A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study of the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease
2 other identifiers
interventional
931
40 countries
452
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started May 2017
Typical duration for phase_3
452 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 4, 2017
CompletedFirst Posted
Study publicly available on registry
April 7, 2017
CompletedStudy Start
First participant enrolled
May 10, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 9, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
April 14, 2021
CompletedResults Posted
Study results publicly available
July 6, 2022
CompletedJuly 6, 2022
June 1, 2022
3.5 years
April 4, 2017
March 31, 2022
June 9, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
The CDAI consists of 8 components; 7 are based on participant diary entries, participant interviews, physical examinations, measurement of body weight and height and 1 is based on laboratory analysis. CDAI clinical remission of Crohn's disease is defined as CDAI \< 150.
Week 12
US Specific: Percentage of Participants With Endoscopic Response
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Week 12
Global Outside of US: Percentage of Participants With Clinical Remission
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Week 12
Global Outside of US: Percentage of Participants With Endoscopic Response
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Week 12
Secondary Outcomes (31)
US Specific: Percentage of Participants With Clinical Remission
Week 12
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Week 4
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Week 12
US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
Week 12
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
Week 4
- +26 more secondary outcomes
Study Arms (6)
Risankizumab Dose 1 (Period 1)
EXPERIMENTALParticipants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion.
Risankizumab Dose 2 (Period 1)
EXPERIMENTALParticipants randomized to receive risankizumab dose 2 administered by intravenous (IV) infusion.
Placebo (Period 1)
PLACEBO COMPARATORParticipants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion.
Risankizumab Dose 1 (Period 2)
EXPERIMENTALParticipants who received placebo in Period 1 and participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Period 2.
Risankizumab Dose 2 (Period 2)
EXPERIMENTALParticipants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Period 2.
Risankizumab Dose 3 (Period 2)
EXPERIMENTALParticipants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Period 2.
Interventions
Placebo for risankizumab administered by intravenous infusion
Risankizumab administered by intravenous infusion
Risankizumab administered by subcutaneous (SC) injection
Eligibility Criteria
You may qualify if:
- Male or female aged \>=18 to \<= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to \< 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
- Diagnosis of CD for at least 3 months prior to Baseline.
- Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD).
- Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD.
- If female, participant must meet the contraception recommendations.
You may not qualify if:
- Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
- Participants with unstable doses of concomitant Crohn's disease therapy.
- Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within 35 days or 5 half-lives prior to Baseline, whichever is longer.
- Prior exposure to p19 inhibitors (e.g., risankizumab).
- Complications of Crohn's disease.
- Having an ostomy or ileoanal pouch.
- Known active Coronavirus Disease 2019 (COVID-19) infection.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
Study Sites (475)
Phoenix VA Health Care System /ID# 162267
Phoenix, Arizona, 85012, United States
HonorHealth Research Institute - Shea /ID# 161783
Scottsdale, Arizona, 85258, United States
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211883
Tempe, Arizona, 85284-2604, United States
University of Arizona /ID# 158469
Tucson, Arizona, 85724, United States
Atria Clinical Research /ID# 164740
Little Rock, Arkansas, 72209-7040, United States
Newport Huntington Medica /ID# 213033
Huntington Beach, California, 92648-5994, United States
United Medical Doctors /ID# 207040
Los Alamitos, California, 90720-3309, United States
TLC Clinical Research Inc /ID# 212503
Los Angeles, California, 90048, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162656
Los Angeles, California, 90067-2001, United States
United Medical Doctors - Murrieta /ID# 158424
Murrieta, California, 92563, United States
Southern CA Research Ctr., Inc /ID# 167875
Riverside, California, 92501, United States
University of California, San Francisco /ID# 157143
San Francisco, California, 94158, United States
Cedars-Sinai Medical Center-West Hollywood /ID# 163842
West Hollywood, California, 90048, United States
Peak Gastroenterology Associates, PC /ID# 165834
Colorado Springs, Colorado, 80907, United States
Rocky Mountain Pediatric Gastroenterology /ID# 207169
Lone Tree, Colorado, 80124-6798, United States
Western Connecticut Medical Group /ID# 165849
Danbury, Connecticut, 06810-6000, United States
Seffner Premier Health Care, PA /ID# 162265
Brandon, Florida, 33510, United States
Clinical Research of West Florida, Inc /ID# 204859
Clearwater, Florida, 33765, United States
Clinical Research of West Florida, Inc /ID# 207450
Clearwater, Florida, 33765, United States
South Lake Pain Institute, Inc /ID# 162825
Clermont, Florida, 34711, United States
Universal Axon Clinical Research /ID# 165432
Doral, Florida, 33166, United States
Nature Coast Clinical Research - Inverness /ID# 159414
Inverness, Florida, 34452-4717, United States
