Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT01810913 | Recruiting Phase 2

• 4 other identifiers: NCI-2013-00500RTOG-1216U10CA021661U10CA180868
• Study Type: interventional
• Target: 613
• Locations: 3 countries
• Sites: 341

Brief Summary

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab.

Conditions

Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma

Outcome Measures

Primary Outcomes (2)

• Disease-free survival (Phase II)

  Estimated using the Kaplan-Meier method for each arm. Their distributions will be compared between treatment arms with a one-sided log rank test.

  From date of randomization until date of local-regional recurrence, distant metastasis or death due to any cause, assessed up to 7 years

• Overall survival (Phase III)

  Estimated using the Kaplan-Meier method for each arm. Their distributions will be compared between treatment arms with a one-sided log rank test. Multivariate analysis will be performed using the Cox proportional hazards model.

  From date of randomization to death due to any cause, assessed up to 7 years

Secondary Outcomes (5)

• Local-regional failure

  From date of randomization until date of local-regional recurrence, assessed up to 7 years

• Distant metastasis

  From date of randomization to date of distant metastasis, assessed up to 7 years

• Toxicity

  From start of treatment to death or last follow-up

• Patient-reported outcome, symptom burden

  Time from randomization to a first recovery within at least one MID unit of total symptom severity compared to the baseline (reference) score

• Quality of life

  Baseline and 1 year post radiation therapy

Study Arms (4)

Arm 1 (IMRT, cisplatin)

EXPERIMENTAL

Patients undergo IMRT QD five days a week for 6 weeks and receive concurrent cisplatin IV over 1-2 hours once weekly for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo collection of blood samples during screening and throughout the study and may undergo CT scans and/or MRI and biopsy as clinically indicated on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Drug: Cisplatin; Procedure: Computed Tomography; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Other: Survey Administration

Arm 2 (IMRT, docetaxel)

EXPERIMENTAL

Patients undergo IMRT as in Arm I and receive concurrent docetaxel IV over 60 minutes once weekly for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo CT scans and/or MRI, and collection of blood during follow-up. (CLOSED AS OF 20-MAR-2020)

Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Docetaxel; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Other: Survey Administration

Arm 3 (IMRT, docetaxel, cetuximab)

EXPERIMENTAL

Patients receive cetuximab IV over 120 minutes on week 1 and over 60 minutes once weekly on weeks 2-7. Patients undergo IMRT as in Arm I and receive concurrent docetaxel once weekly for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo collection of blood samples during screening and throughout the study and may undergo CT scans and/or MRI and biopsy as clinically indicated on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Biological: Cetuximab; Procedure: Computed Tomography; Drug: Docetaxel; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Other: Survey Administration

Arm 4 (IMRT, cisplatin, atezolizumab)

EXPERIMENTAL

Patients undergo IMRT QD five days a week for 6 weeks and receive concurrent cisplatin IV over 1-2 hours once weekly for 6 weeks. Starting 1 week before IMRT, patients also receive atezolizumab IV over 30-60 minutes every 3 weeks for up to 8 doses (weeks -1, 3, 6, 9, 12, 15, 18, and 21) in the absence of disease progression and unacceptable toxicity. Patients undergo collection of blood samples during screening and throughout the study and may undergo CT scans and/or MRI and biopsy as clinically indicated on study.

Drug: Atezolizumab; Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Drug: Cisplatin; Procedure: Computed Tomography; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Other: Survey Administration

Interventions

Atezolizumab DRUG

Given IV

Also known as: MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq

Arm 4 (IMRT, cisplatin, atezolizumab)

Biopsy Procedure PROCEDURE

Undergo biopsy

Also known as: Biopsy, BIOPSY_TYPE, Bx

Arm 1 (IMRT, cisplatin); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Biospecimen Collection PROCEDURE

Undergo collection of blood

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection

Arm 1 (IMRT, cisplatin); Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Cetuximab BIOLOGICAL

Given IV

Also known as: C 225, C-225, C225, Cetuximab Biosimilar CDP-1, Cetuximab Biosimilar CMAB009, Cetuximab Biosimilar KL 140, Chimeric Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225, Chimeric Monoclonal Antibody C225, Erbitux, IMC-C225

Arm 3 (IMRT, docetaxel, cetuximab)

