NCT01707017

Brief Summary

The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults. As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
56

participants targeted

Target at P25-P50 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

October 2, 2012

Completed
13 days until next milestone

First Posted

Study publicly available on registry

October 15, 2012

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
Last Updated

February 20, 2013

Status Verified

November 1, 2011

Enrollment Period

11 months

First QC Date

October 2, 2012

Last Update Submit

February 19, 2013

Conditions

Effects of Strength Training in Older Adults

Outcome Measures

Primary Outcomes (1)

  • Change in force-velocity characteristics of knee extensors

    Baseline, 12weeks, 6 months

Other Outcomes (5)

  • Change in muscle volume

    Baseline, 12weeks, 6 months

  • Change in maximal strength (one repetition maximum)

    Baseline, 4weeks, 8weeks, 12weeks, 6 months

  • Change in motivation

    Baseline, every week for 12 weeks, 6 months

  • +2 more other outcomes

Study Arms (3)

High-load strength training

ACTIVE COMPARATOR
Other: Strength training

Low-load strength training

ACTIVE COMPARATOR
Other: Strength training

Low-load + moderate-load strength training

ACTIVE COMPARATOR
Other: Strength training

Interventions

Strength trainingOTHER
High-load strength trainingLow-load + moderate-load strength trainingLow-load strength training

Eligibility Criteria

Age60 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age 60 to 80 years

You may not qualify if:

  • Knee or hip prothesis
  • Systematic training
  • Cardiovascular disease
  • Acute lower back pain
  • Dementia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Kinesiology and Rehabilitation Sciences

Leuven, Leuven, 3001, Belgium

Location

Related Publications (2)

  • Van Roie E, Walker S, Van Driessche S, Baggen R, Coudyzer W, Bautmans I, Delecluse C. Training load does not affect detraining's effect on muscle volume, muscle strength and functional capacity among older adults. Exp Gerontol. 2017 Nov;98:30-37. doi: 10.1016/j.exger.2017.07.017. Epub 2017 Aug 1.

    PMID: 28778747DERIVED

  • Nuvagah Forti L, Van Roie E, Njemini R, Coudyzer W, Beyer I, Delecluse C, Bautmans I. High Versus Low Load Resistance Training: The Effect of 24 Weeks Detraining on Serum Brain Derived-Neurotrophic Factor (BDNF) in Older Adults. J Frailty Aging. 2017;6(1):53-58. doi: 10.14283/jfa.2017.2.

    PMID: 28244559DERIVED

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 2, 2012

First Posted

October 15, 2012

Study Start

January 1, 2012

Primary Completion

December 1, 2012

Last Updated

February 20, 2013

Record last verified: 2011-11

Locations

BE(1)