SIH Research Mumtaz, Inc /ID# 163082
Kissimmee, Florida, 34741-4161, United States
Alliance Medical Research /ID# 163840
Lighthouse PT, Florida, 33064, United States
Cfagi Llc /Id# 201571
Maitland, Florida, 32751-6108, United States
Vista Health Research, LLC /ID# 212664
Miami, Florida, 33176-1032, United States
ITB Research /ID# 161334
Miami, Florida, 33176, United States
Coral Research Clinic /ID# 158549
Miami, Florida, 33186-4643, United States
South Florida Research Ph I-IV, Inc. /ID# 161836
Miami, Florida, 33193, United States
Gastroenterology Group Naples /ID# 165206
Naples, Florida, 34102, United States
Advanced Research Institute, Inc /ID# 161959
New Port Richey, Florida, 34653, United States
Endoscopic Research, Inc. /ID# 205901
Orlando, Florida, 32803, United States
Omega Research Maitland, LLC /ID# 171081
Orlando, Florida, 32810-2907, United States
IMIC Inc. Medical Research /ID# 154943
Palmetto Bay, Florida, 33157, United States
Clinical Research Trials of Florida, Inc. /ID# 201014
Tampa, Florida, 33607, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 154857
Macon, Georgia, 31201, United States
Northwestern University Division of GI/Hepatology /ID# 158283
Chicago, Illinois, 60611-2927, United States
The University of Chicago Medical Center /ID# 157141
Chicago, Illinois, 60637-1443, United States
NorthShore University HealthSystem /ID# 158287
Evanston, Illinois, 60201, United States
Southwest Gastroenterology /ID# 165002
Oak Lawn, Illinois, 60453, United States
Cotton-O'Neil Clinical Res Ctr /ID# 154738
Topeka, Kansas, 66606, United States
University of Kentucky Chandler Medical Center /ID# 157137
Lexington, Kentucky, 40536, United States
University of Louisville /ID# 210521
Louisville, Kentucky, 40202, United States
Gastroenterology Associates LLC - Jefferson Hwy /ID# 161956
Baton Rouge, Louisiana, 70809, United States
Houma Digestive Health Special /ID# 158286
Houma, Louisiana, 70360, United States
Delricht Research /ID# 206542
New Orleans, Louisiana, 70115, United States
Nola Research Works, LLC /ID# 161330
New Orleans, Louisiana, 70115, United States
Louisana Research Center, LLC /ID# 162236
Shreveport, Louisiana, 71105-6800, United States
MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154839
Chevy Chase, Maryland, 20815, United States
Gastro Center of Maryland /ID# 165004
Columbia, Maryland, 21045, United States
University of Michigan Health Systems /ID# 157144
Ann Arbor, Michigan, 48109, United States
Center for Digestive Health /ID# 154690
Troy, Michigan, 48098-6363, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161328
Wyoming, Michigan, 49519, United States
Mayo Clinic - Rochester /ID# 163085
Rochester, Minnesota, 55905-0001, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 162388
Jackson, Mississippi, 39216, United States
St. Louis University /ID# 161902
St Louis, Missouri, 63104, United States
University of Nebraska Medical Center /ID# 210057
Omaha, Nebraska, 68198-2000, United States
Las Vegas Medical Research /ID# 160172
Las Vegas, Nevada, 89113, United States
Revival Research Institute, Inc /ID# 210984
Las Vegas, Nevada, 89128-3157, United States
NY Scientific /ID# 158418
Brooklyn, New York, 11235, United States
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 212036
Burnt Hills, New York, 12027, United States
Intercity Advanced Gastroentertology Center /ID# 213399
Fresh Meadows, New York, 11366, United States
Duplicate_Long Island Clinical Research /ID# 154836
Great Neck, New York, 11021-5343, United States
Digestive Disease Care /ID# 209619
New Hyde Park, New York, 11040, United States
North Shore University Hospital /ID# 168736
New Hyde Park, New York, 11040, United States
NYU Langone Medical Center /ID# 160171
New York, New York, 10016-6402, United States
Columbia Univ Medical Center /ID# 161911
New York, New York, 10032-3725, United States
Lenox Hill Hospital /ID# 168465
New York, New York, 10075, United States
DiGiovanna Institute for Medical Education & Research /ID# 171118
North Massapequa, New York, 11758, United States
Univ NC Chapel Hill /ID# 154840
Chapel Hill, North Carolina, 27514-4220, United States
Atrium Health Carolinas Medical Center /ID# 158481
Charlotte, North Carolina, 28203, United States
Clinical Trials America /ID# 158484
Hickory, North Carolina, 28601, United States
Vidant Multispecialty Clinic - Kinston /ID# 161111
Kinston, North Carolina, 28501-1589, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154880
Raleigh, North Carolina, 27612, United States
Plains Clinical Research Center, LLC /ID# 169715
Fargo, North Dakota, 58104-5925, United States
Tri-State Endoscopy /ID# 154933
Cincinnati, Ohio, 45219, United States
Cleveland Clinic Main Campus /ID# 208171
Cleveland, Ohio, 44195, United States
The Ohio State University /ID# 164709
Columbus, Ohio, 43210, United States
Optimed Research, Ltd. /ID# 167901
Columbus, Ohio, 43235, United States
Hometown Urgent Care and Resea /ID# 170453
Dayton, Ohio, 45424, United States
Great Lakes Medical Research, LLC /ID# 201732
Mentor, Ohio, 44060-6211, United States
Hightower Clinical /ID# 211938
Oklahoma City, Oklahoma, 73102, United States
Digestive Disease Specialists /ID# 170774
Oklahoma City, Oklahoma, 73112, United States
Adult Gastroenterology Associates - Gen 1 Research /ID# 206125
Tulsa, Oklahoma, 74136-7823, United States
Northwest Gastroenterology Clinic /ID# 158288
Portland, Oregon, 97210, United States
PennState Milton S.Hershey Med /ID# 154883
Hershey, Pennsylvania, 17033, United States
Children's Hospital of Pittsburgh of UPMC /ID# 210920
Pittsburgh, Pennsylvania, 15224-1334, United States
Digestive Disease Associates, LTD /ID# 208847
Wyomissing, Pennsylvania, 19610-2002, United States
Medical University of South Carolina /ID# 212579
