Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
GALACTIC-HF
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)
2 other identifiers
interventional
8,256
35 countries
1016
Brief Summary
The purpose of this study is to determine if treatment with omecamtiv mecarbil when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in adults with chronic heart failure with reduced ejection fraction (HFrEF).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Jan 2017
Typical duration for phase_3 heart-failure
1016 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 30, 2016
CompletedFirst Posted
Study publicly available on registry
October 11, 2016
CompletedStudy Start
First participant enrolled
January 6, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 14, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
September 14, 2020
CompletedResults Posted
Study results publicly available
July 20, 2021
CompletedNovember 5, 2021
November 1, 2021
3.7 years
September 30, 2016
May 24, 2021
November 2, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Time to Cardiovascular Death or First Heart Failure Event
The primary outcome was a composite of a heart-failure (HF) event or cardiovascular (CV) death, whichever occurred first, in a time-to-event analysis. A heart-failure event was defined as an urgent clinic visit, emergency department visit, or hospitalization for subjectively and objectively worsening heart failure leading to treatment intensification beyond a change in oral diuretic therapy. All deaths and HF events were adjudicated by an independent external clinical events committee (CEC) at the Duke Clinical Research Institute, using standardized definitions based on the recent American College of Cardiology/American Heart Association (ACC/AHA) standards for endpoint definitions in cardiovascular clinical trials. Time to cardiovascular death or first HF event was analyzed using Kaplan-Meier (KM) methods. Since the median was not calculated, the percentage of participants with a positively adjudicated event during the study is reported.
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Secondary Outcomes (4)
Time to Cardiovascular Death
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Change From Baseline in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ TSS) at Week 24
Baseline and Week 24
Time to First Heart Failure Hospitalization
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Time to All-cause Death
From randomization up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Study Arms (2)
Omecamtiv Mecarbil
EXPERIMENTALParticipants received oral omecamtiv mecarbil (OM) twice daily in addition to standard heart failure therapy. The starting dose of OM was 25 mg; At week 4, participants with week 2 OM predose plasma concentrations \< 200 ng/mL had their dose increased to 50 mg BID; participants with week 2 predose plasma concentrations ≥ 200 and \< 300 ng/mL had their dose increased to 37.5 mg BID and participants with week 2 predose plasma concentrations ≥ 300 ng/mL and \< 1000 ng/mL maintained a 25 mg BID dosing regimen.
Placebo
PLACEBO COMPARATORParticipants received matching placebo tablets twice a day in addition to standard heart failure therapy.
Interventions
Omecamtiv mecarbil tablets for oral administration
Participants were required to be optimally managed with standard of care therapies for chronic HF (eg, beta blockers, renin angiotensin aldosterone system inhibitors), consistent with regional clinical practice guidelines, unless contraindicated.
Eligibility Criteria
You may qualify if:
- Subject has provided informed consent
- Male or female, ≥ 18 to ≤ 85 years
- History of chronic heart failure (HF), defined as requiring treatment for HF for a minimum of 30 days before randomization
- Left ventricle ejection fraction (LVEF) ≤ 35%, per subjects most recent medical record, within 12 months prior to screening.
- New York Heart Association (NYHA) class II to IV at most recent screening assessment.
- Managed with HF standard of care (SoC) therapies consistent with regional clinical practice guidelines according to investigator judgment of subject's clinical status
- Current hospitalization with primary reason of HF OR one of the following events within 1 year of screening: hospitalization with primary reason of HF; urgent visit to emergency department (ED) with primary reason of HF.
- Elevated B-type natriuretic peptide (BNP) or n-terminal-prohormone brain natriuretic peptide (NT-proBNP)
You may not qualify if:
- Currently receiving treatment in another investigational device or drug study, or \< 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded.
- Malignancy within 5 years prior to randomization with the following exceptions: localized basal or squamous cell carcinoma of the skin, cervical intraepithelial neoplasia, stage 1 prostate carcinoma, breast ductal carcinoma in situ.
- Subject has known sensitivity to any of the products or components to be administered during testing
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cytokineticslead
Study Sites (1033)
Research Site
Birmingham, Alabama, 35233, United States
Research Site
Birmingham, Alabama, 35243, United States
Research Site
Birmingham, Alabama, 35294, United States
Research Site
Fort Payne, Alabama, 35967, United States
Research Site
Huntsville, Alabama, 35801, United States
Research Site
Mobile, Alabama, 36608, United States
Research Site
Scottsboro, Alabama, 35768, United States
Research Site
Tuscumbia, Alabama, 35674, United States
Research Site
Gilbert, Arizona, 85297, United States
Research Site
Phoenix, Arizona, 85032, United States
Research Site
Tucson, Arizona, 85710, United States
Research Site
Tucson, Arizona, 85724, United States
Research Site
Jonesboro, Arkansas, 72401, United States
Research Site
Little Rock, Arkansas, 72205, United States
Research Site
Anaheim, California, 92801, United States
Research Site
Beverly Hills, California, 90211, United States
Research Site
Burbank, California, 91505, United States
Research Site
Carmichael, California, 95608, United States
Research Site
Fresno, California, 93701, United States
Research Site
Huntington Beach, California, 92648, United States
Research Site
Loma Linda, California, 92357, United States
Research Site
Long Beach, California, 90806, United States
Research Site
Long Beach, California, 90822, United States
Research Site
Los Alamitos, California, 90720, United States
Research Site
Los Angeles, California, 90033, United States
Research Site
Los Angeles, California, 90073, United States
Research Site
Mission Viejo, California, 92691, United States
Research Site
Newport Beach, California, 92663, United States
Research Site
Northridge, California, 91325, United States
Research Site
Redondo Beach, California, 90277, United States
Research Site
Riverside, California, 92506, United States
Research Site
Sacramento, California, 95819, United States
Research Site
San Francisco, California, 94115, United States
Research Site
San Pedro, California, 90732, United States
Research Site
Santa Ana, California, 92704, United States
Research Site
Santa Rosa, California, 95405, United States
Research Site
Stanford, California, 94305, United States
Research Site
Stockton, California, 95204, United States
Research Site
Torrance, California, 90502, United States
Research Site
Torrance, California, 90503, United States
Research Site
Tustin, California, 92780, United States
Research Site
Ventura, California, 93003, United States
Research Site
Aurora, Colorado, 80045, United States
Research Site
Colorado Springs, Colorado, 80909, United States
