
Queen Mary Hospital /ID# 171214
Hong Kong, 999077, Hong Kong
Tuen Mun Hospital /ID# 171213
Hong Kong, Hong Kong
Pecsi Tudomanyegyetem Klinikai Kozpont Mohacsi Korhaz /ID# 209440
Mohács, Baranya, 7700, Hungary
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205549
Encs, Borsod-Abauj Zemplen county, 3860, Hungary
Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 216420
Debrecen, Hajdú-Bihar, 4032, Hungary
Gyongyosi Bugat Pal Korhaz /ID# 201885
Gyöngyös, Heves County, 3200, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz (Clinexpert Tatabanya Kft.) /ID# 209896
Tatabánya, Komárom-Esztergom, 2800, Hungary
Kistarcsai Flor Ferenc Korhaz /ID# 206153
Kistarcsa, Pest County, 2143, Hungary
Obudai Egeszsegugyi Centrum /ID# 201886
Budapest, 1036, Hungary
Duplicate_Semmelweis Egyetem /ID# 210166
Budapest, 1085, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont /ID# 200888
Budapest, 1134, Hungary
Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 200887
Debrecen, 4031, Hungary
Mentahaz Maganorvosi Kozpont /ID# 201888
Székesfehérvár, 8000, Hungary
Mercy University Hospital /ID# 206512
Cork, T12 WE28, Ireland
Duplicate_Kaplan Medical Center /ID# 170275
Rehovot, Central District, 7661041, Israel
Yitzhak Shamir Medical Center /ID# 206449
Ẕerifin, Central District, 70300, Israel
Hadassah Medical Center-Hebrew University /ID# 169926
Jerusalem, Jerusalem, 91120, Israel
Barzilai Medical Center /ID# 223374
Ashkelon, Southern District, 7830604, Israel
Soroka University Medical Center /ID# 169911
Beersheba, Southern District, 8443901, Israel
Tel Aviv Sourasky Medical Center /ID# 206450
Tel Aviv, Tel Aviv, 6423906, Israel
Rabin Medical Center. /ID# 202634
Petah Tikva, 4941492, Israel
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 168155
Bologna, Emilia-Romagna, 40138, Italy
IRCCS Istituto Clinico Humanitas /ID# 168153
Rozzano, Lombardy, 20089, Italy
ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168149
Milan, Milano, 20122, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 170906
Milan, Milano, 20162, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 168156
Rome, Roma, 00133, Italy
Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 168152
Rome, Roma, 00152, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 168150
Rome, Roma, 00168, Italy
Duplicate_IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168154
Negrar, Verona, 37024, Italy
Ospedale Cannizzaro /ID# 168161
Catania, 95126, Italy
Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 201986
Catanzaro, 88100, Italy
Policlinico San Martino/Univer /ID# 168162
Genova, 16132, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 200009
Modena, 41124, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 168157
Palermo, 90146, Italy
Duplicate_Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202419
Pisa, 56125, Italy
Fondazione Policlinico Universitario Campus Bio-Medico /ID# 168151
Roma, 00128, Italy
Aichi Medical University Hospital /ID# 165989
Nagakute, Aichi-ken, 480-1195, Japan
Nagoya University Hospital /ID# 165987
Nagoya, Aichi-ken, 466-8560, Japan
Nagoya City University Hospital /ID# 165988
Nagoya, Aichi-ken, 467-8602, Japan
Toyohashi Municipal Hospital /ID# 200176
Toyohashi, Aichi-ken, 441-8570, Japan
National Hospital Organization Hirosaki General Medical Center /ID# 165976
Hirosaki-shi, Aomori, 036-8545, Japan