Charleston, South Carolina, 29425, United States
Gastroenterology Associates, P.A. of Greenville /ID# 154911
Greenville, South Carolina, 29615-3593, United States
Rapid City Medical Center - GI Research /ID# 163841
Rapid City, South Dakota, 57701, United States
Gastro One /ID# 154742
Germantown, Tennessee, 38138, United States
East Tennessee Research Institute /ID# 168737
Johnson City, Tennessee, 37604, United States
Duplicate_Clinical Neuroscience Solutions /ID# 164181
Memphis, Tennessee, 38119-4823, United States
Vanderbilt University Medical Center /ID# 157138
Nashville, Tennessee, 37232-0011, United States
TX Clinical Research Institute /ID# 159410
Arlington, Texas, 76012, United States
Inquest Clinical Research /ID# 165695
Baytown, Texas, 77521-2415, United States
Texas Digestive Disease Consultants /ID# 209596
Cedar Park, Texas, 78613-5028, United States
Texas Digestive Disease Consultants /ID# 209785
Cedar Park, Texas, 78613-5028, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 201848
Dallas, Texas, 75246, United States
DHAT Research Institute /ID# 158217
Garland, Texas, 75044-2208, United States
Vilo Research Group Inc /ID# 206130
Houston, Texas, 77017-2337, United States
CliniCore International, LLC /ID# 158209
Houston, Texas, 77027-6812, United States
Baylor College of Medicine - Baylor Medical Center /ID# 158212
Houston, Texas, 77030-3411, United States
Precision Research Institute, LLC /ID# 200503
Houston, Texas, 77036, United States
Centex Studies, Inc. - Houston /ID# 200720
Houston, Texas, 77058, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 161336
San Antonio, Texas, 78212, United States
Southern Star Research Institute, LLC /ID# 168770
San Antonio, Texas, 78229-5390, United States
Tyler Research Institute, LLC /ID# 166796
Tyler, Texas, 75701-4464, United States
Gastro Health & Nutrition - Victoria /ID# 164296
Victoria, Texas, 77904, United States
HP Clinical Research /ID# 162998
Bountiful, Utah, 84010, United States
Advanced Research Institute /ID# 154914
Ogden, Utah, 84403, United States
Velocity Clinical Research - Salt Lake City /ID# 161781
West Jordan, Utah, 84088, United States
McGuire DV AMC /ID# 159990
Richmond, Virginia, 23249, United States
Washington Gastroenterology Associates /ID# 162120
Bellevue, Washington, 98004, United States
Virginia Mason - Seattle Orthapedics /ID# 155545
Seattle, Washington, 98101, United States
WVU Medicine /ID# 167940
Morgantown, West Virginia, 26506-1200, United States
Duplicate_HOSPITAL CENTENARIO /ID# 170883
Rosario, Santa Fe Province, 2000, Argentina
Hospital Privado Univesitario /ID# 161988
Córdoba, 5016, Argentina
Duplicate_Mater Hospital /ID# 167990
South Brisbane, Queensland, 4101, Australia
Griffith University /ID# 212627
Southport, Queensland, 4222, Australia
Lyell McEwin Hospital /ID# 211363
Elizabeth Vale, South Australia, 5112, Australia
Emeritus Research /ID# 213511
Camberwell, Victoria, 3124, Australia
Footscray Hospital /ID# 211361
Footscray, Victoria, 3011, Australia
Universitaetsklinikum St. Poelten /ID# 166425
Sankt Pölten, Lower Austria, 3100, Austria
Medizinische Universitaet Graz /ID# 158137
Graz, Styria, 8036, Austria
Krankenhaus der Barmherzigen Brueder Wien /ID# 212059
Vienna, Vienna, 1020, Austria
Duplicate_Medical University of Vienna /ID# 158138
Vienna, Vienna, 1090, Austria
Grodno city clinical hospital #2 /ID# 159499
Grodno, 230011, Belarus
Gomel Regional Clinical Hospital /ID# 159498
Homyel, 246029, Belarus
Vitebsk Regional Advanced Clin /ID# 159497
Vitebsk, 210001, Belarus
ULB Hospital Erasme /ID# 157397
Brussels, Brussels Capital, 1070, Belgium
UCL Saint-Luc /ID# 157395
Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium
CHU UCL Namur - site Godinne /ID# 157401
Godinne, Namur, 5530, Belgium
UZ Gent /ID# 157394
Ghent, Oost-Vlaanderen, 9000, Belgium
Universitair Ziekenhuis Leuven /ID# 157396
Leuven, Vlaams-Brabant, 3000, Belgium
Imelda Ziekenhuis /ID# 157392
Bonheiden, 2820, Belgium
CHU de Liege /ID# 157398
Liège, 4000, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 157393
Liège, 4000, Belgium
AZ-Delta /ID# 157391
Roeselare, 8800, Belgium
University Clinical Centre of the Republic of Srpska /ID# 157717
Banja Luka, Republika Srpska, 78000, Bosnia and Herzegovina
University Clinical Centre of the Republic of Srpska /ID# 164512
Banja Luka, Republika Srpska, 78000, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 165134
Sarajevo, 71000, Bosnia and Herzegovina
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157672
Goiânia, Goiás, 74535-170, Brazil
Hospital Nossa Senhora das Graças /ID# 157646
Curitiba, Paraná, 80810-040, Brazil
Hospital de Clinicas de Porto Alegre /ID# 157653
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Upeclin Fmb - Unesp /Id# 157688
Botucatu, São Paulo, 18618-686, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157649
Ribeirão Preto, São Paulo, 14051-140, Brazil
Faculdade de Medicina do ABC /ID# 159672
Santo André, São Paulo, 09060-870, Brazil
Kaiser Clinica e Hospital Dia /ID# 157656
São José do Rio Preto, São Paulo, 15015-110, Brazil
UMHAT Dr Georgi Stranski EAD /ID# 203977
Pleven, 5800, Bulgaria
University Multiprofile Hospit /ID# 158644
Plovdiv, 4001, Bulgaria
Second Multiprofile Hospital f /ID# 158646
Sofia, 1202, Bulgaria
Duplicate_Tokuda Hospital Sofia /ID# 158645
Sofia, 1407, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 204714
Sofia, 1431, Bulgaria
UMHAT Tsaritsa Joanna - ISUL /ID# 211240
Sofia, 1527, Bulgaria
MHAT Trakia /ID# 201672
Stara Zagora, 6004, Bulgaria
University Multiprofile Hospit /ID# 167575
Varna, 9010, Bulgaria
University of Calgary - Heritage Medical Research Clinic /ID# 157152
Calgary, Alberta, T2N 4Z6, Canada
Allen Whey Khye Lim Professional Corporation /ID# 169761
Edmonton, Alberta, T5R 1W2, Canada
