Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%
FINEARTS-HF
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)
2 other identifiers
interventional
6,016
36 countries
652
Brief Summary
The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Sep 2020
Typical duration for phase_3 heart-failure
652 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 15, 2020
CompletedFirst Posted
Study publicly available on registry
June 17, 2020
CompletedStudy Start
First participant enrolled
September 14, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 15, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 14, 2024
CompletedResults Posted
Study results publicly available
August 26, 2025
CompletedAugust 26, 2025
August 1, 2025
3.7 years
June 15, 2020
May 5, 2025
August 25, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
Number of composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
From randomization up until the end of study, with an average study duration of 32 months
Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
Number of participants with composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
From randomization up until the end of study, with an average study duration of 32 months
Secondary Outcomes (6)
Occurrence of Total (First and Recurrent) Heart Failure Events
From randomization up until the end of study, with an average study duration of 32 months
Occurrence of Total (First and Recurrent) Heart Failure Events
From randomization up until the end of study, with an average study duration of 32 months
Change From Baseline in Total Symptom Score (TSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ)
From baseline to Month 6, 9 and 12
Proportion of Participants Who Showed Improvement in NHYA Class
from baseline to Month 12
First Occurrence of Renal Composite Events
From randomization up to end of study visit, with an average study duration of 32 months
- +1 more secondary outcomes
Study Arms (2)
Arm 1_BAY94-8862
EXPERIMENTALAdult patients receive BAY94-8862
Arm 2_Placebo
PLACEBO COMPARATORAdult patients receive placebo
Interventions
For participants with an eGFR ≤60 mL/min/1.73 m\^2: Starting dose is 10 mg OD and maximum dose 20 mg OD. For participants with an eGFR \>60 mL/min/1.73 m\^2: Starting dose is 20 mg OD and maximum dose 40 mg OD. Finerenone is administered orally as immediate release tablets.
Eligibility Criteria
You may qualify if:
- Participant (male or female) must be aged 40 years and older.
- Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
- On diuretic treatment for at least 30 days prior to randomization.
- Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
- Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) \>30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
- n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:
- Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
- Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
- Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.
You may not qualify if:
- Estimated glomerular filtration rate (eGFR) \<25 mL/min/1.73 m² at either screening or randomization visit.
- Serum/plasma potassium \>5.0 mmol/L at either screening or randomization visit.
- Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
- Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
- Coronary artery bypass graft surgery in the 90 days prior to randomization
- Percutaneous coronary intervention in the 30 days prior to randomization
- Stroke or transient ischemic cerebral attack within 90 days prior to randomization
- Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin \<10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) \>50 kg/m2 at screening
- Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
- Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bayerlead
Study Sites (661)
Cardiology, PC
Birmingham, Alabama, 35211, United States
Eastern Shore Research Institute, LLC | Fairhope, AL
Fairhope, Alabama, 36532, United States
Mobile Heart Specialists - Providence
Mobile, Alabama, 36608, United States
University of Arizona Clinical and Translational Sciences Research Center
Tucson, Arizona, 85724, United States
Heart Clinic Arkansas
Little Rock, Arkansas, 72205, United States
WestSide Medical
Beverly Hills, California, 90211, United States
CA Heart and Vein Specialists
Huntington Beach, California, 92648, United States
UCI Medical Center - Neurology
Orange, California, 92868, United States
Sutter Medical Center - Cardiology
Sacramento, California, 95816, United States
NorthBay Clinical Research, LLC | Santa Rosa, CA
Santa Rosa, California, 95405, United States
The Lundquist Institute - Gynecology
Torrance, California, 90502, United States
Blue Coast Research Center, LLC
Vista, California, 92081, United States
Interventional Cardio Medical- DCT Department
West Hills, California, 91307, United States
Interventional Cardiology Medical Group | West Hills, CA
West Hills, California, 91307, United States
VA Eastern Colorado Health Care System
Aurora, Colorado, 80045, United States
Colorado Springs Cardiology - Woodmen Medical Plaza
Colorado Springs, Colorado, 80923, United States
South Denver Cardiology Associates, PC
Littleton, Colorado, 80120, United States
Cardiovascular & Vein Center of Florida | Bradenton, FL
Bradenton, Florida, 34209, United States
Nova Clinical Research - Blake Medical Center
Bradenton, Florida, 34209, United States
Cardiology Associates Research Company
Daytona Beach, Florida, 32117, United States
North Florida Foundation for Research and Education - Clinical Trial Center
Gainesville, Florida, 32608, United States
LifeSpring Research Foundation, LLC
Miami, Florida, 33130, United States
Southwest Florida Research | Naples, FL
Naples, Florida, 34102-8143, United States
East Coast Institute for Research | St. Augustine, FL
Saint Augustine, Florida, 32086, United States
Cardiology Partners Clinical Research Institute | Wellington Office
Wellington, Florida, 33449, United States
Centricity Research at Talbotton
Columbus, Georgia, 31904, United States
Atlanta Heart Specialists - Tucker
Tucker, Georgia, 30084, United States
Advocate Illinois Masonic Medical Center - Cardiology
Chicago, Illinois, 60657, United States
Advocate Good Samaritan Hospital - Cardiology
Downers Grove, Illinois, 60515, United States
Advocate Condell Medical Center
Libertyville, Illinois, 60048, United States
Edward Hospital - Main Campus - Cardiology
Naperville, Illinois, 60540, United States
Captain James A. Lovell Federal Health Care Center
North Chicago, Illinois, 60064, United States
Carle Health Methodist Hospital - Cardiology
Peoria, Illinois, 61603, United States
Midwest Cardiovascular Research and Education Foundation | Elkhart, IN
Elkhart, Indiana, 46514, United States
Reid Physicians Associates - Cardiology Department
Richmond, Indiana, 47374, United States
Kansas Nephrology Research Institute
Wichita, Kansas, 67214, United States
Baptist Health Paducah - Cardiology
Paducah, Kentucky, 42003, United States
Cardiovascular Associates Research, LLC
Covington, Louisiana, 70433, United States
Heart Clinic of Hammond
Hammond, Louisiana, 70403, United States
Louisiana Heart Center - Slidell
Slidell, Louisiana, 70458, United States
Southern Clinical Research, LLC
Zachary, Louisiana, 70791, United States
MaineHealth Cardiology - Scarborough
Scarborough, Maine, 04039, United States
Johns Hopkins Hospital - Cardiology
Baltimore, Maryland, 21287, United States
Suburban Hospital - Cardiology
Bethesda, Maryland, 20814, United States
Cardiovascular Specialists of Central Maryland, PA
Columbia, Maryland, 21044, United States
Henry Ford Hospital - OB/GYN
Detroit, Michigan, 48202, United States
AA Medical Research Center | Flint, MI
Flint, Michigan, 48504, United States
M Health Fairview Heart Clinic - Maplewood
Maplewood, Minnesota, 55109, United States
M Health Fairview Heart Clinic - Fulton
Minneapolis, Minnesota, 55455, United States
St. Cloud Hospital
Saint Cloud, Minnesota, 56303, United States
Baptist Heart -Cardiology - DCT Dept
Jackson, Mississippi, 39202, United States
University Hospital - UMMC - Nephrology
Jackson, Mississippi, 39216, United States
Harry S Truman Memorial Veterans Hospital - Cardiology
Columbia, Missouri, 65201, United States
Clinical Research Consultants
Kansas City, Missouri, 64111, United States
Saint Luke's Mid America Heart Institute
Kansas City, Missouri, 64111, United States
Mercy Hospital Springfield - Cardiology
Springfield, Missouri, 65804, United States
Logan Health Research
Kalispell, Montana, 59901, United States
CHI Health Clinic Heart Institute - Grand Island
Grand Island, Nebraska, 68803, United States
CHI Health Nebraska Heart
Lincoln, Nebraska, 68526, United States
Advanced Heart Care, LLC | Bridgewater, NJ
Bridgewater, New Jersey, 08807, United States
NJ Heart | Linden, NJ
Linden, New Jersey, 07036, United States
Garden State Heart Care
Manalapan, New Jersey, 07726, United States
Nuvance Health - The Heart Center
Poughkeepsie, New York, 12601, United States
Division of Cardiovascular Research at Peconic Bay Medical Center
Riverhead, New York, 11901, United States
Laurelton Heart Specialists
Rosedale, New York, 11422, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, 12866, United States
