A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
U-ACTIVATE
A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis
2 other identifiers
interventional
950
42 countries
469
Brief Summary
This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jan 2017
Longer than P75 for phase_3
469 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 20, 2016
CompletedFirst Posted
Study publicly available on registry
December 30, 2016
CompletedStudy Start
First participant enrolled
January 31, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2027
January 12, 2026
January 1, 2026
10.4 years
December 20, 2016
January 8, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Assessing Treatment-Emergent Adverse Events
Treatment-emergent adverse events are defined as events that begin or worsen either on or after the first dose of the study drug and within 30 days after the last dose of the study drug in the analysis period.
Up to 288 Weeks
Study Arms (5)
Participants receiving Upadacitinib (ABT-494) Dose A
EXPERIMENTALThe participants in this arm will receive Upadacitinib (ABT-494) dose A.
Participants receiving Upadacitinib (ABT-494) Dose B
EXPERIMENTALThe participants in this arm will receive Upadacitinib (ABT-494) dose B.
Participants receiving Upadacitinib (ABT-494) Dose A or Dose B
EXPERIMENTALThe participants in this arm will receive Upadacitinib (ABT-494) dose A or dose B.
Participants receiving Placebo
EXPERIMENTALThe participants in this arm will receive placebo until study is unblinded.
Participants receiving Upadacitinib (ABT-494) Dose C
EXPERIMENTALThe participants in this arm will receive Upadacitinib (ABT-494) dose C.
Interventions
Upadacitinib (ABT-494) will be administered orally.
Eligibility Criteria
You may qualify if:
- Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible
- Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met.
- If female, participant must meet the contraception criteria.
- Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit.
- Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234).
- Must be able and willing to give written informed consent and to comply with the requirements of this study protocol.
You may not qualify if:
- For any reason participant is considered by the investigator to be an unsuitable candidate.
- Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug.
- Known hypersensitivity to upadacitinib or its excipients or had any adverse event (AE) during the preceding studies, that in the investigator's judgment makes the participant unsuitable for this study.
- Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated.
- Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol.
- Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study.
- Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234.
- History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
Study Sites (492)
East View Medical Research, LLC /ID# 171184
Mobile, Alabama, 36606, United States
CB Flock Research Corporation /ID# 165986
Mobile, Alabama, 36608, United States
Delsol Research Management, Ll /Id# 170130
Chandler, Arizona, 85224, United States
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886
Mesa, Arizona, 85206, United States
Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823
Sun City, Arizona, 85306, United States
Adobe Clinical Research LLC /ID# 155249
Tucson, Arizona, 85712, United States
Duplicate_University of Arizona /ID# 150568
Tucson, Arizona, 85724, United States
Citrus Valley Gastroenterology /ID# 151915
Covina, California, 91722-3797, United States
Newport Huntington Medical Group /ID# 217006
Huntington Beach, California, 92648-5994, United States
UC San Diego Health System /ID# 155187
La Jolla, California, 92037, United States
United Medical Doctors /ID# 207467
Los Alamitos, California, 90720-3309, United States
TLC Clinical Research Inc /ID# 216830
Los Angeles, California, 90048, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082
Los Angeles, California, 90067-2001, United States
Facey Medical Foundation /ID# 203135
Mission Hills, California, 91345, United States
United Medical Doctors - Murrieta /ID# 151213
Murrieta, California, 92563, United States
Ventura County Gastroenterology Medical Group /ID# 163417
Oxnard, California, 93030-0190, United States
Inland Empire Clinical Trials, LLC /ID# 216163
Rialto, California, 92377, United States
San Diego Clinical Trials /ID# 212121
San Diego, California, 92120, United States
Medical Assoc Research Grp /ID# 169149
San Diego, California, 92123, United States
Univ of California San Francis /ID# 164583
San Francisco, California, 94158, United States
Delta Waves, Inc. /ID# 151727
Colorado Springs, Colorado, 80918, United States
South Denver Gastroenterology /ID# 151224
Lone Tree, Colorado, 80124, United States
Western States Clinical Res /ID# 158078
Wheat Ridge, Colorado, 80033-2896, United States
Duplicate_Western Connecticut Medical Group /ID# 169211
Danbury, Connecticut, 06810, United States
Gastroenterology Center of Connecticut /ID# 150534
Hamden, Connecticut, 06518, United States
West Central Gastroenterology /ID# 155242
Clearwater, Florida, 33762, United States
Moonshine Research Center, Inc /ID# 152534
Doral, Florida, 33166, United States
Universal Axon Clinical Research /ID# 213463
Doral, Florida, 33166, United States
Palmetto Research, LLC /ID# 151724
Hialeah, Florida, 33016, United States
Nature Coast Clinical Research - Inverness /ID# 154070
Inverness, Florida, 34452-4717, United States
Encore Borland-Groover Clinical Research /Id# 170913
Jacksonville, Florida, 32256, United States
SIH Research Mumtaz, Inc /ID# 163199
Kissimmee, Florida, 34741-4161, United States
Cfagi Llc /Id# 202018
