Protein Ingestion Before Training Low

NCT03147001 | Completed DMC

• 1 other identifier: 50968
• Study Type: interventional
• Target: 9
• Locations: 0 countries
• Sites: N/A

Brief Summary

A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks. The night before the trail each subject will performe a high intense interval trainings session on an ergometer bike. during the night an infusion of aminoacid tracers will be initiated. The subject is woken at 6.30 a.m. Blood samples and a musclebiopsy will be collected prior to the morning bike ride at 8.00a.m. Immediately before the morning bike ride is started the subject will ingest a drink of 0,5g protein or a non-caloric placebo (random order). During the bike ride and the following 4,5 hours blood will be drawn with regular intervals. at time point 0, 60 and 180 min after the training session biopsies are collected.

Conditions

Protein Metabolism

Keywords

Endurance exercise; Dietary protein

Outcome Measures

Primary Outcomes (1)

• Muscle protein fractional synthetic rate (FSR)

  FSR was measure over at time period of six hours

Secondary Outcomes (3)

• Tracer kinetics dilution model

  six hours

• Muscle signalling

  Determined in biopsies sampled before and immediatly after 90min exercise in addition to one and four hours after exercise.

• Nitrogen excretion

  Urine is collected during two periods. Collection period one: 12 hours prior to morning exercise. Collection period 2: During and four hours following exercise. Blood samples is drawn repeatedly from before to four hours after exercise.

Study Arms (2)

Protein ingestion

EXPERIMENTAL

Subjects ingested protein drinks

Other: Protein ingestion

Placebo

PLACEBO COMPARATOR

Subjects ingested a non-caloric placebo drink

Other: Non-caloric placebo ingestion

Interventions

Protein ingestion OTHER

A protein drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).

Protein ingestion

Non-caloric placebo ingestion OTHER

A placebo drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).

Placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy well-trained triathletes or cyclists
• VO2max \> 55 ml O2/kg/min
• Training and has been training more than 7 times a week the last 6 months.

You may not qualify if:

• VO2max \< 55 ml O2/kg/min
• Has chronic disease
• has incjected with tracer on a previous occasion.

Sponsors & Collaborators

• University of Aarhus: lead
• Arla Foods: collaborator
• Team Denmark: collaborator
• Innovation Fund Denmark: collaborator

Related Publications (1)

• Larsen MS, Holm L, Svart MV, Hjelholt AJ, Bengtsen MB, Dollerup OL, Dalgaard LB, Vendelbo MH, van Hall G, Moller N, Mikkelsen UR, Hansen M. Effects of protein intake prior to carbohydrate-restricted endurance exercise: a randomized crossover trial. J Int Soc Sports Nutr. 2020 Jan 28;17(1):7. doi: 10.1186/s12970-020-0338-z.

  PMID: 31992300 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Masking was done by providing similar tasting drinks at both trails. One was placebo, one was protein a drink
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor, PhD

Study Record Dates

• First Submitted: May 8, 2017
• First Posted: May 10, 2017
• Study Start: April 30, 2016
• Primary Completion: January 10, 2017
• Study Completion: January 10, 2017
• Last Updated: May 10, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share