Cardiac Care & Vascular Medicine
The Bronx, New York, 10469, United States
Northwell Health Physician Partners Cardiology at Valley Stream
Valley Stream, New York, 11580, United States
Kernodle Clinic West
Burlington, North Carolina, 27215, United States
University of North Carolina
Chapel Hill, North Carolina, 27514, United States
Wake Forest Baptist Health
Winston-Salem, North Carolina, 27157, United States
Kettering Health Network | Research Institute
Kettering, Ohio, 45429, United States
Rama Research LLC | Marion, OH
Marion, Ohio, 43302-6774, United States
Mercy Health - St. Elizabeth Youngstown Hospital
Youngstown, Ohio, 44501, United States
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, 73135, United States
Capital Area Research | Camp Hill, PA
Camp Hill, Pennsylvania, 17011, United States
Doylestown Health Cardiology - DCA
Doylestown, Pennsylvania, 18901, United States
Kent Hospital
Warwick, Rhode Island, 02886, United States
Trident Cardiology Associates, PA
Ladson, South Carolina, 29456, United States
Carolina Heart Specialists | Lancaster, SC
Lancaster, South Carolina, 29720, United States
Monument Health Clinical Research
Rapid City, South Dakota, 57701, United States
Sanford USD Medical Center - Cardiology
Sioux Falls, South Dakota, 57105, United States
The Stern Cardiovascular Foundation - Germantown, TN
Germantown, Tennessee, 38138, United States
Apex Research Foundation, LLC. | Jackson, TN
Jackson, Tennessee, 38301, United States
Lt. Col. Luke Weathers, Jr. VA Medical Center - Cardiology
Memphis, Tennessee, 38105, United States
Cardiovascular Research of Knoxville
Powell, Tennessee, 37849, United States
Ascension Seton Heart Specialty Care and Transplant Center
Austin, Texas, 78705, United States
Texas Health & Vascular Specialists - Dallas
Dallas, Texas, 75231, United States
Southwest Family Medicine Associates | Dallas, TX
Dallas, Texas, 75235, United States
Texas Health Family Care - W Vickery Blvd
Fort Worth, Texas, 76107, United States
University of Texas Medical Branch at Galveston
Galveston, Texas, 77555, United States
Houston Heart & Vascular Associates
Humble, Texas, 77338, United States
South Texas Cardiovascular Consultants, PLLC / Kerrville, TX
Kerrville, Texas, 78028, United States
North Dallas Research Associates
McKinney, Texas, 75069, United States
ClinRx Research, LLC
Plano, Texas, 75024, United States
South Texas Cardiovascular Consultants - San Antonio
San Antonio, Texas, 78201, United States
Clinical Advancement Center, PLLC
San Antonio, Texas, 78212, United States
Northwest Houston Clinical Research - Tomball
Tomball, Texas, 77375, United States
University of Utah Clinical Neurosciences Center
Salt Lake City, Utah, 84312, United States
Inova Cardiology- Fairfax
Fairfax, Virginia, 22031, United States
Virginia Heart
Falls Church, Virginia, 22042, United States
Virginia Heart - Leesburg
Leesburg, Virginia, 20176, United States
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
Salem VA Medical Center - Cardiology
Salem, Virginia, 24153, United States
Selma Medical Associates
Winchester, Virginia, 22601, United States
William S. Middleton Memorial Veterans Hospital
Madison, Wisconsin, 53705, United States
Aurora Saint Luke's Medical Center - Cardiology
Milwaukee, Wisconsin, 53215, United States
Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina
Ciudad Autónoma de Buenos Aire, Buenos Aires, C1056ABI, Argentina
Clínica Coronel Suarez
Coronel Suárez, Buenos Aires, B7540GHD, Argentina
Hospital Italiano de La Plata | Clinical Research Department
La Plata, Buenos Aires, B1900, Argentina
Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina
Lanús, Buenos Aires, B1824, Argentina
Sanatorio Modelo Quilmes
Quilmes, Buenos Aires, 1878, Argentina
Corporación Médica de General San Martín
San Martín, Buenos Aires, 1650, Argentina
Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina
Zárate, Buenos Aires, B2800DGH, Argentina
Instituto Cardiovascular de Buenos Aires | Buenos Aires, Argentina
Buenos Aires, Buenos Aires F.D., C1428ART, Argentina
Hospital Militar Central "CIR. MY. C. Argerich"
Buenos Aires, Ciudad Auton. de Buenos Aires, 1426, Argentina
Centro de Especialidades Medicas (CEMEDIC)
Buenos Aires, Ciudad Auton. de Buenos Aires, C1440CFD, Argentina
CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina
Grupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante Department
Rosario, Santa Fe Province, 2000, Argentina
Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos
Rosario, Santa Fe Province, S2000DEJ, Argentina
Instituto de Cardiologia | Tucuman, AR
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Investigaciones Medicas IMOBA S.R.L.
Buenos Aires, C1056ABH, Argentina
Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina
Corrientes, 3400, Argentina
Clínica Privada del Prado
Córdoba, 5000, Argentina
Instituto Médico DAMIC- Fundación Rusculleda
Córdoba, 5003, Argentina
Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
Santa Fe, S3000FWO, Argentina
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
Gosford Hospital
Gosford, New South Wales, 2250, Australia
John Hunter Hospital
New Lambton Heights, New South Wales, 2305, Australia
The Wesley Hospital
Auchenflower, Queensland, 4066, Australia
The Prince Charles Hospital
Chermside, Queensland, 4032, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, 4029, Australia
Gold Coast University Hospital
Southport, Queensland, 4215, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, 5068, Australia
Advara HeartCare Ringwood
Bundoora, Victoria, 3083, Australia
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Carinthia, 9020, Austria
Universitätsklinikum St. Pölten
Sankt Pölten, Lower Austria, 3100, Austria
Medizinische Universität Graz
Graz, Styria, 8036, Austria
Krankenhaus St. Josef Braunau | Innere Medizin I
Braunau am Inn, Upper Austria, 5280, Austria
Landeskrankenhaus Feldkirch
Feldkirch, Vorarlberg, 6807, Austria
Uniklinikum Salzburg - Landeskrankenhaus
Salzburg, 5020, Austria
Universitätsklinikum AKH Wien
Vienna, 1090, Austria
Imed19-privat
Vienna, 1190, Austria
Klinik Floridsdorf - Krankenhaus Nord
Vienna, 1210, Austria
Santa Casa de Misericórdia da Bahia
Salvador, Estado de Bahia, 50040-410, Brazil
Hospital do Coração do Brasil
Brasília, Federal District, 70390-700, Brazil
Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia
Goiânia, Goiás, 74605-020, Brazil
Quanta Diagnostico Por Imagem | Research and Innovation Department
Curitiba, Paraná, 80045-170, Brazil
Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa
Paraná, Paraná, 83430-000, Brazil
Fundação Universidade de Caxias do Sul
Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil
Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital Mae de Deus
Porto Alegre, Rio Grande do Sul, 90850-170, Brazil
FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil
Porto Alegre, Rio Grande do Sul, 91350-280, Brazil
MK Consultoria Médico Científica Ltda/Angiocor Blumenau
Blumenau, Santa Catarina, 89020-430, Brazil
Centro de Pesquisa Clinica do Coração | Aracaju, Brasil
Aracaju, Sergipe, 49055-530, Brazil
Hospital Felício Rocho
Belo Horizonte, São Paulo, 30110-130, Brazil
Campinas Clinical Research Institute (IPECC) | Campinas, Brazil
Campinas, São Paulo, 13060-080, Brazil
Instituto do Coração de Marilia | Marilia, Brasil
Marília, São Paulo, 17515-000, Brazil
Centro Avançado de Pesquisa para Diagnóstico - CAPED
Ribeirão Preto, São Paulo, 14026-020, Brazil
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
São Paulo, São Paulo, 13034-685, Brazil
IMC - Instituto de Moléstias Cardiovasculares Tatui
Tatuí, São Paulo, 18270-170, Brazil
Santa Casa de Misericórdia de Votuporanga
Votuporanga, São Paulo, 15500-003, Brazil
Eurolatino Pesquisas Medicas | Uberlandia, MG
Minas Gerais, 38400-368, Brazil
Ambulatory facility for specialized outpatient medical care
Burgas, 8000, Bulgaria
MHAT Haskovo
Haskovo, 6304, Bulgaria
MHAT Zdrave
Pazardzhik, 4400, Bulgaria
Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology
Pernik, 2300, Bulgaria
Medical Center Medconsult Pleven
Pleven, 5800, Bulgaria
Medical centre Hipokrat - N EOOD
Plovdiv, 4000, Bulgaria
Multiprofile Hospital for Active Treatment Medline | Cardiology Department
Plovdiv, 4000, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department
Plovdiv, 4004, Bulgaria
Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine
Shumen, 9700, Bulgaria
MHAT Hadzhi Dimitar
Sliven, 8800, Bulgaria
Second Medical Center Sofia EOOD
Sofia, 1202, Bulgaria
Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department
Sofia, 1233, Bulgaria
NMTH Tzar Boris III
Sofia, 1233, Bulgaria
Multiprofile Hospital for Active Treatment 'National Cardiology Hospital' EAD, Sofia
Sofia, 1309, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
Sofia, 1404, Bulgaria
Medical Center Hera
Sofia, 1510, Bulgaria
UMHAT Tsaritsa Joanna-ISUL EAD Sofia
Sofia, 1527, Bulgaria
MHAT Trakia
Stara Zagora, 6000, Bulgaria
Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department
Veliko Tarnovo, 5000, Bulgaria
Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department
Yambol, 8600, Bulgaria
Fraser Clinical Trials, Inc.