Maitland, Florida, 32751-6108, United States
Duplicate_University of Miami /ID# 215443
Miami, Florida, 33136, United States
Advanced Pharma CR, LLC /ID# 151723
Miami, Florida, 33147, United States
New Horizon Research Center /ID# 152475
Miami, Florida, 33165-3372, United States
Crystal Pharmacology Research /ID# 151848
Miami, Florida, 33165, United States
Coral Research Clinic /ID# 150524
Miami, Florida, 33186-4643, United States
Advanced Research Institute, Inc /ID# 163093
New Port Richey, Florida, 34653, United States
Endoscopic Research, Inc. /ID# 151725
Orlando, Florida, 32803, United States
Omega Research Group /ID# 200271
Orlando, Florida, 32808, United States
Clinical Research Trials of Florida, Inc. /ID# 201791
Tampa, Florida, 33607, United States
Duplicate_University of South Florida /ID# 214494
Tampa, Florida, 33612, United States
Duplicate_AdventHealth Tampa /ID# 200274
Tampa, Florida, 33613-4680, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 165783
Macon, Georgia, 31201, United States
Infinite Clinical Trials /ID# 215342
Riverdale, Georgia, 30274, United States
Atlanta Gastroenterology Spec /ID# 150565
Suwanee, Georgia, 30024, United States
Next Innovative Clinical Research - Chicago /ID# 217323
Chicago, Illinois, 60605-2168, United States
Duplicate_The University of Chicago DCAM /ID# 150564
Chicago, Illinois, 60637, United States
Duplicate_NorthShore University HealthSystem /ID# 150570
Evanston, Illinois, 60201, United States
Northwest Health Care Associates /ID# 151591
Hoffman Estates, Illinois, 60169, United States
Carle Foundation Hospital /ID# 151155
Urbana, Illinois, 61801, United States
MediSphere Medical Research Center /ID# 152080
Evansville, Indiana, 47714-8011, United States
Indianapolis Gastroenterology /ID# 162914
Indianapolis, Indiana, 46237, United States
University of Iowa Hospitals and Clinics /ID# 157059
Iowa City, Iowa, 52242, United States
Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183
Topeka, Kansas, 66606, United States
Tri-State Gastroenterology /ID# 169812
Crestview Hills, Kentucky, 41017, United States
Houma Digestive Health Special /ID# 151851
Houma, Louisiana, 70360, United States
Nola Research Works, LLC /ID# 153365
New Orleans, Louisiana, 70115, United States
Louisiana Research Center, LLC /ID# 150526
Shreveport, Louisiana, 71105-6800, United States
University of Maryland, Baltimore /ID# 150529
Baltimore, Maryland, 21201, United States
Gastro Center of Maryland /ID# 200024
Columbia, Maryland, 21045, United States
Massachusetts General Hospital /ID# 165678
Boston, Massachusetts, 02114, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158
Ann Arbor, Michigan, 48109, United States
Huron Gastroenterology Assoc /ID# 152712
Ann Arbor, Michigan, 48197, United States
Clin Res Inst of Michigan, LLC /ID# 153031
Chesterfield, Michigan, 48047, United States
Clin Res Inst of Michigan, LLC /ID# 161983
Chesterfield, Michigan, 48047, United States
Revival Research Institute, LLC /ID# 207281
Southfield, Michigan, 48034-1659, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487
Wyoming, Michigan, 49519, United States
Mayo Clinic - Rochester /ID# 151681
Rochester, Minnesota, 55905-0001, United States
Minnesota Gastroenterology PA /ID# 151682
Saint Paul, Minnesota, 55114, United States
University of Mississippi Medical Center /ID# 213140
Jackson, Mississippi, 39216-4500, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 170713
Jackson, Mississippi, 39216, United States
Washington University-School of Medicine /ID# 150537
St Louis, Missouri, 63110, United States
Vector Clinical Trials /ID# 153052
Las Vegas, Nevada, 89128, United States
Dartmouth-Hitchcock Medical Center /ID# 150566
Lebanon, New Hampshire, 03756, United States
Cooper Gastroenterology at Fire Road /ID# 153048
Egg Harbor, New Jersey, 08234, United States
Atlantic Digestive Health Inst /ID# 150527
Morristown, New Jersey, 07960, United States
Rutgers Robert Wood Johnson /ID# 155247
New Brunswick, New Jersey, 08901, United States
Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399
Albuquerque, New Mexico, 87131, United States
NY Scientific /ID# 152708
Brooklyn, New York, 11235, United States
Duplicate_NYU Langone Long Island Clinical Research Association /ID# 155271
Great Neck, New York, 11021, United States
Columbia Univ Medical Center /ID# 163409
New York, New York, 10032-3725, United States
Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 201534
North Massapequa, New York, 11758, United States
Premier Medical Group - GI Division /ID# 153366
Poughkeepsie, New York, 12601, United States
Gastoenterology Group of Rochester /ID# 151080
Rochester, New York, 14618-5703, United States
Richmond University Medical Center /ID# 201860
Staten Island, New York, 10310-1664, United States
Montefiore Medical Center - Moses Campus /ID# 150559
The Bronx, New York, 10467, United States
Advantage Clinical Trials /ID# 163940
The Bronx, New York, 10468, United States
Digestive Health Partners - Biltmore Office /ID# 167238
Asheville, North Carolina, 28801, United States
Atrium Health Carolinas Medical Center /ID# 157060
Charlotte, North Carolina, 28203, United States
Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561
Charlotte, North Carolina, 28207, United States
Atlantic Gastroenterology Clinical Research /ID# 151901
Greenville, North Carolina, 27834, United States
Clinical Trials of America /ID# 153453
Winston-Salem, North Carolina, 27103, United States
Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 150528
Winston-Salem, North Carolina, 27157-0001, United States
Plains Clinical Research Center, LLC /ID# 170291
Fargo, North Dakota, 58104-5925, United States
Gastro Health Research /ID# 151683
