The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

NCT03767426 | Recruiting

• 1 other identifier: TC-1
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in emotion processing and regulation. Given the growing societal tendency to view sleep as unproductive-foregoing it to lengthen work days and increase social opportunities- such knowledge would be of practical importance for understanding the role of sleep in healthy emotional functioning, particular for individuals experiencing periods of increased stress and emotional distress (e.g., new parents, hospital staff, or combat troops).

Conditions

Sleep Deprivation; Sleep

Keywords

Emotion; Memory; Sleep; Sleep Deprivation

Outcome Measures

Primary Outcomes (3)

• Morphed Face Accuracy and Intensity

  Participants are asked to identify and rate emotional intensity of ambiguous emotional faces (happy, sad, angry) that have been morphed with neutral faces. Scores for each emotional domain will be calculated as (i) accuracy score (number of faces correctly identified over total faces seen), and (ii) average emotional intensity rating. Task will be completed at baseline, post-sleep/sleep deprivation, and post-nap/no nap, and within-subject comparisons will determine how interventions impact emotional perception.

  1-24 hours

• Emotional Memory Tradeoff Memory Score

  Following sleep or sleep deprivation, participants will complete emotional memory tradeoff recognition task at two time points, separated by a nap or wakefulness. Corrected hit rate will be calculated for negative and neutral scene components as the percentage of correctly identified "old" objects/backgrounds minus percentage of false alarms ("new" pictures marked as "old")

  12-24 hours

• Psychomotor vigilance task lapse rate

  The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.

  1-24 hours

Secondary Outcomes (3)

• fMRI measured neural reactivity (blood oxygen-level dependent signal)

  12-24 hours

• Heart Rate Reactivity (Beats per minute)

  12-24 hours

• Skin Conductance Reactivity (micro Siemens)

  12-24 hours

Study Arms (3)

Overnight sleep

NO INTERVENTION

Subjects are permitted a night of polysomnograph-recorded sleep before participating in training and testing sessions the next day

Sleep deprivation

ACTIVE COMPARATOR

Subjects sleep deprived before participating in training and testing sessions the next day

Behavioral: Sleep Deprivation

Daytime Nap

EXPERIMENTAL

Subjects are trained and then retested after a daytime nap

Behavioral: Sleep Deprivation; Behavioral: Daytime nap

Interventions

Sleep Deprivation BEHAVIORAL

Subjects are sleep deprived for an entire night

Daytime Nap; Sleep deprivation

Daytime nap BEHAVIORAL

After a night of sleep deprivation, participants will be given a 2 hour nap opportunity

Daytime Nap

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• willing and able to follow the protocol
• willing to refrain from alcohol and recreational drugs for the duration of the protocol
• normal or corrected to normal vision is required

You may not qualify if:

• self-reported sleep disturbances
• left-handedness or ambidexterity
• a history of mental illness or neurological disorder
• the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)

Sponsors & Collaborators

• Beth Israel Deaconess Medical Center: lead
• Boston College: collaborator

Study Sites (1)

Tony Cunningham

Boston, Massachusetts, 02215, United States

RECRUITING

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Tony Cunningham, PhD

  Beth Israel Deaconess Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tony J Cunningham, PhD

CONTACT

617-632-7927; acunnin4@bidmc.harvard.edu

Robert Stickgold, PhD

CONTACT

617-233-3768; rstickgold@hms.harvard.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Psychiatry

Model Details: Independent group comparison

Study Record Dates

• First Submitted: December 5, 2018
• First Posted: December 6, 2018
• Study Start: March 1, 2019
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: August 6, 2024

Record last verified: 2024-08

Locations

US (1)