Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)
CEE
2 other identifiers
interventional
26
1 country
1
Brief Summary
In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:
- 1.decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
- 2.increase in resting metabolic rate 48 hours after exercise;
- 3.increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
- 4.decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2009
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 1, 2009
CompletedStudy Start
First participant enrolled
October 1, 2009
CompletedFirst Posted
Study publicly available on registry
October 2, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedDecember 6, 2011
December 1, 2011
2.2 years
October 1, 2009
December 2, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
non-exercise activity calorie expenditure
2 days after exercise sessions
Secondary Outcomes (1)
resting metabolic rate
2 days after exercise sessions
Interventions
exercise sessions at 45% and 60% of maximum effort
Eligibility Criteria
You may qualify if:
- Women
- Age 60-75 years
- normal weight
- Weight-stable (± 5%) within the previous 3 months
- Non-smoking for last year
- Able to provide own transportation to study visits
- Not currently involved in any other research study
- Willing and able to participate in all aspects of the trial including research testing
- Willing to give informed consent to participate
You may not qualify if:
- Self-reported significant cardiovascular disease
- Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
- Medications known to affect exercise performance or metabolism
- Excess caffeine use (\> 500mg/day)
- Any self-reported contraindications to exercise
- Clinical depression
- Abnormal cognitive function -
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Washington University School of Medicine
St Louis, Missouri, 63110, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xuewen Wang, PhD
Washington University School of Medicine
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 1, 2009
First Posted
October 2, 2009
Study Start
October 1, 2009
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
December 6, 2011
Record last verified: 2011-12