Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults
BrainFit
Effects of High Intensity Interval- vs Resistance or Combined- Training for Improving Cognitive Function and Neurotrophic Factors in Overweight Adults (BrainFit Study): Factorial Randomised Controlled Trial
1 other identifier
interventional
60
1 country
1
Brief Summary
The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2016
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2016
CompletedFirst Submitted
Initial submission to the registry
September 22, 2016
CompletedFirst Posted
Study publicly available on registry
September 27, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedOctober 11, 2018
October 1, 2018
3 months
September 22, 2016
October 10, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Change from Baseline in Brain-derived neurotrophic factor
Measurement of serum Brain-derived neurotropic factor true blood samples.
Baseline and 60 minutes immediately after the interventions ends
Secondary Outcomes (3)
Change from Baseline in Neurotrophin-3
Baseline and 60 minutes immediately after the interventions ends
Change from Baseline in Neurotrophin-4
Baseline and 60 minutes immediately after the interventions ends
Change from Baseline change in Cognitive Function
Baseline and 60 minutes immediately after the interventions ends
Study Arms (4)
High Intensity Interval
EXPERIMENTALOne session for 30-60 minutes of high intensity aerobic exercise
Resistance training
EXPERIMENTALOne session for 30-60 minutes of resistance exercise
Plus: High Intensity Interval + Resistance Training
EXPERIMENTALOne session for 30-60 minutes of high intensity aerobic exercise and resistance exercise
Non-exercise
PLACEBO COMPARATORNon-exercise
Interventions
Walking on a treadmill 4min at 80-90% peak heart rate and recovery 4 min at 65% peak heart rate until expenditure of 500 kcal
Completing a resistance circuit (including upper and lower muscle groups) as many times as needed according to subject weight until expenditure of 500 kcal
Walking on a treadmill as intervention 1 until 50% the energy expenditure prescribed is reached, then completing a resistance circuit until 100% energy expenditure is reached
This group will receive the usual clinical care according to the consensus recommendations of the national goals for cardiovascular health promotion and disease reduction of the American Heart Association and Colombian guidelines COLDEPORTES.
Eligibility Criteria
You may qualify if:
- Written informed consent.
- Interested in improving health and fitness.
- Central obesity: waist circumference ≥90cm
- Body mass index ≥ 26 kg/m(2)
You may not qualify if:
- Systemic infections.
- Weight loss or gain of \>10% of body weight in the past 6 months for any reason.
- Currently taking medication that suppresses or stimulates appetite.
- Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
- Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
- Asthma.
- Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
- Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
- Any active use of illegal or illicit drugs.
- Current exerciser (\>30 min organized exercise per week).
- Indication of unsuitability of current health for exercise protocol (PARQ).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Universidad Santo Tomaslead
- Universidad del Rosariocollaborator
- Universidad Nacional de Colombiacollaborator
Study Sites (1)
Robinson Ramírez-Vélez
Bogota, Cundinamarca, 000000000, Colombia
Related Publications (1)
Dominguez-Sanchez MA, Bustos-Cruz RH, Velasco-Orjuela GP, Quintero AP, Tordecilla-Sanders A, Correa-Bautista JE, Triana-Reina HR, Garcia-Hermoso A, Gonzalez-Ruiz K, Pena-Guzman CA, Hernandez E, Pena-Ibagon JC, Tellez-T LA, Izquierdo M, Ramirez-Velez R. Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study. Front Physiol. 2018 Jun 27;9:741. doi: 10.3389/fphys.2018.00741. eCollection 2018.
PMID: 29997519DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Robinson Ramírez-Vélez, Ph.D
Universidad del Rosario
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 22, 2016
First Posted
September 27, 2016
Study Start
September 1, 2016
Primary Completion
December 1, 2016
Study Completion
December 1, 2016
Last Updated
October 11, 2018
Record last verified: 2018-10
Data Sharing
- IPD Sharing
- Will not share