Research Site
Denver, Colorado, 80204, United States
Research Site
Denver, Colorado, 80218, United States
Research Site
Littleton, Colorado, 80120, United States
Research Site
Wheat Ridge, Colorado, 80033, United States
Research Site
Hartford, Connecticut, 06102, United States
Research Site
Stamford, Connecticut, 06905, United States
Research Site
Waterbury, Connecticut, 06708, United States
Research Site
West Haven, Connecticut, 06516, United States
Research Site
Newark, Delaware, 19718, United States
Research Site
Washington D.C., District of Columbia, 20010, United States
Research Site
Washington D.C., District of Columbia, 20037, United States
Research Site
Washington D.C., District of Columbia, 20422, United States
Research Site
Altamonte Springs, Florida, 32714, United States
Research Site
Aventura, Florida, 33180, United States
Research Site
Bay Pines, Florida, 33744, United States
Research Site
Boynton Beach, Florida, 33472, United States
Research Site
Crystal River, Florida, 34429, United States
Research Site
Daytona Beach, Florida, 32117, United States
Research Site
Doral, Florida, 33126, United States
Research Site
Gainesville, Florida, 32608, United States
Research Site
Hialeah, Florida, 33012, United States
Research Site
Hialeah, Florida, 33013, United States
Research Site
Inverness, Florida, 34452, United States
Research Site
Jacksonville, Florida, 32209, United States
Research Site
Jacksonville, Florida, 32216, United States
Research Site
Miami, Florida, 33032, United States
Research Site
Miami, Florida, 33125, United States
Research Site
Miami, Florida, 33126, United States
Research Site
Miami, Florida, 33136, United States
Research Site
Miami, Florida, 33144, United States
Research Site
Miami, Florida, 33145, United States
Research Site
Miami, Florida, 33147, United States
Research Site
Miami, Florida, 33165, United States
Research Site
Miami, Florida, 33166, United States
Research Site
Miami, Florida, 33174, United States
Research Site
Miami Beach, Florida, 33140, United States
Research Site
Naples, Florida, 34102, United States
Research Site
Ocala, Florida, 34471, United States
Research Site
Palm Harbor, Florida, 34684, United States
Research Site
Pembroke Pines, Florida, 33028, United States
Research Site
Sarasota, Florida, 34232, United States
Research Site
Tampa, Florida, 33613, United States
Research Site
Zephyrhills, Florida, 33541, United States
Research Site
Athens, Georgia, 30606, United States
Research Site
Atlanta, Georgia, 30303, United States
Research Site
Atlanta, Georgia, 30309, United States
Research Site
Augusta, Georgia, 30909, United States
Research Site
Columbus, Georgia, 31904, United States
Research Site
Smyrna, Georgia, 30082, United States
Research Site
Woodstock, Georgia, 30189, United States
Research Site
Honolulu, Hawaii, 96813, United States
Research Site
‘Aiea, Hawaii, 96701, United States
Research Site
Arlington Heights, Illinois, 60005, United States
Research Site
Champaign, Illinois, 61820, United States
Research Site
Chicago, Illinois, 60612, United States
Research Site
Fairview Heights, Illinois, 62208, United States
Research Site
Hazel Crest, Illinois, 60429, United States
Research Site
Maywood, Illinois, 60153, United States
Research Site
Oak Lawn, Illinois, 60453, United States
Research Site
Peoria, Illinois, 61606, United States
Research Site
Indianapolis, Indiana, 46227, United States
Research Site
Merrillville, Indiana, 46410, United States
Research Site
Muncie, Indiana, 47303, United States
Research Site
Munster, Indiana, 46321, United States
Research Site
Richmond, Indiana, 47374, United States
Research Site
Valparaiso, Indiana, 46383, United States
Research Site
Des Moines, Iowa, 50314, United States
Research Site
Iowa City, Iowa, 52242, United States
Research Site
Kansas City, Kansas, 66160, United States
Research Site
Overland Park, Kansas, 66209, United States
Research Site
Wichita, Kansas, 67214, United States
Research Site
Wichita, Kansas, 67226, United States
Research Site
Crestview Hills, Kentucky, 41017, United States
Research Site
Lexington, Kentucky, 40503, United States
Research Site
Louisville, Kentucky, 40202, United States
Research Site
Louisville, Kentucky, 40206, United States
Research Site
Louisville, Kentucky, 40216, United States
Research Site
Alexandria, Louisiana, 71301, United States
Research Site
Lake Charles, Louisiana, 70601, United States
Research Site
Monroe, Louisiana, 71201, United States
Research Site
New Orleans, Louisiana, 70112, United States
Research Site
Shreveport, Louisiana, 71103, United States
Research Site
Shreveport, Louisiana, 71105, United States
Research Site
West Monroe, Louisiana, 71291, United States
Research Site
Bangor, Maine, 04401, United States
Research Site
Biddeford, Maine, 04005, United States
Research Site
Portland, Maine, 04101, United States
Research Site
Scarborough, Maine, 04074, United States
Research Site
Baltimore, Maryland, 21201, United States
Research Site
Baltimore, Maryland, 21229, United States
Research Site
Baltimore, Maryland, 21236, United States
Research Site
Columbia, Maryland, 21044, United States
Research Site
Hagerstown, Maryland, 21740, United States
Research Site
Prince Frederick, Maryland, 20678, United States
Research Site
Salisbury, Maryland, 21804, United States
Research Site
Boston, Massachusetts, 02135, United States
Research Site
Haverhill, Massachusetts, 01830, United States
Research Site
Ann Arbor, Michigan, 48109, United States
Research Site
Detroit, Michigan, 48202, United States
Research Site
Grand Blanc, Michigan, 48439, United States
Research Site
Kalamazoo, Michigan, 49008, United States
Research Site
Midland, Michigan, 48670, United States
Research Site
Royal Oak, Michigan, 48073, United States
Research Site
Saginaw, Michigan, 48601, United States
Research Site
Minneapolis, Minnesota, 55417, United States
Research Site
Saint Paul, Minnesota, 55101, United States
Research Site
Port Gibson, Mississippi, 39150, United States
Research Site
Tupelo, Mississippi, 38801, United States
Research Site
Columbia, Missouri, 65201, United States
Research Site
Columbia, Missouri, 65212, United States
Research Site
Jefferson City, Missouri, 65109, United States
Research Site
Kansas City, Missouri, 64108, United States
Research Site
Kansas City, Missouri, 64128, United States
Research Site
Springfield, Missouri, 65807, United States
Research Site
St Louis, Missouri, 63110, United States
Research Site
Lincoln, Nebraska, 68506, United States
Research Site
Omaha, Nebraska, 68198, United States
Research Site
Las Vegas, Nevada, 89118, United States
Research Site
Las Vegas, Nevada, 89128, United States
Research Site
North Las Vegas, Nevada, 89086, United States
Research Site
Reno, Nevada, 89502, United States
Research Site
Lebanon, New Hampshire, 03756, United States
Research Site
Eatontown, New Jersey, 07724, United States
Research Site
Moorestown, New Jersey, 08057, United States
Research Site
Morristown, New Jersey, 07960, United States
Research Site
Newark, New Jersey, 07112, United States
Research Site
Ridgewood, New Jersey, 07450, United States
Research Site
Somerset, New Jersey, 08873, United States
Research Site
Voorhees Township, New Jersey, 08043, United States
Research Site
Albuquerque, New Mexico, 87106, United States
Research Site
Albany, New York, 12208, United States
Research Site
Brooklyn, New York, 11215, United States
Research Site
Buffalo, New York, 14215, United States
Research Site
Cortlandt Manor, New York, 10567, United States
Research Site
Johnson City, New York, 13790, United States
Research Site
Kingston, New York, 12401, United States