Toho University Sakura Medical Center /ID# 165978
Sakura-shi, Chiba, 285-8741, Japan
Fukuoka University Chikushi Hospital /ID# 214402
Chikushino-shi, Fukuoka, 818-8502, Japan
Kurume University Hospital /ID# 165996
Kurume-shi, Fukuoka, 830-0011, Japan
National Hospital Organization Takasaki General Medical Center /ID# 167151
Takasaki-shi, Gunma, 370-0829, Japan
Duplicate_NHO Fukuyama Medical Center /ID# 167155
Fukuyama-shi, Hiroshima, 720-8520, Japan
Hiroshima University Hospital /ID# 165998
Hiroshima, Hiroshima, 734-8551, Japan
Duplicate_Asahikawa Medical University Hospital /ID# 167148
Asahikawa-shi, Hokkaido, 078-8510, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165975
Sapporo, Hokkaido, 060-0033, Japan
Duplicate_Sapporo Medical University Hospital /ID# 167152
Sapporo, Hokkaido, 060-8543, Japan
Sapporo IBD Clinic /ID# 223559
Sapporo, Hokkaido, 064-0919, Japan
Aoyama Clinic /ID# 165993
Kobe, Hyōgo, 650-0015, Japan
Duplicate_Hyogo Medical University Hospital /ID# 165991
Nishinomiya-shi, Hyōgo, 663-8501, Japan
Kanazawa University Hospital /ID# 169212
Kanazawa, Ishikawa-ken, 920-8641, Japan
Iwate Medical University Uchimaru Medical Center /ID# 202465
Morioka, Iwate, 020-8505, Japan
Imamura General Hospital /ID# 227135
Kagoshima, Kagoshima-ken, 890-0064, Japan
Idzuro Imamura Hospital /ID# 206655
Kagoshima, Kagoshima-ken, 892-0824, Japan
Sameshima Hospital /ID# 206677
Kagoshima, Kagoshima-ken, 892-0846, Japan
Duplicate_Yokohama City University Medical Center /ID# 167156
Yokohama, Kanagawa, 232-0024, Japan
Japanese Red Cross Kyoto Daiichi Hosital /ID# 165990
Kyoto, Kyoto, 605-0981, Japan
Duplicate_Kyoto University Hospital /ID# 169887
Kyoto, Kyoto, 606-8507, Japan
Yokkaichi Hazu Medical Center /ID# 167201
Yokkaichi-shi, Mie-ken, 510-0016, Japan
Tohoku University Hospital /ID# 167150
Sendai, Miyagi, 9808574, Japan
Nara Medical University Hospital /ID# 169213
Kashihara-shi, Nara, 634-8522, Japan
Kenseikai Dongo Hospital /ID# 208105
Yamatotakada-shi, Nara, 635-0022, Japan
Duplicate_Niigata University Medical & Dental Hospital /ID# 170042
Niigata, Niigata, 951-8520, Japan
Ishida Clinic of IBD and Gastroenterology /ID# 167149
Ōita, Oita Prefecture, 870-0823, Japan
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 165994
Kurashiki-shi, Okayama-ken, 710-0142, Japan
Duplicate_Okayama University Hospital /ID# 167354
Okayama, Okayama-ken, 700-8558, Japan
Kinshukai Infusion Clinic /ID# 218873
Osaka, Osaka, 530-0011, Japan
Osaka Metropolitan University Hospital /ID# 165999
Osaka, Osaka, 545-8586, Japan
Duplicate_Osaka University Hospital /ID# 169661
Suita-shi, Osaka, 565-0871, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 206323
Takatsuki-shi, Osaka, 569-8686, Japan
Tokitokai Tokito clinic /ID# 165977
Saitama-shi, Saitama, 336-0963, Japan
Duplicate_Shiga University of Medical Science Hospital /ID# 167157
Ōtsu, Shiga, 520-2192, Japan
Duplicate_Hamamatsu University Hospital /ID# 224402
Hamamatsu, Shizuoka, 431-3192, Japan
Duplicate_NHO Shizuoka Medical Center /ID# 167153
Sunto-gun, Shizuoka, 411-8611, Japan
Institute of Science Tokyo Hospital /ID# 165982
Bunkyo-ku, Tokyo, 113-8519, Japan
Tokai University Hachioji Hospital /ID# 165984
Hachioji-shi, Tokyo, 192-0032, Japan
Duplicate_The Jikei University Hospital /ID# 167154
Minato-ku, Tokyo, 105-8471, Japan
Kyorin University Hospital /ID# 165983