New Westminster, British Columbia, V3L 3W4, Canada
St. Boniface Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
G.A. Research Associates, Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
Dalhousie University - Queen Elizabeth II (QEII) Health Sciences Centre - Halifax Infirmary (HI)
Halifax, Nova Scotia, B3H 3A7, Canada
Brampton Clinical Trials
Brampton, Ontario, L6Z 4N5, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6, Canada
Vizel Cardiac Research
Cambridge, Ontario, N1R 7R1, Canada
London Health Sciences Centre (LHSC) - University Hospital
London, Ontario, N6A 5A5, Canada
KMH Cardiology Clinics Inc.
Mississauga, Ontario, L5K 2L3, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, M6B 3H7, Canada
Oakville Cardiovascular Research
Oakville, Ontario, L6K 3W7, Canada
Office of Dr. James Cha, MD
Oshawa, Ontario, L1J 2K1, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
Corcare
Scarborough Village, Ontario, M1B 5N1, Canada
Medicus MFC Inc.
Toronto, Ontario, M4P 1E4, Canada
Mount Sinai Hospital
Toronto, Ontario, M5G 1X5, Canada
Women's College Hospital
Toronto, Ontario, M5S 1B2, Canada
Centre intégré de santé et de services sociaux de Laval, Hôp
Laval, Quebec, H7M 3L9, Canada
Clinique Sante Cardio MC
Montreal, Quebec, H1T 3Y7, Canada
Centre Hospitalier de l'Université de Montréal-CHUM
Montreal, Quebec, H2X 0C1, Canada
Montreal General Hospital
Montreal, Quebec, H4A 3J1, Canada
Fujian Provincial Hospital
Fuzhou, Fujian, 350001, China
Lanzhou University Second Hospital
Lanzhou, Gansu, 730030, China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510000, China
The First Affiliated Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, 510080, China
Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ.
Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Guangzhou University of TCM
Guangzhou, Guangdong, 510405, China
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, 510515, China
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630, China
Guizhou Provincial People's Hospital
Guiyang, Guizhou, 550002, China
Hainan Provincial People's Hospital
Haikou, Hainan, 570311, China
Hainan Third People's Hospital (Province Nongken Sanya Hopt)
Sanya, Hainan, 572000, China
The First Hospital of Hebei Medical Univesity
Shijiazhuang, Hebei, 050000, China
Daqing Oilfield General Hospital
Daqing, Heilongjiang, 163311, China
Xinxiang Central Hospital
Xinxiang, Henan, 453000, China
The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410000, China
Changsha Central Hospital
Changsha, Hunan, 410004, China
Hunan Provincial People's Hospital
Changsha, Hunan, 410005, China
Huai'an First People's Hospital, Nanjing Medical University
Huai'an, Jiangsu, 223300, China
The First People's Hospital of Lianyungang
Lianyungang, Jiangsu, 222002, China
The Second Affiliated Hospital of Nanjing Medical university
Nanjing, Jiangsu, 210000, China
NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
Nanjing, Jiangsu, 210008, China
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009, China
Jiangsu Province Hospital
Nanjing, Jiangsu, 210029, China
Nanjing Jiangning Hospital
Nanjing, Jiangsu, 211103, China
1st Affiliated hospital of Soochow University
Suzhou, Jiangsu, 215000, China
Jilin Province People's Hospital
Changchun, Jilin, 130021, China
The First Hospital of Jilin University
Changchun, Jilin, 130061, China
Panjin Liaohe Oilfield Gem Flower Hospital
Panjin, Liaoning, 124010, China
Yinchuan No.1 People's Hospital
Yinchuan, Ningxia, 750001, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004, China
Shaanxi Provincial People's Hospital
Xi'an, Shaanxi, 710068, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi Sheng, 710061, China
Jinan Central Hospital
Jinan, Shandong, 250013, China
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, 030012, China
West China Hospital Sichuan University
Chengdu, Sichuan, 610041, China
SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
Chengdu, Sichuan, 610072, China
People's Hospital of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang, 830001, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830011, China
1st Affiliated Hospital of College Medicine, Zhejiang Univ.
Hangzhou, Zhejiang, 310003, China
Beijing Anzhen Hospital, Capital Medical University
Beijing, 100029, China
Beijing Friendship Hospital, Capital Medical University
Beijing, 100050, China
Beijing Tsinghua Changgung Hospital
Beijing, 102218, China
Shanghai Tongji Hospital of Tongji University
Shanghai, 200065, China
Shanghai East Hospital Affiated to Tongji University
Shanghai, 200100, China
Tianjin People's Hospital
Tianjin, 300000, China
Hospital Alma Mater de Antioquia
Medellín, Antioquia, 050010, Colombia
Hospital General de Medellin
Medellín, Antioquia, 050015, Colombia
Rodrigo Botero S.A.S
Medellín, Antioquia, 050021, Colombia
Sociedad Médica Rionegro SOMER S.A.
Rionegro, Antioquia, 054040, Colombia
Clínica de la Costa SAS
Baranquilla, Atlántico, 080020, Colombia
Corazón IPS S.A.S.
Barranquilla, Atlántico, 080020, Colombia
IPS Centro Cientifico Asistencial S.A.S
Barranquilla, Atlántico, 080020, Colombia
Caja de Compensación Familiar CAFAM
Bogotá, Bogota D.C., 111061, Colombia
Hospital Universitario Mayor-MÉDERI
Bogotá, Bogota D.C., 111411, Colombia
Cardiomet Cequin Sas
Armenia, Quindío Department, 630004, Colombia
Instituto del Corazón de Bucaramanga
Bucaramanga, Santander Department, 680002, Colombia
Mediservis del Tolima IPS S.A.S
Ibagué, Tolima Department, 730008, Colombia
Clínica Imbanaco S.A.S
Cali, Valle del Cauca Department, 760042, Colombia
Fundacio del Caribe para la Investigacio Bio-Medica (BIOS)
Barranquilla, 080001, Colombia
Fundación Cardioinfantil
Bogotá, 110131, Colombia
Hospital Universitario de San Ignacio
Bogotá, 110231, Colombia
Hospital Universitario Clínica San Rafael
Bogotá, 110621, Colombia
Hospital San Vicente Fundación
Medellín, 050010, Colombia
Clinica Cardio VID
Medellín, 050034, Colombia
Fakultní nemocnice Brno - Interní kardiologická klinika
Brno, South Moravian, 625 00, Czechia
Kardiologie MUDr. Libor Nechvatal s.r.o.
Brno, 602 00, Czechia
Kardiologicka ambulance Brno s.r.o.
Brno, 612 00, Czechia
Kardio Chlumec s.r.o.- Kardiologicka ambulance
Chlumec nad Cidlinou, 503 51, Czechia
Kardiologicka ambulance
Český Krumlov, 381 01, Czechia
Poliklinika Dolní Brežany
Dolní Břežany, 252 41, Czechia
Fakultní Nemocnice Hradec Kralové
Hradec Králové, 500 05, Czechia
Kromerizska nemocnice a.s.
Kroměříž, 767 01, Czechia
LUNACOR, Centrum pro choroby srdce a cev
Kroměříž, 767 01, Czechia
Krajska Nemocnice Liberec
Liberec, 460 63, Czechia
KardioBusak s.r.o.
Louny, 440 01, Czechia
Fakultni nemocnice Plzen
Pilsen, 301 00, Czechia
Kardiologicka a interni ambulance
Písek, 39701, Czechia
Polabska zdravotni, s.r.o.
Poděbrady, 290 01, Czechia
Všeobecná fakultní nemocnice v Praze - II. interní klinika - klinika kardiologie a angiologie
Prague, 12808, Czechia
Institut Klinicke a Experimentalni Mediciny
Prague, 140 21, Czechia
Fakultní nemocnice v Motole
Prague, 150 06, Czechia
Ustredni vojenska nemocnice Praha
Prague, 169 02, Czechia
Affidea Praha s.r.o - Kardiologie
Praha 11 - Chodov, 148 00, Czechia
Kardio s.r.o.
Třebíč, 67401, Czechia
Nemocnice Podlesi
Třinec, 73961, Czechia
Angiocor s.r.o.