Research Site
Laurelton, New York, 11413, United States
Research Site
Mineola, New York, 11501, United States
Research Site
New York, New York, 10016, United States
Research Site
New York, New York, 10025, United States
Research Site
New York, New York, 10029, United States
Research Site
Rochester, New York, 14621, United States
Research Site
Roslyn, New York, 11576, United States
Research Site
Saratoga Springs, New York, 12866, United States
Research Site
Stony Brook, New York, 11794, United States
Research Site
The Bronx, New York, 10467, United States
Research Site
Valhalla, New York, 10595, United States
Research Site
Asheville, North Carolina, 28803, United States
Research Site
Cary, North Carolina, 27518, United States
Research Site
Chapel Hill, North Carolina, 27599, United States
Research Site
Charlotte, North Carolina, 28203, United States
Research Site
Durham, North Carolina, 27705, United States
Research Site
Greensboro, North Carolina, 27401, United States
Research Site
Hickory, North Carolina, 28601, United States
Research Site
Lenoir, North Carolina, 28645, United States
Research Site
Lumberton, North Carolina, 28358, United States
Research Site
Mooresville, North Carolina, 28117, United States
Research Site
Pinehurst, North Carolina, 28374, United States
Research Site
Tabor City, North Carolina, 28463, United States
Research Site
Wilmington, North Carolina, 28401, United States
Research Site
Winston-Salem, North Carolina, 27103, United States
Research Site
Cincinnati, Ohio, 45219, United States
Research Site
Cincinnati, Ohio, 45220, United States
Research Site
Cincinnati, Ohio, 45267, United States
Research Site
Cleveland, Ohio, 44106, United States
Research Site
Cleveland, Ohio, 44195, United States
Research Site
Columbus, Ohio, 43210, United States
Research Site
Columbus, Ohio, 43214, United States
Research Site
Dayton, Ohio, 45414, United States
Research Site
Dayton, Ohio, 45419, United States
Research Site
Kettering, Ohio, 45429, United States
Research Site
Marion, Ohio, 43302, United States
Research Site
Sandusky, Ohio, 44870, United States
Research Site
Wiloughby, Ohio, 44094, United States
Research Site
Oklahoma City, Oklahoma, 73135, United States
Research Site
Tulsa, Oklahoma, 74104, United States
Research Site
Tulsa, Oklahoma, 74127, United States
Research Site
Abington, Pennsylvania, 19001, United States
Research Site
Altoona, Pennsylvania, 16602, United States
Research Site
Butler, Pennsylvania, 16001, United States
Research Site
Camp Hill, Pennsylvania, 17011, United States
Research Site
Erie, Pennsylvania, 16502, United States
Research Site
Hershey, Pennsylvania, 17033, United States
Research Site
Jersey Shore, Pennsylvania, 17740, United States
Research Site
Lancaster, Pennsylvania, 17603, United States
Research Site
Philadelphia, Pennsylvania, 19102, United States
Research Site
Philadelphia, Pennsylvania, 19107, United States
Research Site
Philadelphia, Pennsylvania, 19114, United States
Research Site
Philadelphia, Pennsylvania, 19141, United States
Research Site
Pittsburgh, Pennsylvania, 15212, United States
Research Site
Pittsburgh, Pennsylvania, 15213, United States
Research Site
Sayre, Pennsylvania, 18840, United States
Research Site
Yardley, Pennsylvania, 19067, United States
Research Site
York, Pennsylvania, 17403, United States
Research Site
Pawtucket, Rhode Island, 02860, United States
Research Site
Providence, Rhode Island, 02906, United States
Research Site
Providence, Rhode Island, 02908, United States
Research Site
Warwick, Rhode Island, 02886, United States
Research Site
Charleston, South Carolina, 29401, United States
Research Site
Charleston, South Carolina, 29407, United States
Research Site
Charleston, South Carolina, 29425, United States
Research Site
Fort Mill, South Carolina, 29707, United States
Research Site
Greenville, South Carolina, 29605, United States
Research Site
Rock Hill, South Carolina, 29732, United States
Research Site
Rapid City, South Dakota, 57701, United States
Research Site
Germantown, Tennessee, 38138, United States
Research Site
Jackson, Tennessee, 38301, United States
Research Site
Jackson, Tennessee, 38305, United States
Research Site
Knoxville, Tennessee, 37934, United States
Research Site
Memphis, Tennessee, 38104, United States
Research Site
Nashville, Tennessee, 37208, United States
Research Site
Nashville, Tennessee, 37212, United States
Research Site
Nashville, Tennessee, 37232, United States
Research Site
Oak Ridge, Tennessee, 37830, United States
Research Site
Powell, Tennessee, 37849, United States
Research Site
Tullahoma, Tennessee, 37388, United States
Research Site
Amarillo, Texas, 79106, United States
Research Site
Carrollton, Texas, 75006, United States
Research Site
Carrollton, Texas, 75010, United States
Research Site
Dallas, Texas, 75216, United States
Research Site
Dallas, Texas, 75231, United States
Research Site
Dallas, Texas, 75246, United States
Research Site
Denison, Texas, 75020, United States
Research Site
El Paso, Texas, 79935, United States
Research Site
Fort Sam Houston, Texas, 78234, United States
Research Site
Fort Worth, Texas, 76104, United States
Research Site
Galveston, Texas, 77555-0158, United States
Research Site
Gonzales, Texas, 78629, United States
Research Site
Houston, Texas, 77025, United States
Research Site
Houston, Texas, 77030, United States
Research Site
Huntsville, Texas, 77340, United States
Research Site
Lubbock, Texas, 79430, United States
Research Site
McKinney, Texas, 75071, United States
Research Site
Odessa, Texas, 79761, United States
Research Site
Plano, Texas, 75024, United States
Research Site
San Antonio, Texas, 78229, United States
Research Site
Tomball, Texas, 77375, United States
Research Site
Wichita Falls, Texas, 76301, United States
Research Site
Farmington, Utah, 84025, United States
Research Site
Murray, Utah, 84107, United States
Research Site
Salt Lake City, Utah, 84132, United States
Research Site
Burlington, Vermont, 05401, United States
Research Site
White River Junction, Vermont, 05009, United States
Research Site
Charlottesville, Virginia, 22908, United States
Research Site
Leesburg, Virginia, 20176, United States
Research Site
Lynchburg, Virginia, 24501, United States
Research Site
Manassas, Virginia, 20109, United States
Research Site
Norfolk, Virginia, 23510, United States
Research Site
Richmond, Virginia, 23226, United States
Research Site
Richmond, Virginia, 23249, United States
Research Site
Richmond, Virginia, 23298, United States
Research Site
Virginia Beach, Virginia, 23454, United States
Research Site
Puyallup, Washington, 98372, United States
Research Site
Seattle, Washington, 98122, United States
Research Site
Spokane, Washington, 99204, United States
Research Site
Huntington, West Virginia, 25702, United States
Research Site
Morgantown, West Virginia, 26506, United States
Research Site
Green Bay, Wisconsin, 54301, United States
Research Site
Madison, Wisconsin, 53705, United States
Research Site
Madison, Wisconsin, 53713, United States
Research Site
Madison, Wisconsin, 53792, United States
Research Site
Manitowoc, Wisconsin, 54220, United States
Research Site
Milwaukee, Wisconsin, 53201, United States
Research Site
Milwaukee, Wisconsin, 53226, United States
Research Site
Milwaukee, Wisconsin, 53295, United States
Research Site
Waukesha, Wisconsin, 53188, United States
Research Site
Bahía Blanca, Buenos Aires, B8000FTD, Argentina
Research Site
CABA, Buenos Aires, C1119ACN, Argentina
Research Site
CABA, Buenos Aires, C1406BOA, Argentina
Research Site
CABA, Buenos Aires, C1407GTN, Argentina
Research Site