Mitaka-shi, Tokyo, 181-8611, Japan
Duplicate_Tokyo Women's Medical University Hospital /ID# 205979
Shinjuku-ku, Tokyo, 162-8666, Japan
Toyama Prefectural Central Hospital /ID# 217836
Toyama, Toyama, 930-8550, Japan
Japanese Red Cross Wakayama Medical Center /ID# 200641
Wakayama, Wakayama, 640-8558, Japan
Wakayama Medical University Hospital /ID# 169480
Wakayama, Wakayama, 641-8510, Japan
Yamagata University Hospital /ID# 200158
Yamagata, Yamagata, 990-9585, Japan
VCA Polyclinic Aura /ID# 169499
Riga, 1035, Latvia
Pauls Stradins Clinical University Hospital /ID# 169494
Riga, LV-1002, Latvia
Duplicate_Digestive Disease Center Gastro /ID# 169518
Riga, LV-1079, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207030
Kaunas, 50161, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 203269
Vilnius, 08661, Lithuania
Duplicate_Hospital Sultanah Bahiyah /ID# 201317
Alor Star, Kedah, 05460, Malaysia
Universiti Sains Malaysia /ID# 200101
Kelantan, Kelantan, 16150, Malaysia
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170780
Kuala Lumpur, Selangor, 56000, Malaysia
Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207681
Durango, Durango, 34000, Mexico
Morales Vargas Centro de Investigacion S.C. /ID# 203496
León, Guanajuato, 37000, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 206843
Guadalajara, Jalisco, 44650, Mexico
Radboud Universitair Medisch Centrum /ID# 166931
Nijmegen, Gelderland, 6525 GA, Netherlands
Zuyderland Medisch Centrum /ID# 169699
Heerlen, Limburg, 6419 PC, Netherlands
Amsterdam UMC, Location VUmc /ID# 166930
Amsterdam, North Holland, 1081 HV, Netherlands
Olvg /Id# 166932
Amsterdam, North Holland, 1091 AC, Netherlands
Medisch Spectrum Twente /ID# 170299
Enschede, Overijssel, 7512 KZ, Netherlands
Malopolskie Centrum Kliniczne /ID# 202169
Krakow, Lesser Poland Voivodeship, 30-149, Poland
Vistamed /ID# 208571
Wroclaw, Lower Silesian Voivodeship, 53-149, Poland
Centrum Zdrowia MDM /ID# 200493
Warsaw, Masovian Voivodeship, 00-189, Poland
Duplicate_WIP Warsaw IBD Point Profesor Kierkus /ID# 224302
Warsaw, Masovian Voivodeship, 00-728, Poland
Centrum Medyczne Reuma Park /ID# 200489
Warsaw, Masovian Voivodeship, 02-665, Poland
Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170204
Guimarães, Braga District, 4835-044, Portugal
Hospital Egas Moniz /ID# 170232
Lisbon, Porto District, 1349-019, Portugal
Duplicate_Hospital Garcia de Orta, EPE /ID# 170209
Almada, Setúbal District, 2805-267, Portugal
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200608
Ponte de Lima, Viana do Castelo District, 4990-041, Portugal
Unidade Local de Saude Sao Joao, EPE /ID# 170211
Porto, 4200-319, Portugal
Mindful Medical Research /ID# 203356
San Juan, 00918-3756, Puerto Rico
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166769
San Juan, 00935, Puerto Rico
Fundeni Clinical Institute /ID# 167831
Bucharest, București, 022328, Romania
Duplicate_Clinica GASTRO MED SRL /ID# 206363
Cluj-Napoca, Cluj, 400380, Romania
Cabinet Particular Policlinic Algomed /ID# 167832
Timișoara, 300002, Romania
Immanuel Kant Baltic Federal University /ID# 203810
Kaliningrad, Kaliningrad Oblast, 236016, Russia
Republican hospital named after V.A. Baranov /ID# 206497
Petrozavodsk, Murmansk Oblast, 185019, Russia
LLC Medical Center /ID# 209234
Novosibirsk, Novosibirsk Oblast, 630099, Russia
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202989