Zlín, 760 01, Czechia
Nemocnice Znojmo
Znojmo, 669 02, Czechia
Aarhus Universitetshospital - Børn og Unge
Århus N, 8200, Denmark
Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed
Esbjerg, 6700, Denmark
Capital Region | Gentofte Hospital - Cardiology Research
Hellerup, 2900, Denmark
Capital Region | Herlev Hospital - Heart Disease Department
Herlev, 2730, Denmark
Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research
Herning, 7400, Denmark
Region Sjælland | Holbaek Sygehus - Cardiology department
Holbæk, 4300, Denmark
Hvidovre Hospital - Hjertesygdomme
Hvidovre, 2650, Denmark
Regionshospitalet Randers - Medicinsk afdeling
Randers, 8930, Denmark
Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit
Svendborg, 5700, Denmark
HUS Jorvin sairaala
Espoo, 2740, Finland
Tampereen yliopistollinen sairaala
Tampere, 33520, Finland
Turun yliopistollinen keskussairaala
Turku, 20520, Finland
Herzklinik Ulm GbR
Ulm, Baden-Wurttemberg, 89077, Germany
Klinikum der Universität Würzburg
Würzburg, Bavaria, 97080, Germany
Medizinische Hochschule Hannover (MHH)
Hanover, Lower Saxony, 30625, Germany
Städt. Kliniken Bielefeld gGmbH
Bielefeld, North Rhine-Westphalia, 33604, Germany
Sana-Klinikum Remscheid GmbH
Remscheid, North Rhine-Westphalia, 42859, Germany
Forschungszentrum Ruhr | KliFoCenter GmbH
Witten, North Rhine-Westphalia, 58455, Germany
Universitätsklinikum Hamburg Eppendorf (UKE)
Hamburg, 20246, Germany
KAT General Hospital of Athens
Kifissia, Attica, 14561, Greece
University General Hospital of Alexandroupoli
Alexandroupoli, 68100, Greece
General Hosp of Athens "Korgialenio-Benakeio" RCH
Ampelokipi - Athens, 11526, Greece
HIPPOKRATION General Hospital of Athens
Athens, 115 27, Greece
G. GENNIMATAS General State Hospital of Athens
Athens, 11527, Greece
ALEXANDRA General Hospital of Athens
Athens, 11528, Greece
University General Hospital of Athens "ATTIKON"
Chaïdári, 12462, Greece
University General Hospital of Heraklion - Department of Paediatrics
Heraklion, 711 10, Greece
University General Hospital of Larissa
Larissa, 41110, Greece
Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA
Nea Ionia, 14233, Greece
University General Hospital of Patras
Pátrai, 26504, Greece
Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'
Thessaloniki, 54642, Greece
Prince of Wales Hospital
Hong Kong, N.T, MISSING, Hong Kong
Princess Margaret Hospital
Hong Kong, MISSING, Hong Kong
Queen Mary Hospital
Hong Kong, MISSING, Hong Kong
Queen Elizabeth Hospital Hong Kong
Hong Kong, Hong Kong
Cardiomobile Egeszsegugyi Szolgaltato Kft.
Balatonfüred, 8230, Hungary
Budai Irgalmasrendi Korhaz
Budapest, 1023, Hungary
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
Budapest, 1024, Hungary
University of Semmelweis/ Semmelweis Egyetem
Budapest, 1083, Hungary
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1134, Hungary
Budapesti Uzsoki Utcai Kórház
Budapest, 1145, Hungary
Bugat Pal Korhaz
Gyöngyös, 3200, Hungary
Pharma4Trial Kft.
Gyöngyös, 3200, Hungary
Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny
Hódmezővásárhely, 6800, Hungary
Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz
Miskolc, 3526, Hungary
Nagykanizsai Kanizsai Dorottya Korhaz
Nagykanizsa, 8800, Hungary
Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
Nyíregyháza, 4400, Hungary
Coromed Smo Kft
Pécs, 7623, Hungary
Da Vinci Maganklinika
Pécs, 7635, Hungary
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont
Szeged, 6720, Hungary
Tolna Varmegyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz
Szentes, 6600, Hungary
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz - II. Belgyogyaszat
Székesfehérvár, 8000, Hungary
KEM hospital
Berlin, Maharashtra, 10365, India
Deenanath Mangeshkar Hospital
Pune, Maharashtra, 411004, India
Max Super Speciality Hospital, Saket
New Delhi, National Capital Territory of Delhi, 110017, India
Safdarjung Hospital
New Delhi, National Capital Territory of Delhi, 110029, India
The Madras Medical Mission (MMM)
Chennai, Tamil Nadu, 600037, India
Assuta Ashdod Public Hospital (R.A)
Ashdod, 7747629, Israel
Barzilai Ashkelon University Medical Center | Cardiology Department
Ashkelon, 7830604, Israel
Rambam Health Corporation
Haifa, 3109601, Israel
Bnai Zion Medical Center | Cardiology Department
Haifa, 3339419, Israel
Lady Davis Carmel Medical Center
Haifa, 3436212, Israel
Hadassah Hebrew University Hospital Ein Kerem
Jerusalem, 9112001, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Health Corporation of Galilee Medical Center
Nahariya, 2210001, Israel
Chaim Sheba Medical Center
Ramat Gan, 5262000, Israel
Kaplan Medical Center
Rehovot, 7610001, Israel
Health Corporation of the Ziv Medical Center (R.A.)
Safed, 1311001, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
Poria Medical Center | Cardiovascular Department
Tiberias, 1528001, Israel
Shamir Medical Center (Assaf Harofeh)
Ẕerifin, 7030000, Israel
Azienda Ospedaliero Universitaria Renato Dulbecco
Catanzaro, Calabria, 88100, Italy
Azienda Ospedaliera Universitaria Federico II Di Napoli - DAI Emergenze Cardiovascolari, Medicina Clinica e Dell'Invecchiamento
Napoli, Campania, 80131, Italy
Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Medicina A
Bologna, Emilia-Romagna, 40133, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Medicina Interna Cardiovascolare
Bologna, Emilia-Romagna, 40138, Italy
University Hospital Of Ferrara
Ferrara, Emilia-Romagna, 44124, Italy
Azienda Unita Sanitaria Locale Di Piacenza
Piacenza, Emilia-Romagna, 29121, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1
Bergamo, Lombardy, 24127, Italy
Azienda Socio-Sanitaria Territoriale Del Garda
Brescia, Lombardy, 25085, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Cardiologia
Brescia, Lombardy, 25123, Italy
Azienda Socio Sanitaria Territoriale Di Cremona
Cremona, Lombardy, 26100, Italy
Centro Cardiologico Monzino S.p.A.
Milan, Lombardy, 20138, Italy
ASST di Monza
Monza Brianza, Lombardy, 20832, Italy
IRCCS Fondazione Policlinico San Matteo
Pavia, Lombardy, 27100, Italy
Istituti Clinici Scientifici Maugeri S.p.A
Pavia, Lombardy, 27100, Italy
Humanitas Mirasole S.p.A. - Cardiologia Clinica e Interventistica
Rozzano, Lombardy, 20089, Italy
ASST Sette Laghi_Ospedale Galmarini - Medicina Generale
Tradate, Lombardy, 21049, Italy
Azienda Socio Sanitaria Territoriale Della Brianza _Ospedale di Vimercate - Medicina Interna
Vimercate, Lombardy, 20871, Italy
A.O.U. Maggiore della Carità
Novara, Piedmont, 28100, Italy
Azienda Unita' Sanitaria Locale Toscana Sud Est
Cortona, Tuscany, 52040, Italy
Azienda Ospedaliera Universitaria Senese
Siena, Tuscany, 53100, Italy
A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Cardiologia
Perugia, Umbria, 06129, Italy
Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Cardiologia
Verona, Veneto, 37126, Italy
Kasugai Municipal Hospital
Kasugai, Aichi-ken, 486-8510, Japan
TOYOTA Memorial Hospital
Toyota, Aichi-ken, 471-8513, Japan
Funabashi Municipal Medical Center
Funabashi, Chiba, 273-8588, Japan
Steel Memorial Yawata Hospital
Kitakyushu, Fukuoka, 805-8508, Japan
Onga Nakama Medical Association Onga Hospital
Onga-gun, Fukuoka, 811-4342, Japan
Ogaki Municipal Hospital
Ōgaki, Gifu, 503-8502, Japan
Shobara Red Cross Hospital
Shōbara, Hiroshima, 727-0013, Japan
Hyogo Prefectural HarimaHimeji General Medical Center
Himeji, Hyōgo, 670-8560, Japan
National Hospital Organization Kobe Medical Center
Kobe, Hyōgo, 654-0155, Japan
Higashi Takarazuka Satoh Hospital
Takarazuka, Hyōgo, 665-0873, Japan
JA Toride Medical Center
Toride, Ibaraki, 302-0022, Japan
Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office
Hakusan, Ishikawa-ken, 924-8588, Japan
National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
Kanazawa, Ishikawa-ken, 920-8650, Japan
Iwate Prefectural Central Hospital
Morioka, Iwate, 020-0066, Japan
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, 760-8557, Japan
Mitoyo General Hospital | Kagawa, Japan
Toyohama-Cho,Kanonji-City, Kagawa-ken, 769-1695, Japan
Kitasato University Hospital
Sagamihara, Kanagawa, 252-0375, Japan
Sagamihara Kyodo Hospital
Sagamihara, Kanagawa, 252-5188, Japan
Japan Red Cross Society Azumino Hospital
Azumino, Nagano, 399-8292, Japan
National Hospital Organization Shinshu Ueda Medical Center
Ueda, Nagano, 386-8610, Japan
R.I.A.C Naha City Hospital
Naha, Okinawa, 902-8511, Japan
Kishiwada Tokushukai Hospital
Kishiwada, Osaka, 596-0042, Japan
Takatsuki Red Cross Hospital
Takatsuki, Osaka, 569-1045, Japan
Ageo Central General Hospital
Ageo, Saitama, 362-8588, Japan
Kawaguchi Cardiovascular and Respiratory Hospital
Kawaguchi, Saitama, 333-0842, Japan
Saitama Sekishinkai Hospital
Sayama, Saitama, 350-1305, Japan
National Hospital Organization Hamada Medical Center
Hamada, Shimane, 697-8511, Japan
Nishiarai Heart Central Clinic
Adachi-ku, Tokyo, 123-0845, Japan
Minamino Cardiovascular Hospital
Hachiōji, Tokyo, 192-0918, Japan
National Hospital Organization Tokyo Medical Center
Meguro-ku, Tokyo, 152-8902, Japan
Toho University Omori Medical Center
Ōta-ku, Tokyo, 143-8541, Japan
Japan Organization of Occupational Health and Safety Sanin Rosai Hospital
Yonago, Tottori, 683-8605, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni, Yamaguchi, 740-8510, Japan
JCHO Shimonoseki Medical Center
Shimonoseki, Yamaguchi, 750-0061, Japan
Fukuoka University Nishijin Hospital
Fukuoka, 814-8522, Japan
Gifu Prefectural General Medical Center
Gifu, 500-8717, Japan
National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008, Japan
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
Miyazaki Medical Association Hospital
Miyazaki, 880-2102, Japan
Shinrakuen Hospital
Niigata, 950-2087, Japan
The Sakakibara Heart Institute of Okayama
Okayama, 700-0804, Japan
Osaka Police Hospital | Clinical Research and Trial Center
Osaka, 543-0035, Japan
Osaka General Medical Center
Osaka, 558-8558, Japan
Social Corporation Keigakukai Minamiosaka Hospital
Osaka, 559-0012, Japan
Oita Prefectural Hospital
Ōita, 870-8511, Japan
Toyama University Hospital
Toyama, 930-0194, Japan
Seiyu Memorial Hospital
Wakayama, 649-6335, Japan
Daugavpils Regional Hospital
Daugavpils, LV-5417, Latvia
Jelgava Outpatient Clinic
Jelgava, LV-3001, Latvia
Liepaja Regional Hospital
Liepāja, LV-3414, Latvia
1st Riga Clinical Hospital
Riga, LV-1001, Latvia
P. Stradins Clinical University Hospital
Riga, LV-1002, Latvia
GK Neiroklinika
Riga, LV-1024, Latvia
Gita Rancane - cardiology private practice
Ventspils, LV-3601, Latvia
UAB "Klinikiniai sprendimai" Alytus
Alytus, LT-63200, Lithuania
LUHS Kauno Hospital (Laisves ave.)