CABA, Buenos Aires, C1428ART, Argentina
Research Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, 1209, Argentina
Research Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
Research Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ABP, Argentina
Research Site
Coronel Suárez, Buenos Aires, B7540GHD, Argentina
Research Site
Mar del Plata, Buenos Aires, B7600FZN, Argentina
Research Site
Merlo, Buenos Aires, B1722COV, Argentina
Research Site
Quilmes, Buenos Aires, 1878, Argentina
Research Site
Quilmes, Buenos Aires, B1878DVB, Argentina
Research Site
Ramos Meija, Buenos Aires, B1704ETD, Argentina
Research Site
San Fernando, Buenos Aires, B1646EBJ, Argentina
Research Site
San Isidro, Buenos Aires, B1642DSF, Argentina
Research Site
San Martín, Buenos Aires, B1650CSQ, Argentina
Research Site
San Nicolás de los Arroyos, Buenos Aires, B2900DPA, Argentina
Research Site
Córdoba, Córdoba Province, 5000, Argentina
Research Site
Córdoba, Córdoba Province, X5004BAL, Argentina
Research Site
Córdoba, Córdoba Province, X5006IKK, Argentina
Research Site
Córdoba, Córdoba Province, X5016KEH, Argentina
Research Site
Villa María, Córdoba Province, X5900JKA, Argentina
Research Site
Santa Rosa, La Pampa Province, 6300, Argentina
Research Site
Rosario, Santa Fe Province, 2000, Argentina
Research Site
Rosario, Santa Fe Province, S2000BIF, Argentina
Research Site
Venado Tuerto, Santa Fe Province, 2600, Argentina
Research Site
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Research Site
San Miguel de Tucumán, Tucumán Province, T4000JCV, Argentina
Research Site
Buenos Aires, 1425, Argentina
Research Site
Corrientes, 3400, Argentina
Research Site
Corrientes, W3400AMZ, Argentina
Research Site
Córdoba, 5000, Argentina
Research Site
Córdoba, X5003DCE, Argentina
Research Site
Córdoba, X5021FPQ, Argentina
Research Site
Salta, A4406BPF, Argentina
Research Site
Santa Fe, S3000FWO, Argentina
Research Site
Garran, Australian Capital Territory, 2605, Australia
Research Site
Concord, New South Wales, 2139, Australia
Research Site
Darlinghurst, New South Wales, 2010, Australia
Research Site
Liverpool, New South Wales, 2170, Australia
Research Site
New Lambton Heights, New South Wales, 2305, Australia
Research Site
Chermside, Queensland, 4032, Australia
Research Site
Herston, Queensland, 4029, Australia
Research Site
Woolloongabba, Queensland, 4102, Australia
Research Site
Ashford, South Australia, 5035, Australia
Research Site
Bedford Park, South Australia, 5042, Australia
Research Site
Fullarton, South Australia, 5063, Australia
Research Site
Woodville South, South Australia, 5011, Australia
Research Site
Bundoora, Victoria, 3083, Australia
Research Site
Frankston, Victoria, 3199, Australia
Research Site
Geelong, Victoria, 3220, Australia
Research Site
Richmond, Victoria, 3121, Australia
Research Site
Murdoch, Western Australia, 6150, Australia
Research Site
Feldkirch, 6807, Austria
Research Site
Graz, 8036, Austria
Research Site
Innsbruck, 6020, Austria
Research Site
Linz, 4010, Austria
Research Site
Linz, 4020, Austria
Research Site
Sankt Pölten, 3100, Austria
Research Site
Vienna, 1090, Austria
Research Site
Vienna, 1160, Austria
Research Site
Villach, 9500, Austria
Research Site
Aalst, 9300, Belgium
Research Site
Genk, 3600, Belgium
Research Site
Ghent, 9000, Belgium
Research Site
Leuven, 3000, Belgium
Research Site
Liège, 4000, Belgium
Research Site
Lodelinsart, 6042, Belgium
Research Site
Roeselare, 8800, Belgium
Research Site
Brasília, Federal District, 70673-900, Brazil
Research Site
Goiânia, Goiás, 74223-130, Brazil
Research Site
Goiânia, Goiás, 74605-020, Brazil
Research Site
Belo Horizonte, Minas Gerais, 30150-240, Brazil
Research Site
Belo Horizonte, Minas Gerais, 31110-580, Brazil
Research Site
Uberlândia, Minas Gerais, 38411-186, Brazil
Research Site
Curitiba, Paraná, 80045-170, Brazil
Research Site
Curitiba, Paraná, 80230-130, Brazil
Research Site
Curitiba, Paraná, 80730-150, Brazil
Research Site
Londrina, Paraná, 86038-350, Brazil
Research Site
Natal, Rio Grande do Norte, 59020-035, Brazil
Research Site
Canoas, Rio Grande do Sul, 92425-900, Brazil
Research Site
Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, 90840-440, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Research Site
Aracaju, Sergipe, 49055-530, Brazil
Research Site
Campinas, São Paulo, 13010-001, Brazil
Research Site
Campinas, São Paulo, 13060-080, Brazil
Research Site
Campinas, São Paulo, 13083-888, Brazil
Research Site
Marília, São Paulo, 17515-000, Brazil
Research Site
Ribeirão Preto, São Paulo, 14048-900, Brazil
Research Site
São José do Rio Preto, São Paulo, 15015-770, Brazil
Research Site
São José do Rio Preto, São Paulo, 15090-000, Brazil
Research Site
São Paulo, São Paulo, 01317 002, Brazil
Research Site
São Paulo, São Paulo, 04005-000, Brazil
Research Site
São Paulo, São Paulo, 08270-120, Brazil
Research Site
Rio de Janeiro, 22271-100, Brazil
Research Site
São Paulo, 04012-909, Brazil
Research Site
São Paulo, 05403-000, Brazil
Research Site
Haskovo, 6300, Bulgaria
Research Site
Pleven, 5800, Bulgaria
Research Site
Sandanski, 2800, Bulgaria
Research Site
Sofia, 1202, Bulgaria
Research Site
Sofia, 1233, Bulgaria
Research Site
Sofia, 1407, Bulgaria
Research Site
Sofia, 1527, Bulgaria
Research Site
Sofia, 1750, Bulgaria
Research Site
Edmonton, Alberta, T6G 2B7, Canada
Research Site
Edmonton, Alberta, T6K 4C1, Canada
Research Site
Kelowna, British Columbia, V1Y 1V6, Canada
Research Site
New Westminster, British Columbia, V3L 3W4, Canada
Research Site
North Vancouver, British Columbia, V7M 2H4, Canada
Research Site
Winnipeg, Manitoba, R2H 2A6, Canada
Research Site
Moncton, New Brunswick, E1G 1A7, Canada
Research Site
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Research Site
Halifax, Nova Scotia, B3H 3A7, Canada
Research Site
Brampton, Ontario, L6W 2X7, Canada
Research Site
Brampton, Ontario, L6Z 4N5, Canada
Research Site
Cambridge, Ontario, N1R 6V6, Canada
Research Site
Greater Sudbury, Ontario, P3E 5M4, Canada
Research Site
London, Ontario, N6A 5A5, Canada
Research Site
Oshawa, Ontario, L1J 2J9, Canada
Research Site
Ottawa, Ontario, K1Y 4W7, Canada
Research Site
Peterborough, Ontario, K9J 0B2, Canada
Research Site
Scarborough Village, Ontario, M1P 2V5, Canada
Research Site
Toronto, Ontario, M5B 1W8, Canada
Research Site
Waterloo, Ontario, N2T 0C1, Canada
Research Site
Chicoutimi, Quebec, G7H 7K9, Canada
Research Site
Greenfield Park, Quebec, J4V 2G8, Canada
Research Site
Laval, Quebec, H7M 3L9, Canada
Research Site
Montreal, Quebec, H1T 1C8, Canada
Research Site
Montreal, Quebec, H1T 3Y7, Canada
Research Site
Montreal, Quebec, H3G 1A4, Canada
Research Site
Montreal, Quebec, H4A 3J1, Canada
Research Site
Québec, Quebec, G1V 4G5, Canada
Research Site
Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada
Research Site
Saint-Jérôme, Quebec, J7Z 5T3, Canada
Research Site
Terrebonne, Quebec, J6V 2H2, Canada
Research Site
Temuco, Cautín, 4781156, Chile
Research Site
Temuco, Cautín, 4813299, Chile
Research Site
Talcahuano, Concepción, 4270918, Chile
Research Site
Viña del Mar, Región de Valparaíso, Chile
Research Site
San Miguel, Santiago Metropolitan, 8900085, Chile
Research Site
Osorno, 5311092, Chile
Research Site
Santiago, 7500739, Chile
Research Site
Santiago, 8207257, Chile
Research Site
Santiago, 8330034, Chile
Research Site
Santiago, 8350595, Chile
Research Site
Santiago, 8880300, Chile
Research Site
Santiago, 8910259, Chile
Research Site
Santiago, Chile
Research Site
Beijing, Beijing Municipality, 100043, China
Research Site
Beijing, Beijing Municipality, 100191, China
Research Site
Guangzhou, Guangdong, 510080, China
