NCT02936076

Brief Summary

The purpose of this study is to examine the psychological benefits of chronic exercise as well as the effects of exercise training on eating behaviors and stress-induced overeating in overweight and obese women. Participants will be randomized to an 12-week exercise condition or a delayed exercise condition. Assessments will occur at baseline, 6 weeks, and 12 weeks and will include answering surveys in real-time using smartphones, several assessments of eating behaviors and dietary intake, and questionnaire measures of factors which could mediate the relationship between exercise and eating. Participants will be compensated for completing assessments and for adherence to the exercise protocol.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
49

participants targeted

Target at P25-P50 for not_applicable obesity

Timeline
Completed

Started Jan 2017

Typical duration for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 13, 2016

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 18, 2016

Completed
3 months until next milestone

Study Start

First participant enrolled

January 16, 2017

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2018

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 21, 2019

Completed
5 months until next milestone

Results Posted

Study results publicly available

October 23, 2019

Completed
Last Updated

March 29, 2021

Status Verified

August 1, 2019

Enrollment Period

1.8 years

First QC Date

October 13, 2016

Results QC Date

October 3, 2019

Last Update Submit

March 26, 2021

Conditions

Outcome Measures

Primary Outcomes (2)

  • Stress-induced Overeating Measured Via Smartphone Surveys

    Participants completed EMA surveys (5x/day for 14 days). At each prompt they were asked if an eating episode occurred. If they indicated 'yes', they were asked to check all that apply: a) I ate past the point of feeling full, b) I ate more than usual, c) I had unplanned eating (i.e., consumed food when I don't usually eat and was not making up for a missed meal, or d) None of the above. If the participant responded with a, b, or c, it was classified as an 'overeating episode'. Further, at each prompt, participants were asked to the respond to the following: 'Right now I feel stressed' (1=not at all, 7=very much so). If the stress score was \>=5 at the prompt just prior to an overeating episode, then it was considered a 'stress-induced overeating episode'.

    12 weeks

  • Percentage of Overeating Episodes Characterized as 'Overeating'

    If an eating episode occurred, participants were asked to check all that apply: a) I ate past the point of feeling full, b) I ate more than usual, c) I had unplanned eating (i.e., consumed food when I don't usually eat and was not making up for a missed meal, or d) None of the above. If response was a, b, or c, it was classified as an 'overeating episode'.

    12 weeks

Secondary Outcomes (2)

  • Change in Body Weight (% Initial Weight)

    baseline and 12 weeks

  • Stress as Measured Via Questionnaire

    Baseline and 12 weeks

Study Arms (2)

Exercise condition

ACTIVE COMPARATOR

Participants randomized to the exercise condition will participate in a 12-week exercise training program. The exercise intervention will consist of both supervised and unsupervised exercise sessions and progress to 200 minutes/week of moderate-intensity exercise. Exercise bouts will be spread across 4-6 days and be at least 20 minutes in duration. During supervised visits, heart rate will be monitored by a member of the research staff to ensure that exercise is within the prescribed intensity range and ratings of perceived exertion and feeling state will be assessed periodically. Unsupervised exercise will be verified using objective physical activity monitors.

Other: Exercise intervention

Delayed exercise condition

PLACEBO COMPARATOR

Participants randomized to the delayed exercise condition will be asked not to change their exercise or eating habits over the 12-week period and will complete the same assessment measures as the exercise condition. However, following the completion of the 12-week period, participants will be given two options: 1) receive a one-on-one session with an exercise physiologist at our center and receive a written exercise program, and at this time point all study obligations will be completed, or 2) complete the identical exercise protocol as the 'exercise' condition.

Other: Delayed exercise intervention

Interventions

Exercise condition
Delayed exercise condition

Eligibility Criteria

Age18 Years - 60 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Female
  • years of age
  • BMI 25 to \<40 kg/m2
  • Physically inactive (\<60 min/week of physical activity)
  • Must own a smartphone
  • Must be willing to receive and respond to text message prompts for 14 days at baseline, 6 and 12 weeks

You may not qualify if:

  • Shift workers
  • Individuals who do not endorse stress-eating
  • Recent weight loss or current enrollment in a weight loss program
  • Women who are pregnant or plan on becoming pregnant in the next 6 months
  • Any medical condition that would limit participation in physical activity
  • Diabetes
  • Inability to walk without an assisted device
  • Inability to meet exercise recommendations
  • Failure to adequately complete all baseline assessment measures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Weight Control and Diabetes Research Center

Providence, Rhode Island, 002903, United States

Location

Related Publications (1)

  • Unick JL, Dunsiger SI, Leblond T, Hahn K, Thomas JG, Abrantes AM, Stroud LR, Wing RR. Randomized Trial Examining the Effect of a 12-wk Exercise Program on Hedonic Eating. Med Sci Sports Exerc. 2021 Aug 1;53(8):1638-1647. doi: 10.1249/MSS.0000000000002619.

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Dr. Jessica Unick
Organization
The Miriam Hospital

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 13, 2016

First Posted

October 18, 2016

Study Start

January 16, 2017

Primary Completion

November 1, 2018

Study Completion

May 21, 2019

Last Updated

March 29, 2021

Results First Posted

October 23, 2019

Record last verified: 2019-08

Data Sharing

IPD Sharing
Will not share

Locations