Kaunas, LT-44320, Lithuania
LUHS Kauno Hospital (Josvainiu str.)
Kaunas, LT-47144, Lithuania
Saules family medicine center
Kaunas, LT-49449, Lithuania
Klaipedos Jurininku Ligonine
Klaipėda, LT-92288, Lithuania
Siauliai Republican hospital
Šiauliai, 76231, Lithuania
Vilnius University Hospital Santaros Klinikos
Vilnius, LT-08661, Lithuania
Gleneagles Penang Medical Center
George Town, 10050, Malaysia
Institute Jantung Negara
Kuala Lumpur, 50400, Malaysia
University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Hospital Sultan Idris Shah Serdang (Hospital Serdang)
Kuala Selangor, 43000, Malaysia
Hospital Raja Permaisuri Bainun
Perak, 30450, Malaysia
Hospital Pulau Pinang
Pulau Pinang, 10450, Malaysia
Sarawak Heart Centre
Sarawak, 94300, Malaysia
Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV
Torreón, Coahuila, 27000, Mexico
Hospital General de Acapulco
Acapulco de Juárez, Guerrero, 39910, Mexico
Consultorio de Medicina Especializada del Sector Privado
Guadalajara, Jalisco, 44657, Mexico
Fundación de Atencion e Investigacion Medica Lindavista SC
Alcaldia Gustavo A. Madero, Mexico City, 7300, Mexico
Hospital de Jesús
Alcaldía Cuauhtemoc, Mexico City, 6090, Mexico
Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ)
Querétaro City, Querétaro, 76000, Mexico
Hospital Ángeles de Xalapa
Xalapa, Veracruz, 91193, Mexico
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro de Investigacion y Atencion Integral Durango S.C.
Durango, 34080, Mexico
Catharina Ziekenhuis
Eindhoven, North Brabant, 5623 EJ, Netherlands
Ziekenhuis Groep Twente
Almelo, 7609 PP, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Slingeland Ziekenhuis
Doetinchem, 7009 BL, Netherlands
Ziekenhuis Gelderse Vallei
Ede, 6716 RP, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Ziekenhuis St. Jansdal
Harderwijk, 3844 DG, Netherlands
Tergooiziekenhuizen-Blaricum
Hilversum, 1212 VG, Netherlands
Maastricht UMC
Maastricht, 6229 HX, Netherlands
Isala Meppel
Meppel, 7943 KA, Netherlands
Antonius Ziekenhuis Sneek
Sneek, 8601 ZR, Netherlands
ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis)
Tilburg, 5042 AD, Netherlands
Maxima Medisch Centrum, locatie Veldhoven
Veldhoven, 5504 DB, Netherlands
University of Auckland
Auckland, 1023, New Zealand
Christchurch Heart Institute
Christchurch, 8140, New Zealand
Dunedin Hospital
Dunedin, 9016, New Zealand
P3 Research Ltd Tauranga
Hawkes Bay, 4130, New Zealand
Hutt Hospital
Lower Hutt, 5010, New Zealand
Nelson Hospital
Nelson, 7042, New Zealand
P3 Research
Tauranga, 3110, New Zealand
KLIMED Marek Klimkiewicz
Bialystok, 15-704, Poland
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, 85-065, Poland
Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej
Gdynia, 81-519, Poland
Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II
Grodzisk Mazowiecki, 05 825, Poland
CLINICAL MEDICAL RESEARCH Sp. z o. o.
Katowice, 40-156, Poland
Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn
Krakow, 31-271, Poland
IMEDICA Centrum Medyczne
Lublin, 20-068, Poland
NZOZ "Twoja Przychodnia" Sp. z o.o.
Lublin, 20-857, Poland
Zechowicz Medeusz-Plus Lekarska Spolka Partnerska
Olsztyn, 10-010, Poland
Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.
Oświęcim, 32-600, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, 61-848, Poland
Szpital Specjalistyczny SPZOZ
Puławy, 24-100, Poland
NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych
Sopot, 81-717, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
Szczecin, 71-500, Poland
Gessek Jacek Prywatny Gabinet Lekarski
Torun, 87-100, Poland
Hospital da Senhora da Oliveira | Clinical Research Department
Guimaraes, Braga, Braga District, 4835-044, Portugal
Centro Hospitalar Universitario Cova de Beira | Clinical Research Department
Covilha, Castelo Branco District, 6200-251, Portugal
Hospital Pedro Hispano | Clinical Research Center
Matosinhos Municipality, Porto District, 4464-513, Portugal
Luz Saude | Hospital da Luz Setubal - Clinical Research Department
Setúbal, Setúbal District, 2900-722, Portugal
Hospital Prof. Dr. Fernando Fonseca
Amadora, 2720-276, Portugal
BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos
Aveiro, 3810-501, Portugal
Unidade Local de Saúde de Coimbra, E.P.E. - Cardiology Department - Research Unit
Coimbra, 3004-561, Portugal
ULSG - Unidade Local de Saude da Guarda
Guarda, 6300-659, Portugal
Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
Leiria, 2410-197, Portugal
Unidade Local De Saúde De Lisboa Ocidental E.P.E.
Lisbon, 1449-005, Portugal
Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
Lisbon, 1500-650, Portugal
Centro Hospitalar Universitario do Porto
Porto, 4099-001, Portugal
CMI. Dr. Podoleanu Cristian
Târgu Mureş, Mureș County, TBC, Romania
Spitalul Clinic Municipal de Urgenta "Timisoara"
Timișoara, Timiș County, 300040, Romania
Municipal Clinical Emergency Hospital of Timisoara
Timișoara, Timiș County, 300254, Romania
Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare
Baia Mare, 430031, Romania
S.C Thera Card S.R.L
Brasov, 500102, Romania
Emergency County Hospital, Braila
Brăila, 810318, Romania
Emergency Institute for Cardiovascular Diseases
Bucharest, 22322, Romania
Spitalul Universitar de Urgenta Bucuresti
Bucharest, 50098, Romania
Spitalul Clinic de Urgenta "Sf. Pantelimon"
Bucharest, TBC, Romania
Spitalul Clinic Judetean De Urgenta Craiova
Craiova Dolj, 200642, Romania
Sf. Ap. Andrei Emergency Clinical County Hospital Galati
Galati, 800578, Romania
S.C. CARDIOMED S.R.L. Iasi
Iași, 700732, Romania
S.C. Sal Med SRL
Piteşti, TBC, Romania
S.C. Cardio Med S.R.L.