Cincinnati, Ohio, 45219, United States
University Of Cincinnati Medical Center /ID# 164584
Cincinnati, Ohio, 45219, United States
The Ohio State University /ID# 169417
Columbus, Ohio, 43210, United States
Optimed Research, Ltd. /ID# 169697
Columbus, Ohio, 43235, United States
Hometown Urgent Care and Resea /ID# 200066
Dayton, Ohio, 45424, United States
Dayton Gastroenterology, Inc. /ID# 167632
Englewood, Ohio, 45415, United States
Great Lakes Gastroenterology Research, LLC /ID# 201773
Mentor, Ohio, 44060-6211, United States
Ohio Clinical Research Partner /ID# 154074
Mentor, Ohio, 44060, United States
Hightower Clinical /ID# 216338
Oklahoma City, Oklahoma, 73102, United States
Digestive Disease Specialists /ID# 201057
Oklahoma City, Oklahoma, 73112, United States
Options Health Research, LLC /ID# 150569
Tulsa, Oklahoma, 74104, United States
Healthcare Research Consultant /ID# 163096
Tulsa, Oklahoma, 74135, United States
Northwest Gastroenterology Clinic /ID# 152528
Portland, Oregon, 97210, United States
Guthrie Medical Group, PC /ID# 150533
Sayre, Pennsylvania, 18840, United States
Penn State Health Colonnade /ID# 150267
State College, Pennsylvania, 16803-2309, United States
Pharmacorp Clinical Trials /ID# 153363
Charleston, South Carolina, 29412, United States
Gastroenterology Associates, P.A. of Greenville /ID# 150557
Greenville, South Carolina, 29607, United States
Gastro One /ID# 151154
Cordova, Tennessee, 38018, United States
Duplicate_East Tennessee Research Institute /ID# 203611
Johnson City, Tennessee, 37604, United States
Quality Medical Research /ID# 203427
Nashville, Tennessee, 37211, United States
Vanderbilt University Medical Center /ID# 153364
Nashville, Tennessee, 37232-0011, United States
TX Clinical Research Institute /ID# 151528
Arlington, Texas, 76012, United States
Inquest Clinical Research /ID# 164636
Baytown, Texas, 77521-2415, United States
Texas Digestive Disease Consultants /ID# 209949
Cedar Park, Texas, 78613-5028, United States
GI Alliance /ID# 209806
Cedar Park, Texas, 78613, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771
Dallas, Texas, 75246, United States
Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 151221
Garland, Texas, 75044, United States
Vilo Research Group Inc /ID# 212626
Houston, Texas, 77017-2337, United States
CliniCore International, LLC /ID# 152078
Houston, Texas, 77027-6812, United States
Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 150538
Houston, Texas, 77030-3411, United States
Centex Studies, Inc. - Houston /ID# 201217
Houston, Texas, 77058, United States
GI Specialists of Houston /ID# 202337
Houston, Texas, 77070-4347, United States
Duplicate_Caprock Gastro Research, LLC /ID# 215116
Lubbock, Texas, 79424-3017, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 167954
San Antonio, Texas, 78212, United States
Southern Star Research Institute, LLC /ID# 169397
San Antonio, Texas, 78229-5390, United States
Carl R. Meisner Medical Clinic /ID# 171270
Sugar Land, Texas, 77478, United States
Baylor Scott & White Center for Diagnostic Medicine /ID# 204777
Temple, Texas, 76508, United States
Tyler Research Institute, LLC /ID# 169147
Tyler, Texas, 75701, United States
Gastro Health & Nutrition - Victoria /ID# 167764
Victoria, Texas, 77904, United States
HP Clinical Research /ID# 163941
Bountiful, Utah, 84010, United States
Advanced Research Institute /ID# 162640
Ogden, Utah, 84405, United States
Utah Gastroenternology - St. Mark's Office /ID# 163097
Salt Lake City, Utah, 84124, United States
Duplicate_Velocity Clinical Research - Salt Lake City /ID# 163180
West Jordan, Utah, 84088, United States
Ctr for Gastrointestinal Healt /ID# 153369
Franklin, Virginia, 23851, United States
Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630
Bellevue, Washington, 98004, United States
Virginia Mason Hospital & Medical Center /ID# 153030
Seattle, Washington, 98101, United States
The Polyclinic /ID# 165117
Seattle, Washington, 98122-4201, United States
The Vancouver Clinic, INC. PS /ID# 162334
Vancouver, Washington, 98664, United States
Aurora Medical Center - Grafto /ID# 151726
Grafton, Wisconsin, 53024, United States
Wisconsin Center for Advanced Research /ID# 151845
Milwaukee, Wisconsin, 53215, United States
Duplicate_Medical College of Wisconsin /ID# 151850
Milwaukee, Wisconsin, 53226-3522, United States
Hospital Britanico de Buenos Aires /ID# 209496
Ciudad Autonoma de Buenos Aire, Buenos Aires, 1280, Argentina
Cardio Alem /ID# 211281
San Isidro, Buenos Aires, 1642, Argentina
Gedyt /ID# 210016
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1115, Argentina
Mautalen Salud e Investigacion /ID# 171174
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1128, Argentina
Sanatorio 9 de Julio /ID# 150215
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 164186
Córdoba, 5016, Argentina
Macquarie University Hospital /ID# 211953
Macquarie University, New South Wales, 2109, Australia
Mater Misericordiae Limited /ID# 212686
South Brisbane, Queensland, 4101, Australia
Griffith University /ID# 211954
Southport, Queensland, 4222, Australia
Monash Health - Monash Medical Centre /ID# 150218
Clayton, Victoria, 3168, Australia
St Vincent's Hospital Melbourne /ID# 152503
Fitzroy Melbourne, Victoria, 3065, Australia
Fiona Stanley Hospital /ID# 211641
Murdoch, Western Australia, 6150, Australia
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462
Linz, Upper Austria, 4010, Austria
Klinik Landstrasse /ID# 162867
Vienna, Vienna, 1030, Austria
Medizinische Universitaet Wien /ID# 150616
Vienna, Vienna, 1090, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 150463
Salzburg, 5020, Austria
Vitebsk Regional Advanced Clin /ID# 169592
Vitebsk, 210001, Belarus
Universitair Ziekenhuis Leuven /ID# 150468