University of Alberta - Zeidler Ledcor Centre /ID# 157098
Edmonton, Alberta, T6G 2X8, Canada
Covenant Health /ID# 161617
Edmonton, Alberta, T6K 4B2, Canada
Fraser Clinical Trials Inc /ID# 159053
New Westminster, British Columbia, V3L 3W4, Canada
GIRI Gastrointestinal Research Institute /ID# 157095
Vancouver, British Columbia, V6Z 2K5, Canada
Percuro Clinical Research, Ltd /ID# 161616
Victoria, British Columbia, V8V 3M9, Canada
QEII - Health Sciences Centre /ID# 157087
Halifax, Nova Scotia, B3H 2Y9, Canada
IWK Health Center /ID# 165900
Halifax, Nova Scotia, B3K 6R8, Canada
Medicor Research Inc /ID# 157149
Greater Sudbury, Ontario, P3A 1W8, Canada
London Health Sciences Center /ID# 157160
London, Ontario, N6A 5W9, Canada
Scott Shulman Medicine Professional Corporation /ID# 165903
North Bay, Ontario, P1B 2H3, Canada
Mount Sinai Hospital /ID# 169762
Toronto, Ontario, M5G 1X5, Canada
Toronto Digestive Disease Asso /ID# 157157
Vaughan, Ontario, L4L 4Y7, Canada
CISSS de la Monteregie /ID# 161615
Greenfield Park, Quebec, J4V 2H1, Canada
CHAU- Hotel-Dieu de Levis /ID# 214375
Lévis, Quebec, G6V 3Z1, Canada
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159054
Montreal, Quebec, H1T 2M4, Canada
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167066
Montreal, Quebec, H2X 3E4, Canada
Montreal General Hospital - McGill University Health Center /ID# 157084
Montreal, Quebec, H3G 1A4, Canada
Centro de Investigaciones Clínicas Viña del Mar /ID# 203589
Viña del Mar, Región de Valparaíso, 2540488, Chile
Complejo Asistencial Dr. Sotero del Rio /ID# 169382
Santiago, Santiago Metropolitan, 8207257, Chile
Hospital Guillermo Grant Benavente de Concepción /ID# 210759
Concepción, 4070038, Chile
Hospital Las Higueras /ID# 167090
Talcahuano, 1740000, Chile
Guangdong Provincial People's Hospital /ID# 212948
Guangzhou, Guangdong, 510080, China
The Sixth Affiliated Hosp Sun /ID# 210785
Guangzhou, Guangdong, 510655, China
The Second Hospital of Hebei Medical University /ID# 212740
Shijiazhuang, Hebei, 050000, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210856
Wuhan, Hubei, 430022, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211038
Wuhan, Hubei, 430022, China
Renmin Hospital of Wuhan University /ID# 214873
Wuhan, Hubei, 430060, China
The First Affiliated Hospital of Nanchang University /ID# 211034
Nanchang, Jiangxi, 330006, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210841
Shanghai, Shanghai Municipality, 200065, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210707
Shanghai, Shanghai Municipality, 200127, China
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210725
Hangzhou, Zhejiang, 310009, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210624
Hangzhou, Zhejiang, 310020, China
Jinhua Municipal Central Hospital /ID# 215626
Jinhua, Zhejiang, 321000, China
The Second Hospital Central South University /ID# 211696
Changsha, 410011, China
West China Hospital, Sichuan University /ID# 210889
Chengdu, 610041, China
Shanghai East Hospital /ID# 212683
Pudong New District, 200136, China
Tianjin Medical University General Hospital /ID# 210927
Tianjin, 300052, China
Instituto de Coloproctologia /ID# 158741
Medellín, Antioquia, 050024, Colombia
Hospital Pablo Tobon Uribe /ID# 158735
Medellín, Antioquia, 50034, Colombia
Hospital Univ San Ignacio /ID# 158733
Bogota, Cundinamarca, 110231, Colombia
Hospital Universitario San Vic /ID# 171487
Medellín, 50010, Colombia
Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157565
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Sestre milosrdnice /ID# 157721
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb /ID# 157566
Zagreb, City of Zagreb, 10000, Croatia
UHC Osijek /ID# 157564
Osijek, County of Osijek-Baranja, 31000, Croatia
Klinicki bolnicki centar Split /ID# 157567
Split, Split-Dalmatia County, 21000, Croatia
Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165463
Prague, Praha 4, 140 00, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 163134
Hradec Králové, 500 12, Czechia
CTCenter MaVe s.r.o. /ID# 163149
Olomouc, 779 00, Czechia
Nemocnice Pardubickeho kraje, a.s. /ID# 163182
Pardubice, 530 03, Czechia
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211305
Prague, 118 33, Czechia
Axon Clinical, s.r.o. /ID# 163176
Prague, 140 00, Czechia
Thomayerova nemocnice /ID# 162940
Prague, 140 59, Czechia
ResTrial s.r.o. /ID# 211075
Prague, 143 00, Czechia
NH Hospital a.s. /ID# 211076
Prague, 155 00, Czechia
East Tallinn Central Hospital /ID# 157076
Tallinn, Harju, 10138, Estonia
West Tallinn Central Hospital /ID# 157077
Tallinn, 10617, Estonia
North Estonia Medical Centre /ID# 163507
Tallinn, 13419, Estonia
Universitaetsklinikum Freiburg /ID# 162019
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Praxis fuer Gastroenterologie /ID# 166145
Heidelberg, Baden-Wurttemberg, 69121, Germany
Universitatsklinikum Mannheim /ID# 162020
Mannheim, Baden-Wurttemberg, 68167, Germany
Universitaetsklinikum Tuebingen /ID# 159324
Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Ulm /ID# 164986
Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsklinikum Erlangen /ID# 159315
Erlangen, Bavaria, 91054, Germany
Universitaetsklinikum Frankfurt /ID# 212978
Frankfurt am Main, Hesse, 60590, Germany
Universitaetsklinikum Koeln /ID# 164985
Cologne, North Rhine-Westphalia, 50937, Germany
Evangelisches Krankenhaus Kalk /ID# 212725
Cologne, North Rhine-Westphalia, 51103, Germany
Praxiszentrum fuer Gastroenterologie /ID# 211964
Grevenbroich, North Rhine-Westphalia, 41515, Germany
Universitaetsklinikum Muenster /ID# 159316
Münster, North Rhine-Westphalia, 48149, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210529
Saarbrücken, Saarland, 66111, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159321