Cisplatin DRUG

Given IV

Also known as: Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin

Arm 1 (IMRT, cisplatin); Arm 4 (IMRT, cisplatin, atezolizumab)

Computed Tomography PROCEDURE

Undergo CT

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, Diagnostic CAT Scan, Diagnostic CAT Scan Service Type, tomography

Arm 1 (IMRT, cisplatin); Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Docetaxel DRUG

Given IV

Also known as: Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate

Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab)

Intensity-Modulated Radiation Therapy RADIATION

Undergo IMRT

Also known as: IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy

Arm 1 (IMRT, cisplatin); Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Magnetic Resonance Imaging PROCEDURE

Undergo MRI

Also known as: Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI

Arm 1 (IMRT, cisplatin); Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Survey Administration OTHER

Ancillary studies

Arm 1 (IMRT, cisplatin); Arm 2 (IMRT, docetaxel); Arm 3 (IMRT, docetaxel, cetuximab); Arm 4 (IMRT, cisplatin, atezolizumab)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Pathologically (histologically or cytologically) proven diagnosis of head and neck squamous cell carcinoma (HNSCC) involving the oral cavity (excluding lips), oropharynx (p16 negative), larynx, or hypopharynx
• Patients must have undergone gross total surgical resection of high-risk oral cavity, oropharynx (p16 negative), larynx, or hypopharynx within 63 days prior to registration; Note: patients may have biopsy under general anesthesia in an operating room followed by definitive ablative cancer surgery representing gross total resection; the gross total resection has to be done within 63 days prior to registration; if, however, patients have ablative resection but shortly recur or are determined to have persisting disease requiring re-resection to achieve gross total resection, then the patient is not eligible
• Patients must have at least 1 of the following high-risk pathologic features: extracapsular nodal extension or invasive cancer at the primary tumor resection margin (tumor on ink)
• Pathologic stage III or IV HNSCC, including no distant metastases, based upon the following minimum diagnostic workup:
• General history and physical examination by a radiation oncologist and/or medical oncologist within 84 days prior to registration;
• Examination by an ear nose throat (ENT) or head \& neck surgeon prior to surgery; a laryngopharyngoscopy (mirror and/or fiber optic and/or direct procedure), if appropriate, is recommended but not required; intra-operative examination is acceptable documentation
• Pre-operative (op) Imaging of the head and neck: A neck computed tomography (CT) (with contrast) or CT/positron emission tomography (PET) (with contrast) and/or an magnetic resonance imaging (MRI) of the neck (T1 with gadolinium and T2) within 84 days prior to surgery; Note: this imaging data (diagnostic pre-operative scan showing gross disease) is to be submitted in Digital Imaging and Communications in Medicine (DICOM) format via TRIAD; the report is to be uploaded into Rave
• Chest CT scan (with or without contrast) or CT/PET that includes the chest (with or without contrast) either within 84 days prior to surgery or within 120 days prior to registration; Note: if the CT/PET with or without contrast is done within 84 days prior to surgery, it fulfills the chest imaging requirement
• Zubrod performance status of 0-1 within 14 days prior to registration
• Age \>= 18
• Absolute granulocyte count (AGC) \>= 1,500 cells/mm\^3 (obtained within 14 days prior to registration on study)
• Platelets \>= 100,000 cells/mm\^3 (obtained within 14 days prior to registration on study)
• Hemoglobin \>= 8.0 g/dl (Note: the use of transfusion or other intervention to achieve hemoglobin \[Hgb\] \>= 8.0 g/dl is acceptable)
• Total bilirubin \< 2 x institutional upper limit of normal (ULN) within 14 days prior to registration
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \< 3 x institutional ULN within 14 days prior to registration

You may not qualify if:

• Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 1095 days (3 years); noninvasive cancers (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible) are permitted even if diagnosed and treated \< 3 years ago
• Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T1-2, N0, M0 resected differentiated thyroid carcinoma, who are eligible
• Prior systemic chemotherapy or anti-epidermal growth factor (EGF) therapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
• Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
• Severe, active co-morbidity, defined as follows:
• Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to registration
• Transmural myocardial infarction within 6 months prior to registration
• Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
• Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
• Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to require oxygen therapy within 1 year prior to registration
• Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol
• Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease and Control and Prevention (CDC) definition; note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; the need to exclude patients with AIDS from this protocol is necessary because the treatments involved in this protocol may be significantly immunosuppressive; protocol-specific requirements may also exclude immuno-compromised patients.
• Grade 3-4 electrolyte abnormalities (Common Terminology Criteria for Adverse Events \[CTCAE\], version \[v.\] 4):
• Serum calcium (ionized or adjusted for albumin) \< 7 mg/dl (1.75 mmol/L) or \> 12.5 mg/dl (\> 3.1 mmol/L) despite intervention to normalize levels
• Glucose \< 40 mg/dl (\< 2.2 mmol/L) or \> 250 mg/dl (\> 14 mmol/L)

