Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults

NCT06783075 | Not Yet Recruiting DMC

• 1 other identifier: METC 24-051
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).

Conditions

Protein Metabolism

Keywords

whole-body protein synthesis

Outcome Measures

Primary Outcomes (1)

• Differences in protein intake to maximize whole-body protein synthesis rates in older adults based on consumption of milk protein or wheat protein

  From enrollment to the end of the study at 7 weeks

Secondary Outcomes (4)

• Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in healthy older adults based on milk protein

  From enrollment to the end of the study at 7 weeks

• The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on milk protein

  From enrollment to the end of the study at 7 weeks

• The Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in older adults based on wheat protein

  From enrollment to the end of the study at 7 weeks

• The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on wheat protein

  From enrollment to the end of the study at 7 weeks

Study Arms (2)

MILK

ACTIVE COMPARATOR

Drink containing amino acid composition of milk protein

Other: MILK

WHEAT

ACTIVE COMPARATOR

Drink containing amino acid composition of wheat protein

Other: WHEAT

Interventions

MILK OTHER

Drink containing amino acids in the composition of milk protein

MILK

WHEAT OTHER

Drink containing amino acids in the composition of wheat protein

WHEAT

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Aged between 65-85 years
• BMI between 18.5-30 kg\*m\^-2
• Healthy, recreationally active (maximal one intensive exercise training per week)
• No physical limitations (i.e., able to perform all activities associated with daily living independently)

You may not qualify if:

• Smoking
• Diagnosed musculoskeletal disorders
• Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)
• Chronic use of gastic acid-suppressing medication or anti-coagulants
• Unstable weight over the last 3 months
• Diagnosed GI tract disorders or diseases
• Blood donation in the past 2 months

Sponsors & Collaborators

• Maastricht University Medical Center: lead

Study Sites (1)

Maastricht University Medical Center+

Maastricht, Limburg, Netherlands

Location

MeSH Terms

Interventions

Milk

Intervention Hierarchy (Ancestors)

Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages

Central Study Contacts

Luc van Loon

CONTACT

0031 43 388 1743; l.vanloon@maastrichtuniversity.nl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Protein beverages with milk- or wheat composition will look similar.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Double-blind, randomized, parallel study design

Study Record Dates

• First Submitted: January 14, 2025
• First Posted: January 20, 2025
• Study Start: March 1, 2025
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: January 20, 2025

Record last verified: 2025-01

Locations

NL (1)