Research Site
Guangzhou, Guangdong, 511400, China
Research Site
Haikou, Hainan, 570102, China
Research Site
Harbin, Heilongjiang, 150001, China
Research Site
Luoyang, Henan, 471000, China
Research Site
Luoyang, Henan, 471009, China
Research Site
Xinxiang, Henan, 453000, China
Research Site
Zhengzhou, Henan, 450052, China
Research Site
Hengyang, Hunan, 421001, China
Research Site
Xiangtan, Hunan, 411100, China
Research Site
Hohhot, Inner Mongolia, 010017, China
Research Site
Nanjing, Jiangsu, 211100, China
Research Site
Suzhou, Jiangsu, 215000, China
Research Site
Wuxi, Jiangsu, 214023, China
Research Site
Xuzhou, Jiangsu, 221006, China
Research Site
Changchun, Jilin, 130021, China
Research Site
Changchun, Jilin, 130033, China
Research Site
Shenyang, Liaoning, 110000, China
Research Site
Shenyang, Liaoning, 110004, China
Research Site
Shenyang, Liaoning, 110016, China
Research Site
Xi'an, Shaanxi, 710061, China
Research Site
Heze, Shandong, 274031, China
Research Site
Jinan, Shandong, 250012, China
Research Site
Jining, Shandong, 272009, China
Research Site
Qingdao, Shandong, 266003, China
Research Site
Taiyuan, Shanxi, 030001, China
Research Site
Taiyuan, Shanxi, 030012, China
Research Site
Yuncheng, Shanxi, 044000, China
Research Site
Tianjin, Tianjin Municipality, 300052, China
Research Site
Ürümqi, Xinjiang, 830054, China
Research Site
Hangzhou, Zhejiang, 310000, China
Research Site
Linhai, Zhejiang, 317000, China
Research Site
Ningbo, Zhejiang, 315010, China
Research Site
Beijing, 100020, China
Research Site
Beijing, 100037, China
Research Site
Shanghai, 200080, China
Research Site
Medellín, Antioquia, 05001000, Colombia
Research Site
Medellín, Antioquia, 050012, Colombia
Research Site
Medellín, Antioquia, 050021, Colombia
Research Site
Medellín, Antioquia, 050034, Colombia
Research Site
Barranquilla, Atlántico, 080020, Colombia
Research Site
Barranquilla, Atlántico, Colombia
Research Site
Manizales, Caldas Department, Colombia
Research Site
Cartagena, Departamento de Bolívar, 130010, Colombia
Research Site
Armenia, Quindío Department, 630004, Colombia
Research Site
Bucaramanga, Santander Department, 680008, Colombia
Research Site
Bucaramanga, Santander Department, 681004, Colombia
Research Site
Cali, Valle del Cauca Department, 760032, Colombia
Research Site
Cali, Valle del Cauca Department, 760042, Colombia
Research Site
Bogota D.C., Colombia
Research Site
Beroun, 266 01, Czechia
Research Site
Brandýs nad Labem, 250 01, Czechia
Research Site
Brno, 602 00, Czechia
Research Site
Brno, 625 00, Czechia
Research Site
Brno, 636 00, Czechia
Research Site
Brno, 656 91, Czechia
Research Site
Frýdek-Místek, 738 01, Czechia
Research Site
Havlíčkův Brod, 580 22, Czechia
Research Site
Hradec Králové, 500 05, Czechia
Research Site
Jihlava, 586 33, Czechia
Research Site
Karlovy Vary, 360 01, Czechia
Research Site
Kladno, 272 59, Czechia
Research Site
Klatovy IV, 339 01, Czechia
Research Site
Kolin III, 280 02, Czechia
Research Site
Liberec, 460 63, Czechia
Research Site
Louny, 440 01, Czechia
Research Site
Mariánské Lázně, 353 01, Czechia
Research Site
Mohelnice, 789 85, Czechia
Research Site
Opava, 746 01, Czechia
Research Site
Ostrava, 728 80, Czechia
Research Site
Polička, 572 01, Czechia
Research Site
Prague, 100 34, Czechia
Research Site
Prague, 110 00, Czechia
Research Site
Prague, 128 08, Czechia
Research Site
Praha 5 - Smichov, 150 00, Czechia
Research Site
Pribram VIII, 261 01, Czechia
Research Site
Svitavy, 568 25, Czechia
Research Site
Teplice, 415 01, Czechia
Research Site
Uherské Hradiště, 686 01, Czechia
Research Site
Zlín, 762 75, Czechia
Research Site
Znojmo, 669 02, Czechia
Research Site
Aalborg, 9000, Denmark
Research Site
Aarhus N, 8200, Denmark
Research Site
Esbjerg, 6700, Denmark
Research Site
Glostrup Municipality, 2600, Denmark
Research Site
Hellerup, 2900, Denmark
Research Site
Hillerød, 3400, Denmark
Research Site
Køge, 4600, Denmark
Research Site
Odense, 5000, Denmark
Research Site
Svendborg, 5700, Denmark
Research Site
Béziers, 34525, France
Research Site
Caen, 14033, France
Research Site
Chambray-lès-Tours, 37170, France
Research Site
Corbeil-Essonnes, 91100, France
Research Site
Créteil, 94010, France
Research Site
Dijon, 21000, France
Research Site
Grenoble, 38043, France
Research Site
Le Chesnay, 78157, France
Research Site
Lille, 59000, France
Research Site
Lille, 59037, France
Research Site
Limoges, 87042, France
Research Site
Lyon, 69384, France
Research Site
Montauban, 82017, France
Research Site
Montpellier, 34295, France
Research Site
Nantes, 44093, France
Research Site
Nantes, 44277, France
Research Site
Nîmes, 30029, France
Research Site
Paris, 75010, France
Research Site
Paris, 75014, France
Research Site
Paris, 75018, France
Research Site
Paris, 75651, France
Research Site
Pessac, 33604, France
Research Site
Poitiers, 86000, France
Research Site
Rennes, 35033, France
Research Site
Saint-Denis, 93200, France
Research Site
Toulon, 83056, France
Research Site
Toulouse, 31059, France
Research Site
Tourcoing, 59208, France
Research Site
Valenciennes, 59300, France
Research Site
Bad Neuheim, 61231, Germany
Research Site
Berlin, 13353, Germany
Research Site
Cologne, 50937, Germany
Research Site
Dortmund, 44137, Germany
Research Site
Düsseldorf, 40225, Germany
Research Site
Erfurt, 99089, Germany
Research Site
Erfurt, 99097, Germany
Research Site
Essen, 45147, Germany
Research Site
Frankfurt am Main, 65929, Germany
Research Site
Freiburg im Breisgau, 79106, Germany
Research Site
Göttingen, 37075, Germany
Research Site
Greifswald, 17475, Germany
Research Site
Haßloch, 67454, Germany
Research Site
Heidelberg, 69120, Germany
Research Site
Homburg, 66421, Germany
Research Site
Langen, 63225, Germany
Research Site
Leipzig, 04289, Germany
Research Site
Ludwigshafen, 67063, Germany
Research Site
Mainz, 55131, Germany
Research Site
Markleeberg, 04416, Germany
Research Site
Witten, 58455, Germany
Research Site
Würzburg, 97078, Germany
Research Site
Alexandroupoli, 68100, Greece
Research Site
Athens, 11527, Greece
Research Site
Athens, 14233, Greece
Research Site
Athens, 16673, Greece
Research Site
Chaidari, Athens, 12462, Greece
Research Site
Chalcis, 34100, Greece
Research Site
Heraklion, 71110, Greece
Research Site
Ioannina, 45500, Greece
Research Site
Larissa, 41110, Greece
Research Site
Thessaloniki, 54636, Greece
Research Site
Thessaloniki, 56403, Greece
Research Site
Balatonfüred, 8230, Hungary
Research Site
Berettyóújfalu, 4100, Hungary
Research Site
Békéscsaba, 5600, Hungary
Research Site
Budapest, 1023, Hungary
Research Site
Budapest, 1037, Hungary
Research Site
Budapest, 1085, Hungary
Research Site
Budapest, 1096, Hungary
Research Site
Budapest, 1122, Hungary
Research Site
Budapest, 1125, Hungary
Research Site
Budapest, 1134, Hungary
Research Site
Cegléd, 2700, Hungary
Research Site
Dunaújváros, 2400, Hungary
Research Site
Gyöngyös, 3200, Hungary
Research Site
Gyula, 5700, Hungary
Research Site
Kaposvár, 7400, Hungary
Research Site
Komárom, 2921, Hungary
Research Site
Nyíregyháza, 4400, Hungary
Research Site
Pécs, 7624, Hungary
Research Site
Sopron, 9400, Hungary
Research Site
Szeged, 6725, Hungary
Research Site
Szekszárd, 7100, Hungary
Research Site
Szentes, 6600, Hungary
Research Site
Szolnok, 5004, Hungary
Research Site
Zalaegerszeg, 8900, Hungary
Research Site
Ariccia, 00072, Italy
Research Site
Arzignano, 36071, Italy
Research Site
Bergamo, 24127, Italy
Research Site
Bologna, 40139, Italy
Research Site
Brescia, 25123, Italy
Research Site
Cagliari, 09134, Italy
Research Site
Catania, 95123, Italy
Research Site
Catanzaro, 88100, Italy
