The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

NCT02000076 | Completed

• 1 other identifier: Sleepy Brain Study Wave 1
• Study Type: interventional
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Conditions

Sleep Deprivation

Keywords

Sleep; resting state; functional connectivity; emotional contagion; empathy; emotional regulation

Outcome Measures

Primary Outcomes (1)

• Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)

  This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).

  Change between 1st and 2nd MRI scanning session (approx. 1 month later)

Study Arms (2)

Sleep deprivation

EXPERIMENTAL

Partial sleep deprivation allowing 3 h sleep at night

Behavioral: Partial sleep deprivation allowing 3 h sleep at night

Full sleep

EXPERIMENTAL

Sleep with no restriction

Behavioral: Full sleep

Interventions

Partial sleep deprivation allowing 3 h sleep at night BEHAVIORAL

Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.

Also known as: Sleep restriction, Sleep loss

Sleep deprivation

Full sleep BEHAVIORAL

Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.

Full sleep

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age, inclusive OR 65-75 years of age, inclusive
• Able to understand spoken and written Swedish (in order to understand instructions)
• Normal or corrected-to-normal vision not using glasses
• Not colour blind
• Right-handed
• Free from ferromagnetic objects in body
• No history of any neurologic or psychiatric illness including drug abuse
• No history of diabetes nor hypertension
• No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
• No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
• No use of psychotropic drugs
• Not studying or working in medicine, psychology, nor behavioural science
• Not suffering from severe seasonal allergy
• No use of cortisone, anti-histamines, nor any other immune-modulating drugs
• Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine

Sponsors & Collaborators

• Mats Lekander: lead
• Stockholm University: collaborator

Study Sites (1)

Karolinska Institutet, Karolinska Universitetssjukhuset i Solna

Stockholm, None/Not Applicable, SE-17177, Sweden

Location

Related Publications (1)

• Tamm S, Schwarz J, Thune H, Kecklund G, Petrovic P, Akerstedt T, Fischer H, Lekander M, Nilsonne G. A combined fMRI and EMG study of emotional contagion following partial sleep deprivation in young and older humans. Sci Rep. 2020 Oct 21;10(1):17944. doi: 10.1038/s41598-020-74489-9.

  PMID: 33087746 DERIVED

Related Links

• List of hypotheses

MeSH Terms

Conditions

Sleep Deprivation; Emotional Regulation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Self-Control; Social Behavior; Behavior

Study Officials

• Torbjörn Åkerstedt, PhD

  Stockholm University

  STUDY CHAIR

• Mats Lekander, PhD

  Stockholm University, Karolinska Institutet

  PRINCIPAL INVESTIGATOR

• Håkan Fischer, PhD

  Stockholm University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 13, 2013
• First Posted: December 3, 2013
• Study Start: November 1, 2012
• Primary Completion: March 1, 2014
• Study Completion: May 1, 2014
• Last Updated: May 16, 2016

Record last verified: 2016-05

Data Sharing

• IPD Sharing: Will share

Locations

SE (1)