Kiel, Schleswig-Holstein, 24105, Germany
Universitaetsklinikum Jena /ID# 159323
Jena, Thuringia, 07747, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212219
Berlin, 10117, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212893
Berlin, 10117, Germany
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211972
Berlin, 10787, Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159322
Berlin, 10825, Germany
DRK Kliniken Berlin Westend /ID# 166146
Berlin, 14050, Germany
Krankenhaus Waldfriede /ID# 212728
Berlin-Zehlendorf, 14163, Germany
Stadtisches Klinikum Braunschweig /ID# 163666
Braunschweig, 38126, Germany
Medizinisches Versorgunszentrum Dachau /ID# 211557
Dachau, 85221, Germany
Agaplesion Markus Krankenhaus /ID# 159317
Frankfurt am Main, 60431, Germany
Asklepios Westklinikum Hamburg /ID# 159319
Hamburg, 22559, Germany
Medizinische Hochschule Hannover /ID# 162021
Hanover, 30625, Germany
EUGASTRO GmbH /ID# 212076
Leipzig, 04103, Germany
Klinikum Lueneburg /ID# 163664
Lüneburg, 21339, Germany
Universitaetsklinikum Magdeburg /ID# 211847
Magdeburg, 39120, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162018
Minden, 32423, Germany
Universitaetsklinikum Regensburg /ID# 163665
Regensburg, 93042, Germany
Duplicate_Gastro-Praxis Wiesbaden /ID# 159318
Wiesbaden, 65189, Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 171077
Athens, Attica, 11527, Greece
Tzaneio general hospital of Piraeus /ID# 206445
Piraeus, Attica, 18536, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 157427
Heraklion, Crete, 71307, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157428
Athens, 10676, Greece
University General Hospital of Ioannina /ID# 157425
Ioannina, 45500, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157429
Pireaus, 18454, Greece
Theageneio Anticancer Hospital /ID# 163921
Thessaloniki, 54639, Greece
Queen Mary Hospital /ID# 163902
Hong Kong, 999077, Hong Kong
Tuen Mun Hospital /ID# 163901
Tuenmen, Hong Kong
Beaumont Hospital /ID# 157515
Beaumont, Dublin, D09 XR63, Ireland
St Vincent's University Hospital /ID# 157512
Elm Park, Dublin, D04 T6F4, Ireland
University Hospital Galway /ID# 157513
Galway, H91 YR71, Ireland
Soroka University Medical Center /ID# 157798
Beersheba, Southern District, 8443901, Israel
Sheba Medical Center /ID# 157797
Ramat Gan, Tel Aviv, 5239424, Israel
Sheba Medical Center /ID# 171074
Ramat Gan, Tel Aviv, 5239424, Israel
Tel Aviv Sourasky Medical Center /ID# 157796
Tel Aviv, Tel Aviv, 6423906, Israel
Duplicate_Rambam Medical Center /ID# 171072
Haifa, 3109601, Israel
The Edith Wolfson Medical Center /ID# 217329
Holon, 5822000, Israel
Shaare Zedek Medical Center /ID# 163540
Jerusalem, 91031, Israel
Shaare Zedek Medical Center /ID# 171073
Jerusalem, 91031, Israel
Hadassah Medical Center-Hebrew University /ID# 165913
Jerusalem, 91120, Israel
Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162427
Torrette, Ancona, 60123, Italy
University of Catanzaro /ID# 212012
Catanzaro, Calabria, 88100, Italy
Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212019
Modena, Emilia-Romagna, 41124, Italy
Policlinico Universitario Campus Bio-Medico /ID# 162429
Rome, Lazio, 00128, Italy
Azienda Ospedaliera San Camillo Forlanini /ID# 155636
Rome, Lazio, 00152, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166911
Rome, Lazio, 00161, Italy
Istituto Clinico Humanitas /ID# 155634
Rozzano, Milano, 20089, Italy
Fondazione PTV Policlinico Tor Vergata /ID# 158021
Rome, Roma, 00133, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155632
Rome, Roma, 00168, Italy
Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168051
Florence, Tuscany, 50139, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161305
Negrar, Verona, 37024, Italy
A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155635
Bologna, 40138, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 161306
Catania, 95126, Italy
Ospedale Policlinico San Martino /ID# 162430
Genova, 16132, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155633
Milan, 20122, Italy
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155631
Milan, 20157, Italy
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155637
Palermo, 90146, Italy
Duplicate_Fondazione IRCCS Policlinico San Matteo /ID# 212029
Pavia, 27100, Italy
Aichi Medical University Hospital /ID# 160159
Nagakute-shi, Aichi-ken, 480-1195, Japan
Daido Clinic /ID# 211477
Nagoya, Aichi-ken, 457-0818, Japan
Nagoya University Hospital /ID# 160150
Nagoya, Aichi-ken, 4668560, Japan
Nagoya City University Hospital /ID# 160162
Nagoya, Aichi-ken, 467-8602, Japan
Fujita Health University Hospital /ID# 163214
Toyoake-shi, Aichi-ken, 470-1192, Japan
Tokatsu Tsujinaka Hospital /ID# 163362
Abiko-shi, Chiba, 270-1168, Japan
Chiba University Hospital /ID# 217532
Chiba, Chiba, 260-8677, Japan
Tsujinaka Hospital Kashiwanoha /ID# 213847
Kashiwa-shi, Chiba, 277-0871, Japan
The Jikei University Kashiwa Hospital /ID# 200007
Kashiwa-shi, Chiba, 277-8567, Japan
Toho University Sakura Medical Center /ID# 160161
Sakura-shi, Chiba, 285-8741, Japan
Fukuoka University Hospital /ID# 217792
Fukuoka, Fukuoka, 814-0180, Japan
Kurume University Hospital /ID# 160138
Kurume-shi, Fukuoka, 830-0011, Japan
NHO Fukuyama Medical Center /ID# 163578
Fukuyama-shi, Hiroshima, 720-8520, Japan
Hiroshima University Hospital /ID# 160139
Hiroshima, Hiroshima, 734-8551, Japan
Asahikawa Medical University Hospital /ID# 162844
Midorigaokahiga-shi, Hokkaido, 078-8510, Japan
Sapporo Tokushukai Hospital /ID# 213493
Sapporo, Hokkaido, 004-0041, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160158
Sapporo, Hokkaido, 060-0033, Japan
Sapporo Medical University Hospital /ID# 163028
Sapporo, Hokkaido, 060-8543, Japan
Nishinomiya Munic Central Hospital /ID# 210104
Nishinomiya-shi, Hyōgo, 663-8014, Japan