Leuven, Vlaams-Brabant, 3000, Belgium
AZ-Delta /ID# 150467
Roeselare, West-Vlaanderen, 8800, Belgium
AZ Maria Middelares /ID# 150466
Ghent, 9000, Belgium
Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150223
Banja Luka, Republika Srpska, 78000, Bosnia and Herzegovina
Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150712
Banja Luka, Republika Srpska, 78000, Bosnia and Herzegovina
University Clinical Center Tuzla /ID# 150224
Tuzla, Tuzlanski, 75000, Bosnia and Herzegovina
University Clinical Hospital Mostar /ID# 150711
Mostar, 88000, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 150222
Sarajevo, 71000, Bosnia and Herzegovina
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744
Goiânia, Goiás, 74535-170, Brazil
Faculdade de Medicina do ABC /ID# 152489
Santo André, La Spezia, 09060-870, Brazil
Hospital Nossa Senhora das Graças /ID# 152488
Curitiba, Paraná, 80810-040, Brazil
Hospital de Clinicas de Porto Alegre /ID# 153745
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Upeclin Fmb - Unesp /Id# 152493
Botucatu, São Paulo, 18618-686, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 152492
Ribeirão Preto, São Paulo, 14049-900, Brazil
Kaiser Clinica e Hospital Dia /ID# 152491
São José do Rio Preto, São Paulo, 15015-110, Brazil
University of Calgary /ID# 151818
Calgary, Alberta, T2N 4Z6, Canada
Allen Whey Khye Lim Professional Corporation /ID# 211169
Edmonton, Alberta, T5R 1W2, Canada
University of Alberta Hospital /ID# 151824
Edmonton, Alberta, T6G 2B7, Canada
Covenant Health /ID# 158931
Edmonton, Alberta, T6K 4B2, Canada
OCT Research ULC /ID# 153179
Kelowna, British Columbia, V1Y 1Z9, Canada
Percuro Clinical Research, Ltd /ID# 150479
Victoria, British Columbia, V8V 3M9, Canada
Medicor Research Inc /ID# 151825
Greater Sudbury, Ontario, P3A 1W8, Canada
Duplicate_Hamilton Health Sciences -McMaster University Medical Centre /ID# 150477
Hamilton, Ontario, L8S 4K1, Canada
Ottawa Hospital Research Institute /ID# 151817
Ottawa, Ontario, K1H 8L6, Canada
Toronto Digestive Disease Associates /ID# 150475
Vaughan, Ontario, L4L 4Y7, Canada
CISSS de la Monteregie /ID# 159271
Greenfield Park, Quebec, J4V 2H1, Canada
Duplicate_CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150473
Lévis, Quebec, G6V 3Z1, Canada
Recherche GCP Research /ID# 151819
Montreal, Quebec, H1M 1B1, Canada
Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167170
Montreal, Quebec, H2X 0A9, Canada
Montreal General Hospital - McGill University Health Centre /ID# 170013
Montreal, Quebec, H3G 1A4, Canada
CIUSSS de l'Estrie - CHUS /ID# 150478
Sherbrooke, Quebec, J1G 2E8, Canada
Hospital Guillermo Grant Benavente de Concepción /ID# 212425
Concepción, Bio-Bio, 4070038, Chile
CTR Estudios Clinicos /ID# 200111
Providencia, Region Metropolitana Santiago, 7500571, Chile
M y F Estudios Clínicos /ID# 200112
Santiago, Region Metropolitana Santiago, 7750495, Chile
Centro de Investigaciones Clínicas Viña del Mar /ID# 150226
Viña del Mar, Región de Valparaíso, 2540488, Chile
Research Group /ID# 203177
Santiago, Santiago Metropolitan, 2540364, Chile
Hospital Clinico Universidad De Los Andes /ID# 207427
Santiago, 7501504, Chile
The First Affiliated Hospital, Sun Yat-sen University /ID# 150517
Guangzhou, Guangdong, 510080, China
The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 150518
Guangzhou, Guangdong, 510655, China
Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407
Shiyan, Hubei, 442700, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089
Wuhan, Hubei, 430022, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079
Wuhan, Hubei, 430022, China
Duplicate_Xiangya Hospital Central South University /ID# 167230
Changsha, Hunan, 410008, China
The First Affiliated Hospital of Nanchang University /ID# 212185
Nanchang, Jiangxi, 330006, China
The First Hospital of Jilin University /ID# 210087
Changchun, Jilin, 130021, China
Shengjing Hospital of China Medical University /ID# 166921
Shenyang, Liaoning, 110022, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523
Shanghai, Shanghai Municipality, 200065, China
Shanghai Tenth People's Hospital /ID# 150522
Shanghai, Shanghai Municipality, 200072, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826
Shanghai, Shanghai Municipality, 200127, China
West China Hospital, Sichuan University /ID# 167041
Chengdu, Sichuan, 610041, China
Tianjin Medical University General Hospital /ID# 170605
Tianjin, Tianjin Municipality, 300052, China
The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 165813
Hangzhou, Zhejiang, 310009, China
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516
Hangzhou, Zhejiang, 310018, China
Hospital Universitario de San /ID# 155388
Medellín, Antioquia, Colombia
Coorp Hosp Juan Ciudad Sede Hospital Universitario Mayor Mederi /ID# 152811
Bogota DC, Cundinamarca, 111221, Colombia
Imat Oncomedica /ID# 207052
Montería, Departamento de Córdoba, 230018, Colombia
Duplicate_Poliklinika Solmed /ID# 211567
Grad Zagreb, City of Zagreb, 10000, Croatia
Klinicka bolnica Dubrava Zagreb /ID# 150228
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb /ID# 150262
Zagreb, City of Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb /ID# 150715
Zagreb, City of Zagreb, 10000, Croatia
Duplicate_Klinicki bolnicki centar Osijek /ID# 150229
Osijek, County of Osijek-Baranja, 31000, Croatia
Klinicki bolnicki centar Rijeka /ID# 150714
Rijeka, Primorje-Gorski Kotar County, 51000, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 213989
Split, Split-Dalmatia County, 21000, Croatia
Zadar General Hospital /ID# 150261
Zadar, 23000, Croatia
Iscare Klinické Centrum /ID# 209279
Prague, Praha 9, 190 00, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 150946
