Impacts of Resistance Training on Acute Secretion of Irisin in Obese Older and Young Adults

NCT03715088 | Completed

• 1 other identifier: UNB Fredericton
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

It is established that resistance training improves metabolic health; however, the mechanisms of this process are not fully understood. A biologically active substance, irisin, has recently received interest in the scientific community with respect to its effects on energy expenditure and weight loss. The purpose of this study is to compare the different irisin release response during a resistance exercise training session. The study will compare individuals two different age groups (young adults: age 18-30; older adults: age 65-75) living with obesity.

Conditions

Obesity

Keywords

Irisin; Obesity; Resistance Training; Older Adults; Younger Adults; Myokines

Outcome Measures

Primary Outcomes (1)

• Irisin

  The primary outcome is the change in irisin during an acute bout of resistance exercise training.

  Baseline (0 minute), 15 minutes, 30 minutes, and 45 minutes during exercise and 45 minutes post exercise

Study Arms (2)

Older Adults (BMI ≥30 kg/m2)

EXPERIMENTAL

Individuals aged 65-75 living with obesity will perform the Resistance Training Intervention.

Behavioral: Resistance Training Intervention

Younger Adults (BMI ≥30 kg/m2)

EXPERIMENTAL

Individuals aged 18-30 living with obesity will perform Resistance Training Intervention.

Behavioral: Resistance Training Intervention

Interventions

Resistance Training Intervention BEHAVIORAL

Participants will perform 10 different resistance exercises consisting of three sets of 8-10 repetitions, at 80% of 1-RM, separated by 60-second rest intervals between sets. This exercise protocol was chosen based on literature that suggests that the protocol and intensity do not enhance mitochondria biogenesis. Also, it was well tolerated by obese and older individuals.

Older Adults (BMI ≥30 kg/m2); Younger Adults (BMI ≥30 kg/m2)

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18-35 or 60-75 years old
• Physically inactive (engaging in less than 150 minutes of moderate to vigorous aerobic exercise)
• No previous diagnosis of Type 2 diabetes
• Obese (BMI ≥30kg/m2)

You may not qualify if:

• BMI less than 30kg/m2
• History of Type 2 diabetes
• Physically active (engaging in atleast 150 minutes of moderate to vigorous aerobic exercise)
• Injury or condition that prevents performance of resistance training exercise.

Sponsors & Collaborators

• University of New Brunswick: lead

Study Sites (1)

University of New Brunswick - Kinesiology

Fredericton, New Brunswick, E3B 5A3, Canada

Location

Related Publications (1)

• Rioux BV, Brunt KR, Eadie AL, Bouchard DR, Fox J, Senechal M. Impact of acute circuit training on irisin in younger and older overweight adults. Appl Physiol Nutr Metab. 2021 Oct;46(10):1248-1256. doi: 10.1139/apnm-2020-1087. Epub 2021 Apr 22.

  PMID: 33887165 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Martin Senechal, PhD

  University of New Brunswick

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 18, 2018
• First Posted: October 22, 2018
• Study Start: May 1, 2016
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2016
• Last Updated: October 22, 2018

Record last verified: 2018-06

Locations

CA (1)