Târgu Mureş, 540124, Romania
Institutul De Boli Cardiovasculare Timisoara
Timișoara, 300310, Romania
SBHI of Sverdlovsk Region Aramil City Hospital
Aramil, 624003, Russia
First City Clinical Hospital n.a. E.E. Volosevich
Arkhangelsk, 163001, Russia
Altai Regional Cardiological Dispensary
Barnaul, 656055, Russia
SBEI "Chita State Medical Academy"
Chita, 672000, Russia
Izhevsk City Clinical Hospital #9
Izhevsk, 426063, Russia
Kazan Federal University
Kazan', 420043, Russia
Clinical Diagnostic Center
Kazan', 420101, Russia
Sci-Res. Institute of Complex Cardiovascular Disorders
Kemerovo, 650002, Russia
Center of cardiology and neurology
Kirov, 610014, Russia
Research center of therapy and prophylactic medicine
Moscow, 101990, Russia
City Clinical Hospital #29 n.a. N.E. Bauman - Clinical-Diagnostic dept
Moscow, 111020, Russia
City clinical hospital n.a. V.V. Vinogradov
Moscow, 117292, Russia
Moscow State University n.a. M.V. Lomonosov
Moscow, 119192, Russia
Russian Clinical and Research Center of Gerontology
Moscow, 129226, Russia
State Novosibirsk Regional Clinical Hospital
Novosibirsk, 630087, Russia
Omsk Region "Clinical Health Unit No. 9"
Omsk, 644018, Russia
Penza Regional Clinical Hospital n.a. N.N. Burdenko
Penza, 440026, Russia
Perm Regional Hospital for War Veterans
Perm, 614097, Russia
Rostov-on-Don Emergency Clinical Hospital
Rostov-on-Don, 344068, Russia
SBI of the Ryazan region "Regional clinical hospital"
Ryazan, 390039, Russia
Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze
Saint Petersburg, 192242, Russia
St. Petersburg Clinical Hospital of RAS
Saint Petersburg, 194017, Russia
LLC Astarta
Saint Petersburg, 199226, Russia
Samara Regional Clinical Cardiology Dispensary n.a. Polyakov
Samara, 443070, Russia
Clinical Hospital #3 n.a. S.R. Mirotvortsev
Saratov, 410054, Russia
Scientific Research Institute of Cardiology
Tomsk, 634012, Russia
Tomsk Regional Clinical Hospital
Tomsk, 634063, Russia
Sverdlovsk Regional Clinical Hospital #1
Yekaterinburg, 620102, Russia
Stredoslovensky ustav srdcovych a cievnych chorob, a.s.
Banská Bystrica, 974 01, Slovakia
ALIAN s.r.o.
Bardejov, 085 01, Slovakia
Nemocnica svateho Michala, a.s.
Bratislava, 81108, Slovakia
Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
Bratislava, 813 69, Slovakia
Narodny ustav srdcovych a cievnych chorob, a.s
Bratislava, 833 48, Slovakia
Centrum interv. neuroradiologie a endovaskularnej liecby
Bratislava, 84103, Slovakia
Kardiosanus | Bratislava, Slovakia
Bratislava, 84107, Slovakia
Nemocnica s poliklinikou Brezno, n.o.
Brezno, 977 01, Slovakia
Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
Dolný Kubín, 026 14, Slovakia
JG-COR s.r.o.
Košice, 040 01, Slovakia
Medical Group Kosice s.r.o. | Kosice, Slovakia
Košice, 04001, Slovakia
KARDIO-ANGIO s.r.o.
Levice, 93401, Slovakia
KardioMed s.r.o.
Lučenec, 984 01, Slovakia
MEDI M&M, s.r.o.
Moldava nad Bodvou, 045 01, Slovakia
Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department
Nitra, 949 01, Slovakia
KARDIOMED NZ s.r.o.
Nové Zámky, 940 01, Slovakia
MEDISPOL s.r.o.
Prešov, 08001, Slovakia
COR, s.r.o
Šahy, 936 01, Slovakia
Medivasa s.r.o.
Žilina, 1001, Slovakia
Yonsei University Wonju Christian Hospital
Wŏnju, Gang''weondo, 26426, South Korea
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggido, 14068, South Korea
Bundang Cha Hospital
Seongnam-si, Gyeonggido, 13496, South Korea
Chungbuk National University Hospital
Cheongju-si, North Chungcheong, 28644, South Korea
Severance Hospital, Yonsei University Health System
Seoul, Seoul Teugbyeolsi, 03722, South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 3080, South Korea
Dong-A University Hospital
Busan, 49201, South Korea
Pusan National University Hospital
Busan, 49241, South Korea
Chung Nam National University Hospital
Daejeon, 35015, South Korea
Chonnam National University Hospital
Gwangju, 501-757, South Korea
Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial
Ferrol, A Coruña, 15405, Spain
Hospital Vega Baja De Orihuela - Medicina Interna
San Bartolomé, Alicante, 03314, Spain
Hospital Santa María del Puerto - Medicina Interna
El Puerto de Santa María, Cádiz, 11500, Spain
Hospital Virgen del Camino - Medicina Interna
Sanlúcar de Barrameda, Cádiz, 11540, Spain
Hospital Virgen De Las Montanas - Medicina Interna
Villamartín, Cádiz, 11650, Spain
Hospital Universitario de Gran Canaria Dr. Negrin - Cardiologia
Las Palmas de Gran Canaria, Las Palmas, 35010, Spain
Hospital Universitario Virgen De La Victoria - Cardiologia
Málaga, Málaga, 29010, Spain
Hospital Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
Hospital Alta Resolucion de Utrera - Cardiologia
Utrera, Sevilla, 41710, Spain
Instituto Medico Quirurgico San Rafael S.A. - Cardiologia
A Coruña, 15006, Spain
Hospital del Mar
Barcelona, 08003, Spain
Ciutat Sanitaria i Universitaria de la Vall d'Hebron
Barcelona, 08035, Spain
Hospital Universitari de Bellvitge (HUB)
Barcelona, 8908, Spain
Hospital Universitario Virgen De Las Nieves - Cardiologia
Granada, 18014, Spain
Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Medicina Interna
Lleida, 25198, Spain
Hospital Universitario La Zarzuela - Cardiologia
Madrid, 28023, Spain
Hospital Ramón y Cajal | Medicina Interna
Madrid, 28034, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario Virgen de Valme - Medicina Interna
Seville, 41014, Spain
Hospital Clinico Universitario de Valencia (CHUV)
Valencia, 46010, Spain
Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Universitario Y Politecnico La Fe - Cardiologia
Valencia, 46026, Spain
Hospital de Manises - Medicina Interna
Valencia, 46940, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Kaohsiung, 807377, Taiwan
Changhua Christian Hospital
Changhua, 50006, Taiwan
Mackay Memorial Hospital - Hsinchu Branch
Hsinchu, 300, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipei Medical University Hospital
Taipei, 100, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Chang Gung Memorial Hospital at Linkou
Taoyuan District, 33305, Taiwan
Afyonkarahisar Saglik Bilimleri Universitesi
Afyonkarahisar, 3218, Turkey (Türkiye)
Saglik Bilimleri Universitesi Antalya EA Hastanesi
Antalya, 7100, Turkey (Türkiye)
Trakya Univ. Tip Fak.
Edirne, 22030, Turkey (Türkiye)
Eskisehir Osmangazi Universitesi Tip Fakultesi
Eskişehir, 26480, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi
Istanbul, 34098, Turkey (Türkiye)
Istanbul Universitesi Kardiyoloji Enstitusu
Istanbul, 34304, Turkey (Türkiye)
Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.