Sponsors & Collaborators

• NRG Oncology: collaborator
• National Cancer Institute (NCI): lead

Study Sites (341)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

ACTIVE NOT RECRUITING

The Kirklin Clinic at Acton Road

Birmingham, Alabama, 35243, United States

SUSPENDED

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States

RECRUITING

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

ACTIVE NOT RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States

RECRUITING

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States

RECRUITING

Mercy San Juan Medical Center

Carmichael, California, 95608, United States

RECRUITING

UC San Diego Health System - Encinitas

Encinitas, California, 92024, United States

SUSPENDED

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

SUSPENDED

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

Memorial Medical Center

Modesto, California, 95355, United States

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States

ACTIVE NOT RECRUITING

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States

RECRUITING

Sutter Medical Center Sacramento

Sacramento, California, 95816, United States

RECRUITING

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

SUSPENDED

UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States

SUSPENDED

UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States

SUSPENDED

Mills Health Center

San Mateo, California, 94401, United States

RECRUITING

Saint Helena Hospital

St. Helena, California, 94574, United States

ACTIVE NOT RECRUITING

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States

ACTIVE NOT RECRUITING

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

RECRUITING

AdventHealth Porter

Denver, Colorado, 80210, United States

RECRUITING

Shaw Cancer Center

Edwards, Colorado, 81632, United States

RECRUITING

Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States

SUSPENDED

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States

ACTIVE NOT RECRUITING

Longmont United Hospital

Longmont, Colorado, 80501, United States

RECRUITING

Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States

SUSPENDED

AdventHealth Parker

Parker, Colorado, 80138, United States

RECRUITING

University of Connecticut

Farmington, Connecticut, 06030, United States

ACTIVE NOT RECRUITING

Yale University

New Haven, Connecticut, 06520, United States

RECRUITING

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States

RECRUITING

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

SUSPENDED

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States

SUSPENDED

George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States

ACTIVE NOT RECRUITING

Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States

ACTIVE NOT RECRUITING

AdventHealth Orlando

Orlando, Florida, 32803, United States

ACTIVE NOT RECRUITING

Orlando Health Cancer Institute

Orlando, Florida, 32806, United States

RECRUITING

Moffitt Cancer Center at SouthShore

Ruskin, Florida, 33570, United States

RECRUITING

Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States

RECRUITING

Moffitt Cancer Center

Tampa, Florida, 33612, United States

RECRUITING

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

RECRUITING

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

RECRUITING

Augusta University Medical Center

Augusta, Georgia, 30912, United States

RECRUITING

Memorial Health University Medical Center

Savannah, Georgia, 31404, United States

RECRUITING

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States

ACTIVE NOT RECRUITING

Queen's Medical Center

Honolulu, Hawaii, 96813, United States

ACTIVE NOT RECRUITING

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States

ACTIVE NOT RECRUITING

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Northwestern University

Chicago, Illinois, 60611, United States

SUSPENDED

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States

RECRUITING

Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States

ACTIVE NOT RECRUITING

University of Illinois

Chicago, Illinois, 60612, United States

ACTIVE NOT RECRUITING

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

RECRUITING

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

RECRUITING

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

RECRUITING

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269, United States

RECRUITING

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States

ACTIVE NOT RECRUITING

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States

RECRUITING

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

RECRUITING

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States

RECRUITING

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

RECRUITING

Carle Cancer Center

Urbana, Illinois, 61801, United States

RECRUITING

Ascension Saint Vincent Anderson

Anderson, Indiana, 46016, United States

ACTIVE NOT RECRUITING

Elkhart General Hospital

Elkhart, Indiana, 46515, United States

ACTIVE NOT RECRUITING

Radiation Oncology Associates PC

Fort Wayne, Indiana, 46804, United States

SUSPENDED

Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States

ACTIVE NOT RECRUITING

Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States

ACTIVE NOT RECRUITING

Goshen Center for Cancer Care

Goshen, Indiana, 46526, United States

ACTIVE NOT RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

SUSPENDED

IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States

SUSPENDED

IU Health Central Indiana Cancer Centers-East

Indianapolis, Indiana, 46219, United States

ACTIVE NOT RECRUITING

Michiana Hematology Oncology PC-Mishawaka

Mishawaka, Indiana, 46545, United States

ACTIVE NOT RECRUITING

Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States

ACTIVE NOT RECRUITING

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

ACTIVE NOT RECRUITING

Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States

ACTIVE NOT RECRUITING

University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States

RECRUITING

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

RECRUITING

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

RECRUITING

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States

RECRUITING

Salina Regional Health Center

Salina, Kansas, 67401, United States

RECRUITING

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States

ACTIVE NOT RECRUITING

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States

RECRUITING