Hradec Králové, 500 12, Czechia
CTCenter MaVe s.r.o. /ID# 150903
Olomouc, 779 00, Czechia
ARTROSCAN s.r.o. /ID# 150502
Ostrava, 722 00, Czechia
Nemocnice Pardubickeho kraje, a.s. /ID# 213541
Pardubice, 530 03, Czechia
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224
Prague, 118 33, Czechia
Axon Clinical, s.r.o. /ID# 152477
Prague, 140 00, Czechia
North Estonia Medical Centre /ID# 160871
Mustamäe, Harju, 13419, Estonia
West Tallinn Central Hospital /ID# 150490
Tallinn, Harju, 10617, Estonia
East Tallinn Central Hospital - Magdaleena Unit /ID# 150488
Tallinn, Harju, 11312, Estonia
Tartu University Hospital /ID# 150489
Tartu, 50406, Estonia
Tampereen yliopistollinen sairaala /ID# 150376
Tampere, Pirkanmaa, 33520, Finland
Turku University Hospital /ID# 169895
Turku, Southwest Finland, 20520, Finland
Duplicate_Helsinki Univ Central Hospital /ID# 154283
Helsinki, 00290, Finland
Keski-Suomen Sairaala Nova /ID# 155665
Jyväskylä, 40620, Finland
Laakarikeskus Ikioma /ID# 150377
Mikkeli, 50100, Finland
Chu de Nice-Hopital Larchet Ii /Id# 152608
Nice, Alpes-Maritimes, 06202, France
CHU Montpellier - Hopital Saint Eloi /ID# 200088
Montpellier, Herault, 34295, France
CHRU Lille - Hopital Claude Huriez /ID# 152609
Lille, Nord, 59037, France
HCL - Hopital Lyon Sud /ID# 152540
Pierre-Bénite, Rhone, 69495, France
Centre Hospitalier Departemental Vendee (Chd Vendee) /ID# 165749
La Roche-sur-Yon, Vendee, 85925, France
CHU de Saint-Etienne, Hopital Nord /ID# 165756
Saint-Etienne, 42270, France
Universitatsklinikum Mannheim /ID# 150405
Mannheim, Baden-Wurttemberg, 68167, Germany
Universitaetsklinikum Tuebingen /ID# 151698
Tübingen, Baden-Wurttemberg, 72076, Germany
Duplicate_Agaplesion Markus Krankenhaus /ID# 161870
Frankfurt am Main, Hesse, 60431, Germany
Duplicate_Universitaetsklinikum Muenster /ID# 150402
Munster, Lower Saxony, 48149, Germany
Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575
Herne, North Rhine-Westphalia, 44623, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812
Saarbrücken, Saarland, 66111, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871
Kiel, Schleswig-Holstein, 24105, Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697
Berlin, 10825, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 207136
Münster, 48155, Germany
Praxis medicum /ID# 150404
Wiesbaden, 65189, Germany
General Hospital of Athens Laiko /ID# 208672
Athens, Attica, 11527, Greece
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101
Athens, Attica, 11527, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 150236
Heraklion, Crete, 71500, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406
Athens, 10676, Greece
University General Hospital of Ioannina /ID# 164247
Ioannina, 45500, Greece
Theageneio Anticancer Hospital /ID# 164187
Thessaloniki, 54639, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 209522
Thessaloniki, 54642, Greece
Meditres Kft. /ID# 151597
Kecskemét, Bács-Kiskun county, 6000, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 150410
Szombathely, Vas County, 9700, Hungary
Bekes Megyei Kozponti Korhaz /ID# 151601
Békéscsaba, 5600, Hungary
Semmelweis Egyetem /ID# 150409
Budapest, 1085, Hungary
Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599
Sopron, 9400, Hungary
Mentahaz Maganorvosi Kozpont /ID# 206977
Székesfehérvár, 8000, Hungary
St James Hospital /ID# 150413
Dublin, Dublin, D08 NHY1, Ireland
St Vincents University Hospital /ID# 150411
Elm Park, Dublin, D04 T6F4, Ireland
Mercy University Hospital /ID# 153794
Cork, T12 WE28, Ireland
Beaumont Hospital /ID# 150414
Dublin, D09 XR63, Ireland
University Hospital Galway /ID# 150412
Galway, H91 YR71, Ireland
Shaare Zedek Medical Center /ID# 163139
Jerusalem, Jerusalem, 91031, Israel
Hadassah Medical Center-Hebrew University /ID# 165119
Jerusalem, Jerusalem, 91120, Israel
Soroka University Medical Center /ID# 156562
Beersheba, Southern District, 8410101, Israel
Rambam Health Care Campus /ID# 150416
Haifa, 3109601, Israel
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 150424
Bologna, Emilia-Romagna, 40138, Italy
IRCCS Istituto Clinico Humanitas /ID# 151363
Rozzano, Lombardy, 20089, Italy
ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605
Milan, Milano, 20122, Italy
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673
Rho, Milano, 20017, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 150425
Rome, Roma, 00133, Italy
Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 151362
Rome, Roma, 00152, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420
Rome, Roma, 00168, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726
Negrar, Verona, 37024, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 150421
Milan, 20122, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 150263
Palermo, 90146, Italy
Aichi Medical University Hospital /ID# 151994
Nagakute, Aichi-ken, 480-1195, Japan
Nagoya University Hospital /ID# 152728
Nagoya, Aichi-ken, 466-8560, Japan
Nagoya City University Hospital /ID# 151949
Nagoya, Aichi-ken, 467-8602, Japan
Toyohashi Municipal Hospital /ID# 171470
Toyohashi, Aichi-ken, 441-8570, Japan
Ieda Hospital /ID# 157782
Toyota-shi, Aichi-ken, 470-1219, Japan
National Hospital Organization Hirosaki General Medical Center /ID# 152761
Hirosaki-shi, Aomori, 036-8545, Japan
Tokatsu Tsujinaka Hospital /ID# 214964
Abiko-shi, Chiba, 270-1168, Japan
Tsujinaka Hospital - Kashiwanoha /ID# 209572
Kashiwa-shi, Chiba, 277-0871, Japan
Toho University Sakura Medical Center /ID# 151935
Sakura-shi, Chiba, 285-8741, Japan
Juntendo University Urayasu Hospital /ID# 208783
Urayasu-shi, Chiba, 279-0021, Japan
Fukui Prefectural Hospital /ID# 210450
Fukui-shi, Fukui, 910-8526, Japan
Fukuoka University Chikushi Hospital /ID# 152627