Research Site
Cona FE, 44124, Italy
Research Site
Cuneo, 12100, Italy
Research Site
Foggia, 71100, Italy
Research Site
Milan, 20132, Italy
Research Site
Milan, 20138, Italy
Research Site
Milan, 20162, Italy
Research Site
Monza, 20900, Italy
Research Site
Monza (MB), 20900, Italy
Research Site
Napoli, 80131, Italy
Research Site
Palermo, 90146, Italy
Research Site
Pavia, 27100, Italy
Research Site
Perugia, 06156, Italy
Research Site
Piacenza, 29121, Italy
Research Site
Rimini, 47923, Italy
Research Site
Roma, 00163, Italy
Research Site
Rozzano MI, 20089, Italy
Research Site
Seriate, 24068, Italy
Research Site
Siena, 53100, Italy
Research Site
Torrette Di Ancona, 60126, Italy
Research Site
Trieste, 34149, Italy
Research Site
Vimercate MB, 20871, Italy
Research Site
Ichinomiya-shi, Aichi-ken, 491-8551, Japan
Research Site
Nagakute-shi, Aichi-ken, 480-1195, Japan
Research Site
Nagoya, Aichi-ken, 454-8509, Japan
Research Site
Nagoya, Aichi-ken, 466-8560, Japan
Research Site
Seto-shi, Aichi-ken, 489-8642, Japan
Research Site
Asahi-shi, Chiba, 289-2511, Japan
Research Site
Chiba, Chiba, 260-8606, Japan
Research Site
Funabashi-shi, Chiba, 273-8588, Japan
Research Site
Urayasu-shi, Chiba, 279-0021, Japan
Research Site
Imabari, Ehime, 794-0006, Japan
Research Site
Matsuyama, Ehime, 790-0067, Japan
Research Site
Chikushino-shi, Fukuoka, 818-8516, Japan
Research Site
Fukuoka, Fukuoka, 810-0001, Japan
Research Site
Fukuoka, Fukuoka, 810-8539, Japan
Research Site
Fukuoka, Fukuoka, 811-0213, Japan
Research Site
Fukuoka, Fukuoka, 812-0033, Japan
Research Site
Fukuoka, Fukuoka, 814-0180, Japan
Research Site
Fukuoka, Fukuoka, 815-8555, Japan
Research Site
Fukuoka, Fukuoka, 815-8588, Japan
Research Site
Kasuya-gun, Fukuoka, 811-2316, Japan
Research Site
Kitakyushu-shi, Fukuoka, 802-0077, Japan
Research Site
Kitakyushu-shi, Fukuoka, 802-8555, Japan
Research Site
Kitakyushu-shi, Fukuoka, 805-8508, Japan
Research Site
Koga-shi, Fukuoka, 811-3195, Japan
Research Site
Kurume-shi, Fukuoka, 830-8577, Japan
Research Site
Kurume-shi, Fukuoka, 839-0863, Japan
Research Site
Onga-gun, Fukuoka, 807-0051, Japan
Research Site
Fukushima, Fukushima, 960-1295, Japan
Research Site
Fukushima, Fukushima, 960-8251, Japan
Research Site
Fukushima, Fukushima, 960-8530, Japan
Research Site
Ogaki-shi, Gifu, 503-8502, Japan
Research Site
Maebashi, Gunma, 371-8511, Japan
Research Site
Takasaki-shi, Gunma, 370-0829, Japan
Research Site
Fukuyama-shi, Hiroshima, 721-8511, Japan
Research Site
Hiroshima, Hiroshima, 734-8551, Japan
Research Site
Kure-shi, Hiroshima, 737-0023, Japan
Research Site
Hakodate-shi, Hokkaido, 041-8512, Japan
Research Site
Sapporo, Hokkaido, 063-0005, Japan
Research Site
Amagasaki-shi, Hyōgo, 660-8550, Japan
Research Site
Himeji-shi, Hyōgo, 670-0981, Japan
Research Site
Kawanishi-shi, Hyōgo, 666-0125, Japan
Research Site
Nishinomiya-shi, Hyōgo, 663-8501, Japan
Research Site
Takarazuka-shi, Hyōgo, 665-0873, Japan
Research Site
Higashiibaraki-gun, Ibaraki, 311-3193, Japan
Research Site
Kahoku-gun, Ishikawa-ken, 920-0293, Japan
Research Site
Kanazawa, Ishikawa-ken, 920-8650, Japan
Research Site
Morioka, Iwate, 020-0066, Japan
Research Site
Takamatsu, Kagawa-ken, 760-8557, Japan
Research Site
Hayama, Kanagawa, 240-0116, Japan
Research Site
Kawasaki-shi, Kanagawa, 210-0852, Japan
Research Site
Kawasaki-shi, Kanagawa, 211-8533, Japan
Research Site
Kawasaki-shi, Kanagawa, 216-8511, Japan
Research Site
Odawara-shi, Kanagawa, 250-8558, Japan
Research Site
Sagamihara-shi, Kanagawa, 252-0392, Japan
Research Site
Sagamihara-shi, Kanagawa, 252-5188, Japan
Research Site
Yokohama, Kanagawa, 227-8501, Japan
Research Site
Yokohama, Kanagawa, 231-8682, Japan
Research Site
Yokohama, Kanagawa, 247-8581, Japan
Research Site
Nankoku-shi, Kochi, 783-8505, Japan
Research Site
Kumamoto, Kumamoto, 861-4193, Japan
Research Site
Sendai, Miyagi, 980-8574, Japan
Research Site
Nagano, Nagano, 381-8551, Japan
Research Site
Kashihara-shi, Nara, 634-8522, Japan
Research Site
Ōita, Oita Prefecture, 870-0192, Japan
Research Site
Okayama, Okayama-ken, 700-8558, Japan
Research Site
Naha, Okinawa, 902-8511, Japan
Research Site
Shimajiri-gun, Okinawa, 901-0493, Japan
Research Site
Urasoe-shi, Okinawa, 901-2132, Japan
Research Site
Higashiosaka-shi, Osaka, 579-8056, Japan
Research Site
Matsubara-shi, Osaka, 580-0032, Japan
Research Site
Osaka, Osaka, 530-0001, Japan
Research Site
Osaka, Osaka, 533-0024, Japan
Research Site
Osaka, Osaka, 540-0006, Japan
Research Site
Osaka, Osaka, 556-0017, Japan
Research Site
Osaka, Osaka, 559-0012, Japan
Research Site
Suita-shi, Osaka, 565-0871, Japan
Research Site
Saga, Saga-ken, 849-8501, Japan
Research Site
Ureshino-shi, Saga-ken, 843-0301, Japan
Research Site
Ageo-shi, Saitama, 362-8588, Japan
Research Site
Koshigaya-shi, Saitama, 343-8577, Japan
Research Site
Wako-shi, Saitama, 351-0102, Japan
Research Site
Kusatsu-shi, Shiga, 525-8585, Japan
Research Site
Sunto-gun, Shizuoka, 411-8611, Japan
Research Site
Akishima-shi, Tokyo, 196-0003, Japan
Research Site
Bunkyo-ku, Tokyo, 113-8519, Japan
Research Site
Bunkyo-ku, Tokyo, 113-8603, Japan
Research Site
Chuo-ku, Tokyo, 104-8560, Japan
Research Site
Fussa-shi, Tokyo, 197-8511, Japan
Research Site
Hachioji-shi, Tokyo, 192-0918, Japan
Research Site
Itabashi-ku, Tokyo, 173-8610, Japan
Research Site
Kodaira-shi, Tokyo, 187-8510, Japan
Research Site
Meguro-ku, Tokyo, 152-8902, Japan
Research Site
Minato-ku, Tokyo, 108-8642, Japan
Research Site
Shinagawa-ku, Tokyo, 140-8522, Japan
Research Site
Shinjuku-ku, Tokyo, 162-8655, Japan
Research Site
Toyama, Toyama, 939-8511, Japan
Research Site
Kaunas, 50009, Lithuania
Research Site
Klaipėda, 92288, Lithuania
Research Site
Vilnius, 08661, Lithuania
Research Site
Vilnius, 08861, Lithuania
Research Site
Torreón, Coahuila, 27000, Mexico
Research Site
Pachuca, Hidalgo, 42070, Mexico
Research Site
Guadalajara, Jalisco, 44280, Mexico
Research Site
Guadalajara, Jalisco, 44340, Mexico
Research Site
Guadalajara, Jalisco, 44670, Mexico
Research Site
Zapopan, Jalisco, 45030, Mexico
Research Site
Mexico City, Mexico City, 06700, Mexico
Research Site
Mexico City, Mexico City, 11650, Mexico
Research Site
Mexico City, Mexico City, 14080, Mexico
Research Site
Monterrey, Nuevo León, 64060, Mexico
Research Site
Monterrey, Nuevo León, 64460, Mexico
Research Site
Querétaro City, Querétaro, 76000, Mexico
Research Site
San Luis Potosí City, San Luis Potosí, 78200, Mexico
Research Site
Culiacán, Sinaloa, 80230, Mexico
Research Site
Xalapa, Veracruz, 91193, Mexico
Research Site
Aguascalientes, 20230, Mexico
Research Site
's-Hertogenbosch, 5223 GZ, Netherlands
Research Site
Almelo, 7609 PP, Netherlands
Research Site
Arnhem, 6815 AD, Netherlands
Research Site
Breda, 4818 CK, Netherlands
Research Site
Capelle aan den IJssel, 2906 ZC, Netherlands
Research Site
Den Helder, 1782 GZ, Netherlands
Research Site
Deventer, 7416 SE, Netherlands
Research Site
Doetinchem, 7009 BL, Netherlands
Research Site
Emmen, 7824 AA, Netherlands
Research Site
Goes, 4462 RA, Netherlands
Research Site
Groningen, 9713 GZ, Netherlands
Research Site
Groningen, 9728 NT, Netherlands
Research Site
Leiderdorp, 2353 GA, Netherlands
Research Site
Nijmegen, 6532 SZ, Netherlands
Research Site
Tiel, 4002 WP, Netherlands
Research Site
Tilburg, 5022 GC, Netherlands
Research Site
Tilburg, 5042 AD, Netherlands
Research Site
Uden, 5406 PT, Netherlands
Research Site
Zwolle, 8025 AB, Netherlands
Research Site
Christchurch, 8011, New Zealand
Research Site
Papatoetoe, Auckland, 2025, New Zealand
Research Site
Takapuna, Auckland, 0620, New Zealand
Research Site
Bialystok, 15-276, Poland
Research Site