Perm, Permskiy Kray, 614109, Russia
LLC Novaya Klinika /ID# 206613
Pyatigorsk, Stavropol Kray, 357500, Russia
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202996
Stavropol, Stavropol Kray, 355012, Russia
Kazan State Medical University /ID# 169589
Kazan', Tatarstan, Respublika, 420012, Russia
Olla-Med Clinic /ID# 208723
Moscow, 105554, Russia
P.A. Bayandin Murmansk Regiona /ID# 169590
Murmansk, 183047, Russia
Euromedservice /ID# 206608
Pushkin, 196603, Russia
X7 Clinical Research Center /ID# 216348
Saint Petersburg, 194156, Russia
City Clinical Hospital No. 31 /ID# 208871
Saint Petersburg, 197110, Russia
Clinical Hosp Center Zvezdara /ID# 168216
Belgrade, Beograd, 11000, Serbia
Military Medical Academy /ID# 168785
Belgrade, Beograd, 11000, Serbia
University Clinical Center Serbia /ID# 168217
Belgrade, Beograd, 11000, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 168787
Belgrade, Beograd, 11080, Serbia
Duplicate_University Clinical Center Kragujevac /ID# 205856
Kragujevac, Sumadijski Okrug, 34000, Serbia
Duplicate_Clinical Center Vojvodina /ID# 168196
Novi Sad, Vojvodina, 21000, Serbia
Duplicate_KL Ling Gastroenterology and Liver Clinic /ID# 205739
Singapore, Central Singapore, 228510, Singapore
Gleneagles Medical Centre /ID# 206019
Singapore, 258499, Singapore
Tan Tock Seng Hospital /ID# 203158
Singapore, 308433, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169960
Banská Bystrica, Banská Bystrica Region, 975 17, Slovakia
KM Management, spol. s.r.o. /ID# 170202
Nitra, Nitra Region, 949 01, Slovakia
Univ Medical Ctr Ljubljana /ID# 211041
Ljubljana, 1000, Slovenia
Farmovs (Pty) Ltd /Id# 207534
Bloemfontein, Free State, 9301, South Africa
Lenasia Clinical Trial Centre /ID# 205143
Johannesburg, Gauteng, 1820, South Africa
Wits Clinical Research /ID# 170850
Johannesburg, Gauteng, 1864, South Africa
Allergy & Immunology (AIU) /ID# 171427
Cape Town, Western Cape, 7700, South Africa
Dr JP Wright /ID# 170882
Cape Town, Western Cape, 7708, South Africa
Private Practice Dr MN Rajabally /ID# 169851
Cape Town, Western Cape, 7800, South Africa
Inje University Haeundae Hospital /ID# 202631
Busan, Busan Gwang Yeogsi, 48108, South Korea
Dong-A University Medical Center /ID# 167568
Busan, Busan Gwang Yeogsi, 49201, South Korea
Duplicate_Pusan National University Hospital /ID# 167565
Busan, Busan Gwang Yeogsi, 49241, South Korea
Kyungpook National University Hospital /ID# 207020
Daegu, Daegu Gwang Yeogsi, 41944, South Korea
Duplicate_Hanyang University Gurihospital /ID# 167563
Guri-si, Gyeonggido, 11923, South Korea
Duplicate_CHA University Bundang Medical Center /ID# 167569
Seongnam-si, Gyeonggido, 13496, South Korea
Chungang University Hospital /ID# 207021
Dongjak-gu, Seoul Teugbyeolsi, 06973, South Korea
Kangbuk Samsung Hospital /ID# 167562
Seoul, Seoul Teugbyeolsi, 03181, South Korea
Samsung Medical Center /ID# 167564
Seoul, Seoul Teugbyeolsi, 06351, South Korea
Yonsei University Health System Severance Hospital /ID# 167567
Seoul, 03722, South Korea
Hospital Universitari Son Espases /ID# 201969
Palma de Mallorca, Balearic Islands, 07120, Spain
Hospital Universitario Marques de Valdecilla /ID# 202495
Santander, Cantabria, 39008, Spain
Hospital Universitario Dr. Negrin /ID# 202723
Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
Hospital Universitario de Navarra /ID# 202354