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

RECRUITING

LSU Health Baton Rouge-North Clinic

Baton Rouge, Louisiana, 70805, United States

RECRUITING

Our Lady of The Lake

Baton Rouge, Louisiana, 70808, United States

SUSPENDED

Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States

ACTIVE NOT RECRUITING

University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States

RECRUITING

Touro Infirmary

New Orleans, Louisiana, 70115, United States

RECRUITING

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States

ACTIVE NOT RECRUITING

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

RECRUITING

Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

RECRUITING

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States

RECRUITING

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044, United States

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States

RECRUITING

Holy Cross Hospital

Silver Spring, Maryland, 20910, United States

ACTIVE NOT RECRUITING

Boston Medical Center

Boston, Massachusetts, 02118, United States

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

RECRUITING

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States

ACTIVE NOT RECRUITING

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States

RECRUITING

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116, United States

ACTIVE NOT RECRUITING

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States

RECRUITING

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States

RECRUITING

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States

RECRUITING

Henry Ford Hospital

Detroit, Michigan, 48202, United States

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Allegiance Health

Jackson, Michigan, 49201, United States

RECRUITING

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

RECRUITING

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

RECRUITING

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States

RECRUITING

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States

ACTIVE NOT RECRUITING

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

RECRUITING

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States

ACTIVE NOT RECRUITING

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States

RECRUITING

Henry Ford Wyandotte Hospital

Wyandotte, Michigan, 48192, United States

RECRUITING

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

RECRUITING

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States

RECRUITING

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

RECRUITING

Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States

RECRUITING

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

RECRUITING

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

RECRUITING

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States

RECRUITING

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

SUSPENDED

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

RECRUITING

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

RECRUITING

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States

ACTIVE NOT RECRUITING

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

RECRUITING

North Kansas City Hospital

Kansas City, Missouri, 64116, United States

SUSPENDED

The University of Kansas Cancer Center-South

Kansas City, Missouri, 64131, United States

SUSPENDED

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States

RECRUITING

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States

RECRUITING

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States

RECRUITING

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

RECRUITING

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

RECRUITING

Washington University School of Medicine

St Louis, Missouri, 63110, United States

RECRUITING

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

ACTIVE NOT RECRUITING

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

RECRUITING

CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States

RECRUITING

Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States

ACTIVE NOT RECRUITING

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States

RECRUITING

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States

RECRUITING

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690, United States

RECRUITING

Saint Barnabas Medical Center

Livingston, New Jersey, 07039, United States

RECRUITING

Monmouth Medical Center

Long Branch, New Jersey, 07740, United States

RECRUITING

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States

RECRUITING

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States

RECRUITING

Virtua Memorial

Mount Holly, New Jersey, 08060, United States

ACTIVE NOT RECRUITING

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

RECRUITING

Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States

RECRUITING

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States

RECRUITING

Sparta Cancer Treatment Center

Sparta, New Jersey, 07871, United States

SUSPENDED

Community Medical Center

Toms River, New Jersey, 08755, United States

RECRUITING

Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States

ACTIVE NOT RECRUITING

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

RECRUITING

New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, 87109, United States

RECRUITING

South Shore University Hospital

Bay Shore, New York, 11706, United States

ACTIVE NOT RECRUITING

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States

SUSPENDED

NYU Langone Hospital - Brooklyn

Brooklyn, New York, 11220, United States

ACTIVE NOT RECRUITING

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

ACTIVE NOT RECRUITING

Sands Cancer Center

Canandaigua, New York, 14424, United States

RECRUITING

Memorial Sloan Kettering Commack

Commack, New York, 11725, United States

RECRUITING

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States

SUSPENDED

Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

RECRUITING

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

ACTIVE NOT RECRUITING

NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States

RECRUITING

Mount Sinai Union Square

New York, New York, 10003, United States

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States

ACTIVE NOT RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

RECRUITING

Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, New York, 14606, United States