Istanbul, TBC, Turkey (Türkiye)
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35340, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi
Kayseri, 38039, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi
Kocaeli, 41380, Turkey (Türkiye)
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi
Konya, 42080, Turkey (Türkiye)
Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti
Kütahya, 43040, Turkey (Türkiye)
Mersin Universitesi Tip Fakultesi
Mersin, 33079, Turkey (Türkiye)
MNPE "Cherkasy Regional Cardiology Center" - Department of Coronary Heart Disease and Non-Coronary Myocardial Diseases
Cherkasy, 18009, Ukraine
Clinical Emergency Hospital" of Dnipro City Council - Department of Cardiology
Dnipro, 49006, Ukraine
National Institute of Therapy L.T.Maloyi, Department of Chronic Non-Communicable Diseases
Kharkiv, 61039, Ukraine
Regional Dispensary of Radiation Protection of Population - Cardiology Department
Kharkiv, 61166, Ukraine
MNPE "City Clinical Hospital No. 8" of the Kharkiv City Council, Cardiology Department No. 2
Kharkiv, 61176, Ukraine
Municipal Non-Profit Enterprise "Kyiv City Clinical Hospital No. 1" - Department of Cardiology
Kiev, 02 091, Ukraine
Medical Center "Medbud" - Treatment and prophylactic department
Kyiv, 03037, Ukraine
National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Cardiac Arrhythmias
Kyiv, 03151, Ukraine
National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Heart Failure
Kyiv, 03151, Ukraine
National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Hypertension
Kyiv, 03151, Ukraine
LLC "Medical Center "Consilium Medical", Clinical and Consultative Departmen 1
Kyiv, 04050, Ukraine
Railway Clinical Hospital #2
Kyiv, 3049, Ukraine
Lviv Regional Clinical Treatment and Diagnostic Cardiology Center, consulting polyclinic
Lviv, 79015, Ukraine
Poltava Regional Clinical Hospital. M.V. Sklifosovsky, Cardiology Department
Poltava, 36011, Ukraine
Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser, Infarction department
Uzhhorod, 880000, Ukraine
Vinnytsia Regional Clinical Hospital, Clinical Cardiology Department
Vinnytsia, 21018, Ukraine
Vinnytsia City Clinical Hospital #1, Therapeutic Department
Vinnytsia, 21029, Ukraine
Regional Medical Center for Cardiovascular Diseases-Heart failure department
Zaporizhzhia, 69005, Ukraine
Zaporizhia Municipal Clinical Hospital No.10, Cardiology Department
Zaporizhzhya, 69001, Ukraine
Zaporizhzhya City Emergency Care Hospital, Cardiology Department
Zaporizhzhya, 69005, Ukraine
Hospital No. 1 of the Zhytomyr City - consulting and treatment department Scientific and research center
Zhytomyr, 10002, Ukraine
Royal Bournemouth General Hospital
Bournemouth, Dorset, BH7 7DW, United Kingdom
Poole Hospital NHS Trust
Poole, Dorset, BH15 2JB, United Kingdom
Queen Elizabeth University Hospital
Glasgow, Glasgow City, G51 4TF, United Kingdom
North Hampshire Hospital
Basingstoke, Hampshire, RG24 9NA, United Kingdom
Lister Hospital
Stevenage, Hertfordshire, SG1 4AB, United Kingdom
Blackpool Victoria Hospital
Blackpool, Lancashire, FY3 8NR, United Kingdom
University Hospitals Leicester
Leicester, Leicestershire, LE3 9QP, United Kingdom
Wansbeck General Hospital
Ashington, Northumberland, NE63 9JJ, United Kingdom
Dudley Group NHS Foundation Trust ¦Russells Hall Hopsital - Oncology
Dudley, West Midlands, DY1 2HQ, United Kingdom
University Hospitals Sussex NHS Foundation Trust | St Richard's Hospital - Cardiology services
Chichester, West Sussex, PO19 6SE, United Kingdom
Hull University Teaching Hospitals NHS Trust | Castle Hill Hospital - Cardiology
Cottingham, HU16 5JQ, United Kingdom
NHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology
Glasgow, G31 2ER, United Kingdom
Manchester Royal Infirmary
Manchester, M13 9WL, United Kingdom
Great Western Hospital
Swindon, SN3 6BB, United Kingdom
Related Publications (34)
Bhatt AS, Chatur S, Claggett BL, Lay-Flurrie J, Viswanathan P, Vardeny O, Kosiborod MN, Sharma K, Solomon SD, Vaduganathan M. Gamified Behavioral Science Intervention to Enhance Trial Enrollment: An Embedded Study Within the FINEARTS-HF Trial. JACC Heart Fail. 2024 Nov;12(11):1939-1941. doi: 10.1016/j.jchf.2024.05.002. Epub 2024 May 11. No abstract available.
PMID: 38944793RESULTJhund PS, Talebi A, Henderson AD, Claggett BL, Vaduganathan M, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Solomon SD, McMurray JJV. Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis. Lancet. 2024 Sep 21;404(10458):1119-1131. doi: 10.1016/S0140-6736(24)01733-1. Epub 2024 Sep 1.
PMID: 39232490RESULTKondo T, Henderson AD, Docherty KF, Jhund PS, Vaduganathan M, Solomon SD, McMurray JJV. Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? J Am Coll Cardiol. 2024 Nov 26;84(22):2233-2240. doi: 10.1016/j.jacc.2024.08.033. Epub 2024 Sep 1.
PMID: 39217560RESULTOstrominski JW, Aggarwal R, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD, Vaduganathan M. Generalizability of the Spectrum of Kidney Risk in the FINEARTS-HF Trial to U.S. Adults With Heart Failure. J Card Fail. 2024 Sep;30(9):1170-1174. doi: 10.1016/j.cardfail.2024.04.015. Epub 2024 May 11. No abstract available.
PMID: 38740173RESULTOstrominski JW, Claggett BL, Miao ZM, Mc Causland FR, Anand IS, Desai AS, Jhund PS, Lam CSP, Pfeffer MA, Pitt B, Zannad F, Zile MR, Bomfim Wirtz A, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD, Vaduganathan M. Cardiovascular-Kidney-Metabolic Overlap in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Trial-Level Analysis. J Am Coll Cardiol. 2024 Jul 9;84(2):223-228. doi: 10.1016/j.jacc.2024.05.005. Epub 2024 May 12. No abstract available.
PMID: 38744407RESULTSolomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperon G, Mareev V, Martinez FA, Melenovsky V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2024 Oct 24;391(16):1475-1485. doi: 10.1056/NEJMoa2407107. Epub 2024 Sep 1.
PMID: 39225278RESULTSolomon SD, Ostrominski JW, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Ma CS, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang SM, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperon G, Mareev V, Martinez FA, Melenovsky V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov LG, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Viswanathan P, McMurray JJV. Baseline characteristics of patients with heart failure with mildly reduced or preserved ejection fraction: The FINEARTS-HF trial. Eur J Heart Fail. 2024 Jun;26(6):1334-1346. doi: 10.1002/ejhf.3266. Epub 2024 May 11.
PMID: 38733212RESULTVaduganathan M, Claggett BL, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Desai AS, Jhund PS, Viswanathan P, Bomfim Wirtz A, Schloemer P, Lay-Flurrie J, McMurray JJV, Solomon SD. Finerenone in patients with heart failure with mildly reduced or preserved ejection fraction: Rationale and design of the FINEARTS-HF trial. Eur J Heart Fail. 2024 Jun;26(6):1324-1333. doi: 10.1002/ejhf.3253. Epub 2024 May 14.
PMID: 38742248RESULTVaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J, Viswanathan P, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Rossing P, Ruilope LM, Anker SD, Pitt B, Agarwal R, McMurray JJV, Solomon SD. Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes. Nat Med. 2024 Dec;30(12):3758-3764. doi: 10.1038/s41591-024-03264-4. Epub 2024 Sep 1.
PMID: 39218030RESULTVaduganathan M, Neuen BL, McCausland F, Jhund PS, Docherty KF, McMurray JJV, Solomon SD. Why Has it Been Challenging to Modify Kidney Disease Progression in Patients With Heart Failure? J Am Coll Cardiol. 2024 Nov 26;84(22):2241-2245. doi: 10.1016/j.jacc.2024.08.034. Epub 2024 Sep 1. No abstract available.
PMID: 39217561RESULTButt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Borentain M, Rohwedder K, Dayoub R, De Sanctis Y, Lam CSP, Senni M, Shah SJ, Voors AA, Bauersachs J, Fonseca C, Linssen GCM, Petrie MC, Schou M, Verma S, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone, Liver Biomarkers, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: An Analysis of FINEARTS-HF. Circ Heart Fail. 2026 Jan 29:e013201. doi: 10.1161/CIRCHEARTFAILURE.125.013201. Online ahead of print.
PMID: 41608790DERIVEDFoa A, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Henderson AD, Chatur S, Amarante F, Hofmeister L, Horvat-Broecker A, Kuhls S, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, McMurray JJV, Solomon SD. Finerenone-Related Risk of Hypotension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JACC Heart Fail. 2025 Dec 6:102779. doi: 10.1016/j.jchf.2025.102779. Online ahead of print.
PMID: 41364043DERIVEDOstrominski JW, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Rohwedder K, Brinker M, Schloemer P, McMurray JJV, Solomon SD, Vaduganathan M. Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS-HF trial. Eur J Heart Fail. 2025 Sep 8. doi: 10.1002/ejhf.70034. Online ahead of print.
PMID: 40916719DERIVEDLu H, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, Voors AA, Senni M, Zannad F, Pitt B, Shah SJ, Lam CSP, Scheerer MF, Scalise A, Mueller K, Berger M, Goea L, McMurray JJV, Solomon SD. Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JACC Heart Fail. 2025 Oct;13(10):102590. doi: 10.1016/j.jchf.2025.102590. Epub 2025 Aug 25.
PMID: 40857999DERIVEDChimura M, Jhund PS, Henderson AD, Yang M, Claggett BL, Desai AS, Rohwedder K, Lage A, Scalise A, Mueller K, Schou M, Lam CSP, Senni M, Voors AA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Efficacy and Tolerability of Finerenone According to the Use and Dosage of Diuretics: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Aug 13;10(10):979-89. doi: 10.1001/jamacardio.2025.2551. Online ahead of print.
PMID: 40802267DERIVEDButt JH, Jhund PS, Henderson AD, Claggett BL, Chiang CE, Linssen GCM, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, von Lewinski D, Lay-Flurrie J, Scalise A, Rohwedder K, Desai AS, Lam CSP, Senni M, Shah SJ, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone According to Frailty in Heart Failure: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Aug 1;10(8):829-840. doi: 10.1001/jamacardio.2025.1775.