Pamplona, Navarre, 31008, Spain
Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 203909
A Coruña, 15006, Spain
Hospital Universitario Vall de Hebron /ID# 202721
Barcelona, 08035, Spain
Hospital Clinic de Barcelona /ID# 202726
Barcelona, 08036, Spain
Hospital Universitario de Girona Doctor Josep Trueta /ID# 202644
Girona, 17007, Spain
Hospital Juan Ramon Jimenez /ID# 202727
Huelva, 21005, Spain
Hospital Universitario La Paz /ID# 202725
Madrid, 28046, Spain
Hospital Universitario de Salamanca /ID# 206359
Salamanca, 37711, Spain
Hospital Universitario Virgen Macarena /ID# 202722
Seville, 41009, Spain
Hospital Clinico Universitario de Valencia /ID# 209658
Valencia, 46010, Spain
Hospital Universitario y Politecnico La Fe /ID# 202720
Valencia, 46026, Spain
Hallands Hospital Halmstad /ID# 170815
Halmstad, Halland County, 302 33, Sweden
Karolinska University Hospital Solna /ID# 224489
Solna, Stockholm County, 171 64, Sweden
Alingsas lasarett /ID# 170814
Alingsås, Västra Götaland County, 441 33, Sweden
Sodra Alvsborgs sjukhus /ID# 203078
Borås, Västra Götaland County, 501 82, Sweden
Duplicate_Sahlgrenska University Hospital /ID# 169032
Gothenburg, Västra Götaland County, 413 46, Sweden
Duplicate_Sahlgrenska University Hospital /ID# 169170
Gothenburg, Västra Götaland County, 413 46, Sweden
Duplicate_Universitatsspital Zurich /ID# 171000
Zurich, Canton of Zurich, 8091, Switzerland
Inselspital, Universitaetsspital Bern /ID# 170994
Bern, 3010, Switzerland
National Taiwan University Hospital /ID# 169805
Taipei City, Taipei, 100, Taiwan
China Medical University Hospital /ID# 169803
Taichung, 40447, Taiwan
Taichung Veterans General Hospital /ID# 169802
Taichung, 40705, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 169804
Taoyuan, 333, Taiwan
Gazi Universitesi Tip Fakultes /ID# 217445
Yenimahalle, Ankara, 06560, Turkey (Türkiye)
Acibadem Kozyatagi Hospital /ID# 209404
Kadıköy, Istanbul, 34742, Turkey (Türkiye)
Sisli Etfal Train & Res Hosp /ID# 171327
Şişli, Istanbul, 34371, Turkey (Türkiye)
Duplicate_Erciyes University Medical Fac /ID# 171325
Melikgazi, Kayseri, 38030, Turkey (Türkiye)
Ankara Univ Medical Faculty /ID# 206408
Ankara, 06590, Turkey (Türkiye)
Inonu Universitesi Turgut Ozal /ID# 201266
Battalgazi/malatya, 44280, Turkey (Türkiye)
Mustafa Kemal University Medic /ID# 171328
Hatay, 31001, Turkey (Türkiye)
Duplicate_Istanbul University Istanbul Medical Faculty /ID# 171365
Istanbul, 34093, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171326
Istanbul, 34899, Turkey (Türkiye)
Mersin University Medical /ID# 171330
Mersin, 33343, Turkey (Türkiye)
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167917
Lviv, Lviv Oblast, 79000, Ukraine
MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 222111
Vinnytsia, Vinnytsia Oblast, 21018, Ukraine
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167918
Kharkiv, 61037, Ukraine
Kyiv City Clinical Hospital No.18 /ID# 207890
Kyiv, 01030, Ukraine
Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203739
Kyiv, 01030, Ukraine
MNE KRC Kyiv Regional Clinical Hospital /ID# 202456
Kyiv, 04106, Ukraine
Duplicate_Royal United Hospitals Bath /ID# 169062
Bath, Bath And North East Somerset, BA1 3NG, United Kingdom
Warrington and Halton Hospitals NHS Foundation Trust /ID# 171396
Warrington, Cheshire West And Chester, WA5 1QG, United Kingdom
Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 218830
London, Greater London, E1 2ES, United Kingdom
Kings College Hospital NHS Foundation Trust /ID# 169060
London, Greater London, SE5 9RS, United Kingdom
St George University Hospitals NHS Foundation Trust /ID# 205550
London, Greater London, SW17 0QT, United Kingdom
Taunton and Somerset NHS Foundation Trust /ID# 209666
Taunton, Somerset, TA1 5DA, United Kingdom
Mersey and West Lancashire NHS teaching hospitals trust /ID# 209087
Prescot, Warrington, L35 5DR, United Kingdom
Ulster Hospital - South Eastern Health & Social Care Trust /ID# 205324
Belfast, BT16 1RH, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 169058
Birmingham, B15 2TH, United Kingdom
The Dudley Group NHS Foundation Trust /ID# 169057
Dudley, DY1 2HQ, United Kingdom
London North West University Healthcare NHS Trust /ID# 169056
Harrow, HA1 3UJ, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169063
Newcastle upon Tyne, NE3 3HD, United Kingdom
Duplicate_Stockport NHS foundation trust /ID# 208717
Stockport, SK2 7JE, United Kingdom
The Royal Wolverhampton NHS Trust /ID# 171395
Wolverhampton, WV10 0QP, United Kingdom
Related Publications (12)
Panaccione R, Panes J, Peyrin-Biroulet L, Colombel JF, Lindsay JO, Baert F, Atreya R, Vermeire S, Fujii T, Dubcenco E, Klaff J, Duncan B, Suravaram S, Fish I, Lacerda AP, Vladea R, Ford S, Shah S, Anyanwu SI, Rubin DT. Long-Term Safety of Upadacitinib in Patients With Inflammatory Bowel Disease: Integrated Analysis of Phase 2/3 Studies. Clin Gastroenterol Hepatol. 2026 Feb 27:S1542-3565(26)00145-X. doi: 10.1016/j.cgh.2026.02.018. Online ahead of print.
PMID: 41763462DERIVEDVermeire S, Colombel JF, Danese S, Panaccione R, Peyrin-Biroulet L, Beck K, Chaparro M, Gisbert JP, Dubcenco E, Klaff J, Naling G, Ford S, Remple V, Joshi N, Suravaram S, Duncan B, Wang Y, Wick-Urban B, Loftus EV. Benefit-risk profile of upadacitinib: exploratory post hoc analysis of phase 2b/3 studies in patients with moderately to severely active ulcerative colitis or Crohn's disease. J Crohns Colitis. 2026 Jan 9;20(1):jjaf198. doi: 10.1093/ecco-jcc/jjaf198.
PMID: 41264726DERIVEDDubinsky MC, D'Haens G, Dewit O, Juillerat P, Panaccione R, Fujii T, Dubcenco E, Lacerda AP, Anyanwu SI, Ford S, Cunneen C, Fish I, Joshi N, Garrison A, Loftus EV. Efficacy and Safety with Upadacitinib by Baseline Corticosteroid Use in Patients with Moderately to Severely Active Crohn's Disease. Inflamm Bowel Dis. 2026 Mar 1;32(3):498-511. doi: 10.1093/ibd/izaf250.
PMID: 41189093DERIVEDBurmester GR, Deodhar A, Irvine AD, Panaccione R, Winthrop KL, Vleugels RA, Levy G, Suravaram S, Palac H, Wegrzyn L, Ford S, Meerwein S, Guttman-Yassky E. Safety Profile of Upadacitinib: Descriptive Analysis in Over 27,000 Patient-Years Across Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Atopic Dermatitis, and Inflammatory Bowel Disease. Adv Ther. 2025 Oct;42(10):5215-5237. doi: 10.1007/s12325-025-03328-y. Epub 2025 Aug 28.
PMID: 40875187DERIVEDPanaccione R, Regueiro M, Lee SD, Atreya R, Pedersen G, Broide E, Rodriguez C, van Bodegraven AA, Dubcenco E, Lacerda AP, Feng T, Geng Z, Wang T, van Haaren S, Anyanwu SI, Panes J. Upadacitinib Maintenance Therapy in Crohn's Disease: Final Results From the Randomized Phase 3 U-ENDURE Study. Clin Gastroenterol Hepatol. 2026 Mar;24(3):772-783. doi: 10.1016/j.cgh.2025.07.028. Epub 2025 Jul 28.