RECRUITING

Highland Hospital

Rochester, New York, 14620, United States

RECRUITING

University of Rochester

Rochester, New York, 14642, United States

RECRUITING

Memorial Sloan Kettering Sleepy Hollow

Sleepy Hollow, New York, 10591, United States

ACTIVE NOT RECRUITING

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

RECRUITING

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States

RECRUITING

Atrium Health Stanly/LCI-Albemarle

Albemarle, North Carolina, 28002, United States

RECRUITING

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

RECRUITING

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States

RECRUITING

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210, United States

RECRUITING

Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262, United States

RECRUITING

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States

RECRUITING

East Carolina University

Greenville, North Carolina, 27834, United States

SUSPENDED

ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States

RECRUITING

Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112, United States

RECRUITING

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

ACTIVE NOT RECRUITING

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States

RECRUITING

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States

RECRUITING

Summa Health System - Akron Campus

Akron, Ohio, 44304, United States

ACTIVE NOT RECRUITING

Cleveland Clinic Akron General

Akron, Ohio, 44307, United States

ACTIVE NOT RECRUITING

UH Seidman Cancer Center at UH Avon Health Center

Avon, Ohio, 44011, United States

RECRUITING

Summa Health System - Barberton Campus

Barberton, Ohio, 44203, United States

ACTIVE NOT RECRUITING

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States

RECRUITING

Geauga Hospital

Chardon, Ohio, 44024, United States

RECRUITING

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

SUSPENDED

Case Western Reserve University

Cleveland, Ohio, 44106, United States

RECRUITING

MetroHealth Medical Center

Cleveland, Ohio, 44109, United States

ACTIVE NOT RECRUITING

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States

ACTIVE NOT RECRUITING

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States

SUSPENDED

Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States

SUSPENDED

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

SUSPENDED

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States

ACTIVE NOT RECRUITING

Summa Health Medina Medical Center

Medina, Ohio, 44256, United States

ACTIVE NOT RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States

RECRUITING

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States

RECRUITING

University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States

RECRUITING

Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States

RECRUITING

University Hospitals Portage Medical Center

Ravenna, Ohio, 44266, United States

RECRUITING

North Coast Cancer Care

Sandusky, Ohio, 44870, United States

ACTIVE NOT RECRUITING

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870, United States

RECRUITING

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States

RECRUITING

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

SUSPENDED

UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States

RECRUITING

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States

RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

RECRUITING

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

RECRUITING

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104, United States

RECRUITING

UPMC Altoona

Altoona, Pennsylvania, 16601, United States

RECRUITING

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009, United States

RECRUITING

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

RECRUITING

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015, United States

RECRUITING

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States

RECRUITING

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045, United States

RECRUITING

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States

RECRUITING

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121, United States

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

RECRUITING

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

ACTIVE NOT RECRUITING

IRMC Cancer Center

Indiana, Pennsylvania, 15701, United States

RECRUITING

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901, United States

RECRUITING

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132, United States

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050, United States

RECRUITING

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146, United States

RECRUITING

UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, 15108, United States

RECRUITING

UPMC Cancer Center-Natrona Heights

Natrona Heights, Pennsylvania, 15065, United States

SUSPENDED

UPMC Jameson

New Castle, Pennsylvania, 16105, United States

SUSPENDED

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

RECRUITING

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

RECRUITING

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States

RECRUITING

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215, United States

RECRUITING

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

UPMC Jefferson Regional Radiation Oncology

Pittsburgh, Pennsylvania, 15236, United States

SUSPENDED

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States

RECRUITING

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243, United States

RECRUITING

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951, United States

RECRUITING

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346, United States

RECRUITING

Saint Luke's Hospital - Monroe Campus

Stroudsburg, Pennsylvania, 18360, United States

RECRUITING

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401, United States

RECRUITING

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301, United States

RECRUITING

Reading Hospital

West Reading, Pennsylvania, 19611, United States