Bytom, 41-902, Poland
Research Site
Gdansk, 80-262, Poland
Research Site
Gdynia, 81-157, Poland
Research Site
Gdynia, 81-423, Poland
Research Site
Giżycko, 11-500, Poland
Research Site
Kazimierza Wielka, 28-500, Poland
Research Site
Kielce, 25-736, Poland
Research Site
Krakow, 30-069, Poland
Research Site
Krakow, 30-082, Poland
Research Site
Krakow, 31-202, Poland
Research Site
Kłodzko, 57-300, Poland
Research Site
Lodz, 90-549, Poland
Research Site
Lodz, 91-347, Poland
Research Site
Lodz, 92-213, Poland
Research Site
Lublin, 20-078, Poland
Research Site
Lublin, 20-857, Poland
Research Site
Miechów, 32-200, Poland
Research Site
Oława, 55-200, Poland
Research Site
Piotrkow Trybunalski, 97-300, Poland
Research Site
Poznan, 61-848, Poland
Research Site
Ruda Śląska, 41-709, Poland
Research Site
Skierniewice, 96-100, Poland
Research Site
Stalowa Wola, 37-450, Poland
Research Site
Świdnik, 21-040, Poland
Research Site
Tarnów, 33-100, Poland
Research Site
Torun, 87-100, Poland
Research Site
Warsaw, 02-097, Poland
Research Site
Warsaw, 04-628, Poland
Research Site
Wroclaw, 51-124, Poland
Research Site
Włocławek, 87-800, Poland
Research Site
Zabrze, 41-800, Poland
Research Site
Aveiro, 3814-501, Portugal
Research Site
Coimbra, 3000-075, Portugal
Research Site
Covilha, 6200-251, Portugal
Research Site
Guimarães, 4835-044, Portugal
Research Site
Lisbon, 1449-005, Portugal
Research Site
Lisbon, 1500-650, Portugal
Research Site
Lisbon, 1649-035, Portugal
Research Site
Setúbal, 2910-446, Portugal
Research Site
San Juan, 00926-2832, Puerto Rico
Research Site
Bucharest, 014461, Romania
Research Site
Bucharest, 021659, Romania
Research Site
Bucharest, 022322, Romania
Research Site
Bucharest, 050098, Romania
Research Site
Cluj-Napoca, 400347, Romania
Research Site
Craiova, 200383, Romania
Research Site
Craiova, 200642, Romania
Research Site
Iași, 700661, Romania
Research Site
Iași, 700732, Romania
Research Site
Oradea, 410169, Romania
Research Site
Piteşti, 110438, Romania
Research Site
Târgovişte, 130095, Romania
Research Site
Târgu Mureş, 540143, Romania
Research Site
Timișoara, 300079, Romania
Research Site
Arkhangelsk, 163001, Russia
Research Site
Barnaul, 656038, Russia
Research Site
Ivanovo, 153012, Russia
Research Site
Izhevsk, 426063, Russia
Research Site
Kemerovo, 650002, Russia
Research Site
Kemerovo, 650099, Russia
Research Site
Kirov, 610014, Russia
Research Site
Korolyov, 141060, Russia
Research Site
Krasnodar, 350086, Russia
Research Site
Lomonosov, 198412, Russia
Research Site
Moscow, 101990, Russia
Research Site
Moscow, 117292, Russia
Research Site
Moscow, 119192, Russia
Research Site
Moscow, 121552, Russia
Research Site
Moscow, 123182, Russia
Research Site
Moscow, 127299, Russia
Research Site
Moscow, 129090, Russia
Research Site
Moscow, 129327, Russia
Research Site
Nizhny Novgorod, 603076, Russia
Research Site
Nizhny Novgorod, 603126, Russia
Research Site
Novosibirsk, 630008, Russia
Research Site
Novosibirsk, 630087, Russia
Research Site
Novosibirsk, 630089, Russia
Research Site
Omsk, 644018, Russia
Research Site
Saint Petersburg, 191015, Russia
Research Site
Saint Petersburg, 192242, Russia
Research Site
Saint Petersburg, 194156, Russia
Research Site
Saint Petersburg, 195112, Russia
Research Site
Saint Petersburg, 196601, Russia
Research Site
Saint Petersburg, 197022, Russia
Research Site
Saint Petersburg, 198205, Russia
Research Site
Saint Petersburg, 199106, Russia
Research Site
Saratov, 410054, Russia
Research Site
Tomsk, 634012, Russia
Research Site
Village Novoseltsy, 214016, Russia
Research Site
Vladimir, 600020, Russia
Research Site
Yaroslavl, 150030, Russia
Research Site
Yekaterinburg, 620102, Russia
Research Site
Banská Bystrica, 974 01, Slovakia
Research Site
Bardejov, 085 01, Slovakia
Research Site
Bratislava, 811 08, Slovakia
Research Site
Bratislava, 826 06, Slovakia
Research Site
Bratislava, 833 48, Slovakia
Research Site
Brezno, 977 42, Slovakia
Research Site
Košice, 040 01, Slovakia
Research Site
Levice, 934 01, Slovakia
Research Site
Nitra, 950 01, Slovakia
Research Site
Prešov, 080 01, Slovakia
Research Site
Rimavská Sobota, 979 01, Slovakia
Research Site
Snina, 069 01, Slovakia
Research Site
Svidník, 089 01, Slovakia
Research Site
Trnava, 917 75, Slovakia
Research Site
Bloemfontein, Free State, 9301, South Africa
Research Site
Parktown, Gauteng, 2193, South Africa
Research Site
Soweto, Gauteng, 2013, South Africa
Research Site
Sunninghill, Gauteng, 2157, South Africa
Research Site
Durban, KwaZulu-Natal, 4001, South Africa
Research Site
Umhlanga, KwaZulu-Natal, 4320, South Africa
Research Site
Parow, Western Cape, 7505, South Africa
Research Site
Somerset West, Western Cape, 7130, South Africa
Research Site
Worcester, Western Cape, 6850, South Africa
Research Site
Córdoba, Andalusia, 14004, Spain
Research Site
Granada, Andalusia, 18014, Spain
Research Site
Málaga, Andalusia, 29010, Spain
Research Site
Seville, Andalusia, 41009, Spain
Research Site
Úbeda, Andalusia, 23400, Spain
Research Site
Zaragoza, Aragon, 50009, Spain
Research Site
San Cristóbal de La Laguna, Canary Islands, 38320, Spain
Research Site
Santander, Cantabria, 39008, Spain
Research Site
Valladolid, Castille and León, 47005, Spain
Research Site
Barcelona, Catalonia, 08041, Spain
Research Site
A Coruña, Galicia, 15006, Spain
Research Site
Santiago de Compostela, Galicia, 15706, Spain
Research Site
Vigo, Galicia, 36312, Spain
Research Site
Majadahonda, Madrid, 28222, Spain
Research Site
El Palmar, Murcia, 30120, Spain
Research Site
Oviedo, Principality of Asturias, 33011, Spain
Research Site
Alicante, Valencia, 03010, Spain
Research Site
Valencia, Valencia, 46010, Spain
Research Site
Valencia, Valencia, 46026, Spain
Research Site
Madrid, 28007, Spain
Research Site
Madrid, 28040, Spain
Research Site
Madrid, 28041, Spain
Research Site
Falun, 791 82, Sweden
Research Site
Jönköping, 553 05, Sweden
Research Site
Lidköping, 531 85, Sweden
Research Site
Linköping, 581 85, Sweden
Research Site
Lund, 222 21, Sweden
Research Site
Örebro, 701 85, Sweden
Research Site
Skellefteå, 931 86, Sweden
Research Site
Basel, 4031, Switzerland
Research Site
Bern, 3010, Switzerland
Research Site
Fribourg, 1708, Switzerland
Research Site
Geneva, 1211, Switzerland
Research Site
Lausanne, 1011, Switzerland
Research Site
Lugano, 6900, Switzerland
Research Site
Zurich, 8032, Switzerland
Research Site
Adana, 01330, Turkey (Türkiye)
Research Site
Afyonkarahisar, 03218, Turkey (Türkiye)
Research Site
Ankara, 06100, Turkey (Türkiye)
Research Site
Ankara, 06490, Turkey (Türkiye)
Research Site
Çorum, 19040, Turkey (Türkiye)
Research Site
Eskişehir, 26040, Turkey (Türkiye)
Research Site
Istanbul, 34096, Turkey (Türkiye)
Research Site
Istanbul, 34098, Turkey (Türkiye)
Research Site
Istanbul, 34200, Turkey (Türkiye)
Research Site
Istanbul, 34865, Turkey (Türkiye)
Research Site
Izmir, 35100, Turkey (Türkiye)
Research Site
Izmir, 35340, Turkey (Türkiye)
Research Site
Kocaeli, 41380, Turkey (Türkiye)
Research Site
Konya, 42080, Turkey (Türkiye)
Research Site
Kırıkkale, 71100, Turkey (Türkiye)
Research Site
Mersin, 33343, Turkey (Türkiye)
Research Site
Sakarya, 54100, Turkey (Türkiye)
Research Site
Sivas, 58140, Turkey (Türkiye)
Research Site
Van, 65100, Turkey (Türkiye)
Research Site
Dnipropetrovsk, 49060, Ukraine
Research Site
Ivano-Frankivsk, 76018, Ukraine
Research Site
Kharkiv, 61002, Ukraine
Research Site
Kharkiv, 61018, Ukraine
Research Site
Kharkiv, 61039, Ukraine
Research Site
Kharkiv, 61106, Ukraine
Research Site
Kharkiv, 61176, Ukraine
Research Site
Kyiv, 01601, Ukraine
Research Site
Kyiv, 02091, Ukraine
Research Site