Chikushino-shi, Fukuoka, 818-8502, Japan
Saiseikai Fukuoka Genaral Hospital /ID# 209481
Fukuoka, Fukuoka, 810-0001, Japan
Kyushu University Hospital /ID# 152525
Fukuoka, Fukuoka, 812-8582, Japan
Duplicate_Kitakyushu Municipal Medical Center /ID# 152589
Kitakyushu, Fukuoka, 8020077, Japan
Kurume University Hospital /ID# 151977
Kurume-shi, Fukuoka, 830-0011, Japan
Ogaki Municipal Hospital /ID# 208226
Ogaki-shi, Gifu, 503-8502, Japan
National Hospital Organization Fukuyama Medical Center /ID# 206294
Fukuyama-shi, Hiroshima, 720-8520, Japan
Hiroshima University Hospital /ID# 151952
Hiroshima, Hiroshima, 734-8551, Japan
Duplicate_Asahikawa Medical University Hospital /ID# 170281
Asahikawa-shi, Hokkaido, 078-8510, Japan
Obihiro kosei Hospital /ID# 210425
Obihiro-shi, Hokkaido, 080-0024, Japan
Sapporo Tokushukai Hospital /ID# 209449
Sapporo, Hokkaido, 004-0041, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705
Sapporo, Hokkaido, 060-0033, Japan
Sapporo Medical University Hospital /ID# 206493
Sapporo, Hokkaido, 060-8543, Japan
Sapporo Higashi Tokushukai Hospital /ID# 208495
Sapporo, Hokkaido, 065-0033, Japan
Aoyama Clinic /ID# 152048
Kobe, Hyōgo, 650-0015, Japan
Duplicate_Hyogo Medical University Hospital /ID# 152433
Nishinomiya-shi, Hyōgo, 663-8501, Japan
Duplicate_National Hospital Organization Mito Medical Center /ID# 152626
Higashi Ibaraki-gun, Ibaraki, 311-3193, Japan
Kanazawa University Hospital /ID# 207810
Kanazawa, Ishikawa-ken, 920-8641, Japan
Iwate Medical University Uchimaru Medical Center /ID# 203412
Morioka, Iwate, 020-8505, Japan
Imamura General Hospital /ID# 227138
Kagoshima, Kagoshima-ken, 890-0064, Japan
Idzuro Imamura Hospital /ID# 207640
Kagoshima, Kagoshima-ken, 892-0824, Japan
Sameshima Hospital /ID# 206673
Kagoshima, Kagoshima-ken, 892-0846, Japan
Kagoshima IBD Gastroenterology Clinic /ID# 245222
Kagoshima, Kagoshima-ken, 8920804, Japan
St Marianna University School Of Medicine /ID# 209452
Kawasaki-shi, Kanagawa, 216-8511, Japan
SHOWA Medical University Fujigaoka Hospital /ID# 208223
Yokohama, Kanagawa, 227-8501, Japan
Yokohama City University Medical Center /ID# 169900
Yokohama, Kanagawa, 232-0024, Japan
Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358
Kyoto, Kyoto, 605-0981, Japan
Kyoto University Hospital /ID# 211808
Kyoto, Kyoto, 606-8507, Japan
Mie University Hospital /ID# 207253
Tsu, Mie-ken, 514-8507, Japan
Yokkaichi Hazu Medical Center /ID# 214349
Yokkaichi-shi, Mie-ken, 510-0016, Japan
National Hospital Organization Sendai Medical Center /ID# 209529
Sendai, Miyagi, 983-8520, Japan
NHO Nagasaki Medical Center /ID# 210821
Omura-shi, Nagasaki, 856-8562, Japan
Kenseikai Dongo Hospital /ID# 208102
Yamatotakada-shi, Nara, 635-0022, Japan
Saiseikai Niigata Hospital /ID# 209923
Niigata, Niigata, 950-1104, Japan
Duplicate_Niigata University Medical & Dental Hospital /ID# 218050
Niigata, Niigata, 951-8520, Japan
Ishida Clinic of IBD and Gastroenterology /ID# 210118
Ōita, Oita Prefecture, 870-0823, Japan
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820
Kurashiki-shi, Okayama-ken, 710-0142, Japan
Duplicate_Okayama University Hospital /ID# 217924
Okayama, Okayama-ken, 700-8558, Japan
Kinshukai Infusion Clinic /ID# 207866
Osaka, Osaka, 530-0011, Japan
Kitano Hospital, Tazuke Kofukai Medical Research Institute /ID# 210396
Osaka, Osaka, 530-8480, Japan
Osaka City General Hospital /ID# 152703
Osaka, Osaka, 534-0021, Japan
Osaka Red Cross Hospital /ID# 209477
Osaka, Osaka, 543-8555, Japan
Osaka Metropolitan University Hospital /ID# 152681
Osaka, Osaka, 545-8586, Japan
Shoyukai Fujita Gastroenterological Hospital /ID# 216494
Takatsuki-shi, Osaka, 569-0086, Japan
Toyonaka Municipal Hospital /ID# 217083
Toyonaka-shi, Osaka, 560-0055, Japan
Duplicate_Saga University Hospital /ID# 209272
Saga, Saga-ken, 849-8501, Japan
Saitama Medical Center /ID# 152019
Kawagoe, Saitama, 350-8550, Japan
Tokitokai Tokito clinic /ID# 152676
Saitama-shi, Saitama, 336-0963, Japan
National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711
Higashi-ohmi-shi, Shiga, 527-8505, Japan
Shimane University Hospital /ID# 208906
Izumo-shi, Shimane, 693-8501, Japan
Hamamatsu University Hospital /ID# 205709
Hamamatsu, Shizuoka, 431-3192, Japan
NHO Shizuoka Medical Center /ID# 163571
Sunto-gun, Shizuoka, 411-8611, Japan
Institute of Science Tokyo Hospital /ID# 152017
Bunkyo-ku, Tokyo, 113-8519, Japan
St. Lukes International Hospital /ID# 208075
Chuo-ku, Tokyo, 104-8560, Japan
Tokai University Hachioji Hospital /ID# 152584
Hachioji-shi, Tokyo, 192-0032, Japan
Kitasato University Kitasato Institute Hospital /ID# 152687
Minato-ku, Tokyo, 108-8642, Japan
Kyorin University Hospital /ID# 153195
Mitaka-shi, Tokyo, 181-8611, Japan
Duplicate_Center hospital of the National Center for Global Health and Medicine /ID# 209533
Shinjuku-ku, Tokyo, 162-8655, Japan
Duplicate_Tokyo Women's Medical University Hospital /ID# 205978
Shinjuku-ku, Tokyo, 162-8666, Japan
Yamagata University Hospital /ID# 171468
Yamagata, Yamagata, 990-9585, Japan
Tokuyama Central Hospital /ID# 216995
Shunan-shi, Yamaguchi, 745-8522, Japan
Yamanashi Prefectural Central Hospital /ID# 151909
Kofu, Yamanashi, 400-8506, Japan
Teikyo University Hospital /ID# 209865
Tokyo, 173-8605, Japan
VCA Polyclinic Aura /ID# 150436
Riga, 1035, Latvia
Pauls Stradins Clinical University Hospital /ID# 153183
Riga, LV-1002, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439
Kaunas, 50161, Lithuania
Klaipeda university hospital /ID# 163501
Klaipėda, 92288, Lithuania
Klaipeda University Hospital /ID# 163719
Klaipėda, 92288, Lithuania
Duplicate_Vilnius University Hospital /ID# 164172
Vilnius, LT-08661, Lithuania
Hospital Sultanah Bahiyah /ID# 152310