Hyogo College of Medicine College Hospital /Id# 160164
Nishinomiya-shi, Hyōgo, 663-8501, Japan
National Hospital Organization Mito Medical Center /ID# 160154
Higashi Ibaraki-gun, Ibaraki, 311-3193, Japan
Kanazawa University Hospital /ID# 201766
Kanazawa, Ishikawa-ken, 920-8641, Japan
Gokeikai Ofuna Chuo Hospital /ID# 171070
Kamakura-shi, Kanagawa, 247-0056, Japan
Kitasato University Hospital /ID# 171071
Sagamihara-shi, Kanagawa, 252-0375, Japan
Yokohama City University Medical Center /ID# 163906
Yokohama, Kanagawa, 232-0024, Japan
Yokohama Municipal Citizen's Hospital /ID# 204126
Yokohama, Kanagawa, 240-8555, Japan
Mie University Hospital /ID# 203639
Tsu, Mie-ken, 514-8507, Japan
Yokkaichi Hazu Medical Center /ID# 163741
Yokkaichi-shi, Mie-ken, 510-0016, Japan
Tohoku University Hospital /ID# 162843
Sendai, Miyagi, 9808574, Japan
Duplicate_Tohoku Rosai Hospital /ID# 163189
Sendai, Miyagi, 981-8563, Japan
Osaka City University Hospital /ID# 160146
Osaka, Osaka, 545-8586, Japan
Saitama Medical Center /ID# 160155
Kawagoe-shi, Saitama, 350-8550, Japan
Tokitokai Tokito clinic /ID# 160145
Saitama-shi, Saitama, 336-0963, Japan
Shiga University of Medical Science Hospital /ID# 164022
Ōtsu, Shiga, 520-2192, Japan
Hamamatsu University Hospital /ID# 205689
Hamamatsu, Shizuoka, 431-3192, Japan
NHO Shizuoka Medical Center /ID# 163029
Sunto-gun, Shizuoka, 411-8611, Japan
Tokyo Medical And Dental University, Medical Hospital /ID# 160157
Bunkyo-ku, Tokyo, 113-8519, Japan
Duplicate_Tokai University Hachioji Hospital /ID# 160160
Hachioji-shi, Tokyo, 192-0032, Japan
The Jikei University Hospital /ID# 163190
Minato-ku, Tokyo, 105-8471, Japan
Duplicate_Kitasato University Kitasato Institute Hospital /ID# 160144
Minato-ku, Tokyo, 108-8642, Japan
Kyorin University Hospital /ID# 160149
Mitaka-shi, Tokyo, 181-8611, Japan
Tokyo Women's Medical University Hospital /ID# 205973
Shinjuku-ku, Tokyo, 162-8666, Japan
Wakayama Medical University Hospital /ID# 200183
Wakayama, Wakayama, 641-8510, Japan
Yamagata University Hospital /ID# 200154
Yamagata, Yamagata, 990-9585, Japan
Yamanashi Prefectural Central Hospital /ID# 160156
Kofu, Yamanashi, 400-8506, Japan
Pauls Stradins Clinical University Hospital /ID# 159614
Riga, 1002, Latvia
Digestive Disease Center Gastro /ID# 163105
Riga, LV-1079, Latvia
Riga East Clinical University Hospital /ID# 159613
Riga, LV-1079, Latvia
Duplicate_Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162582
Kaunas, 50161, Lithuania
Duplicate_Vilnius University Hospital /ID# 162507
Vilnius, LT-08661, Lithuania
Universiti Sains Malaysia /ID# 160656
Kelantan, Kelantan, 16150, Malaysia
Queen Elizabeth Hospital /ID# 160654
Division Pantai Barat Utara, Sabah, 88200, Malaysia
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 163654
Kuala Lumpur, Selangor, 56000, Malaysia
Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 167648
Zapopan, Jalisco, 45070, Mexico
JM Research SC /ID# 161733
Cuernavaca, Morelos, 62290, Mexico
Unidad de Atencion Medica e Investigacion en Salud /ID# 163624
Mérida, Yucatán, 97000, Mexico
Health Pharma Professional Research S.A de C.V /ID# 161734
Del. Benito Juárez, 03810, Mexico
Academisch Medisch Centrum /ID# 157950
Amsterdam, 1105 AZ, Netherlands
Elisabeth Tweesteden Ziekenhuis /ID# 163631
Tilburg, 5022 GC, Netherlands
Christchurch Hospital /ID# 163074
Christchurch, Canterbury, 8011, New Zealand
Dunedin Hospital /ID# 167989
Dunedin, Otago, 9016, New Zealand
Wellington Regional Hospital /ID# 167987
Newtown Wellington, Wellington Region, 6021, New Zealand
Akershus universitetssykehus /ID# 169378
Nordbyhagen, Akershus, 1474, Norway
Helse More og Romsdal HF, Alesund sjukehus /ID# 212811
Ålesund, 6017, Norway
Vestre viken - Baerum Sykehus /ID# 157886
Gjettum, 1346, Norway
Sykehuset Levanger Helse NT /ID# 157885
Levanger, 7601, Norway
Gastromed /Id# 212099
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Planetmed Sp. z o.o. /ID# 202798
Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209985
Lublin, Lublin Voivodeship, 20-049, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209981
Lublin, Lublin Voivodeship, 20-954, Poland
Centrum Zdrowia MDM /ID# 160794
Warsaw, Masovian Voivodeship, 00-635, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 160797
Warsaw, Masovian Voivodeship, 02-507, Poland
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213579
Warsaw, Masovian Voivodeship, 04-730, Poland
Centrum Medyczne Medyk /ID# 212889
Rzeszów, Podkarpackie Voivodeship, 35-326, Poland
Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212081
Chojnice, Pomeranian Voivodeship, 89-600, Poland
H-T. Centrum Medyczne - Endoterapia /ID# 212459
Tychy, Silesian Voivodeship, 43-100, Poland
Wojewodzki Szpital Specjalistyczny /ID# 212402
Olsztyn, Warmian-Masurian Voivodeship, 10-561, Poland
Duplicate_SOLUMED Sp. z o.o., Sp.k. /ID# 160793
Poznan, 60-529, Poland
Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 205160
Warsaw, 03-580, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212602
Wroclaw, 50-556, Poland
Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212297
Lodz, Łódź Voivodeship, 90-153, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160739
Guimarães, Braga District, 4835-044, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167750
Portimão, Faro District, 8500-338, Portugal
Centro Hospitalar de Entre Douro e Vouga /ID# 160674
Santa Maria DA Feira, Porto District, 4520-211, Portugal
Hospital Garcia de Orta, EPE /ID# 160747
Almada, 2805-267, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160715
Faro, 8000-386, Portugal
Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160675
Lisbon, 1169-050, Portugal
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167749
Lisbon, 1349-019, Portugal
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160694