PMID: 40738276DERIVEDLoftus EV Jr, D'Haens G, Louis E, Regueiro M, Jairath V, Magro F, Nakase H, Dubcenco E, Lacerda AP, Ford S, Feng T, Duncan B, Fish I, Cunneen C, Anyanwu SI, Aponte F, Griffith J, Blumenstein I. Efficacy and safety of upadacitinib maintenance therapy in patients with moderately to severely active Crohn's disease: 2-year results from the U-ENDURE Long-Term Extension study. J Crohns Colitis. 2025 Sep 7;19(8):jjaf138. doi: 10.1093/ecco-jcc/jjaf138.
PMID: 40704669DERIVEDColombel JF, Lacerda AP, Irving PM, Panaccione R, Reinisch W, Rieder F, Steinlauf A, Schwartz D, Feng T, Dubcenco E, Anyanwu SI, Laroux FS, Cunneen C, Powell N. Efficacy and Safety of Upadacitinib for Perianal Fistulizing Crohn's Disease: A Post Hoc Analysis of 3 Phase 3 Trials. Clin Gastroenterol Hepatol. 2025 May;23(6):1019-1029. doi: 10.1016/j.cgh.2024.08.032. Epub 2024 Sep 24.
PMID: 39326583DERIVEDPanes J, Louis E, Bossuyt P, Joshi N, Lee WJ, Lacerda AP, Kligys K, Xuan S, Shukla N, Loftus EV Jr. Induction of Endoscopic Response, Remission, and Ulcer-Free Endoscopy With Upadacitinib Is Associated With Improved Clinical Outcomes and Quality of Life in Patients With Crohn's Disease. Inflamm Bowel Dis. 2025 Feb 6;31(2):394-403. doi: 10.1093/ibd/izae200.
PMID: 39231444DERIVEDGhosh S, Feagan BG, Parra RS, Lopes S, Steinlauf A, Kakuta Y, Joshi N, Lee WJ, Lacerda AP, Zhou Q, Xuan S, Kligys K, Shukla N, Louis E. Impact of Upadacitinib Induction and Maintenance Therapy on Health-related Quality of Life, Fatigue, and Work Productivity in Patients with Moderately-to-severely Active Crohn's Disease. J Crohns Colitis. 2024 Nov 4;18(11):1804-1818. doi: 10.1093/ecco-jcc/jjae083.
PMID: 38835235DERIVEDPeyrin-Biroulet L, Panaccione R, Louis E, Atreya R, Rubin DT, Lindsay JO, Siffledeen J, Lukin DJ, Wright J, Watanabe K, Ford S, Remple VP, Lacerda AP, Dubcenco E, Garrison A, Zhou Q, Berg S, Anyanwu SI, Schreiber S. Upadacitinib Achieves Clinical and Endoscopic Outcomes in Crohn's Disease Regardless of Prior Biologic Exposure. Clin Gastroenterol Hepatol. 2024 Oct;22(10):2096-2106. doi: 10.1016/j.cgh.2024.02.026. Epub 2024 Mar 15.
PMID: 38492904DERIVEDColombel JF, Hisamatsu T, Atreya R, Bresso F, Thin L, Panaccione R, Parra RS, Ford S, Remple VP, Lacerda AP, Anyanwu SI, Mallick M, Garrison A, Regueiro M. Upadacitinib Reduces Crohn's Disease Symptoms Within the First Week of Induction Therapy. Clin Gastroenterol Hepatol. 2024 Aug;22(8):1668-1677. doi: 10.1016/j.cgh.2024.02.027. Epub 2024 Mar 15.
PMID: 38492903DERIVEDLoftus EV Jr, Panes J, Lacerda AP, Peyrin-Biroulet L, D'Haens G, Panaccione R, Reinisch W, Louis E, Chen M, Nakase H, Begun J, Boland BS, Phillips C, Mohamed MF, Liu J, Geng Z, Feng T, Dubcenco E, Colombel JF. Upadacitinib Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2023 May 25;388(21):1966-1980. doi: 10.1056/NEJMoa2212728.
PMID: 37224198DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- SEQUENTIAL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 15, 2017
First Posted
November 17, 2017
Study Start
March 21, 2018
Primary Completion (Estimated)
September 1, 2027
Study Completion (Estimated)
September 1, 2027
Last Updated
April 9, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- For details on when studies are available for sharing visit https://vivli.org/ ourmember/abbvie/
- Access Criteria
- To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.