Alor Star, Kedah, 05460, Malaysia
Hospital Ampang /ID# 152311
Ampang, Selangor, 68000, Malaysia
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313
Kuala Lumpur, Selangor, 56000, Malaysia
Uni Malaya MC /ID# 150440
Kuala Lumpur, 59100, Malaysia
Morales Vargas Centro de Investigacion S.C. /ID# 211327
León, Guanajuato, 37000, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334
Guadalajara, Jalisco, 44650, Mexico
Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265
Monterrey, Nuevo León, 64610, Mexico
Radboud Universitair Medisch Centrum /ID# 151701
Nijmegen, Gelderland, 6525 GA, Netherlands
Amsterdam UMC, locatie AMC /ID# 150617
Amsterdam, North Holland, 1105 AZ, Netherlands
Leids Universitair Medisch Centrum /ID# 152625
Leiden, South Holland, 2333 ZA, Netherlands
Duplicate_Erasmus Medisch Centrum /ID# 150619
Rotterdam, South Holland, 3015 GD, Netherlands
Universitair Medisch Centrum Utrecht /ID# 152776
Utrecht, 3584 CX, Netherlands
Akershus Universitetssykehus_MAIN /ID# 150622
Lorenskog, Akershus, 1478, Norway
Universitetssykehuset I Nord-Norge /ID# 152836
Tromsø, Troms, 9019, Norway
Gastromed Sp. z o.o /ID# 216198
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Centrum Zdrowia MDM /ID# 150626
Warsaw, Masovian Voivodeship, 00-189, Poland
Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 150627
Warsaw, Masovian Voivodeship, 02-507, Poland
Centrum Medyczne Reuma Park /ID# 150624
Warsaw, Masovian Voivodeship, 02-665, Poland
Vivamed Sp. z o.o. /ID# 216743
Warsaw, Masovian Voivodeship, 03-580, Poland
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733
Warsaw, Masovian Voivodeship, 04-730, Poland
Endoskopia Sp. z o.o. /ID# 152940
Sopot, Pomeranian Voivodeship, 81-756, Poland
Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616
Guimarães, Braga District, 4835-044, Portugal
Centro Hospitalar de Entre Douro e Vouga /ID# 152336
Santa Maria DA Feira, Porto District, 4520-211, Portugal
Duplicate_Hospital Garcia de Orta, EPE /ID# 151622
Almada, Setúbal District, 2805-267, Portugal
2CA-Braga, Hospital de Braga /ID# 151617
Braga, 4710-243, Portugal
Duplicate_Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Cap /ID# 151620
Lisbon, 1169-050, Portugal
Unidade Local de Saude de Santa Maria, EPE /ID# 151615
Lisbon, 1649-035, Portugal
Unidade Local de Saude Sao Joao, EPE /ID# 151619
Porto, 4200-319, Portugal
Unidade Local de Saude do Alto Minho, EPE /ID# 151618
Viana do Castelo, 4904-858, Portugal
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629
San Juan, 00935, Puerto Rico
Immanuel Kant Baltic Federal University /ID# 202129
Kaliningrad, Kaliningrad Oblast, 236016, Russia
NW State Medical Univ na Mechn /ID# 169332
Saint Petersburg, Leningradskaya Oblast', 191015, Russia
Republican hospital named after V.A. Baranov /ID# 206508
Petrozavodsk, Murmansk Oblast, 185019, Russia
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634
Perm, Permskiy Kray, 614109, Russia
Medical Company Hepatology /ID# 200208
Samara, Samara Oblast, 443011, Russia
LLC Novaya Klinika /ID# 208106
Pyatigorsk, Stavropol Kray, 357500, Russia
Kazan State Medical University /ID# 166040
Kazan', Tatarstan, Respublika, 420012, Russia
Olla-Med Clinic /ID# 215334
Moscow, 105554, Russia
Euromedservice /ID# 208968
Pushkin, 196603, Russia
Duplicate_Stavropol State Medical Univ /ID# 150635
Stavropol, 355017, Russia
Clinical Hosp Center Zvezdara /ID# 150641
Belgrade, Beograd, 11000, Serbia
Military Medical Academy /ID# 150643
Belgrade, Beograd, 11000, Serbia
University Clinical Center Serbia /ID# 150642
Belgrade, Beograd, 11000, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 150640
Belgrade, Beograd, 11080, Serbia
General Hospital Leskovac /ID# 217882
Leskovac, Jablanicki Okrug, 16000, Serbia
Duplicate_University Clinical Center of Nis /ID# 151902
Niš, Nisavski Okrug, 18000, Serbia
University Clinical Center Kragujevac /ID# 150644
Kragujevac, Sumadijski Okrug, 34000, Serbia
University Clinical Center Vojvodina /ID# 150759
Novi Sad, 21000, Serbia
National University Hospital /ID# 150583
Singapore, 119074, Singapore
Gleneagles Medical Centre /ID# 206020
Singapore, 258499, Singapore
Tan Tock Seng Hospital /ID# 150646
Singapore, 308433, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869
Banská Bystrica, Banská Bystrica Region, 975 17, Slovakia
B+B MED, s.r.o. /ID# 150584
Košice, Košice Region, 040 01, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371
Nové Zámky, Nitra Region, 940 34, Slovakia
Gastro I., s.r.o. /ID# 150585
Prešov, Presov, 080 01, Slovakia
Medak s.r.o. /ID# 150550
Bratislava, 851 01, Slovakia
Slovak Research Center Team Me /ID# 150240
Ilava, 019 01, Slovakia
MD Search /ID# 157524
Boksburg North, Gauteng, 1460, South Africa
Clinresco Centers /ID# 163625
Johannesburg, Gauteng, 1619, South Africa
Lenasia Clinical Trial Centre /ID# 214361
Johannesburg, Gauteng, 1820, South Africa
Wits Clinical Research /ID# 150586
Johannesburg, Gauteng, 1864, South Africa
Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730
Johannesburg, Gauteng, 2193, South Africa
Kingsbury Hospital /ID# 150587
Cape Town, Western Cape, 7708, South Africa
Private Practice Dr MN Rajabally /ID# 155145
Cape Town, Western Cape, 7800, South Africa
Spoke Research Inc /ID# 162203
CAPE TOWN Milnerton, Western Cape, 7441, South Africa
Dong-A University Medical Center /ID# 161568
Busan, Busan Gwang Yeogsi, 49201, South Korea
Pusan National University Hospital /ID# 161569
Busan, Busan Gwang Yeogsi, 49241, South Korea
Duplicate_Hanyang University Gurihospital /ID# 150431
Guri-si, Gyeonggido, 11923, South Korea
Duplicate_CHA University Bundang Medical Center /ID# 161567
Seongnam, Gyeonggido, 13496, South Korea
The Catholic University Of Korea St. Vincent's Hospital /ID# 150434