SUSPENDED

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States

RECRUITING

AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States

SUSPENDED

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States

ACTIVE NOT RECRUITING

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States

SUSPENDED

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

RECRUITING

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States

RECRUITING

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States

RECRUITING

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

RECRUITING

Rock Hill Radiation Therapy Center

Rock Hill, South Carolina, 29730, United States

RECRUITING

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

RECRUITING

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

RECRUITING

Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States

ACTIVE NOT RECRUITING

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

RECRUITING

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States

ACTIVE NOT RECRUITING

MD Anderson in The Woodlands

Conroe, Texas, 77384, United States

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

ACTIVE NOT RECRUITING

University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States

ACTIVE NOT RECRUITING

M D Anderson Cancer Center

Houston, Texas, 77030, United States

RECRUITING

MD Anderson West Houston

Houston, Texas, 77079, United States

RECRUITING

MD Anderson League City

League City, Texas, 77573, United States

RECRUITING

UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States

ACTIVE NOT RECRUITING

Covenant Medical Center-Lakeside

Lubbock, Texas, 79410, United States

ACTIVE NOT RECRUITING

MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States

RECRUITING

Intermountain Medical Center

Murray, Utah, 84107, United States

ACTIVE NOT RECRUITING

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States

ACTIVE NOT RECRUITING

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

RECRUITING

Saint George Regional Medical Center

St. George, Utah, 84770, United States

ACTIVE NOT RECRUITING

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States

RECRUITING

Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States

ACTIVE NOT RECRUITING

Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, 23666, United States

ACTIVE NOT RECRUITING

Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States

ACTIVE NOT RECRUITING

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

ACTIVE NOT RECRUITING

Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, 23454, United States

ACTIVE NOT RECRUITING

Saint Francis Hospital

Federal Way, Washington, 98003, United States

SUSPENDED

Tri-Cities Cancer Center

Kennewick, Washington, 99336, United States

SUSPENDED

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

RECRUITING

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, 98274, United States

RECRUITING

University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States

RECRUITING

Spokane Valley Cancer Center-Mayfair

Spokane, Washington, 99208, United States

SUSPENDED

Spokane Valley Cancer Center-Mission

Spokane, Washington, 99216, United States

SUSPENDED

Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, 98801, United States

RECRUITING

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

RECRUITING

Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States

RECRUITING

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States

RECRUITING

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

ACTIVE NOT RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States

ACTIVE NOT RECRUITING

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States

RECRUITING

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

ACTIVE NOT RECRUITING

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States

ACTIVE NOT RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

RECRUITING

Bay Area Medical Center

Marinette, Wisconsin, 54143, United States

ACTIVE NOT RECRUITING

Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States

ACTIVE NOT RECRUITING

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States

RECRUITING

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

ACTIVE NOT RECRUITING

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

RECRUITING

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154, United States

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States

RECRUITING

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States

ACTIVE NOT RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States

ACTIVE NOT RECRUITING

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States

RECRUITING

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

SUSPENDED

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada

SUSPENDED

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada

ACTIVE NOT RECRUITING

Chinese University of Hong Kong-Prince of Wales Hospital

Shatin, Hong Kong

ACTIVE NOT RECRUITING

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and Neck

Interventions

atezolizumab; Biopsy; Specimen Handling; Cetuximab; (225)Ac-DOTA-c(RGDyK); Cisplatin; 1,2-diaminocyclohexaneplatinum II citrate; Platinum; Docetaxel; Radiotherapy, Intensity-Modulated; Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Head and Neck Neoplasms; Neoplasms by Site

Intervention Hierarchy (Ancestors)

Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Investigative Techniques; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds; Metals, Heavy; Elements; Transition Elements; Metals; Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Diterpenes; Terpenes; Radiotherapy, Conformal; Radiotherapy, Computer-Assisted; Radiotherapy; Therapeutics; Spectrum Analysis; Chemistry Techniques, Analytical

Study Officials

• Paul M Harari

  NRG Oncology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2013
• First Posted: March 14, 2013
• Study Start: March 22, 2013
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: May 4, 2026

Record last verified: 2026-04

Locations

CA (3); HK (1); US (337)