Metabolic and Cognitive Parameters Following Partial Sleep Deprivation
Metabolic and Cognitive Effects of Sleep Deprivation
1 other identifier
interventional
20
1 country
1
Brief Summary
The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2013
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 21, 2013
CompletedStudy Start
First participant enrolled
April 1, 2013
CompletedFirst Posted
Study publicly available on registry
April 4, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2015
CompletedDecember 2, 2014
November 1, 2014
1.9 years
February 21, 2013
November 27, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Memory tasks
Procedural memory performance after learning a procedural memory task close to going to bed, followed by either partial sleep deprivation (PSD) or normal sleep (NS), and comparing the performance the following morning at two time points. Participants spatial memory performance in the morning at two time points, following PSD will also be compared with that following NS, after having learned such a memory task in the evening before going to bed.
Change in memory performance between learning (at 2230 hours in NS and PSD condition) before going to sleep, and at 0800 and 0930 hours (following PSD or NS)
Secondary Outcomes (4)
Circulating hormone levels
Change in circulating hormone levels and other metabolism-linked and neurodegeneration-associated molecules at 0730, 0830, 0910, 0925, 0940, 1010, 1040, 1105, and 1150 hours following the respective nighttime intervention and after the interference task
Intake task
Change in intake at around 1200 hours, following the respective nighttime intervention (NS or PSD)
Working memory function task
Change in memory performance at 0800 hours and after the interference task again at 0930 hours (between and following PSD or NS)
Portion Size Task
Change in selected portion size from baseline (at 0800 hours following the nighttime intervention), to one hour later, i.e. after an interference task
Study Arms (2)
Partial sleep deprivation
EXPERIMENTALPartial sleep deprivation: participants will have a 4-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed by repeated blood sampling and an 'Intake task'.
Normal sleep
EXPERIMENTALNormal sleep: participants will have an 8-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed with repeated blood sampling and an 'Intake task'.
Interventions
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
Eligibility Criteria
You may qualify if:
- Male
- Age 20-28y
- Healthy (self-reported) and not on medication
- Non-smoking
- Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
- Normal dietary habits (regular meal pattern with daily breakfast)
You may not qualify if:
- Major illness
- Taking any serious medications
- Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
- Any dietary issues with the food items provided
- A history of endocrine, neurological or psychiatric disorders
- Shift work in the previous 3 months
- Travel over several time zones within the previous two months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Neuroscience, Uppsala University
Uppsala, Uppsala County, 75105, Sweden
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christian Benedict, PhD
Department of Neuroscience, Uppsala University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 21, 2013
First Posted
April 4, 2013
Study Start
April 1, 2013
Primary Completion
March 1, 2015
Study Completion
March 1, 2015
Last Updated
December 2, 2014
Record last verified: 2014-11