Suwon, Gyeonggido, 16247, South Korea
Kangbuk Samsung Hospital /ID# 150435
Seoul, Seoul Teugbyeolsi, 03181, South Korea
Asan Medical Center /ID# 159155
Seoul, Seoul Teugbyeolsi, 05505, South Korea
Samsung Medical Center /ID# 150433
Seoul, Seoul Teugbyeolsi, 06351, South Korea
Yeungnam University Medical Center /ID# 150432
Daegu, 42415, South Korea
Yonsei University Health System Severance Hospital /ID# 161566
Seoul, 03722, South Korea
Complejo Hospitalario Universitario A Coruña /ID# 203912
A Coruña, A Coruna, 15006, Spain
Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 171492
Santiago de Compostela, A Coruna, 15706, Spain
Hospital Universitario Marques de Valdecilla /ID# 216621
Santander, Cantabria, 39008, Spain
Hospital Universitario Dr. Negrin /ID# 203965
Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
Hospital Clinic de Barcelona /ID# 150598
Barcelona, 08036, Spain
Duplicate_Hospital Universitario Reina Sofia /ID# 154031
Córdoba, 14004, Spain
Hospital Universitario Ramon y Cajal /ID# 171491
Madrid, 28034, Spain
Hospital Universitario La Paz /ID# 214541
Madrid, 28046, Spain
Hospital Universitario de Salamanca /ID# 150590
Salamanca, 37711, Spain
Hospital Universitario y Politecnico La Fe /ID# 150591
Valencia, 46026, Spain
Duplicate_Sahlgrenska University Hospital /ID# 152326
Gothenburg, Västra Götaland County, 413 45, Sweden
University Hospital Basel /ID# 161732
Basel Town, Canton of Basel-City, 4031, Switzerland
Kantonsspital St. Gallen /ID# 152601
Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
University Hospital Zurich /ID# 152603
Zurich, Canton of Zurich, 8091, Switzerland
Inselspital, Universitaetsspital Bern /ID# 152602
Bern, 3010, Switzerland
National Taiwan University Hospital /ID# 150604
Taipei City, Taipei, 100, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606
Kaohsiung City, 807, Taiwan
Duplicate_Chung Shan Medical University Hospital /ID# 150603
Taichung, 40201, Taiwan
China Medical University Hospital /ID# 150600
Taichung, 40447, Taiwan
National Cheng Kung University Hospital /ID# 151751
Tainan, 704, Taiwan
Taipei Veterans General Hosp /ID# 151750
Taipei, 11217, Taiwan
Gazi Universitesi Tip Fakultes /ID# 150493
Yenimahalle, Ankara, 06560, Turkey (Türkiye)
Duplicate_Erciyes University Medical Fac /ID# 150495
Melikgazi, Kayseri, 38030, Turkey (Türkiye)
Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491
Cerrahpaşa, 34098, Turkey (Türkiye)
Umraniye Training and Res Hosp /ID# 163136
Istanbul, 34764, Turkey (Türkiye)
Marmara University Medical Fac /ID# 214573
Istanbul, 34899, Turkey (Türkiye)
Mersin University Medical /ID# 163135
Mersin, 33343, Turkey (Türkiye)
CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941
Kharkiv, Kharkivs’ka Oblast’, 61058, Ukraine
Lviv Regional Clinical Hospital /ID# 150508
Lviv, Lviv Oblast, 79010, Ukraine
Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502
Odesa, Odesa Oblast, 65025, Ukraine
Medical Center of the “Health /ID# 162501
Vinnytsia, Vinnytsia Oblast, 21009, Ukraine
MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216302
Vinnytsia, Vinnytsia Oblast, 21018, Ukraine
Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731
Dnipro, 49005, Ukraine
PE PMC Acinus, Medical and Diagnostic Center /ID# 217219
Kropyvnytskyi, 25006, Ukraine
Kyiv City Clinical Hospital No.18 /ID# 150505
Kyiv, 01030, Ukraine
Medical Center of LLC "Medical Center "Consilium Medical" /ID# 217448
Kyiv, 04050, Ukraine
CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374
Kyiv, 04073, Ukraine
Duplicate_Royal United Hospitals Bath /ID# 154211
Bath, Bath And North East Somerset, BA1 3NG, United Kingdom
Royal Devon & Exeter Hospital /ID# 150510
Exeter, Devon, EX2 5DW, United Kingdom
Hampshire Hospitals NHS Foundation Trust /ID# 150511
Basingstoke, Essex, RG24 9NA, United Kingdom
Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 150515
London, Greater London, E1 2ES, United Kingdom
Duplicate_St George's University Hospitals NHS Foundation Trust /ID# 208376
London, Greater London, SW17 0QT, United Kingdom
Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 163788
Glasgow, Lanarkshire, G51 4TF, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 150513
Birmingham, B15 2TH, United Kingdom
Calderdale and Huddersfield NHS Foundation Trust /ID# 217659
Huddersfield, HX3 0PW, United Kingdom
Related Publications (2)
Panaccione R, Panes J, Peyrin-Biroulet L, Colombel JF, Lindsay JO, Baert F, Atreya R, Vermeire S, Fujii T, Dubcenco E, Klaff J, Duncan B, Suravaram S, Fish I, Lacerda AP, Vladea R, Ford S, Shah S, Anyanwu SI, Rubin DT. Long-Term Safety of Upadacitinib in Patients With Inflammatory Bowel Disease: Integrated Analysis of Phase 2/3 Studies. Clin Gastroenterol Hepatol. 2026 Feb 27:S1542-3565(26)00145-X. doi: 10.1016/j.cgh.2026.02.018. Online ahead of print.
PMID: 41763462DERIVEDPanaccione R, Vermeire S, Danese S, Higgins PDR, Lichtenstein GR, Nakase H, Glover S, Colombel JF, Eccleston J, Kujawski M, Remple V, Yao X, Geng Z, Palac H, Sharma D, Suravaram S, Schreiber S. Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study. Lancet Gastroenterol Hepatol. 2025 Jun;10(6):507-519. doi: 10.1016/S2468-1253(25)00017-2.
PMID: 40347957DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NON RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 20, 2016
First Posted
December 30, 2016
Study Start
January 31, 2017
Primary Completion (Estimated)
July 1, 2027
Study Completion (Estimated)
July 1, 2027
Last Updated
January 12, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ANALYTIC CODE
- Time Frame
- For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/
- Access Criteria
- To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.