Lisbon, 1649-035, Portugal
Hospital Beatriz Ângelo /ID# 207757
Loures, 2674-514, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160695
Porto, 4200-319, Portugal
Centro Hosp de Tondela-Viseu /ID# 160697
Viseu, 3504-509, Portugal
Institutul Clinic Fundeni /ID# 163046
Sector 2, București, 022328, Romania
Institutul Clinic Fundeni /ID# 163264
Sector 2, București, 022328, Romania
Tvm Med Serv Srl /Id# 166294
Cluj-Napoca, 400132, Romania
Cabinet Particular Policlinic Algomed /ID# 163047
Timișoara, 300002, Romania
Duplicate_Centrul Medical Tuculanu SRL /ID# 166295
Timișoara, 300168, Romania
Kuzbass Regional Clinical Hospital /ID# 161310
Kemerovo, Kemerovo Oblast, 650099, Russia
Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207440
Perm, Permskiy Kray, 614990, Russia
Duplicate_St. Petersburg State Pediatric Medical University /ID# 211977
Saint Petersburg, Sankt-Peterburg, 194100, Russia
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 156949
Stavropol, Stavropol Kray, 355012, Russia
Tver Regional Clinical Hospital /ID# 205925
Tver', Tver Oblast, 170036, Russia
Regional Clinical Hospital #1 /ID# 163453
Tyumen, Tyumen Oblast, 625023, Russia
Alliance Biomedical Ural Group /ID# 156950
Izhevsk, Udmurtiya Republic, 426061, Russia
State Scientific Ctr Coloproct /ID# 204809
Moscow, 123423, Russia
Novosibirski Gastrocenter /ID# 217554
Novosibirsk, 630007, Russia
City Clinical Hospital No. 31 /ID# 208866
Saint Petersburg, 197110, Russia
Duplicate_Ulyanovsk State clinical hospi /ID# 156946
Ulyanovsk, 432063, Russia
Clinical Hosp Center Zvezdara /ID# 156978
Belgrade, Beograd, 11000, Serbia
Military Medical Academy /ID# 156979
Belgrade, Beograd, 11000, Serbia
University Clinical Center Serbia /ID# 156973
Belgrade, Beograd, 11000, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 156976
Belgrade, Beograd, 11080, Serbia
University Clinical Center Kragujevac /ID# 156975
Kragujevac, Sumadijski Okrug, 34000, Serbia
Clinical Center Vojvodina /ID# 156972
Novi Sad, Vojvodina, 21000, Serbia
University Children's Hospital 'Tirsova' /ID# 211481
Belgrade, 11000, Serbia
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212797
Belgrade, 11040, Serbia
General Hospital Leskovac /ID# 209574
Leskovac, 16000, Serbia
National University Hospital /ID# 160658
Singapore, 119074, Singapore
Singapore General Hospital /ID# 160657
Singapore, 169608, Singapore
KL Ling Gastroenterology and Liver Clinic /ID# 205737
Singapore, 228510, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156465
Banská Bystrica, 975 17, Slovakia
Univerzitna nemocnica Martin /ID# 163200
Martin, 036 01, Slovakia
KM Management, spol. s.r.o. /ID# 206763
Nitra, 949 01, Slovakia
GASTRO I., s.r.o. /ID# 156466
Prešov, 080 01, Slovakia
Clinresco Centers /ID# 163864
Johannesburg, Gauteng, 1619, South Africa
Wits Clinical Research Site /ID# 158115
Johannesburg, Gauteng, 2193, South Africa
Kingsbury Hospital /ID# 163116
Cape Town, Western Cape, 7708, South Africa
Private Practice Dr MN Rajabally /ID# 163115
Cape Town, Western Cape, 7800, South Africa
Spoke Research Inc /ID# 158117
CAPE TOWN Milnerton, Western Cape, 7441, South Africa
Hanyang University Guri Hospital /ID# 158673
Guri-si, Gyeonggido, 11923, South Korea
Duplicate_CHA bundang medical center CHA University /ID# 158672
Seongnam-si, Gyeonggido, 13496, South Korea
Duplicate_The Catholic University of Korea, ST. Vincent's Hospital /ID# 158681
Suwon, Gyeonggido, 16247, South Korea
Kangbuk Samsung Hospital /ID# 158676
Seoul, Seoul Teugbyeolsi, 03181, South Korea
Severance Hospital /ID# 158671
Seoul, Seoul Teugbyeolsi, 03722, South Korea
Dong-A University Hospital /ID# 158675
Busan, 49201, South Korea
Pusan National University Hospital /ID# 158677
Busan, 49241, South Korea
Yeungnam University Medical Center /ID# 158680
Daegu, 42415, South Korea
The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213552
Daejeon, 34943, South Korea
Asan Medical Center /ID# 158678
Seoul, 05505, South Korea
Samsung Medical Center /ID# 158674
Seoul, 06351, South Korea
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157527
Ferrol, A Coruna, 15405, Spain
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159230
Sabadell, Barcelona, 08208, Spain
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157575
Majadahonda, Madrid, 28222, Spain
Hospital Universitario Basurto /ID# 205189
Bilbao, Vizcaya, 48013, Spain
Hospital Clinic de Barcelona /ID# 157526
Barcelona, 08036, Spain
Hospital General Universitario Gregorio Maranon /ID# 161435
Madrid, 28007, Spain
Hospital Universitario La Paz /ID# 159228
Madrid, 28046, Spain
Hospital Clinico Universitario de Salamanca /ID# 157532
Salamanca, 37007, Spain
Hospital Universitario Virgen Macarena /ID# 160819
Seville, 41009, Spain
Hospital Universitario y Politecnico La Fe /ID# 157530
Valencia, 46026, Spain
Hospital Clinico Universitario Lozano Blesa /ID# 212523
Zaragoza, 50009, Spain
Hospital Universitario Miguel Servet /ID# 157531
Zaragoza, 50009, Spain
Skane University hospital /ID# 211235
Malmo, Skåne County, 214 28, Sweden
Duplicate_GHP Stockholm Gastro Center /ID# 210479
Stockholm, Stockholm County, 114 28, Sweden
Ersta diakoni /ID# 157878
Stockholm, Stockholm County, 116 91, Sweden
Danderyd Hospital /ID# 202136
Stockholm, Stockholm County, 182 88, Sweden
Sahlgrenska University Hospital /ID# 157879
Gothenburg, Västra Götaland County, 413 45, Sweden
Duplicate_SU Molndal. /ID# 157880
Mölndal, 431 80, Sweden
Duplicate_Karolinska Univ Sjukhuset /ID# 209966
Solna, 171 64, Sweden
Universitätsspital Zürich /ID# 163532
Zurich, Canton of Zurich, 8091, Switzerland
Duplicate_Universitaetsspital Basel /ID# 164555
Basel, 4031, Switzerland
Inselspital, Universitätsspital Bern /ID# 163531
Bern, 3010, Switzerland