Kyiv, 02232, Ukraine
Research Site
Kyiv, 02660, Ukraine
Research Site
Kyiv, 03151, Ukraine
Research Site
Kyiv, 03680, Ukraine
Research Site
Lutsk, 43024, Ukraine
Research Site
Uzhhorod, 88014, Ukraine
Research Site
Vinnytsia, 21001, Ukraine
Research Site
Vinnytsia, 21018, Ukraine
Research Site
Vinnytsia, 21029, Ukraine
Research Site
Zaporizhzhia, 69035, Ukraine
Research Site
Zaporizhzhya, 69600, Ukraine
Research Site
Ayr, KA6 6DX, United Kingdom
Research Site
Basingstoke, RG24 9NA, United Kingdom
Research Site
Belfast, BT16 1RH, United Kingdom
Research Site
Blackpool, FY3 8NR, United Kingdom
Research Site
Corby, NN17 2UR, United Kingdom
Research Site
Cottingham, HU16 5JQ, United Kingdom
Research Site
Dudley, DY1 2HQ, United Kingdom
Research Site
Dundee, DD1 9SY, United Kingdom
Research Site
Exeter, EX2 5DW, United Kingdom
Research Site
Gillingham, ME7 5NY, United Kingdom
Research Site
Glasgow, G75 8RG, United Kingdom
Research Site
Harlow, CM20 1QX, United Kingdom
Research Site
High Wycombe, HP11 2TT, United Kingdom
Research Site
London, N18 1QX, United Kingdom
Research Site
London, SW3 6NP, United Kingdom
Research Site
London, W12 0HS, United Kingdom
Research Site
Merthyr Tydfil, CF47 9DT, United Kingdom
Research Site
Newport, PO30 5TG, United Kingdom
Research Site
Northampton, NN1 5BD, United Kingdom
Research Site
Northwood, HA6 2RN, United Kingdom
Research Site
Norwich, NR4 7UY, United Kingdom
Research Site
Peterborough, PE3 9GZ, United Kingdom
Research Site
Portsmouth, PO6 3LY, United Kingdom
Research Site
Romford, RM1 3PJ, United Kingdom
Research Site
Sheffield, S5 7AU, United Kingdom
Research Site
Shipley, BD18 3SA, United Kingdom
Research Site
Sidcup, DA14 6LT, United Kingdom
Research Site
Solihull, B91 2JL, United Kingdom
Research Site
Stevenage, SG1 4AB, United Kingdom
Research Site
Sunderland, SR4 7TP, United Kingdom
Research Site
Swindon, SN3 6BB, United Kingdom
Research Site
Taunton, TA1 5DA, United Kingdom
Research Site
Torquay, TQ2 7AA, United Kingdom
Research Site
Worcester, WR5 1DD, United Kingdom
Related Publications (10)
Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Biering-Sorensen T, Bohm M, Bonderman D, Fang JC, Lanfear DE, Lund M, Momomura SI, O'Meara E, Ponikowski P, Spinar J, Flores-Arredondo JH, Claggett BL, Heitner SB, Kupfer S, Abbasi SA, Malik FI; GALACTIC-HF Investigators. Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF. J Am Coll Cardiol. 2021 Jul 13;78(2):97-108. doi: 10.1016/j.jacc.2021.04.065. Epub 2021 May 17.
PMID: 34015475BACKGROUNDOno R, Chimura M, Docherty KF, Jhund PS, Yang M, Henderson AD, Metra M, Liu G, Divanji PH, Heitner SB, Kupfer S, Malik FI, Felker GM, Solomon SD, Teerlink JR, McMurray JJV. Lactate Dehydrogenase and Outcomes in Patients With HF and Reduced Ejection Fraction: Insights From GALACTIC-HF. JACC Heart Fail. 2026 Jan 10:102900. doi: 10.1016/j.jchf.2025.102900. Online ahead of print.
PMID: 41528277DERIVEDLu H, Claggett BL, Felker GM, McMurray JJV, Teerlink JR, Inciardi RM, Metra M, Heitner SB, Diaz R, Malik F, Vaduganathan M, Solomon SD. Efficacy and Safety of Omecamtiv Mecarbil in Heart Failure With Reduced Ejection Fraction According to Age: The GALACTIC-HF Trial. JACC Heart Fail. 2025 Oct 22:102703. doi: 10.1016/j.jchf.2025.102703. Online ahead of print.
PMID: 41123512DERIVEDFelker GM, Solomon SD, Metra M, Mcmurray JJV, Diaz R, Claggett B, Lanfear DE, Vandekerckhove H, Biering-Sorensen T, Lopes RD, Arias-Mendoza A, Momomura SI, Corbalan R, Ramires FJA, Zannad F, Heitner SB, Divanji PH, Kupfer S, Malik FI, Teerlink JR. Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results From the GALACTIC-HF Study. J Card Fail. 2024 Jun;30(6):755-763. doi: 10.1016/j.cardfail.2023.11.021. Epub 2024 Jan 11.
PMID: 38215932DERIVEDPabon M, Cunningham J, Claggett B, Felker GM, McMurray JJV, Metra M, Diaz R, Wang X, Arias-Mendoza A, Bonderman D, Crespo-Leiro M, Fonseca C, Goncalvesova E, Lund M, O'Meara E, Sliwa-Hahnle K, Malik FI, Solomon SD, Teerlink JR; GALACTIC-HF Investigators. Sex Differences in Heart Failure With Reduced Ejection Fraction in the GALACTIC-HF Trial. JACC Heart Fail. 2023 Dec;11(12):1729-1738. doi: 10.1016/j.jchf.2023.07.029. Epub 2023 Oct 11.
PMID: 37831045DERIVEDDocherty KF, McMurray JJV, Claggett BL, Miao ZM, Adams KF, Arias-Mendoza A, Cleland JGF, Diaz R, Echeverria Correa LE, Felker GM, Fonseca C, Li J, Metra M, Sliwa-Hahnle K, Solomon SD, Vandekerckhove HJ, Vinereanu D, Voors AA, Heitner SB, Kupfer S, Malik FI, Meng L, Teerlink JR. Efficacy of omecamtiv mecarbil in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide level: insights from the GALACTIC-HF trial. Eur J Heart Fail. 2023 Feb;25(2):248-259. doi: 10.1002/ejhf.2763. Epub 2023 Jan 16.
PMID: 36597719DERIVEDSolomon SD, Claggett BL, Miao ZM, Diaz R, Felker GM, McMurray JJV, Metra M, Corbalan R, Filippatos G, Goudev AR, Mareev V, Serpytis P, Suter T, Yilmaz MB, Zannad F, Kupfer S, Heitner SB, Malik FI, Teerlink JR. Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial. Eur Heart J. 2022 Jun 14;43(23):2212-2220. doi: 10.1093/eurheartj/ehac144.
PMID: 35325102DERIVEDFelker GM, Solomon SD, Claggett B, Diaz R, McMurray JJV, Metra M, Anand I, Crespo-Leiro MG, Dahlstrom U, Goncalvesova E, Howlett JG, MacDonald P, Parkhomenko A, Tomcsanyi J, Abbasi SA, Heitner SB, Hucko T, Kupfer S, Malik FI, Teerlink JR. Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial. JAMA Cardiol. 2022 Jan 1;7(1):26-34. doi: 10.1001/jamacardio.2021.4027.
PMID: 34643642DERIVEDTeerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Adams KF, Anand I, Arias-Mendoza A, Biering-Sorensen T, Bohm M, Bonderman D, Cleland JGF, Corbalan R, Crespo-Leiro MG, Dahlstrom U, Echeverria LE, Fang JC, Filippatos G, Fonseca C, Goncalvesova E, Goudev AR, Howlett JG, Lanfear DE, Li J, Lund M, Macdonald P, Mareev V, Momomura SI, O'Meara E, Parkhomenko A, Ponikowski P, Ramires FJA, Serpytis P, Sliwa K, Spinar J, Suter TM, Tomcsanyi J, Vandekerckhove H, Vinereanu D, Voors AA, Yilmaz MB, Zannad F, Sharpsten L, Legg JC, Varin C, Honarpour N, Abbasi SA, Malik FI, Kurtz CE; GALACTIC-HF Investigators. Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. N Engl J Med. 2021 Jan 14;384(2):105-116. doi: 10.1056/NEJMoa2025797. Epub 2020 Nov 13.
PMID: 33185990DERIVEDTeerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Legg JC, Buchele G, Varin C, Kurtz CE, Malik FI, Honarpour N. Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF. JACC Heart Fail. 2020 Apr;8(4):329-340. doi: 10.1016/j.jchf.2019.12.001. Epub 2020 Feb 6.
PMID: 32035892DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study Director
- Organization
- Amgen Inc.
Study Officials
- STUDY DIRECTOR
MD
Amgen
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 30, 2016
First Posted
October 11, 2016
Study Start
January 6, 2017
Primary Completion
September 14, 2020
Study Completion
September 14, 2020
Last Updated
November 5, 2021
Results First Posted
July 20, 2021
Record last verified: 2021-11
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF, CSR
- Time Frame
- Data sharing requests relating to this study will be considered beginning 18 months after the study has ended and either 1) the product and indication (or other new use) have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this study.
- Access Criteria
- Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen study/studies in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors, and if not approved, may be further arbitrated by a Data Sharing Independent Review Panel. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.
De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request