PMID: 40531488DERIVEDPabon MA, Vardeny O, Vaduganathan M, Desai AS, Claggett BL, Kulac IJ, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Saldarriaga CI, Petrie MC, Merkely B, Borentain M, Mueller K, Viswanathan P, Amarante F, Morris A, McMurray JJV, Solomon SD. Finerenone in Heart Failure With Improved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Jul 1;10(7):740-745. doi: 10.1001/jamacardio.2025.1101.
PMID: 40397470DERIVEDChimura M, Yang M, Henderson AD, Jhund PS, Docherty KF, Claggett BL, Desai AS, Filippatos G, Gajos G, Mueller K, Glasauer A, Rohwedder K, Viswanathan P, Lam CSP, Sato N, Senni M, Voors AA, Zannad F, Yilmaz MB, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV; FINEARTS-HF Committees and Investigators. Anaemia in patients with heart failure and mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS-HF trial. Eur J Heart Fail. 2025 Nov;27(11):2301-2312. doi: 10.1002/ejhf.3682. Epub 2025 May 16.
PMID: 40377177DERIVEDKondo T, Jhund PS, Henderson AD, Claggett BL, Desai AS, Brinker M, Lay-Flurrie J, Schloemer P, Viswanathan P, Amarante F, Chiang CE, Filippatos G, Lam CSP, Petrie MC, Senni M, Schou M, Verma S, Voors AA, von Lewinski D, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. The efficacy of finerenone on hierarchical composite endpoint analysed using win statistics in patients with heart failure and mildly reduced or preserved ejection fraction: A prespecified analysis of FINEARTS-HF. Eur J Heart Fail. 2025 Aug;27(8):1459-1471. doi: 10.1002/ejhf.3669. Epub 2025 Apr 29.
PMID: 40300840DERIVEDOstrominski JW, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Borentian M, Rohwedder K, Lay-Flurrie J, Lavagnino MA, McMurray JJV, Solomon SD. Finerenone and NYHA Functional Class in Heart Failure: The FINEARTS-HF Trial. JACC Heart Fail. 2026 Jan;14(1):102440. doi: 10.1016/j.jchf.2025.03.007. Epub 2025 Apr 2.
PMID: 40232214DERIVEDButt JH, Jhund PS, Henderson AD, Claggett BL, Desai AS, Lam CSP, Mueller K, Scheerer MF, Viswanathan P, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone, chronic obstructive pulmonary disease, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS-HF trial. Eur J Heart Fail. 2025 Aug;27(8):1444-1458. doi: 10.1002/ejhf.3661. Epub 2025 Apr 13.
PMID: 40222820DERIVEDOstrominski JW, Mc Causland FR, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Schloemer P, Brinker M, Scheerer MF, McMurray JJV, Solomon SD, Vaduganathan M. Finerenone Across the Spectrum of Kidney Risk in Heart Failure: The FINEARTS-HF Trial. JACC Heart Fail. 2025 Apr 2:102439. doi: 10.1016/j.jchf.2025.03.006. Online ahead of print.
PMID: 40208137DERIVEDDesai AS, Jhund PS, Vaduganathan M, Claggett BL, Cunningham JW, Pabon MA, Lam CSP, Senni M, Shah S, Voors AA, Zannad F, Pitt B, Amarante F, Lay-Flurrie J, Scheerer MF, Lage A, McMurray JJV, Solomon SD. Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Jul 1;10(7):678-685. doi: 10.1001/jamacardio.2025.0860.
PMID: 40159247DERIVEDMatsumoto S, Henderson AD, Jhund PS, Bauersachs J, Chioncel O, Claggett BL, Comin-Colet J, Desai AS, Filippatos G, Lam CSP, Pitt B, Scheerer MF, Lay-Flurrie J, Amarante F, Brinker M, Schou M, Senni M, Shah SJ, Voors AA, Zannad F, Zieroth S, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone and Atrial Fibrillation in Heart Failure: A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Jul 1;10(7):696-707. doi: 10.1001/jamacardio.2025.0848.
PMID: 40156827DERIVEDMcDowell K, Docherty KF, Campbell RT, Henderson AD, Jhund PS, Claggett BL, Desai AS, Lay-Flurrie J, Hofmeister L, Scalise A, Lam CSP, Petrie MC, Schou M, Senni M, Shah SJ, Udell JA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF Model: A Secondary Analysis of FINEARTS-HF. JAMA Cardiol. 2025 Jun 1;10(6):535-544. doi: 10.1001/jamacardio.2025.0025.
PMID: 40042880DERIVEDCunningham JW, Chatur S, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, Llamas Esperon G, Lam CSP, Sato N, Senni M, Shah S, Voors A, Zannad F, Pitt B, Zieroth S, Brinker M, Rohwedder K, Kim SY, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD. Finerenone and Outpatient Worsening Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Feb 26;10(4):370-8. doi: 10.1001/jamacardio.2025.0016. Online ahead of print.
PMID: 40009358DERIVEDButt JH, Jhund PS, Henderson AD, Claggett BL, Desai AS, Viswanathan P, Kolkhof P, Schloemer P, Amarante F, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV; FINEARTS-HF Committees and Investigators. Finerenone and new-onset diabetes in heart failure: a prespecified analysis of the FINEARTS-HF trial. Lancet Diabetes Endocrinol. 2025 Feb;13(2):107-118. doi: 10.1016/S2213-8587(24)00309-7. Epub 2025 Jan 13.
PMID: 39818225DERIVEDButt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Lay-Flurrie J, Viswanathan P, Lage A, Scheerer MF, Lam CSP, Senni M, Shah SJ, Voors AA, Bauersachs J, Fonseca C, Kosiborod MN, Linssen GCM, Petrie MC, Schou M, Verma S, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF. J Am Coll Cardiol. 2025 Jan 21;85(2):140-155. doi: 10.1016/j.jacc.2024.10.111. Epub 2024 Dec 10.
PMID: 39665701DERIVEDChimura M, Wang X, Jhund PS, Henderson AD, Claggett BL, Desai AS, Fonseca C, Goncalvesova E, Katova T, Mueller K, Glasauer A, Rohwedder K, Viswanathan P, Nodari S, Lam CSP, Saldarriaga CI, Senni M, Sharma K, Voors AA, Zannad F, Pitt B, Vardeny O, Vaduganathan M, Solomon SD, McMurray JJV. Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Jan 1;10(1):59-70. doi: 10.1001/jamacardio.2024.4613.
PMID: 39550721DERIVEDVardeny O, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Matsumoto S, Merkely B, Zieroth S, Yilmaz MB, Lay-Flurrie J, Viswanathan P, Horvat-Broecker A, Scalise A, McMurray JJV, Solomon SD. Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JAMA Cardiol. 2025 Jan 1;10(1):42-48. doi: 10.1001/jamacardio.2024.4539.
PMID: 39550716DERIVEDMc Causland FR, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Brinker M, Perkins R, Scheerer MF, Schloemer P, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, McMurray JJV, Solomon SD. Finerenone and Kidney Outcomes in Patients With Heart Failure: The FINEARTS-HF Trial. J Am Coll Cardiol. 2025 Jan 21;85(2):159-168. doi: 10.1016/j.jacc.2024.10.091. Epub 2024 Oct 25.
PMID: 39490700DERIVEDDocherty KF, Henderson AD, Jhund PS, Claggett BL, Desai AS, Mueller K, Viswanathan P, Scalise A, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial. Circulation. 2025 Jan 7;151(1):45-58. doi: 10.1161/CIRCULATIONAHA.124.072011. Epub 2024 Sep 29.
PMID: 39342512DERIVEDVaduganathan M, Claggett BL, Kulac IJ, Miao ZM, Desai AS, Jhund PS, Henderson AD, Brinker M, Lay-Flurrie J, Viswanathan P, Scheerer MF, Lage A, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, McMurray JJV, Solomon SD. Effects of the Nonsteroidal MRA Finerenone With and Without Concomitant SGLT2 Inhibitor Use in Heart Failure. Circulation. 2025 Jan 14;151(2):149-158. doi: 10.1161/CIRCULATIONAHA.124.072055. Epub 2024 Sep 28.
PMID: 39340828DERIVEDVaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Borentian M, Lay-Flurrie J, Viswanathan P, Behmenburg FU, McMurray JJV, Solomon SD. Estimated Long-Term Benefits of Finerenone in Heart Failure: A Prespecified Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2025 Feb 1;10(2):176-181. doi: 10.1001/jamacardio.2024.3782.
PMID: 39332395DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Therapeutic Area Head
- Organization
- Bayer
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- GT60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 15, 2020
First Posted
June 17, 2020
Study Start
September 14, 2020
Primary Completion
May 15, 2024
Study Completion
June 14, 2024
Last Updated
August 26, 2025
Results First Posted
August 26, 2025
Record last verified: 2025-08
Data Sharing
- IPD Sharing
- Will not share
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.