Scientific Research Institute of Invalid Rehabilitation /ID# 211516
Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165649
Kharkiv, 61037, Ukraine
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212050
Kherson, 73000, Ukraine
Kyiv Municipal Clinical Hospital #18 /ID# 162521
Kyiv, 01030, Ukraine
International Institute of Clinical Research LLC /ID# 211997
Kyiv, 02091, Ukraine
Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165651
Kyiv, 02232, Ukraine
Medical Center of LLC Medbud-Clinic /ID# 216929
Kyiv, 03037, Ukraine
Kyiv Railway Clinical Hosp No.2 /ID# 217330
Kyiv, 03049, Ukraine
Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 206788
Lutsk, 43005, Ukraine
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165650
Lviv, 79000, Ukraine
Duplicate_Transcarpathian Regional Clin. /ID# 168419
Uzhhorod, 88000, Ukraine
MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216265
Vinnytsia, 21018, Ukraine
Royal Devon and Exeter NHS Trust Hospital /ID# 157517
Exeter, Devon, EX2 5DW, United Kingdom
Barts Health NHS Trust /ID# 163710
London, London, City of, E1 2ES, United Kingdom
Guy's and St Thomas' NHS Foundation Trust /ID# 157519
London, London, City of, SE1 9RT, United Kingdom
Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207937
Chertsey, Surrey, KT16 0PZ, United Kingdom
Cambridge University Hospitals NHS Foundation Trust /ID# 158031
Cambridge, CB2 0QQ, United Kingdom
NHS Lothian /ID# 207447
Edinburgh, EH3 9HE, United Kingdom
Calderdale and Huddersfield NHS Foundation Trust /ID# 209569
Huddersfield, HX3 0PW, United Kingdom
Hull University Teaching Hospitals NHS Trust /ID# 158757
Hull, HU3 2JZ, United Kingdom
Leeds Teaching Hospitals NHS Trust /ID# 157523
Leeds, LS9 7TF, United Kingdom
Duplicate_King's College Hospital NHS Foundation Trusts /ID# 158756
London, SE5 9RS, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163709
Newcastle upon Tyne, NE7 7DN, United Kingdom
Oxford University Hospitals NHS Foundation Trust /ID# 158033
Oxford, OX3 9DU, United Kingdom
Duplicate_Northern Care Alliance NHS Group /ID# 207764
Salford, M6 8HD, United Kingdom
Related Publications (7)
Panaccione R, Ferrante M, Dotan I, Panes J, Hisamatsu T, Bossuyt P, Danese S, Song A, Kalabic J, Joshi N, Zambrano J, Zhang Y, Duan WR, Kligys K, Dubinsky MC, Lindsay JO, Vermeire S, Siegmund B, Irving PM, D'Haens G. Extended Risankizumab Treatment in Patients With Crohn's Disease Who Did Not Achieve Clinical Response to Induction Treatment. Clin Gastroenterol Hepatol. 2025 Oct;23(11):2012-2022.e6. doi: 10.1016/j.cgh.2024.12.023. Epub 2025 Feb 3.
PMID: 39909280DERIVEDAtreya R, Ferrante M, Panaccione R, Feagan B, Shchukina O, Jairath V, Rieder F, Hisamatsu T, Siegmund B, Kligys K, Song A, Zambrano J, Mallick M, Zhang Y, Armuzzi A, D'Haens G. Risankizumab Is Associated With Normalization of Biomarkers in Patients With Crohn's Disease: Results From the Phase 3 ADVANCE, MOTIVATE, and FORTIFY Studies. J Crohns Colitis. 2025 Apr 4;19(4):jjae164. doi: 10.1093/ecco-jcc/jjae164.
PMID: 39485390DERIVEDPeyrin-Biroulet L, Colombel JF, Louis E, Ferrante M, Motoya S, Panaccione R, Torres J, Ungaro RC, Kligys K, Kalabic J, Zambrano J, Zhang Y, D'Haens G. Shorter Crohn's Disease Duration Is Associated With Better Clinical and Endoscopic Outcomes With Risankizumab in Phase 3 Studies. Gastro Hep Adv. 2024 Mar 7;3(4):539-550. doi: 10.1016/j.gastha.2024.02.008. eCollection 2024.
PMID: 39131711DERIVEDLouis E, Lee WJ, Litcher-Kelly L, Ollis S, Pranschke E, Fitzgerald K, Lacerda AP, Neimark E, Sanchez Gonzalez Y, Panes J. Content Validity and Psychometric Evaluation of the Crohn's Symptom Severity (CSS) Questionnaire in Patients with Moderately to Severely Active Crohn's Disease. Adv Ther. 2024 Sep;41(9):3678-3705. doi: 10.1007/s12325-024-02923-9. Epub 2024 Aug 6.
PMID: 39105965DERIVEDDubinsky M, Ma C, Griffith J, Crowell M, Neimark E, Kligys K, O'Connell T. Matching-Adjusted Indirect Comparison Between Risankizumab and Ustekinumab for Induction and Maintenance Treatment of Moderately to Severely Active Crohn's Disease. Adv Ther. 2023 Sep;40(9):3896-3911. doi: 10.1007/s12325-023-02546-6. Epub 2023 Jun 27.
PMID: 37368103DERIVEDLoftus EV Jr, Ananthakrishnan AN, Lee WJ, Gonzalez YS, Fitzgerald KA, Wallace K, Zhou W, Litcher-Kelly L, Ollis SB, Su S, Danese S. Content Validity and Psychometric Evaluation of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) in Patients with Crohn's Disease and Ulcerative Colitis. Pharmacoecon Open. 2023 Sep;7(5):823-840. doi: 10.1007/s41669-023-00419-w. Epub 2023 Jun 9.
PMID: 37296268DERIVEDD'Haens G, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, Dubinsky M, Feagan BG, Hisamatsu T, Lim A, Lindsay JO, Loftus EV Jr, Panes J, Peyrin-Biroulet L, Ran Z, Rubin DT, Sandborn WJ, Schreiber S, Neimark E, Song A, Kligys K, Pang Y, Pivorunas V, Berg S, Duan WR, Huang B, Kalabic J, Liao X, Robinson A, Wallace K, Ferrante M. Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet. 2022 May 28;399(10340):2015-2030. doi: 10.1016/S0140-6736(22)00467-6.
PMID: 35644154DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Global Medical Services
- Organization
- AbbVie
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
April 4, 2017
First Posted
April 7, 2017
Study Start
May 10, 2017
Primary Completion
November 9, 2020
Study Completion
April 14, 2021
Last Updated
July 6, 2022
Results First Posted
July 6, 2022
Record last verified: 2022-06
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- For details on when studies are available for sharing, please refer to the link below.
- Access Criteria
- Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Use Agreement (DUA). For more information on the process, or to submit a request, visit the following link.
AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.