Effects of Napping in Sleep-Restricted Adolescents

NCT02838095 | Completed DMC

• 1 other identifier: NFS2
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

To examine the neurobehavioural responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive performance, alertness, and mood. 57 participants, aged 15 to 19 years old, were divided into nap and no-nap groups. Both groups underwent two cycles of sleep restriction and recovery over 15 days. The nap group received an afternoon sleep opportunity lasting 1 hour.

Conditions

Sleep Deprivation; Sleep

Keywords

nap; sleep restriction; recovery sleep; cognitive performance; subjective sleepiness; mood; neurobehavioural functions

Outcome Measures

Primary Outcomes (8)

• Change in sustained attention assessed with the Psychomotor Vigilance Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Number of attention lapses (\>500ms)

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in working memory assessed with the 1-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Number of correct responses in the 1-back task

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in executive functions assessed with the 3-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Number of correct responses in the 3-back task

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in the level of subjective sleepiness assessed with the Karolinska Sleepiness Scale from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Score on the Karolinska Sleepiness Scale (1-9 points)

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in positive mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Total score on the positive subscale of the PANAS

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in negative mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Total score on the negative subscale of the PANAS

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in speed of processing assessed with the Mental Arithmetic Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Number of correct responses in the task

  3 times daily (10:00, 15:45, and 20:00) for 15 days

• Change in speed of processing assessed with the Symbol Digit Modalities Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery

  Number of correct responses in the task

  3 times daily (10:00, 15:45, and 20:00) for 15 days

Secondary Outcomes (10)

• Change in total sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery

  Nocturnal sleep on nights 1 & 3 (baseline), 4, 6 & 8 (first sleep restriction period), 9 (first recovery period), 11 & 13 (second sleep restriction period), & 14 (second recovery period)

• Change in N1 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery

  Nocturnal sleep on nights 1 & 3 (baseline), 4, 6 & 8 (first sleep restriction period), 9 (first recovery period), 11 & 13 (second sleep restriction period), & 14 (second recovery period)

• Change in N2 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery

  Nocturnal sleep on nights 1 & 3 (baseline), 4, 6 & 8 (first sleep restriction period), 9 (first recovery period), 11 & 13 (second sleep restriction period), & 14 (second recovery period)

• Change in N3 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery

  Nocturnal sleep on nights 1 & 3 (baseline), 4, 6 & 8 (first sleep restriction period), 9 (first recovery period), 11 & 13 (second sleep restriction period), & 14 (second recovery period)

• Change in REM sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery

  Nocturnal sleep on nights 1 & 3 (baseline), 4, 6 & 8 (first sleep restriction period), 9 (first recovery period), 11 & 13 (second sleep restriction period), & 14 (second recovery period)

Study Arms (2)

No nap

NO INTERVENTION

After each night with a 5-hour sleep opportunity, participants did not have a daytime nap opportunity, but instead watched documentaries.

Nap

EXPERIMENTAL

After each night with a 5-hour sleep opportunity, participants had the chance to take a daytime nap from 14:00 to 15:00.

Behavioral: Nap

Interventions

Nap BEHAVIORAL

A 1-hour daytime nap opportunity

Nap

Eligibility Criteria

• Age: 15 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• healthy
• no sleep disorder
• body mass index not greater than 30

You may not qualify if:

• smoker
• habitual short sleeper (time in bed during term time of less than 6 hours and no sign of sleep extension of greater than 1 hour on weekends)
• consumption of more than 5 cups of caffeinated beverages a day
• travelling across more than 2 time zones in the month prior to the study protocol
• diagnosed with any psychiatric conditions

Sponsors & Collaborators

• Duke-NUS Graduate Medical School: lead
• National Medical Research Council (NMRC), Singapore: collaborator

Study Sites (1)

Duke-NUS Medical School

Singapore, Singapore, 169857, Singapore

Location

Related Publications (2)

• Lo JC, Ang JWA, Koa TB, Ong JL, Lim J. Predicting vigilance vulnerability during 1 and 2 weeks of sleep restriction with baseline performance metrics. Sleep Adv. 2022 Oct 25;3(1):zpac040. doi: 10.1093/sleepadvances/zpac040. eCollection 2022.

  PMID: 37193393 DERIVED

• Lo JC, Koa TB, Ong JL, Gooley JJ, Chee MWL. Staying vigilant during recurrent sleep restriction: dose-response effects of time-in-bed and benefits of daytime napping. Sleep. 2022 Apr 11;45(4):zsac023. doi: 10.1093/sleep/zsac023.

  PMID: 35089345 DERIVED

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Michael WL Chee, MBBS

  Duke-NUS Graduate Medical School

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Neuroscience and Behavioural Disorders Program; Director, Centre for Cognitive Neuroscience

Study Record Dates

• First Submitted: June 15, 2016
• First Posted: July 20, 2016
• Study Start: August 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: July 20, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)